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Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation
Estudio Inmunohistoquímico de la Calretinina en el Folículo Piloso Normal y Neoplasias Con Diferenciación Folicular
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Marcoval, A. Moreno, A. Torras, E. Baumann, J. Graells, M.I. Gallego" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Marcoval" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Moreno" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Torras" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Baumann" ] 4 => array:2 [ "nombre" => "J." "apellidos" => "Graells" ] 5 => array:2 [ "nombre" => "M.I." "apellidos" => "Gallego" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702907?idApp=UINPBA000044" "url" => "/15782190/0000009900000006/v1_201304241435/S1578219008702907/v1_201304241435/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219008702889" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70288-9" "estado" => "S300" "fechaPublicacion" => "2008-08-01" "aid" => "70288" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:441-55" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3171 "formatos" => array:3 [ "EPUB" => 27 "HTML" => 1545 "PDF" => 1599 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>" "titulo" => "Practical Management of the Most Common Autoimmune Bullous Diseases" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "441" "paginaFinal" => "455" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Manejo Práctico de las Enfermedades Ampollosas Autoinmunes más Frecuentes" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "R. Suárez-Fernández, A. España-Alonso, J.E. Herrero-González, J.M. Mascaró-Galy" "autores" => array:4 [ 0 => array:2 [ "nombre" => "R." "apellidos" => "Suárez-Fernández" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "España-Alonso" ] 2 => array:2 [ "nombre" => "J.E." "apellidos" => "Herrero-González" ] 3 => array:2 [ "nombre" => "J.M." "apellidos" => "Mascaró-Galy" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702889?idApp=UINPBA000044" "url" => "/15782190/0000009900000006/v1_201304241435/S1578219008702889/v1_201304241435/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "456" "paginaFinal" => "463" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "E. González-Guerra, L. Requena, H. Kutzner" "autores" => array:3 [ 0 => array:4 [ "nombre" => "E." "apellidos" => "González-Guerra" "email" => array:1 [ 0 => "elenagonzalezguerra@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Requena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "H." "apellidos" => "Kutzner" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Fundación Jiménez Díaz, Madrid, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Dermatopathology Laboratory, Friedrichshafen, Germany" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: C/ Cabo Cañaveral, n.° 12, bajo A, 28023 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio Inmunohistoquímico de la Calretinina en el Folículo Piloso Normal y Neoplasias Con Diferenciación Folicular" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-10-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84235" "palabras" => array:4 [ 0 => "calretinin" 1 => "cutaneous adnexal tumors" 2 => "follicular differentiation" 3 => "companion layer" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84236" "palabras" => array:3 [ 0 => "calretinina" 1 => "neoplasias anexiales con diferenciación folicular" 2 => "capa compañera" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Selective immunostaining for calretinin labels the innermost layer of the outer root sheath of normal hair follicles, which is difficult to distinguish with hematoxylin-eosin staining.</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed the staining pattern for calretinin by immunohistochemistry in 49 biopsies of cutaneous adnexal tumors with follicular differentiation.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Fifteen biopsies corresponded to trichilemmomas/inverted follicular keratosis and had staining for calretinin in the epithelium of the most superficial areas of the lesions and in squamous eddies. Ten were trichilemmal cysts, which displayed staining of the cyst wall. Three were basal cell carcinomas with variable staining according to the type of follicular differentiation in each variant. One was a panfolliculoma that had focal staining. Two were folliculosebaceous cystic hamartomas with staining of the excretory duct of the sebaceous glands. Two pilomatricomas and 3 proliferative trichilemmal tumors had positive staining in the cellular layers close to the lumen of the cystic structures. Nine trichoblastomas/trichoepitheliomas, 2 infundibular cysts, 1 dilated pore of Winer, and 2 acanthomas of the follicular sheath were negative for calretinin.</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors of the hair follicle or a component of the follicle with differentiation towards cells of the outer root sheath.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">La inmunotinción selectiva con calretinina evidencia la capa más interna de la vaina radicular externa del folículo piloso normal, difícil de distinguir con la tinción de hematoxilina-eosina.</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer si calretinina nos permite identificar neoplasias anexiales con diferenciación hacia la vaina radicular externa del folículo piloso.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos analizado el patrón de inmunotinción para calretinina en 49 biopsias de distintas neoplasias anexiales cutáneas con diferenciación folicular.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Quince de las 49 tinciones correspondían a tricolemomas/queratosis folicular invertida, observándose positividad con calretinina en el epitelio de las áreas más superficiales de la lesión y en los remolinos escamosos; 10 quistes tricolémicos con positividad en su pared, tres carcinomas basocelulares con positividad variable dependiendo del tipo de diferenciación folicular de cada variante, un panfoliculoma con positividad focal, dos hamartomas sebáceos infundíbulo-quísticos con positividad en el conducto excretor de las glándulas sebáceas, dos pilomatricomas y tres tumores tricolemales proliferantes con positividad en las capas celulares cercanas a la luz de las estructuras quísticas, 9 tricoblastomas/tricoepiteliomas, dos quistes infundibulares, un poro dilatado de Winer y dos acantomas de la vaina folicular resultaron negativos.</p> <span class="elsevierStyleSectionTitle">Conclusión</span><p class="elsevierStyleSimplePara elsevierViewall">El estudio inmunohistoquímico de la calretinina nos permite identificar neoplasias anexiales del folículo piloso o componentes de éste, con diferenciación hacia la vaina radicular externa del folículo piloso.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 9 | 6 | 15 |
| 2024 Octubre | 56 | 48 | 104 |
| 2024 Septiembre | 82 | 41 | 123 |
| 2024 Agosto | 126 | 62 | 188 |
| 2024 Julio | 68 | 62 | 130 |
| 2024 Junio | 80 | 75 | 155 |
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| 2024 Enero | 58 | 50 | 108 |
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| 2023 Noviembre | 62 | 36 | 98 |
| 2023 Octubre | 48 | 24 | 72 |
| 2023 Septiembre | 41 | 43 | 84 |
| 2023 Agosto | 32 | 19 | 51 |
| 2023 Julio | 30 | 44 | 74 |
| 2023 Junio | 39 | 32 | 71 |
| 2023 Mayo | 40 | 32 | 72 |
| 2023 Abril | 24 | 20 | 44 |
| 2023 Marzo | 26 | 29 | 55 |
| 2023 Febrero | 27 | 16 | 43 |
| 2023 Enero | 32 | 28 | 60 |
| 2022 Diciembre | 35 | 31 | 66 |
| 2022 Noviembre | 23 | 29 | 52 |
| 2022 Octubre | 18 | 20 | 38 |
| 2022 Septiembre | 19 | 34 | 53 |
| 2022 Agosto | 37 | 56 | 93 |
| 2022 Julio | 18 | 28 | 46 |
| 2022 Junio | 25 | 22 | 47 |
| 2022 Mayo | 40 | 59 | 99 |
| 2022 Abril | 58 | 35 | 93 |
| 2022 Marzo | 31 | 51 | 82 |
| 2022 Febrero | 25 | 20 | 45 |
| 2022 Enero | 44 | 33 | 77 |
| 2021 Diciembre | 25 | 31 | 56 |
| 2021 Noviembre | 30 | 44 | 74 |
| 2021 Octubre | 38 | 45 | 83 |
| 2021 Septiembre | 40 | 39 | 79 |
| 2021 Agosto | 37 | 31 | 68 |
| 2021 Julio | 12 | 28 | 40 |
| 2021 Junio | 24 | 35 | 59 |
| 2021 Mayo | 30 | 26 | 56 |
| 2021 Abril | 72 | 57 | 129 |
| 2021 Marzo | 40 | 38 | 78 |
| 2021 Febrero | 77 | 29 | 106 |
| 2021 Enero | 44 | 17 | 61 |
| 2020 Diciembre | 21 | 21 | 42 |
| 2020 Noviembre | 25 | 15 | 40 |
| 2020 Octubre | 23 | 8 | 31 |
| 2020 Septiembre | 23 | 7 | 30 |
| 2020 Agosto | 25 | 23 | 48 |
| 2020 Julio | 8 | 11 | 19 |
| 2020 Junio | 30 | 26 | 56 |
| 2020 Mayo | 32 | 27 | 59 |
| 2020 Abril | 23 | 30 | 53 |
| 2020 Marzo | 26 | 21 | 47 |
| 2020 Febrero | 2 | 4 | 6 |
| 2020 Enero | 0 | 10 | 10 |
| 2019 Diciembre | 0 | 11 | 11 |
| 2019 Noviembre | 0 | 4 | 4 |
| 2019 Octubre | 0 | 8 | 8 |
| 2019 Septiembre | 0 | 12 | 12 |
| 2019 Agosto | 0 | 4 | 4 |
| 2019 Julio | 0 | 18 | 18 |
| 2019 Junio | 0 | 20 | 20 |
| 2019 Mayo | 0 | 82 | 82 |
| 2019 Abril | 0 | 1 | 1 |
| 2019 Marzo | 0 | 3 | 3 |
| 2019 Febrero | 0 | 3 | 3 |
| 2018 Diciembre | 0 | 3 | 3 |
| 2018 Noviembre | 0 | 2 | 2 |
| 2018 Octubre | 0 | 1 | 1 |
| 2018 Septiembre | 0 | 3 | 3 |
| 2018 Agosto | 0 | 6 | 6 |
| 2018 Julio | 0 | 6 | 6 |
| 2018 Junio | 0 | 4 | 4 |
| 2018 Mayo | 0 | 7 | 7 |
| 2018 Abril | 0 | 3 | 3 |
| 2018 Marzo | 0 | 2 | 2 |
| 2018 Febrero | 12 | 5 | 17 |
| 2018 Enero | 14 | 11 | 25 |
| 2017 Diciembre | 22 | 20 | 42 |
| 2017 Noviembre | 18 | 9 | 27 |
| 2017 Octubre | 17 | 12 | 29 |
| 2017 Septiembre | 16 | 15 | 31 |
| 2017 Agosto | 20 | 34 | 54 |
| 2017 Julio | 15 | 13 | 28 |
| 2017 Junio | 35 | 36 | 71 |
| 2017 Mayo | 33 | 15 | 48 |
| 2017 Abril | 33 | 39 | 72 |
| 2017 Marzo | 49 | 37 | 86 |
| 2017 Febrero | 27 | 16 | 43 |
| 2017 Enero | 23 | 13 | 36 |
| 2016 Diciembre | 36 | 12 | 48 |
| 2016 Noviembre | 27 | 17 | 44 |
| 2016 Octubre | 31 | 12 | 43 |
| 2016 Septiembre | 28 | 24 | 52 |
| 2016 Agosto | 32 | 16 | 48 |
| 2016 Julio | 22 | 11 | 33 |
| 2016 Junio | 11 | 11 | 22 |
| 2016 Mayo | 11 | 5 | 16 |
| 2016 Abril | 7 | 14 | 21 |
| 2016 Marzo | 5 | 22 | 27 |
| 2016 Febrero | 7 | 9 | 16 |
| 2016 Enero | 7 | 10 | 17 |
| 2015 Diciembre | 11 | 5 | 16 |
| 2015 Noviembre | 7 | 11 | 18 |
| 2015 Octubre | 6 | 12 | 18 |
| 2015 Septiembre | 5 | 8 | 13 |
| 2015 Agosto | 17 | 4 | 21 |
| 2015 Julio | 37 | 12 | 49 |
| 2015 Junio | 37 | 15 | 52 |
| 2015 Mayo | 80 | 32 | 112 |
| 2015 Abril | 28 | 19 | 47 |
| 2015 Marzo | 36 | 13 | 49 |
| 2015 Febrero | 30 | 21 | 51 |
| 2015 Enero | 14 | 18 | 32 |
| 2014 Diciembre | 23 | 12 | 35 |
| 2014 Noviembre | 17 | 12 | 29 |
| 2014 Octubre | 23 | 20 | 43 |
| 2014 Septiembre | 24 | 24 | 48 |
| 2014 Agosto | 42 | 19 | 61 |
| 2014 Julio | 32 | 23 | 55 |
| 2014 Junio | 29 | 17 | 46 |
| 2014 Mayo | 33 | 12 | 45 |
| 2014 Abril | 37 | 8 | 45 |
| 2014 Marzo | 37 | 24 | 61 |
| 2014 Febrero | 29 | 22 | 51 |
| 2014 Enero | 36 | 16 | 52 |
| 2013 Diciembre | 42 | 21 | 63 |
| 2013 Noviembre | 28 | 20 | 48 |
| 2013 Octubre | 37 | 32 | 69 |
| 2013 Septiembre | 41 | 33 | 74 |
| 2013 Agosto | 24 | 47 | 71 |
| 2013 Julio | 25 | 46 | 71 |
| 2013 Junio | 32 | 21 | 53 |
| 2013 Mayo | 26 | 37 | 63 |
| 2013 Abril | 26 | 39 | 65 |
| 2013 Marzo | 33 | 39 | 72 |
| 2013 Febrero | 42 | 15 | 57 |
| 2013 Enero | 13 | 4 | 17 |
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