Advances in dermatology
Genotypic Analysis in Primary Cutaneous Lymphomas Using the Standardized Biomed-2 Polymerase Chain Reaction Protocols
Aplicación de los Protocolos de PCR Biomed-2 en el Análisis Genotípico de los Linfomas Cutáneos Primarios
F. Gallardoa,
, B. Bellosillob, S. Serranob, R.M. Pujola
Autor para correspondencia
FGallardo@imas.imim.es
Correspondence: Servicio de Dermatología, Hospital del Mar, IMAS, Passeig Marítim, 25-29, 08003 Barcelona, Spain.
Correspondence: Servicio de Dermatología, Hospital del Mar, IMAS, Passeig Marítim, 25-29, 08003 Barcelona, Spain.
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Pujol" "autores" => array:4 [ 0 => array:4 [ "nombre" => "F." "apellidos" => "Gallardo" "email" => array:1 [ 0 => "FGallardo@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "B." "apellidos" => "Bellosillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "S." "apellidos" => "Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "R.M." "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Servicio de Patología, Hospital del Mar, IMAS, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Laboratorio de Biología Molecular, Servicio de Patología, Hospital del Mar, IMAS, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital del Mar, IMAS, Passeig Marítim, 25-29, 08003 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aplicación de los Protocolos de PCR Biomed-2 en el Análisis Genotípico de los Linfomas Cutáneos Primarios" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-28" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84271" "palabras" => array:6 [ 0 => "cutaneous lymphoma" 1 => "gene rearrangement" 2 => "clonality" 3 => "polymerase chain reaction" 4 => "BIOMED-2" 5 => "GeneScan" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84272" "palabras" => array:6 [ 0 => "linfoma cutáneo" 1 => "reordenamiento genético" 2 => "clonalidad" 3 => "reacción en cadena de la polimerasa" 4 => "BIOMED-2" 5 => "GeneScan" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">The European Biomedicine and Health (BIOMED-2) Concerted Action Project BMH4-CT98-3936 has defined standardized protocols for polymerase chain reaction (PCR) amplification of different loci of the T-cell receptor (TCR) and immunoglobulin (Ig) genes with a view to achieving greater sensitivity and specificity in the assessment of clonality of lymphoid neoplasms. To assess T-cell clonality, analysis of TCRβ gene and TCRδ rearrangements (useful in cases of Tγδ+ cell neoplasms) is proposed alongside that of TCRγ. For analysis of B-cell clonality, along with the framework (FR) III segment of the IgH gene, other segments are studied (FRI, FRII) in addition to Igγ and Igκ genes or incomplete DJ rearrangements of the IgH gene and the κ deleting element. The results of the amplification are read using automatic reading systems (GeneScan) or using a heteroduplex system.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El proyecto europeo BIOMED-2 Concerted Action BMH4-CT98-3936 describe protocolos estandarizados de amplificación por reacción en cadena de la polimerasa (PCR) de los diferentes <span class="elsevierStyleItalic">loci</span> de los genes del receptor de la célula T (TCR) e inmunoglobulinas (Ig) con el objetivo de obtener una mayor sensibilidad y especificidad en el estudio de clonalidad de las neoplasias linfoides. En el estudio de clonalidad T, además del TCRγ se propone el estudio adicional de los reordenamientos del gen TCRβ y del <span class="elsevierStyleItalic">locus</span> TCRδ (útil en casos de neoplasias de células Tγδ+). En el estudio de clonalidad B, junto al segmento FRIII del gen IgH se diseña el estudio de otros segmentos (FRI, FRII), así como de los genes Igλ e Igκ o reordenamientos incompletos DJ del gen IgH y κde (<span class="elsevierStyleItalic">kappa deleting element</span>). La lectura de los resultados de la amplificación se realiza mediante sistemas automatizados de lectura (GeneScan) o mediante el sistema heterodúplex.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This study was partly funded by the FIS 03/394 grant from the Spanish Ministry of Health and Consumer Affairs.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:71 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 7 | 9 | 16 |
| 2024 Octubre | 63 | 39 | 102 |
| 2024 Septiembre | 56 | 26 | 82 |
| 2024 Agosto | 90 | 51 | 141 |
| 2024 Julio | 61 | 34 | 95 |
| 2024 Junio | 61 | 30 | 91 |
| 2024 Mayo | 51 | 41 | 92 |
| 2024 Abril | 51 | 38 | 89 |
| 2024 Marzo | 54 | 39 | 93 |
| 2024 Febrero | 59 | 37 | 96 |
| 2024 Enero | 53 | 49 | 102 |
| 2023 Diciembre | 50 | 24 | 74 |
| 2023 Noviembre | 62 | 42 | 104 |
| 2023 Octubre | 34 | 30 | 64 |
| 2023 Septiembre | 38 | 25 | 63 |
| 2023 Agosto | 27 | 22 | 49 |
| 2023 Julio | 46 | 85 | 131 |
| 2023 Junio | 44 | 25 | 69 |
| 2023 Mayo | 38 | 24 | 62 |
| 2023 Abril | 26 | 24 | 50 |
| 2023 Marzo | 27 | 28 | 55 |
| 2023 Febrero | 24 | 16 | 40 |
| 2023 Enero | 38 | 21 | 59 |
| 2022 Diciembre | 25 | 36 | 61 |
| 2022 Noviembre | 15 | 24 | 39 |
| 2022 Octubre | 16 | 19 | 35 |
| 2022 Septiembre | 17 | 49 | 66 |
| 2022 Agosto | 13 | 47 | 60 |
| 2022 Julio | 13 | 21 | 34 |
| 2022 Junio | 33 | 35 | 68 |
| 2022 Mayo | 53 | 81 | 134 |
| 2022 Abril | 53 | 58 | 111 |
| 2022 Marzo | 40 | 79 | 119 |
| 2022 Febrero | 32 | 41 | 73 |
| 2022 Enero | 42 | 36 | 78 |
| 2021 Diciembre | 20 | 45 | 65 |
| 2021 Noviembre | 32 | 51 | 83 |
| 2021 Octubre | 26 | 69 | 95 |
| 2021 Septiembre | 22 | 40 | 62 |
| 2021 Agosto | 58 | 40 | 98 |
| 2021 Julio | 19 | 26 | 45 |
| 2021 Junio | 32 | 20 | 52 |
| 2021 Mayo | 32 | 34 | 66 |
| 2021 Abril | 92 | 79 | 171 |
| 2021 Marzo | 104 | 43 | 147 |
| 2021 Febrero | 77 | 26 | 103 |
| 2021 Enero | 43 | 17 | 60 |
| 2020 Diciembre | 26 | 17 | 43 |
| 2020 Noviembre | 25 | 28 | 53 |
| 2020 Octubre | 17 | 24 | 41 |
| 2020 Septiembre | 43 | 21 | 64 |
| 2020 Agosto | 28 | 18 | 46 |
| 2020 Julio | 38 | 10 | 48 |
| 2020 Junio | 31 | 30 | 61 |
| 2020 Mayo | 39 | 30 | 69 |
| 2020 Abril | 31 | 21 | 52 |
| 2020 Marzo | 25 | 30 | 55 |
| 2020 Febrero | 2 | 13 | 15 |
| 2020 Enero | 0 | 13 | 13 |
| 2019 Diciembre | 0 | 17 | 17 |
| 2019 Noviembre | 0 | 4 | 4 |
| 2019 Octubre | 0 | 6 | 6 |
| 2019 Septiembre | 0 | 9 | 9 |
| 2019 Agosto | 0 | 5 | 5 |
| 2019 Julio | 0 | 19 | 19 |
| 2019 Junio | 1 | 17 | 18 |
| 2019 Mayo | 1 | 37 | 38 |
| 2019 Abril | 0 | 16 | 16 |
| 2019 Marzo | 0 | 14 | 14 |
| 2019 Febrero | 0 | 13 | 13 |
| 2019 Enero | 0 | 5 | 5 |
| 2018 Diciembre | 1 | 5 | 6 |
| 2018 Noviembre | 0 | 4 | 4 |
| 2018 Septiembre | 1 | 0 | 1 |
| 2018 Agosto | 0 | 6 | 6 |
| 2018 Julio | 0 | 8 | 8 |
| 2018 Junio | 0 | 32 | 32 |
| 2018 Mayo | 0 | 3 | 3 |
| 2018 Marzo | 1 | 2 | 3 |
| 2018 Febrero | 16 | 9 | 25 |
| 2018 Enero | 21 | 9 | 30 |
| 2017 Diciembre | 25 | 7 | 32 |
| 2017 Noviembre | 22 | 9 | 31 |
| 2017 Octubre | 24 | 12 | 36 |
| 2017 Septiembre | 16 | 12 | 28 |
| 2017 Agosto | 14 | 12 | 26 |
| 2017 Julio | 17 | 9 | 26 |
| 2017 Junio | 24 | 32 | 56 |
| 2017 Mayo | 22 | 21 | 43 |
| 2017 Abril | 35 | 15 | 50 |
| 2017 Marzo | 20 | 30 | 50 |
| 2017 Febrero | 16 | 7 | 23 |
| 2017 Enero | 8 | 6 | 14 |
| 2016 Diciembre | 26 | 15 | 41 |
| 2016 Noviembre | 28 | 15 | 43 |
| 2016 Octubre | 18 | 12 | 30 |
| 2016 Septiembre | 26 | 13 | 39 |
| 2016 Agosto | 24 | 9 | 33 |
| 2016 Julio | 19 | 5 | 24 |
| 2016 Junio | 9 | 8 | 17 |
| 2016 Mayo | 10 | 25 | 35 |
| 2016 Abril | 8 | 22 | 30 |
| 2016 Marzo | 3 | 6 | 9 |
| 2016 Febrero | 5 | 9 | 14 |
| 2016 Enero | 10 | 9 | 19 |
| 2015 Diciembre | 8 | 3 | 11 |
| 2015 Noviembre | 13 | 4 | 17 |
| 2015 Octubre | 11 | 3 | 14 |
| 2015 Septiembre | 7 | 6 | 13 |
| 2015 Agosto | 13 | 5 | 18 |
| 2015 Julio | 32 | 7 | 39 |
| 2015 Junio | 33 | 14 | 47 |
| 2015 Mayo | 78 | 18 | 96 |
| 2015 Abril | 47 | 19 | 66 |
| 2015 Marzo | 47 | 10 | 57 |
| 2015 Febrero | 19 | 19 | 38 |
| 2015 Enero | 24 | 19 | 43 |
| 2014 Diciembre | 30 | 11 | 41 |
| 2014 Noviembre | 37 | 17 | 54 |
| 2014 Octubre | 24 | 16 | 40 |
| 2014 Septiembre | 28 | 10 | 38 |
| 2014 Agosto | 33 | 18 | 51 |
| 2014 Julio | 36 | 18 | 54 |
| 2014 Junio | 35 | 18 | 53 |
| 2014 Mayo | 48 | 13 | 61 |
| 2014 Abril | 27 | 17 | 44 |
| 2014 Marzo | 38 | 16 | 54 |
| 2014 Febrero | 16 | 15 | 31 |
| 2014 Enero | 32 | 22 | 54 |
| 2013 Diciembre | 32 | 15 | 47 |
| 2013 Noviembre | 32 | 37 | 69 |
| 2013 Octubre | 21 | 43 | 64 |
| 2013 Septiembre | 30 | 19 | 49 |
| 2013 Agosto | 25 | 26 | 51 |
| 2013 Julio | 35 | 34 | 69 |
| 2013 Junio | 27 | 24 | 51 |
| 2013 Mayo | 30 | 22 | 52 |
| 2013 Abril | 21 | 40 | 61 |
| 2013 Marzo | 33 | 26 | 59 |
| 2013 Febrero | 35 | 21 | 56 |
| 2013 Enero | 18 | 5 | 23 |
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