Case reports
Exacerbation of Skin Lesions During Fever in a Patient With Chronic Infantile Neurologic Cutaneous Articular Syndrome
Síndrome Cinca: Presentación de un Caso Con Exacerbación Febril de Sus Lesiones Cutáneas
S. Aboín-Gonzáleza,
, I. Aldanondo-Fernández de la Moraa, C.R. García-Acebesa, R. Carrillo-Gijónb, A. Harto-Castañoa, P. Jaén-Olasoloa
Autor para correspondencia
asonsoles@hotmail.com
Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal Universidad de Alcalá de Henares, Carretera de Colmenar Viejo, km 9,400, 28034 Madrid, Spain.
Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal Universidad de Alcalá de Henares, Carretera de Colmenar Viejo, km 9,400, 28034 Madrid, Spain.
Leído
6120
Vecesse ha leído el artículo
2625
Total PDF
3495
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S1578219008702944" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70294-4" "estado" => "S300" "fechaPublicacion" => "2008-08-01" "aid" => "70294" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "copyrightAnyo" => "2008" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2008;99:481-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2515 "formatos" => array:3 [ "EPUB" => 34 "HTML" => 1528 "PDF" => 953 ] ] "itemSiguiente" => array:18 [ "pii" => "S1578219008702956" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70295-6" "estado" => "S300" "fechaPublicacion" => "2008-08-01" "aid" => "70295" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2008;99:485-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2019 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 1358 "PDF" => 626 ] ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Cases for diagnosis</span>" "titulo" => "Nodules on the Legs" "tienePdf" => "en" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "485" "paginaFinal" => "486" ] ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "I. Cervigón, M. Mollejo, D. García-Almagro" "autores" => array:3 [ 0 => array:2 [ "nombre" => "I." "apellidos" => "Cervigón" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Mollejo" ] 2 => array:2 [ "nombre" => "D." "apellidos" => "García-Almagro" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702956?idApp=UINPBA000044" "url" => "/15782190/0000009900000006/v1_201304241435/S1578219008702956/v1_201304241435/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219008702932" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70293-2" "estado" => "S300" "fechaPublicacion" => "2008-08-01" "aid" => "70293" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2008;99:477-80" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 2517 "formatos" => array:3 [ "EPUB" => 35 "HTML" => 1472 "PDF" => 1010 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Pyoderma Gangrenosum Following Cesarean Delivery" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "477" "paginaFinal" => "480" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Pioderma Gangrenoso Después del Parto por Cesárea" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "C. Sanz-Muñoz, C. Martínez-Morán, A. Miranda-Romero" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Sanz-Muñoz" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Martínez-Morán" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Miranda-Romero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702932?idApp=UINPBA000044" "url" => "/15782190/0000009900000006/v1_201304241435/S1578219008702932/v1_201304241435/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case reports</span>" "titulo" => "Exacerbation of Skin Lesions During Fever in a Patient With Chronic Infantile Neurologic Cutaneous Articular Syndrome" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "481" "paginaFinal" => "484" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "S. Aboín-González, I. Aldanondo-Fernández de la Mora, C.R. García-Acebes, R. Carrillo-Gijón, A. Harto-Castaño, P. Jaén-Olasolo" "autores" => array:6 [ 0 => array:4 [ "nombre" => "S." "apellidos" => "Aboín-González" "email" => array:1 [ 0 => "asonsoles@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "I." "apellidos" => "Aldanondo-Fernández de la Mora" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "C.R." "apellidos" => "García-Acebes" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "R." "apellidos" => "Carrillo-Gijón" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "A." "apellidos" => "Harto-Castaño" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "P." "apellidos" => "Jaén-Olasolo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Ramón y Cajal, Universidad de Alcalá de Henares, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital Ramón y Cajal Universidad de Alcalá de Henares, Carretera de Colmenar Viejo, km 9,400, 28034 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Síndrome Cinca: Presentación de un Caso Con Exacerbación Febril de Sus Lesiones Cutáneas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-12-12" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84233" "palabras" => array:4 [ 0 => "chronic infantile neurologic cutaneous and articular syndrome" 1 => "neonatal onset multi-inflammatory disease" 2 => "neutrophilic dermatitis" 3 => "cryopyrin" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84234" "palabras" => array:4 [ 0 => "CINCA (<span class="elsevierStyleItalic">Chronic Infantile Neurologic Cutaneous Articular Syndrome</span>)" 1 => "NOMID (<span class="elsevierStyleItalic">Neonatal Onset Multi-Inflammatory Disease</span>)" 2 => "dermatitis neutrofílica" 3 => "criopirina" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Chronic infantile neurologic cutaneous articular (CINCA) syndrome is a serious chronic systemic inflammatory disease that presents at a young age and that is characterized by skin, joint, and central nervous system disease. Skin symptoms are the first to appear, in the form of a longstanding nonpruritic urticarial rash, with exacerbations coinciding with episodes of fever, arthritis, and enlarged lymph nodes. The findings of biopsy of skin lesions are extremely variable but characterized by perivascular neutrophilic infiltrate. With the discovery of mutations in the <span class="elsevierStyleItalic">CIAS1</span> gene, which encodes a protein known as cryopyrin, this entity has been classified as one of the cryopyrin-associated autoinflammatory diseases, along with familial cold urticaria and Muckle-Wells syndrome. This discovery has also made available new therapeutic options. We present the case of a boy diagnosed with CINCA syndrome who presented with an outbreak of painful skin lesions and fever. These lesions were thought to be an exacerbation of underlying lesions during an episode of fever.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">El síndrome CINCA (<span class="elsevierStyleItalic">Chronic Infantile Neurologic Cutaneous Articular Syndrome</span>) es una grave enfermedad inflamatoria sistémica crónica, de instauración temprana, que se caracteriza por afectación cutánea, articular y del sistema nervioso central (SNC). La clínica cutánea en forma de exantema urticariforme no pruriginoso es la primera en aparecer, siendo más o menos permanente con exacerbaciones que coinciden con brotes de fiebre, artritis y adenopatías. La biopsia de las lesiones cutáneas es muy variable, aunque destaca un infiltrado neutrofílico perivascular. El descubrimiento de mutaciones en el gen CIAS1, que codifica una proteína llamada criopirina, ha permitido añadir esta entidad al espectro de las enfermedades autoinflamatorias asociadas a criopirinas, junto con la urticaria familiar por frío y el síndrome de Muckle-Wells, implicando además nuevas opciones terapéuticas. Presentamos el caso de un varón diagnosticado de síndrome CINCA que presentó un brote de lesiones cutáneas dolorosas y fiebre, interpretándose éstas como una exacerbación de sus lesiones habituales durante un episodio febril.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:17 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A chronic infantile, neurological, cutaneous and articular (CINCA) syndrome. A specific entity analysed in 30 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.M. Prieur" 1 => "C. Griscelli" 2 => "F. Lampert" 3 => "H. Truckenbrodt" 4 => "M.A. Guggenheim" 5 => "D.J. Lovell" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Scand J Rheumatol Suppl" "fecha" => "1987" "volumen" => "66" "paginaInicial" => "57" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3482735" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fiebre periódica" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "F.I. Mongil" 1 => "V. Canduela" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "An Esp Pediatr" "fecha" => "2002" "volumen" => "57" "paginaInicial" => "334" "paginaFinal" => "344" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12392668" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A recently recognized chronic inflammatory disease of early onset characterized by the triad of rash, central nervous system involvement and arthropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.M. Prieur" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Rheumatol" "fecha" => "2001" "volumen" => "19" "paginaInicial" => "403" "paginaFinal" => "406" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11491495" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Feldmann" 1 => "A.M. Prieur" 2 => "P. Quartier" 3 => "P. Berquin" 4 => "S. Certain" 5 => "E. Cortis" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Hum Genet" "fecha" => "2002" "volumen" => "71" "paginaInicial" => "198" "paginaFinal" => "203" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12032915" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "De novo CIAS1 mutations cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Aksentijevich" 1 => "M. Nowak" 2 => "M. Mallah" 3 => "J.J. Chae" 4 => "W.T. Watford" 5 => "S.R. Hofmann" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/art.10688" "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2002" "volumen" => "46" "paginaInicial" => "3340" "paginaFinal" => "3348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12483741" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arthropathy with rash, chronic meningitis, eye lesions and mental retardation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Prieur" 1 => "C. Griscelli" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1981" "volumen" => "99" "paginaInicial" => "79" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7252669" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal onset multisystem inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "S.G. Hassink" 1 => "D.P. Goldsmith" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "1983" "volumen" => "26" "paginaInicial" => "668" "paginaFinal" => "673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6847730" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic infantile neurological cutaneous articular syndrome: CD10 over expression in neutrophils is a possible key to the pathogenesis of the disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Leone" 1 => "G. Presani" 2 => "S. Perticarari" 3 => "A. Tommasini" 4 => "S. Crovella" 5 => "A. Lenhardt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00431-003-1284-x" "Revista" => array:6 [ "tituloSerie" => "Eur J Pediatr" "fecha" => "2003" "volumen" => "162" "paginaInicial" => "669" "paginaFinal" => "673" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12928894" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The CINCA syndrome: a rare cause of chronic arthritis and multisystem inflammatory disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "H. De Boeck" 1 => "T. Scheerlinck" 2 => "J. Otten" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Acta Orthop Belg" "fecha" => "2000" "volumen" => "66" "paginaInicial" => "433" "paginaFinal" => "437" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11196366" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673603127729" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The expanding spectrum of systemic autoinflammatory disorders and their rheumatic manifestations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "K.M. Hull" 1 => "N. Shoham" 2 => "J.J. Chae" 3 => "I. Aksentijevich" 4 => "D.L. Kastner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Curr Opin Rheumatol" "fecha" => "2003" "volumen" => "15" "paginaInicial" => "61" "paginaFinal" => "69" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12496512" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CIAS1 mutation in a patient with overlap between Muckle-Wells and chronic infantile neurological cutaneous and articular syndromes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Granel" 1 => "N. Philip" 2 => "J. Serratrice" 3 => "N. Ene" 4 => "G. Grateau" 5 => "C. Dodé" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "68883" "Revista" => array:6 [ "tituloSerie" => "Dermatology" "fecha" => "2003" "volumen" => "206" "paginaInicial" => "257" "paginaFinal" => "259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12673085" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrafamilial variable phenotypic expression of a CIAS1 mutation: from Muckle-Wells to chronic infantile neurological cutaneous and articular syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "V. Hentgen" 1 => "V. Despert" 2 => "A.C. Lepretre" 3 => "L. Cuisset" 4 => "J. Chevrant-Breton" 5 => "P. Jego" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Rheumatol" "fecha" => "2005" "volumen" => "32" "paginaInicial" => "747" "paginaFinal" => "751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15801036" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.M. Hoffman" 1 => "J.L. Mueller" 2 => "D.H. Broide" 3 => "A.A. Wanderer" 4 => "R.D. Kolodner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ng756" "Revista" => array:6 [ "tituloSerie" => "Nature Genet" "fecha" => "2001" "volumen" => "29" "paginaInicial" => "301" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11687797" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal onset multisystem inflammatory disorder: the emerging role of pyrin genes in autoinflammatory diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Kilcline" 1 => "K. Shinkai" 2 => "A. Bree" 3 => "R. Modica" 4 => "E. Von Scheven" 5 => "I.J. Frieden" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.141.2.248" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2005" "volumen" => "141" "paginaInicial" => "248" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15724022" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal-onset multisystem inflammatory disease responsive to interleukin-Ibeta Inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Goldbach-Mansky" 1 => "N.J. Daily" 2 => "S.W. Canna" 3 => "A. Gelabert" 4 => "J. Jones" 5 => "B.I. Rubin" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2006" "volumen" => "355" "paginaInicial" => "646" "paginaFinal" => "647" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interleukin-1 blockade by anakinra improves clinical and symptoms in patients with neonatal onset multisystem inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.J. Lovell" 1 => "S.L. Bowyer" 2 => "A.M. Solinger" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2005" "volumen" => "52" "paginaInicial" => "183" "paginaFinal" => "184" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anakinra in mutationnegative CINCA syndrome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Jl. Callejas" 1 => "J. Oliver" 2 => "J. Martín" 3 => "N. Ortego" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10067-005-0168-z" "Revista" => array:6 [ "tituloSerie" => "Clin Rheumatol" "fecha" => "2007" "volumen" => "26" "paginaInicial" => "576" "paginaFinal" => "577" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16440135" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000006/v1_201304241435/S1578219008702944/v1_201304241435/en/main.assets" "Apartado" => array:4 [ "identificador" => "6183" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case Reports" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000006/v1_201304241435/S1578219008702944/v1_201304241435/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702944?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 14 | 23 |
| 2024 Octubre | 58 | 44 | 102 |
| 2024 Septiembre | 56 | 31 | 87 |
| 2024 Agosto | 85 | 51 | 136 |
| 2024 Julio | 74 | 32 | 106 |
| 2024 Junio | 68 | 24 | 92 |
| 2024 Mayo | 72 | 35 | 107 |
| 2024 Abril | 61 | 31 | 92 |
| 2024 Marzo | 68 | 48 | 116 |
| 2024 Febrero | 56 | 38 | 94 |
| 2024 Enero | 52 | 63 | 115 |
| 2023 Diciembre | 36 | 31 | 67 |
| 2023 Noviembre | 50 | 37 | 87 |
| 2023 Octubre | 43 | 27 | 70 |
| 2023 Septiembre | 69 | 39 | 108 |
| 2023 Agosto | 28 | 25 | 53 |
| 2023 Julio | 30 | 34 | 64 |
| 2023 Junio | 43 | 21 | 64 |
| 2023 Mayo | 34 | 23 | 57 |
| 2023 Abril | 28 | 18 | 46 |
| 2023 Marzo | 22 | 18 | 40 |
| 2023 Febrero | 23 | 17 | 40 |
| 2023 Enero | 31 | 22 | 53 |
| 2022 Diciembre | 32 | 37 | 69 |
| 2022 Noviembre | 17 | 33 | 50 |
| 2022 Octubre | 19 | 13 | 32 |
| 2022 Septiembre | 17 | 36 | 53 |
| 2022 Agosto | 17 | 35 | 52 |
| 2022 Julio | 14 | 15 | 29 |
| 2022 Junio | 15 | 32 | 47 |
| 2022 Mayo | 31 | 27 | 58 |
| 2022 Abril | 35 | 35 | 70 |
| 2022 Marzo | 34 | 51 | 85 |
| 2022 Febrero | 31 | 25 | 56 |
| 2022 Enero | 23 | 43 | 66 |
| 2021 Diciembre | 23 | 36 | 59 |
| 2021 Noviembre | 31 | 48 | 79 |
| 2021 Octubre | 24 | 41 | 65 |
| 2021 Septiembre | 19 | 32 | 51 |
| 2021 Agosto | 20 | 19 | 39 |
| 2021 Julio | 16 | 27 | 43 |
| 2021 Junio | 20 | 25 | 45 |
| 2021 Mayo | 14 | 26 | 40 |
| 2021 Abril | 55 | 68 | 123 |
| 2021 Marzo | 70 | 23 | 93 |
| 2021 Febrero | 62 | 19 | 81 |
| 2021 Enero | 27 | 20 | 47 |
| 2020 Diciembre | 24 | 17 | 41 |
| 2020 Noviembre | 31 | 16 | 47 |
| 2020 Octubre | 22 | 10 | 32 |
| 2020 Septiembre | 9 | 12 | 21 |
| 2020 Agosto | 22 | 26 | 48 |
| 2020 Julio | 14 | 10 | 24 |
| 2020 Junio | 18 | 25 | 43 |
| 2020 Mayo | 22 | 19 | 41 |
| 2020 Abril | 21 | 18 | 39 |
| 2020 Marzo | 19 | 28 | 47 |
| 2020 Febrero | 3 | 2 | 5 |
| 2020 Enero | 0 | 10 | 10 |
| 2019 Diciembre | 0 | 10 | 10 |
| 2019 Noviembre | 0 | 1 | 1 |
| 2019 Octubre | 0 | 1 | 1 |
| 2019 Septiembre | 0 | 1 | 1 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Julio | 0 | 1 | 1 |
| 2019 Junio | 0 | 1 | 1 |
| 2019 Mayo | 0 | 39 | 39 |
| 2019 Abril | 0 | 2 | 2 |
| 2019 Marzo | 0 | 1 | 1 |
| 2019 Febrero | 0 | 6 | 6 |
| 2018 Diciembre | 0 | 1 | 1 |
| 2018 Noviembre | 0 | 1 | 1 |
| 2018 Octubre | 0 | 1 | 1 |
| 2018 Abril | 0 | 1 | 1 |
| 2018 Marzo | 8 | 3 | 11 |
| 2018 Febrero | 9 | 6 | 15 |
| 2018 Enero | 28 | 10 | 38 |
| 2017 Diciembre | 16 | 13 | 29 |
| 2017 Noviembre | 10 | 2 | 12 |
| 2017 Octubre | 14 | 6 | 20 |
| 2017 Septiembre | 17 | 13 | 30 |
| 2017 Agosto | 23 | 8 | 31 |
| 2017 Julio | 8 | 9 | 17 |
| 2017 Junio | 15 | 19 | 34 |
| 2017 Mayo | 15 | 5 | 20 |
| 2017 Abril | 22 | 19 | 41 |
| 2017 Marzo | 19 | 67 | 86 |
| 2017 Febrero | 18 | 15 | 33 |
| 2017 Enero | 13 | 11 | 24 |
| 2016 Diciembre | 23 | 14 | 37 |
| 2016 Noviembre | 23 | 9 | 32 |
| 2016 Octubre | 27 | 16 | 43 |
| 2016 Septiembre | 32 | 9 | 41 |
| 2016 Agosto | 30 | 12 | 42 |
| 2016 Julio | 23 | 15 | 38 |
| 2016 Junio | 12 | 8 | 20 |
| 2016 Mayo | 9 | 7 | 16 |
| 2016 Abril | 8 | 15 | 23 |
| 2016 Marzo | 6 | 13 | 19 |
| 2016 Febrero | 7 | 10 | 17 |
| 2016 Enero | 7 | 11 | 18 |
| 2015 Diciembre | 5 | 9 | 14 |
| 2015 Noviembre | 15 | 6 | 21 |
| 2015 Octubre | 9 | 10 | 19 |
| 2015 Septiembre | 12 | 7 | 19 |
| 2015 Agosto | 12 | 2 | 14 |
| 2015 Julio | 36 | 12 | 48 |
| 2015 Junio | 28 | 7 | 35 |
| 2015 Mayo | 73 | 15 | 88 |
| 2015 Abril | 33 | 14 | 47 |
| 2015 Marzo | 54 | 7 | 61 |
| 2015 Febrero | 26 | 23 | 49 |
| 2015 Enero | 23 | 12 | 35 |
| 2014 Diciembre | 21 | 11 | 32 |
| 2014 Noviembre | 25 | 13 | 38 |
| 2014 Octubre | 41 | 17 | 58 |
| 2014 Septiembre | 24 | 12 | 36 |
| 2014 Agosto | 38 | 15 | 53 |
| 2014 Julio | 47 | 21 | 68 |
| 2014 Junio | 42 | 12 | 54 |
| 2014 Mayo | 52 | 11 | 63 |
| 2014 Abril | 30 | 9 | 39 |
| 2014 Marzo | 49 | 19 | 68 |
| 2014 Febrero | 24 | 20 | 44 |
| 2014 Enero | 34 | 14 | 48 |
| 2013 Diciembre | 36 | 12 | 48 |
| 2013 Noviembre | 29 | 11 | 40 |
| 2013 Octubre | 25 | 15 | 40 |
| 2013 Septiembre | 34 | 28 | 62 |
| 2013 Agosto | 28 | 28 | 56 |
| 2013 Julio | 29 | 24 | 53 |
| 2013 Junio | 29 | 28 | 57 |
| 2013 Mayo | 26 | 25 | 51 |
| 2013 Abril | 33 | 21 | 54 |
| 2013 Marzo | 26 | 23 | 49 |
| 2013 Febrero | 26 | 12 | 38 |
| 2013 Enero | 12 | 5 | 17 |
Mostrar todo
