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        "titulo" => "Estudio Inmunohistoqu&#237;mico de la Calretinina en el Fol&#237;culo Piloso Normal y Neoplasias Con Diferenciaci&#243;n Folicular"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Selective immunostaining for calretinin labels the innermost layer of the outer root sheath of normal hair follicles&#44; which is difficult to distinguish with hematoxylin-eosin staining&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed the staining pattern for calretinin by immunohistochemistry in 49 biopsies of cutaneous adnexal tumors with follicular differentiation&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Fifteen biopsies corresponded to trichilemmomas&#47;inverted follicular keratosis and had staining for calretinin in the epithelium of the most superficial areas of the lesions and in squamous eddies&#46; Ten were trichilemmal cysts&#44; which displayed staining of the cyst wall&#46; Three were basal cell carcinomas with variable staining according to the type of follicular differentiation in each variant&#46; One was a panfolliculoma that had focal staining&#46; Two were folliculosebaceous cystic hamartomas with staining of the excretory duct of the sebaceous glands&#46; Two pilomatricomas and 3 proliferative trichilemmal tumors had positive staining in the cellular layers close to the lumen of the cystic structures&#46; Nine trichoblastomas&#47;trichoepitheliomas&#44; 2 infundibular cysts&#44; 1 dilated pore of Winer&#44; and 2 acanthomas of the follicular sheath were negative for calretinin&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors of the hair follicle or a component of the follicle with differentiation towards cells of the outer root sheath&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La inmunotinci&#243;n selectiva con calretinina evidencia la capa m&#225;s interna de la vaina radicular externa del fol&#237;culo piloso normal&#44; dif&#237;cil de distinguir con la tinci&#243;n de hematoxilina-eosina&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer si calretinina nos permite identificar neoplasias anexiales con diferenciaci&#243;n hacia la vaina radicular externa del fol&#237;culo piloso&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos analizado el patr&#243;n de inmunotinci&#243;n para calretinina en 49 biopsias de distintas neoplasias anexiales cut&#225;neas con diferenciaci&#243;n folicular&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Quince de las 49 tinciones correspond&#237;an a tricolemomas&#47;queratosis folicular invertida&#44; observ&#225;ndose positividad con calretinina en el epitelio de las &#225;reas m&#225;s superficiales de la lesi&#243;n y en los remolinos escamosos&#59; 10 quistes tricol&#233;micos con positividad en su pared&#44; tres carcinomas basocelulares con positividad variable dependiendo del tipo de diferenciaci&#243;n folicular de cada variante&#44; un panfoliculoma con positividad focal&#44; dos hamartomas seb&#225;ceos infund&#237;bulo-qu&#237;sticos con positividad en el conducto excretor de las gl&#225;ndulas seb&#225;ceas&#44; dos pilomatricomas y tres tumores tricolemales proliferantes con positividad en las capas celulares cercanas a la luz de las estructuras qu&#237;sticas&#44; 9 tricoblastomas&#47;tricoepiteliomas&#44; dos quistes infundibulares&#44; un poro dilatado de Winer y dos acantomas de la vaina folicular resultaron negativos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El estudio inmunohistoqu&#237;mico de la calretinina nos permite identificar neoplasias anexiales del fol&#237;culo piloso o componentes de &#233;ste&#44; con diferenciaci&#243;n hacia la vaina radicular externa del fol&#237;culo piloso&#46;</p>"
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Original articles
Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation
Estudio Inmunohistoquímico de la Calretinina en el Folículo Piloso Normal y Neoplasias Con Diferenciación Folicular
E. González-Guerraa,
Autor para correspondencia
elenagonzalezguerra@yahoo.es

Correspondence: C/ Cabo Cañaveral, n.° 12, bajo A, 28023 Madrid, Spain.
, L. Requenaa, H. Kutznerb
a Servicio de Dermatología, Fundación Jiménez Díaz, Madrid, Spain
b Dermatopathology Laboratory, Friedrichshafen, Germany
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    "titulo" => "Immunohistochemical Study of Calretinin in Normal Hair Follicles and Tumors With Follicular Differentiation"
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        "titulo" => "Estudio Inmunohistoqu&#237;mico de la Calretinina en el Fol&#237;culo Piloso Normal y Neoplasias Con Diferenciaci&#243;n Folicular"
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            0 => "calretinin"
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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p class="elsevierStyleSimplePara elsevierViewall">Selective immunostaining for calretinin labels the innermost layer of the outer root sheath of normal hair follicles&#44; which is difficult to distinguish with hematoxylin-eosin staining&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to determine whether immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors with follicular differentiation towards cells of the outer root sheath&#46;</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We analyzed the staining pattern for calretinin by immunohistochemistry in 49 biopsies of cutaneous adnexal tumors with follicular differentiation&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Fifteen biopsies corresponded to trichilemmomas&#47;inverted follicular keratosis and had staining for calretinin in the epithelium of the most superficial areas of the lesions and in squamous eddies&#46; Ten were trichilemmal cysts&#44; which displayed staining of the cyst wall&#46; Three were basal cell carcinomas with variable staining according to the type of follicular differentiation in each variant&#46; One was a panfolliculoma that had focal staining&#46; Two were folliculosebaceous cystic hamartomas with staining of the excretory duct of the sebaceous glands&#46; Two pilomatricomas and 3 proliferative trichilemmal tumors had positive staining in the cellular layers close to the lumen of the cystic structures&#46; Nine trichoblastomas&#47;trichoepitheliomas&#44; 2 infundibular cysts&#44; 1 dilated pore of Winer&#44; and 2 acanthomas of the follicular sheath were negative for calretinin&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">Immunohistochemistry for calretinin allows identification of cutaneous adnexal tumors of the hair follicle or a component of the follicle with differentiation towards cells of the outer root sheath&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Introducci&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">La inmunotinci&#243;n selectiva con calretinina evidencia la capa m&#225;s interna de la vaina radicular externa del fol&#237;culo piloso normal&#44; dif&#237;cil de distinguir con la tinci&#243;n de hematoxilina-eosina&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Conocer si calretinina nos permite identificar neoplasias anexiales con diferenciaci&#243;n hacia la vaina radicular externa del fol&#237;culo piloso&#46;</p> <span class="elsevierStyleSectionTitle">Material y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos analizado el patr&#243;n de inmunotinci&#243;n para calretinina en 49 biopsias de distintas neoplasias anexiales cut&#225;neas con diferenciaci&#243;n folicular&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Quince de las 49 tinciones correspond&#237;an a tricolemomas&#47;queratosis folicular invertida&#44; observ&#225;ndose positividad con calretinina en el epitelio de las &#225;reas m&#225;s superficiales de la lesi&#243;n y en los remolinos escamosos&#59; 10 quistes tricol&#233;micos con positividad en su pared&#44; tres carcinomas basocelulares con positividad variable dependiendo del tipo de diferenciaci&#243;n folicular de cada variante&#44; un panfoliculoma con positividad focal&#44; dos hamartomas seb&#225;ceos infund&#237;bulo-qu&#237;sticos con positividad en el conducto excretor de las gl&#225;ndulas seb&#225;ceas&#44; dos pilomatricomas y tres tumores tricolemales proliferantes con positividad en las capas celulares cercanas a la luz de las estructuras qu&#237;sticas&#44; 9 tricoblastomas&#47;tricoepiteliomas&#44; dos quistes infundibulares&#44; un poro dilatado de Winer y dos acantomas de la vaina folicular resultaron negativos&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">El estudio inmunohistoqu&#237;mico de la calretinina nos permite identificar neoplasias anexiales del fol&#237;culo piloso o componentes de &#233;ste&#44; con diferenciaci&#243;n hacia la vaina radicular externa del fol&#237;culo piloso&#46;</p>"
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