Original articles
Clinical Follow-up and Presence of Visceral Tumors in 12 Patients With Sebaceous Gland Tumors
Tumores Sebáceos: Seguimiento Clínico y Presencia de Neoplasias en Una Serie de 12 Pacientes
Leído
5602
Vecesse ha leído el artículo
2398
Total PDF
3204
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S157821900870310X" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70310-X" "estado" => "S300" "fechaPublicacion" => "2008-09-01" "aid" => "70310" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:532-9" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2261 "formatos" => array:3 [ "EPUB" => 37 "HTML" => 1360 "PDF" => 864 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219008703111" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70311-1" "estado" => "S300" "fechaPublicacion" => "2008-09-01" "aid" => "70311" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:540-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2070 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 1318 "PDF" => 717 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original article</span>" "titulo" => "Clinical Experience With Etanercept in the Treatment of Psoriasis" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "540" "paginaFinal" => "545" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Etanercept en la Psoriasis. Experiencia Clínica" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Martín, J.L. Sánchez-Carazo, A. Pérez-Ferriols, C. Laguna, V. Oliver, V. Alegre" "autores" => array:6 [ 0 => array:2 [ "nombre" => "B." "apellidos" => "Martín" ] 1 => array:2 [ "nombre" => "J.L." "apellidos" => "Sánchez-Carazo" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Pérez-Ferriols" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Laguna" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Oliver" ] 5 => array:2 [ "nombre" => "V." "apellidos" => "Alegre" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703111?idApp=UINPBA000044" "url" => "/15782190/0000009900000007/v1_201304241437/S1578219008703111/v1_201304241437/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219008703093" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70309-3" "estado" => "S300" "fechaPublicacion" => "2008-09-01" "aid" => "70309" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:528-31" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2479 "formatos" => array:3 [ "EPUB" => 32 "HTML" => 1321 "PDF" => 1126 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Advances in dermatology</span>" "titulo" => "Clinical Applications of Reflectance Confocal Microscopy in the Management of Cutaneous Tumors" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "528" "paginaFinal" => "531" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Aplicaciones Clínicas de la Microscopía Confocal de Reflectancia en el Manejo de Los Tumores Cutáneos" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "S. González" "autores" => array:1 [ 0 => array:2 [ "nombre" => "S." "apellidos" => "González" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008703093?idApp=UINPBA000044" "url" => "/15782190/0000009900000007/v1_201304241437/S1578219008703093/v1_201304241437/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Clinical Follow-up and Presence of Visceral Tumors in 12 Patients With Sebaceous Gland Tumors" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "532" "paginaFinal" => "539" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "P. Mercader, M.L. García-Melgares, E. Roche, J.L. Sánchez-Carazo, V. Alegre-de Miquel" "autores" => array:5 [ 0 => array:4 [ "nombre" => "P." "apellidos" => "Mercader" "email" => array:1 [ 0 => "pedromercader@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "M.L." "apellidos" => "García-Melgares" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "E." "apellidos" => "Roche" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "J.L." "apellidos" => "Sánchez-Carazo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Alegre-de Miquel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Morales Meseguer, Murcia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Morales Meseguer, Avda/Marqués de los Vélez, s/n., 30008 Murcia, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tumores Sebáceos: Seguimiento Clínico y Presencia de Neoplasias en Una Serie de 12 Pacientes" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2008-02-27" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84247" "palabras" => array:3 [ 0 => "Muir-Torre syndrome" 1 => "Lynch syndrome" 2 => "sebaceous gland tumors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84248" "palabras" => array:3 [ 0 => "síndrome de Muir-Torre" 1 => "síndrome de Lynch" 2 => "neoplasias de la glándula sebácea" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Sebaceous gland tumors are a rare type of neoplasm. In some cases they have been associated with visceral tumors in patients with Muir-Torre syndrome, a hereditary form of nonpolyposis colorectal cancer. The aim of this study was to review the diagnosis and follow-up of a series of patients with sebaceous gland tumors to assess how many met the criteria for Muir-Torre syndrome.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">A search was performed of records from 1990 to 2005 in the database of the Department of Dermatology of the Consorcio Hospital General Universitario de Valencia in Valencia, Spain, to identify patients with sebaceous gland tumors. The biopsy material was reviewed to confirm the diagnosis. We also searched the patient histories for information suggestive of a diagnosis of Muir-Torre syndrome; when the histories were incomplete, we contacted the patients by telephone.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">We identified 20 patients diagnosed with sebaceous gland tumors, but after reviewing the biopsy material diagnosis was only confirmed in 12. Two patients belonged to a family with a history of visceral tumors that met the clinical criteria for hereditary nonpolyposis colorectal cancer syndrome. Follow-up was not uniform in all patients and not all underwent the same tests.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">It is essential to rule out the presence of Muir-Torre syndrome in patients with sebaceous gland tumors. The use of new techniques such as immunohistochemistry or detection of microsatellite instability may help to identify families at increased risk of Muir-Torre syndrome.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Los tumores sebáceos son un grupo infrecuente de neoplasias. En algunos casos se han relacionado con neoplasias viscerales en pacientes con el síndrome de Muir-Torre; una variante clínica del síndrome de cáncer de colon hereditario no polipósico. El objetivo de este trabajo es revisar el diagnóstico y el seguimiento de una serie de pacientes con tumores sebáceos para comprobar cuántos de ellos cumplían criterios de síndrome de Muir-Torre.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se realizó una búsqueda en la base de datos del Servicio de Dermatología del Consorcio Hospital General Universitario de Valencia entre 1990 y 2005, buscando pacientes con tumores sebáceos. Se revisaron las biopsias para confirmar el diagnóstico. También buscamos datos en las historias clínicas que sugiriesen un diagnóstico de síndrome de Muir-Torre, cuando las historias estaban incompletas nos pusimos en contacto por teléfono con los pacientes.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Encontramos 20 pacientes diagnosticados de tumores sebáceos, pero después de revisar la biopsia sólo confirmamos este diagnóstico en 12 pacientes. Dos pacientes pertenecían a una familia con antecedentes de neoplasias viscerales, que cumplía los criterios clínicos de síndrome de cáncer de colon hereditario no polipósico. No hubo un seguimiento uniforme de los pacientes ni se realizaron las mismas pruebas en todos ellos.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Es fundamental descartar la presencia de un síndrome de Muir-Torre en pacientes con tumores sebáceos. El uso de nuevas técnicas como la detección de la inestabilidad de microsatélites o la inmunohistoquímica pueden ayudar a detectar a las familias que tienen un mayor riesgo de padecer el síndrome de Muir-Torre.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:27 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clasificación de las proliferaciones con diferenciación sebácea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Requena" 1 => "L. Requena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neoplasias anexiales cutáneas" "paginaInicial" => "365" "paginaFinal" => "369" "serieFecha" => "2004" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple primary carcinoma of the colon, duodenum and larynx associated with keratoacanthomata of the face" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E.G. Muir" 1 => "A.J.Y. Bell" 2 => "K.A. Barlow" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Surg" "fecha" => "1967" "volumen" => "54" "paginaInicial" => "191" "paginaFinal" => "195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6020987" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multiple sebaceous tumours" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D. Torre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1968" "volumen" => "98" "paginaInicial" => "549" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5684233" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Muir-Torre syndrome: a 25 years retrospect" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.A. Schwartz" 1 => "D.P. Torre" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1995" "volumen" => "33" "paginaInicial" => "90" "paginaFinal" => "104" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7601953" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "National Center for Biotechnology Information. OMIM: online Mendelian inheritance in man. Disponible en: <a class="elsevierStyleInterRef" href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id">www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id</a> = 158320" ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of Muir-Torre syndrome among patients with sebaceous tumors and keratoacanthomas. Role of clinical features, microsatellite instability and immunohistochemistry" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Ponti" 1 => "L. Losi" 2 => "C. Di Gregorio" 3 => "L. Roncucci" 4 => "M. Pedroni" 5 => "A. Scarselli" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/cncr.20873" "Revista" => array:6 [ "tituloSerie" => "Cancer" "fecha" => "2005" "volumen" => "103" "paginaInicial" => "1018" "paginaFinal" => "1025" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15662714" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sebaceous gland tumors and systemic disease: a clinicopathologic analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.C. Finan" 1 => "S.M. Connolly" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Medicine" "fecha" => "1984" "volumen" => "63" "paginaInicial" => "232" "paginaFinal" => "242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6738344" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The cancer family syndrome: rare cutaneous phenotypic linkage of Torre's syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.T. Lynch" 1 => "P.M. Lynch" 2 => "J. Pester" 3 => "R.M. Fusaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "1981" "volumen" => "141" "paginaInicial" => "607" "paginaFinal" => "611" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7224741" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Is the mismatch repair deficiency type of Muir-Torre syndrome confined to mutations in the hMSH2 gene?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Kruse" 1 => "C. Lamberti" 2 => "Y. Wang" 3 => "C. Ruelfs" 4 => "A. Bruns" 5 => "C. Esche" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hum Genet" "fecha" => "1996" "volumen" => "59" "paginaInicial" => "736" "paginaFinal" => "739" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The genetics basis of Muir-Torre syndrome includes the hMLH1 locus" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Bapat" 1 => "L. Xia" 2 => "L. Madlensky" 3 => "A. Mitri" 4 => "P. Tonin" 5 => "S.A. Narod" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "1996" "volumen" => "98" "paginaInicial" => "747" "paginaFinal" => "750" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Muir-Torre syndrome in kindreds with hereditary nonpolyposis colorectal cancer (Lynch syndrome): a classic obligation in preventive medicine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.T. Lynch" 1 => "R.M. Fusaro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "797" "paginaFinal" => "799" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10534651" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.F. Vasen" 1 => "J.P. Mecklin" 2 => "P.M. Khan" 3 => "H.T. Lynch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dis Colon Rectum" "fecha" => "1991" "volumen" => "34" "paginaInicial" => "424" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2022152" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.F. Vasen" 1 => "P. Watson" 2 => "J.P. Mecklin" 3 => "H.T. Lynch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "1999" "volumen" => "116" "paginaInicial" => "1453" "paginaFinal" => "1456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10348829" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch Syndrome) and microsatellite instability" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Umar" 1 => "C.R. Boland" 2 => "J.P. Terdiman" 3 => "D. Syngal" 4 => "A. de la Chapelle" 5 => "J. Rüschoff" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2004" "volumen" => "96" "paginaInicial" => "261" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14970275" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Criterios histopatológicos de diferenciación sebácea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Requena" 1 => "L. Requena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neoplasias anexiales cutáneas" "paginaInicial" => "359" "paginaFinal" => "363" "serieFecha" => "2004" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinoma basocelular de diferenciación sebácea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. Requena" 1 => "C. Requena" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Neoplasias anexiales cutáneas" "paginaInicial" => "459" "paginaFinal" => "465" "serieFecha" => "2004" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sebomatricoma: a unifying term that encompasses all benign neoplams with sebaceous differentiation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Sánchez Yus" 1 => "L. Requena" 2 => "P. Simón" 3 => "E. del Río" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Dermatopathol" "fecha" => "1995" "volumen" => "17" "paginaInicial" => "213" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8599428" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Proliferaciones con diferenciación sebácea. II: Hiperplasias y neoplasias" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R.S. Simón" 1 => "E. Eusebio" 2 => "A. Álvarez Viéitez" 3 => "E. Sánchez Yus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "1998" "volumen" => "89" "paginaInicial" => "651" "paginaFinal" => "664" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Muir-Torre syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "G. Ponti" 1 => "M. Ponz de León" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1470-2045(05)70465-4" "Revista" => array:6 [ "tituloSerie" => "Lancet Oncol" "fecha" => "2005" "volumen" => "6" "paginaInicial" => "980" "paginaFinal" => "987" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16321766" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hereditary non-polyposis colorectal cancer: the rise and fall of a confusing term" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.R. Jass" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2006" "volumen" => "21" "paginaInicial" => "4943" "paginaFinal" => "4950" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of DNA mismatch repair proteins in skin tumors from patients with Muir-Torre syndrome and MSH2 or MLH1 germline mutations: establishment of immunohistochemical analysis as a screening test" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Mathiak" 1 => "A. Rutten" 2 => "E. Mangold" 3 => "H.P. Fischer" 4 => "T. Ruzicka" 5 => "W. Friedl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Surg Pathol" "fecha" => "2002" "volumen" => "26" "paginaInicial" => "338" "paginaFinal" => "343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11859205" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genotype-phenotype correlation in HNPCC: strong predominance of MSH2 mutations in 41 patients with Muir-Torre syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Mangold" 1 => "C. Pagenstecher" 2 => "M. Leister" 3 => "M. Mathiak" 4 => "A. Rutten" 5 => "W. Friedl" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Med Genet" "fecha" => "2004" "volumen" => "41" "paginaInicial" => "567" "paginaFinal" => "572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15235030" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "MSH6 mutation in Muir—Torre syndrome: could this be a rare finding?" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Mangold" 1 => "N. Rahner" 2 => "N. Friedrichs" 3 => "R. Buettner" 4 => "C. Pagenstecher" 5 => "S. Aretz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07607.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "158" "paginaFinal" => "162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17199584" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Muir-Torre syndrome: case report of a patient with concurrent jejunal and ureteral cancer and a review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Akthar" 1 => "K.K. Oza" 2 => "S.A. Khan" 3 => "J. Wrigth" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "681" "paginaFinal" => "686" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10534628" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A century of progress in hereditary nonpolyposis colorectal cancer (Lynch syndrome)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.G. Thorson" 1 => "J.A. Knezetic" 2 => "H.T. Lynch" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dis Colon Rectum" "fecha" => "1999" "volumen" => "42" "paginaInicial" => "1" "paginaFinal" => "9" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10211513" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of sebaceous gland tumors and internal malignancy: the Muir-Torre syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.R. Cohen" 1 => "S.R. Kohn" 2 => "R. Kurzrock" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Med" "fecha" => "1991" "volumen" => "90" "paginaInicial" => "606" "paginaFinal" => "613" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2029018" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A Muir-Torre syndrome family" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "H.J. Serleth" 1 => "W.A. Kisken" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am Surg" "fecha" => "1998" "volumen" => "64" "paginaInicial" => "365" "paginaFinal" => "369" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9544152" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000007/v1_201304241437/S157821900870310X/v1_201304241437/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000007/v1_201304241437/S157821900870310X/v1_201304241437/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157821900870310X?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 8 | 5 | 13 |
| 2024 Octubre | 62 | 57 | 119 |
| 2024 Septiembre | 59 | 33 | 92 |
| 2024 Agosto | 83 | 66 | 149 |
| 2024 Julio | 52 | 35 | 87 |
| 2024 Junio | 56 | 28 | 84 |
| 2024 Mayo | 48 | 23 | 71 |
| 2024 Abril | 54 | 31 | 85 |
| 2024 Marzo | 53 | 27 | 80 |
| 2024 Febrero | 47 | 32 | 79 |
| 2024 Enero | 46 | 43 | 89 |
| 2023 Diciembre | 47 | 26 | 73 |
| 2023 Noviembre | 49 | 32 | 81 |
| 2023 Octubre | 33 | 22 | 55 |
| 2023 Septiembre | 39 | 21 | 60 |
| 2023 Agosto | 32 | 22 | 54 |
| 2023 Julio | 35 | 39 | 74 |
| 2023 Junio | 49 | 24 | 73 |
| 2023 Mayo | 29 | 15 | 44 |
| 2023 Abril | 33 | 17 | 50 |
| 2023 Marzo | 23 | 15 | 38 |
| 2023 Febrero | 29 | 17 | 46 |
| 2023 Enero | 24 | 18 | 42 |
| 2022 Diciembre | 32 | 25 | 57 |
| 2022 Noviembre | 9 | 30 | 39 |
| 2022 Octubre | 9 | 21 | 30 |
| 2022 Septiembre | 17 | 43 | 60 |
| 2022 Agosto | 12 | 33 | 45 |
| 2022 Julio | 11 | 27 | 38 |
| 2022 Junio | 13 | 24 | 37 |
| 2022 Mayo | 24 | 35 | 59 |
| 2022 Abril | 23 | 29 | 52 |
| 2022 Marzo | 38 | 50 | 88 |
| 2022 Febrero | 17 | 31 | 48 |
| 2022 Enero | 20 | 38 | 58 |
| 2021 Diciembre | 22 | 45 | 67 |
| 2021 Noviembre | 28 | 35 | 63 |
| 2021 Octubre | 77 | 44 | 121 |
| 2021 Septiembre | 33 | 35 | 68 |
| 2021 Agosto | 17 | 18 | 35 |
| 2021 Julio | 16 | 23 | 39 |
| 2021 Junio | 17 | 25 | 42 |
| 2021 Mayo | 19 | 33 | 52 |
| 2021 Abril | 37 | 40 | 77 |
| 2021 Marzo | 42 | 25 | 67 |
| 2021 Febrero | 45 | 15 | 60 |
| 2021 Enero | 24 | 15 | 39 |
| 2020 Diciembre | 28 | 8 | 36 |
| 2020 Noviembre | 25 | 13 | 38 |
| 2020 Octubre | 28 | 5 | 33 |
| 2020 Septiembre | 41 | 16 | 57 |
| 2020 Agosto | 20 | 17 | 37 |
| 2020 Julio | 19 | 14 | 33 |
| 2020 Junio | 20 | 19 | 39 |
| 2020 Mayo | 21 | 23 | 44 |
| 2020 Abril | 32 | 24 | 56 |
| 2020 Marzo | 17 | 8 | 25 |
| 2020 Febrero | 1 | 1 | 2 |
| 2020 Enero | 0 | 3 | 3 |
| 2019 Diciembre | 0 | 9 | 9 |
| 2019 Noviembre | 0 | 2 | 2 |
| 2019 Octubre | 0 | 3 | 3 |
| 2019 Septiembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 3 | 3 |
| 2019 Julio | 0 | 5 | 5 |
| 2019 Junio | 0 | 3 | 3 |
| 2019 Mayo | 0 | 51 | 51 |
| 2019 Abril | 0 | 17 | 17 |
| 2019 Marzo | 0 | 34 | 34 |
| 2019 Febrero | 0 | 1 | 1 |
| 2018 Septiembre | 0 | 1 | 1 |
| 2018 Febrero | 11 | 8 | 19 |
| 2018 Enero | 14 | 10 | 24 |
| 2017 Diciembre | 12 | 4 | 16 |
| 2017 Noviembre | 16 | 6 | 22 |
| 2017 Octubre | 12 | 5 | 17 |
| 2017 Septiembre | 16 | 2 | 18 |
| 2017 Agosto | 19 | 16 | 35 |
| 2017 Julio | 13 | 9 | 22 |
| 2017 Junio | 18 | 12 | 30 |
| 2017 Mayo | 17 | 8 | 25 |
| 2017 Abril | 24 | 18 | 42 |
| 2017 Marzo | 18 | 25 | 43 |
| 2017 Febrero | 13 | 10 | 23 |
| 2017 Enero | 8 | 5 | 13 |
| 2016 Diciembre | 24 | 18 | 42 |
| 2016 Noviembre | 30 | 14 | 44 |
| 2016 Octubre | 29 | 16 | 45 |
| 2016 Septiembre | 27 | 8 | 35 |
| 2016 Agosto | 35 | 5 | 40 |
| 2016 Julio | 20 | 5 | 25 |
| 2016 Junio | 13 | 7 | 20 |
| 2016 Mayo | 6 | 5 | 11 |
| 2016 Abril | 6 | 20 | 26 |
| 2016 Marzo | 6 | 11 | 17 |
| 2016 Febrero | 11 | 12 | 23 |
| 2016 Enero | 9 | 12 | 21 |
| 2015 Diciembre | 6 | 1 | 7 |
| 2015 Noviembre | 12 | 12 | 24 |
| 2015 Octubre | 14 | 16 | 30 |
| 2015 Septiembre | 5 | 4 | 9 |
| 2015 Agosto | 11 | 3 | 14 |
| 2015 Julio | 27 | 7 | 34 |
| 2015 Junio | 26 | 4 | 30 |
| 2015 Mayo | 64 | 6 | 70 |
| 2015 Abril | 27 | 11 | 38 |
| 2015 Marzo | 24 | 4 | 28 |
| 2015 Febrero | 26 | 5 | 31 |
| 2015 Enero | 10 | 4 | 14 |
| 2014 Diciembre | 10 | 3 | 13 |
| 2014 Noviembre | 20 | 10 | 30 |
| 2014 Octubre | 23 | 12 | 35 |
| 2014 Septiembre | 22 | 8 | 30 |
| 2014 Agosto | 28 | 9 | 37 |
| 2014 Julio | 33 | 20 | 53 |
| 2014 Junio | 38 | 11 | 49 |
| 2014 Mayo | 26 | 12 | 38 |
| 2014 Abril | 31 | 10 | 41 |
| 2014 Marzo | 41 | 13 | 54 |
| 2014 Febrero | 34 | 18 | 52 |
| 2014 Enero | 31 | 10 | 41 |
| 2013 Diciembre | 38 | 16 | 54 |
| 2013 Noviembre | 43 | 22 | 65 |
| 2013 Octubre | 30 | 15 | 45 |
| 2013 Septiembre | 24 | 32 | 56 |
| 2013 Agosto | 23 | 34 | 57 |
| 2013 Julio | 34 | 28 | 62 |
| 2013 Junio | 24 | 32 | 56 |
| 2013 Mayo | 30 | 19 | 49 |
| 2013 Abril | 28 | 14 | 42 |
| 2013 Marzo | 25 | 18 | 43 |
| 2013 Febrero | 26 | 11 | 37 |
| 2013 Enero | 19 | 4 | 23 |
Mostrar todo
