Case report
Autologous Hematopoietic Stem Cell Transplantation Followed by Oral Bexarotene in a Patient With Advanced Mycosis Fungoides
Trasplante Autólogo de Progenitores Hematopoyéticos Seguido de Bexaroteno Oral en Paciente Con Micosis Fungoide Avanzada
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"apellidos" => "Pérez-Barrio" "email" => array:1 [ 0 => "spbarrio@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Izu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "J.C." "apellidos" => "García-Ruiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "Acebo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Z." "apellidos" => "Martínez de Lagrán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "J.L." "apellidos" => "Díaz-Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital de Cruces. Baracaldo, Vizcaya, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Hematología, Hospital de Cruces. Baracaldo, Vizcaya, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Hospital de Cruces, Servicio de Dermatología, Polígono de Cruces, s/n, 48903 Baracaldo, Vizcaya, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Trasplante Autólogo de Progenitores Hematopoyéticos Seguido de Bexaroteno Oral en Paciente Con Micosis Fungoide Avanzada" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84258" "palabras" => array:4 [ 0 => "autologous hematopoietic stem cell transplant" 1 => "bexarotene" 2 => "cutaneous T-cell lymphoma" 3 => "mycosis fungoides" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84257" "palabras" => array:4 [ 0 => "trasplante autólogo de precursores hematopoyéticos" 1 => "bexaroteno" 2 => "linfoma cutáneo de células T" 3 => "micosis fungoide" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">We describe the case of a 17-year-old patient with rapidly progressing and aggressive mycosis fungoides, with multiple cutaneous tumors and large cell transformation. She was initially treated with 3 cycles of high-dose chemotherapy with mega-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) without response, leading to the decision to undertake autologous hematopoietic stem cell transplantation. Partial remission of the disease was achieved with this treatment and subsequent introduction of oral bexarotene led to complete remission, which has been maintained for more than 3 years with good tolerance of oral therapy. We discuss the advantages and disadvantages of autologous hematopoietic stem cell transplantation and the use of oral bexarotene.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Exponemos el caso de una paciente de 17 años que presentó una micosis fungoide de evolución rápida y agresiva, con múltiples tumores cutáneos y transformación fenotípica celular a linfoma de células grandes. Fue tratada inicialmente con 3 ciclos de quimioterapia en dosis altas (MEGA-CHOP) sin respuesta, por lo que se decidió realizar un trasplante autólogo de progenitores hematopoyéticos. Este tratamiento consiguió una remisión parcial de la enfermedad, y con la posterior introducción del bexaroteno oral se logró la remisión completa, que se ha mantenido durante más de 3 años con muy buena tolerancia al bexaroteno oral.</p><p class="elsevierStyleSimplePara elsevierViewall">Analizamos las ventajas y desventajas de la utilización del trasplante autólogo de progenitores hematopoyéticos y del uso de bexaroteno oral.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "British Association of Dermatologists; U.K. Cutaneous Lymphoma Group. 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| 2021 Julio | 25 | 29 | 54 |
| 2021 Junio | 33 | 24 | 57 |
| 2021 Mayo | 28 | 35 | 63 |
| 2021 Abril | 44 | 53 | 97 |
| 2021 Marzo | 72 | 24 | 96 |
| 2021 Febrero | 54 | 25 | 79 |
| 2021 Enero | 41 | 14 | 55 |
| 2020 Diciembre | 23 | 18 | 41 |
| 2020 Noviembre | 15 | 13 | 28 |
| 2020 Octubre | 16 | 6 | 22 |
| 2020 Septiembre | 6 | 9 | 15 |
| 2020 Agosto | 30 | 30 | 60 |
| 2020 Julio | 30 | 11 | 41 |
| 2020 Junio | 20 | 31 | 51 |
| 2020 Mayo | 25 | 20 | 45 |
| 2020 Abril | 26 | 15 | 41 |
| 2020 Marzo | 22 | 19 | 41 |
| 2020 Febrero | 2 | 2 | 4 |
| 2020 Enero | 0 | 4 | 4 |
| 2019 Diciembre | 0 | 10 | 10 |
| 2019 Noviembre | 0 | 2 | 2 |
| 2019 Octubre | 0 | 1 | 1 |
| 2019 Septiembre | 0 | 1 | 1 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 7 | 7 |
| 2019 Junio | 0 | 2 | 2 |
| 2019 Mayo | 1 | 47 | 48 |
| 2019 Marzo | 0 | 2 | 2 |
| 2019 Febrero | 0 | 4 | 4 |
| 2019 Enero | 1 | 0 | 1 |
| 2018 Septiembre | 1 | 0 | 1 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 1 | 0 | 1 |
| 2018 Febrero | 12 | 4 | 16 |
| 2018 Enero | 13 | 10 | 23 |
| 2017 Diciembre | 13 | 8 | 21 |
| 2017 Noviembre | 11 | 5 | 16 |
| 2017 Octubre | 10 | 8 | 18 |
| 2017 Septiembre | 15 | 4 | 19 |
| 2017 Agosto | 14 | 8 | 22 |
| 2017 Julio | 13 | 6 | 19 |
| 2017 Junio | 28 | 23 | 51 |
| 2017 Mayo | 23 | 4 | 27 |
| 2017 Abril | 25 | 3 | 28 |
| 2017 Marzo | 27 | 9 | 36 |
| 2017 Febrero | 16 | 6 | 22 |
| 2017 Enero | 9 | 4 | 13 |
| 2016 Diciembre | 23 | 11 | 34 |
| 2016 Noviembre | 21 | 7 | 28 |
| 2016 Octubre | 15 | 19 | 34 |
| 2016 Septiembre | 18 | 10 | 28 |
| 2016 Agosto | 25 | 8 | 33 |
| 2016 Julio | 22 | 8 | 30 |
| 2016 Junio | 16 | 8 | 24 |
| 2016 Mayo | 8 | 7 | 15 |
| 2016 Abril | 10 | 17 | 27 |
| 2016 Marzo | 11 | 9 | 20 |
| 2016 Febrero | 14 | 9 | 23 |
| 2016 Enero | 15 | 4 | 19 |
| 2015 Diciembre | 9 | 1 | 10 |
| 2015 Noviembre | 9 | 4 | 13 |
| 2015 Octubre | 7 | 3 | 10 |
| 2015 Septiembre | 12 | 3 | 15 |
| 2015 Agosto | 18 | 4 | 22 |
| 2015 Julio | 27 | 4 | 31 |
| 2015 Junio | 27 | 4 | 31 |
| 2015 Mayo | 65 | 7 | 72 |
| 2015 Abril | 35 | 9 | 44 |
| 2015 Marzo | 22 | 8 | 30 |
| 2015 Febrero | 37 | 9 | 46 |
| 2015 Enero | 24 | 6 | 30 |
| 2014 Diciembre | 19 | 6 | 25 |
| 2014 Noviembre | 18 | 11 | 29 |
| 2014 Octubre | 31 | 10 | 41 |
| 2014 Septiembre | 32 | 8 | 40 |
| 2014 Agosto | 34 | 8 | 42 |
| 2014 Julio | 29 | 18 | 47 |
| 2014 Junio | 36 | 19 | 55 |
| 2014 Mayo | 32 | 17 | 49 |
| 2014 Abril | 23 | 6 | 29 |
| 2014 Marzo | 47 | 16 | 63 |
| 2014 Febrero | 28 | 14 | 42 |
| 2014 Enero | 32 | 20 | 52 |
| 2013 Diciembre | 40 | 14 | 54 |
| 2013 Noviembre | 34 | 17 | 51 |
| 2013 Octubre | 30 | 16 | 46 |
| 2013 Septiembre | 28 | 19 | 47 |
| 2013 Agosto | 24 | 18 | 42 |
| 2013 Julio | 33 | 23 | 56 |
| 2013 Junio | 18 | 21 | 39 |
| 2013 Mayo | 16 | 17 | 33 |
| 2013 Abril | 15 | 14 | 29 |
| 2013 Marzo | 27 | 26 | 53 |
| 2013 Febrero | 29 | 10 | 39 |
| 2013 Enero | 18 | 4 | 22 |
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