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        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Mohs surgery was first described by Frederic Mohs in 1941 to eliminate high-risk cutaneous tumors&#46; The technique involves histological examination of the margins&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to describe the clinical findings and compare the grade and subclinical extension of the tumor&#8212;as measured by the number of Mohs stages needed for complete elimination&#8212;according to whether the tumor presented high-risk factors&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We included 100 patients with 105 tumors&#46; In all cases&#44; age&#44; sex&#44; tumor site&#44; tumor type&#44; histological subtype in the case of basal cell carcinoma&#44; size&#44; recurrences&#44; number of Mohs stages&#44; and reconstruction technique were recorded&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The study group comprised 44 men and 56 women aged between 28 and 88 years &#40;mean&#44; 72&#46;6 years&#41;&#46; Of the tumors&#44; 80&#37; corresponded to basal cell carcinoma&#44; 12&#46;38&#37; to squamous cell carcinoma&#44; 4&#46;76&#37; to dermatofibrosarcoma protuberans&#44; 0&#46;95&#37; to Merkel cell carcinoma&#44; 0&#46;95&#37; to microcystic adnexal carcinoma&#44; and 0&#46;95&#37; to lentigo maligna melanoma&#46; Most tumors were located on the head and 60&#37; required more than one Mohs stage for complete elimination&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">This series is characterized by a high percentage of high-risk cutaneous tumors&#46; After assessing the risk factors independently&#44; we found that the size of the tumor is the risk factor most closely related to grade and subclinical extension in the case of basal cell carcinoma&#44; although similar conclusions cannot be drawn for the other types of tumor studied&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Definici&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Descrita por Frederic Mohs en 1941&#44; la cirug&#237;a de Mohs es una t&#233;cnica quir&#250;rgica con control histol&#243;gico de los bordes&#44; utilizada para eliminar tumores cut&#225;neos de alto riesgo&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo de este art&#237;culo es informar de los hallazgos cl&#237;nicos y comparar la agresividad-extensi&#243;n subcl&#237;nica del tumor&#44; medida como n&#250;mero de estadios de Mohs necesarios para eliminar completamente el tumor&#44; en funci&#243;n de que el tumor presente o no factores de alto riesgo&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyen 100 pacientes con 105 tumores y en todos los casos se obtuvieron las variables de edad y sexo del paciente&#44; localizaci&#243;n&#44; tipo de tumor y subtipo histol&#243;gico en el caso del carcinoma basocelular&#44; tama&#241;o&#44; existencia de recurrencias&#44; n&#250;mero de estadios de Mohs y t&#233;cnica de reconstrucci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyen 44 hombres y 56 mujeres de edades comprendidas entre los 28 y 88 a&#241;os &#40;media 72&#44;6&#41;&#46; El 80&#37; eran carcinomas basocelulares&#44; el 12&#44;38&#37; carcinomas espinocelulares&#44; el 4&#44;76&#37; dermatofibrosarcomas <span class="elsevierStyleItalic">protuberans</span>&#44; el 0&#44;95&#37; carcinoma de c&#233;lulas de Merkel&#44; el 0&#44;9 5&#37; carcinoma anexial microqu&#237;stico y el 0&#44;95&#37; lentigo maligno melanoma&#46; La mayor&#237;a estaban localizados en la cabeza y el 60&#37; precis&#243; m&#225;s de un estadio de Mohs para ser eliminado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Esta serie se caracteriza por presentar un alto porcentaje de tumores cut&#225;neos de alto riesgo&#46; Valorando estos factores de riesgo de forma independiente podemos concluir que el tama&#241;o del tumor es el factor de riesgo que m&#225;s se relaciona con la agresividad y la extensi&#243;n subcl&#237;nica en el caso del carcinoma basocelular&#44; no pudiendo llegar a conclusiones similares para el resto de los tumores incluidos en este trabajo&#46;</p>"
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Original articles
Mohs Micrographic Surgery: Our First 100 Patients
Cirugía de Mohs: Nuestros Primeros Cien Pacientes
T. Alonso
Autor para correspondencia
teresa@aedv.es

Correspondence: Servicio de Dermatología. Hospital de León, C/ Altos de Nava, s/n, 24280 León, Spain.
, P. Sánchez, A. González, J. Ingelmo, I. Ruiz, S. Delgado, M.A. Rodríguez
Servicio de Dermatología, Hospital de León, León, Spain
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          "identificador" => "xpalclavsec84184"
          "palabras" => array:4 [
            0 => "cirug&#237;a de Mohs"
            1 => "tumores cut&#225;neos"
            2 => "cirug&#237;a"
            3 => "tratamiento"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Mohs surgery was first described by Frederic Mohs in 1941 to eliminate high-risk cutaneous tumors&#46; The technique involves histological examination of the margins&#46;</p> <span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">The aim of this study was to describe the clinical findings and compare the grade and subclinical extension of the tumor&#8212;as measured by the number of Mohs stages needed for complete elimination&#8212;according to whether the tumor presented high-risk factors&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">We included 100 patients with 105 tumors&#46; In all cases&#44; age&#44; sex&#44; tumor site&#44; tumor type&#44; histological subtype in the case of basal cell carcinoma&#44; size&#44; recurrences&#44; number of Mohs stages&#44; and reconstruction technique were recorded&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The study group comprised 44 men and 56 women aged between 28 and 88 years &#40;mean&#44; 72&#46;6 years&#41;&#46; Of the tumors&#44; 80&#37; corresponded to basal cell carcinoma&#44; 12&#46;38&#37; to squamous cell carcinoma&#44; 4&#46;76&#37; to dermatofibrosarcoma protuberans&#44; 0&#46;95&#37; to Merkel cell carcinoma&#44; 0&#46;95&#37; to microcystic adnexal carcinoma&#44; and 0&#46;95&#37; to lentigo maligna melanoma&#46; Most tumors were located on the head and 60&#37; required more than one Mohs stage for complete elimination&#46;</p> <span class="elsevierStyleSectionTitle">Conclusion</span><p class="elsevierStyleSimplePara elsevierViewall">This series is characterized by a high percentage of high-risk cutaneous tumors&#46; After assessing the risk factors independently&#44; we found that the size of the tumor is the risk factor most closely related to grade and subclinical extension in the case of basal cell carcinoma&#44; although similar conclusions cannot be drawn for the other types of tumor studied&#46;</p>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span class="elsevierStyleSectionTitle">Definici&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Descrita por Frederic Mohs en 1941&#44; la cirug&#237;a de Mohs es una t&#233;cnica quir&#250;rgica con control histol&#243;gico de los bordes&#44; utilizada para eliminar tumores cut&#225;neos de alto riesgo&#46;</p> <span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">El objetivo de este art&#237;culo es informar de los hallazgos cl&#237;nicos y comparar la agresividad-extensi&#243;n subcl&#237;nica del tumor&#44; medida como n&#250;mero de estadios de Mohs necesarios para eliminar completamente el tumor&#44; en funci&#243;n de que el tumor presente o no factores de alto riesgo&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyen 100 pacientes con 105 tumores y en todos los casos se obtuvieron las variables de edad y sexo del paciente&#44; localizaci&#243;n&#44; tipo de tumor y subtipo histol&#243;gico en el caso del carcinoma basocelular&#44; tama&#241;o&#44; existencia de recurrencias&#44; n&#250;mero de estadios de Mohs y t&#233;cnica de reconstrucci&#243;n&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Se incluyen 44 hombres y 56 mujeres de edades comprendidas entre los 28 y 88 a&#241;os &#40;media 72&#44;6&#41;&#46; El 80&#37; eran carcinomas basocelulares&#44; el 12&#44;38&#37; carcinomas espinocelulares&#44; el 4&#44;76&#37; dermatofibrosarcomas <span class="elsevierStyleItalic">protuberans</span>&#44; el 0&#44;95&#37; carcinoma de c&#233;lulas de Merkel&#44; el 0&#44;9 5&#37; carcinoma anexial microqu&#237;stico y el 0&#44;95&#37; lentigo maligno melanoma&#46; La mayor&#237;a estaban localizados en la cabeza y el 60&#37; precis&#243; m&#225;s de un estadio de Mohs para ser eliminado&#46;</p> <span class="elsevierStyleSectionTitle">Conclusi&#243;n</span><p class="elsevierStyleSimplePara elsevierViewall">Esta serie se caracteriza por presentar un alto porcentaje de tumores cut&#225;neos de alto riesgo&#46; Valorando estos factores de riesgo de forma independiente podemos concluir que el tama&#241;o del tumor es el factor de riesgo que m&#225;s se relaciona con la agresividad y la extensi&#243;n subcl&#237;nica en el caso del carcinoma basocelular&#44; no pudiendo llegar a conclusiones similares para el resto de los tumores incluidos en este trabajo&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:32 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
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                  "host" => array:1 [
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                        0 => array:2 [
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            3 => array:3 [
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                    0 => array:2 [
                      "doi" => "10.1136/bmj.327.7418.794"
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                      "autores" => array:1 [
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                          "etal" => false
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                            0 => "D&#46; Weedon"
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                        ]
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                      "Libro" => array:4 [
                        "titulo" => "Skin pathology"
                        "fecha" => "1997"
                        "editorial" => "Churchill-Livingstone"
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              "identificador" => "bib6"
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                0 => array:1 [
                  "referenciaCompleta" => "Bastiaens MT&#44; Hoefnagel JJ&#44; Bruijn JA&#44; Westendorp RG&#44; Vermeer BJ&#44; Bouwes Bavinck JN&#46; Differences in age&#44; site distribution and sex between nodular and superficial basal cell carcinomas indicate different type of tumors&#46; J Invest Dermatol&#46; 998&#59;110&#58;880-4&#46;"
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                      "titulo" => "Epidemiology and aetiology of basal cell carcinoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "H&#46; Tran"
                            1 => "K&#46; Chen"
                            2 => "S&#46; Shumack"
                          ]
                        ]
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                    0 => array:1 [
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            7 => array:3 [
              "identificador" => "bib8"
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                      "titulo" => "Variations of basal cell carcinomas according to gender&#44; age&#44; location and histopathological subtype"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "Y&#46; Scrivener"
                            1 => "E&#46; Grosshans"
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                          ]
                        ]
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                    ]
                  ]
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                    0 => array:1 [
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                        "tituloSerie" => "Br J Dermatol"
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            8 => array:3 [
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              "etiqueta" => "9&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "HA&#46; Mohs&#8217; micrographic surgery for treatment of basal cell carcinoma of the face&#8211;results of a retrospective study and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46;W&#46; Smeets"
                            1 => "D&#46;I&#46; Kuijpers"
                            2 => "P&#46; Nelemans"
                            3 => "J&#46;U&#46; Ostertag"
                            4 => "M&#46;E&#46; Verhaegh"
                            5 => "G&#46;A&#46; Krekels"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                        "fecha" => "2004"
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                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
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                      "titulo" => "Predictors of extensive subclinical spread in nonmelanoma skin cancer treated with Mohs micrographic surgery"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46;S&#46; Batra"
                            1 => "L&#46;C&#46; Kelley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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              ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            0 => "I&#46;F&#46; Orengo"
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                        ]
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                    ]
                  ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "I&#46; Leibovitch"
                            1 => "S&#46;C&#46; Huilgol"
                            2 => "D&#46; Selva"
                            3 => "S&#46; Richards"
                            4 => "R&#46; Paver"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                        ]
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                    ]
                  ]
                ]
              ]
            ]
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                            0 => "H&#46;C&#46; Bieley"
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                      ]
                    ]
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              ]
            ]
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                        0 => array:2 [
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                        ]
                      ]
                    ]
                  ]
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                ]
              ]
            ]
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                          ]
                        ]
                      ]
                    ]
                  ]
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            ]
            15 => array:3 [
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                      "titulo" => "Cutaneous squamous cell carcinoma treated with Mohs micrographic surgery in Australia I&#46; Experience over 10 years"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "I&#46; Leibovitch"
                            1 => "S&#46;C&#46; Huilgol"
                            2 => "D&#46; Selva"
                            3 => "D&#46; Hill"
                            4 => "S&#46; Richards"
                            5 => "R&#46; Paver"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "fecha" => "2005"
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2022 Enero 28 36 64
2021 Diciembre 26 37 63
2021 Noviembre 42 37 79
2021 Octubre 55 44 99
2021 Septiembre 47 41 88
2021 Agosto 34 28 62
2021 Julio 35 36 71
2021 Junio 25 53 78
2021 Mayo 43 34 77
2021 Abril 95 50 145
2021 Marzo 56 30 86
2021 Febrero 58 28 86
2021 Enero 44 19 63
2020 Diciembre 38 20 58
2020 Noviembre 22 15 37
2020 Octubre 38 7 45
2020 Septiembre 27 11 38
2020 Agosto 27 26 53
2020 Julio 16 7 23
2020 Junio 39 26 65
2020 Mayo 41 23 64
2020 Abril 27 29 56
2020 Marzo 43 16 59
2020 Febrero 1 7 8
2020 Enero 0 5 5
2019 Diciembre 0 18 18
2019 Noviembre 0 3 3
2019 Octubre 0 5 5
2019 Septiembre 0 5 5
2019 Agosto 0 7 7
2019 Julio 0 10 10
2019 Junio 0 9 9
2019 Mayo 0 38 38
2019 Abril 0 6 6
2019 Marzo 0 6 6
2019 Febrero 0 8 8
2019 Enero 0 4 4
2018 Marzo 1 1 2
2018 Febrero 12 3 15
2018 Enero 18 6 24
2017 Diciembre 17 6 23
2017 Noviembre 12 5 17
2017 Octubre 17 4 21
2017 Septiembre 10 3 13
2017 Agosto 13 5 18
2017 Julio 9 2 11
2017 Junio 18 3 21
2017 Mayo 18 4 22
2017 Abril 19 7 26
2017 Marzo 26 8 34
2017 Febrero 20 6 26
2017 Enero 18 9 27
2016 Diciembre 41 7 48
2016 Noviembre 24 10 34
2016 Octubre 19 6 25
2016 Septiembre 30 5 35
2016 Agosto 23 6 29
2016 Julio 35 10 45
2016 Junio 9 14 23
2016 Mayo 8 5 13
2016 Abril 8 3 11
2016 Marzo 5 1 6
2016 Febrero 9 5 14
2016 Enero 9 0 9
2015 Diciembre 9 3 12
2015 Noviembre 13 1 14
2015 Octubre 11 3 14
2015 Septiembre 5 3 8
2015 Agosto 7 1 8
2015 Julio 27 10 37
2015 Junio 25 2 27
2015 Mayo 87 6 93
2015 Abril 43 10 53
2015 Marzo 45 6 51
2015 Febrero 36 9 45
2015 Enero 30 12 42
2014 Diciembre 19 6 25
2014 Noviembre 28 8 36
2014 Octubre 39 9 48
2014 Septiembre 28 9 37
2014 Agosto 34 16 50
2014 Julio 39 21 60
2014 Junio 45 11 56
2014 Mayo 49 12 61
2014 Abril 33 7 40
2014 Marzo 41 18 59
2014 Febrero 27 13 40
2014 Enero 33 12 45
2013 Diciembre 50 16 66
2013 Noviembre 24 11 35
2013 Octubre 37 19 56
2013 Septiembre 25 17 42
2013 Agosto 34 30 64
2013 Julio 34 47 81
2013 Junio 26 40 66
2013 Mayo 26 26 52
2013 Abril 23 26 49
2013 Marzo 22 27 49
2013 Febrero 27 14 41
2013 Enero 14 3 17
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