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Analysis of Cytogenetic Abnormalities in Squamous Cell Carcinoma by Array Comparative Genomic Hybridization
Estudio de Las Lesiones Citogenéticas en el Carcinoma Escamoso Cutá-Neo Mediante la Técnica de Arrays de Hibridación Genómica Comparada
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Porta, J. San Juan, M.P. Grasa, E. Simal, M. Ara, I. Querol" "autores" => array:6 [ 0 => array:2 [ "nombre" => "N." "apellidos" => "Porta" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "San Juan" ] 2 => array:2 [ "nombre" => "M.P." "apellidos" => "Grasa" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Simal" ] 4 => array:2 [ "nombre" => "M." "apellidos" => "Ara" ] 5 => array:2 [ "nombre" => "I." "apellidos" => "Querol" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702336?idApp=UINPBA000044" "url" => "/15782190/0000009900000003/v1_201304241428/S1578219008702336/v1_201304241428/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1578219008702312" "issn" => "15782190" "doi" => "10.1016/S1578-2190(08)70231-2" "estado" => "S300" "fechaPublicacion" => "2008-04-01" "aid" => "70231" "copyright" => "Academia Española de Dermatología y Venereología and Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Actas Dermosifiliogr. 2008;99:190-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 5492 "formatos" => array:3 [ "EPUB" => 33 "HTML" => 2398 "PDF" => 3061 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Practical dermatology</span>" "titulo" => "Recurrent Vulvovaginitis: Diagnostic Assessment and Therapeutic Management" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "190" "paginaFinal" => "198" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vulvovaginitis de Repetición. Valoración Diagnóstica y Manejo Terapéutico" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Ramírez-Santos, M. Pereiro, J. Toribio" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Ramírez-Santos" ] 1 => array:3 [ "nombre" => "M." "apellidos" => "Pereiro" "sufijo" => "Jr" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Toribio" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702312?idApp=UINPBA000044" "url" => "/15782190/0000009900000003/v1_201304241428/S1578219008702312/v1_201304241428/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original articles</span>" "titulo" => "Analysis of Cytogenetic Abnormalities in Squamous Cell Carcinoma by Array Comparative Genomic Hybridization" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "199" "paginaFinal" => "206" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "R. Salgado, A. Toll, B. Espinet, E. González-Roca, C.L. Barranco, S. Serrano, F. Solé, R.M. Pujol" "autores" => array:8 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Salgado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 1 => array:4 [ "nombre" => "A." "apellidos" => "Toll" "email" => array:1 [ 0 => "93828@imas.imim.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 2 => array:3 [ "nombre" => "B." "apellidos" => "Espinet" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "E." "apellidos" => "González-Roca" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] ] 4 => array:3 [ "nombre" => "C.L." "apellidos" => "Barranco" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 5 => array:3 [ "nombre" => "S." "apellidos" => "Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 6 => array:3 [ "nombre" => "F." "apellidos" => "Solé" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 7 => array:3 [ "nombre" => "R.M." "apellidos" => "Pujol" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Laboratorio de Citogenética y Biología Molecular, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital del Mar, Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Laboratorio de Microarrays, Departamento de Bioinformática i Genòmica, Centro de Regulación Genómica (CRG), Barcelona, Spain" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff3" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital del Mar, Passeig Marítim, 25-29, 08003 Barcelona, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Estudio de Las Lesiones Citogenéticas en el Carcinoma Escamoso Cutá-Neo Mediante la Técnica de <span class="elsevierStyleItalic">Arrays</span> de Hibridación Genómica Comparada" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-09-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84151" "palabras" => array:4 [ 0 => "array" 1 => "comparative genomic hybridization" 2 => "cytogenetics" 3 => "cutaneous squamous cell carcinoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84152" "palabras" => array:4 [ 0 => "<span class="elsevierStyleItalic">array</span>" 1 => "hibridación genómica comparada" 2 => "citogenética" 3 => "carcinoma escamoso cutáneo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Few conventional cytogenetic studies of squamous cell carcinoma (SCC) have been performed to date. The introduction of cytogenetic techniques such as comparative genomic hybridization (CGH) has resolved some of the problems associated with conventional cytogenetics. The aim of this study was to analyze the presence of genetic abnormalities in a series of patients with SCC using the technique of array CGH.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">The study included 8 patients (7 men and 1 woman; mean age, 75 years) diagnosed with primary SCC. DNA was extracted from frozen tissue and analyzed by array CGH.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">All cases had genetic alterations, with gains more frequent than losses. The chromosomal regions with gains, in descending order of frequency, were as follows: 5p15.2, 9q31.3-q33.2, 13q, 18q22, 1p21-p22, 1q24-q25, 3p13, 4q33-q34 (<span class="elsevierStyleItalic">HMGB2</span>, <span class="elsevierStyleItalic">SAP30</span>), 20p12.2 (<span class="elsevierStyleItalic">JAG1</span>), 21q21.1, and Xq21.33. The region 9p13.1-p13.3 was the only one to display recurrent loss. No correlation was observed between the presence of gains or losses and the clinical and pathologic characteristics of the tumors.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">This is the first study to use the technique of array CGH to analyze genetic alterations in SCC. The finding of certain previously described aberrations (gain of 5p) suggests the existence of recurrent abnormalities. Likewise, the observation of alterations in small regions of chromosome 1 highlights the sensitivity of the technique to detect small changes. Application of the technique to a larger series of cases will provide greater insight into the genetic abnormalities implicated in the process of tumorigenesis in SCC.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">Los estudios de citogenética convencional realizados en el carcinoma escamoso cutáneo (CEC) son escasos. La introducción de las técnicas de citogenética, como la de hibridación genómica comparada (HGC), solventan algunos de los inconvenientes planteados por las técnicas de citogenética convencional. El objetivo de este estudio es analizar la presencia de alteraciones genéticas mediante la técnica de <span class="elsevierStyleItalic">array</span>-HGC en una serie de CEC.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudiaron un total de 8 pacientes (7 varones/una mujer; edad media: 75 años) diagnosticados de CEC primario. Se realizó extracción de ADN a partir de material congelado y se realizó la técnica de <span class="elsevierStyleItalic">array</span>-HGC.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Todos los casos mostraron alteraciones genéticas, siendo más frecuentes las ganancias que las pérdidas. Las regiones cromosómicas en las que se observaron ganancias, en orden decreciente, fueron 5p15.2, 9q31.3-q33.2, 13q, 18q22, 1p21-p22, 1q24-q25, 3p13, 4q33-q34 (HMGB2, SAP30), 20p12.2 (JAG1), 21q21.1, Xq21.33. La región 9p13.1-p13.3 fue la única que mostró una pérdida recurrente. No se detectó una correlación entre la presencia de ganancias o pérdidas y las características clínico-patológicas de los tumores.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Este estudio es el primero descrito en el que se utiliza la técnica de <span class="elsevierStyleItalic">array</span>-HGC con el fin de analizar las alteraciones genéticas del CEC. El hallazgo de algunas aberraciones ya descritas (ganancia de 5p) muestra la posibilidad de que existan lesiones recurrentes. Asimismo, la observación de pequeñas regiones alteradas (cromosoma 1) demuestra la sensibilidad de esta técnica en la detección de alteraciones de pequeño tamaño. Su aplicación en una serie amplia de casos podrá proporcionar un mayor conocimiento de las alteraciones genéticas implicadas en el proceso de tumorogénesis del CEC.</p>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara">This study was funded by a grant from the Health Research Fund (Fondo de Investigación Sanitaria) of the Spanish Ministry of Health (grant PI041728).</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:25 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DNA content and proliferative index in cutaneous squamous cell carcinoma and keratoacanthoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M.B. Randall" 1 => "K.R. Geisinger" 2 => "T.E. Kute" 3 => "D.H. Buss" 4 => "R.W. Prichard" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "1990" "volumen" => "93" "paginaInicial" => "259" "paginaFinal" => "262" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2301286" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sunlight and skin cancer: another link revealed" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "K.H. Kraemer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci" "fecha" => "1997" "volumen" => "94" "paginaInicial" => "11" "paginaFinal" => "14" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8990152" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics instabilities in human cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Lengauer" 1 => "K.W. Kinzler" 2 => "B. Vogelstein" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/25292" "Revista" => array:6 [ "tituloSerie" => "Nature" "fecha" => "1998" "volumen" => "396" "paginaInicial" => "643" "paginaFinal" => "649" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872311" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ultraviolet radiation and skin carcinogenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A.G. Quinn" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Br J Hosp Med" "fecha" => "1997" "volumen" => "58" "paginaInicial" => "261" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9488800" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low doses of UVB or UVA induce chromosomal aberrations in cultured human skin cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Emri" 1 => "E. Wenczl" 2 => "P. Van Erp" 3 => "J. Jans" 4 => "L. Roza" 5 => "I. Horkay" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1747.2000.00057.x" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2000" "volumen" => "115" "paginaInicial" => "435" "paginaFinal" => "440" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10951280" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Basal cell carcinomas and squamous cell carcinomas of human skin show distinct patterns of chromosome loss" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.G. Quinn" 1 => "S. Sikkink" 2 => "J.L. Rees" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Res" "fecha" => "1994" "volumen" => "54" "paginaInicial" => "4756" "paginaFinal" => "4759" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8062275" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of heterozygosity in human skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "R. Happle" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "1999" "volumen" => "41" "paginaInicial" => "143" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10426882" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular cytogenetic aspects of hematological malignancies: clinical implications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Z. Chen" 1 => "A.A. Sandberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/ajmg.10689" "Revista" => array:6 [ "tituloSerie" => "Am J Med Genet" "fecha" => "2002" "volumen" => "115" "paginaInicial" => "130" "paginaFinal" => "141" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12407693" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Advances in cytogenetic analysis of solid tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L. James" 1 => "J. Varley" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Chromosome Res" "fecha" => "1996" "volumen" => "4" "paginaInicial" => "479" "paginaFinal" => "485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8939358" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442209702996" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytogenetic and interphase FISH analysis of 73 basal cell and three squamous cell carcinoma: different findings in direct preparations and short-term culture" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Casalone" 1 => "D. Mazzola" 2 => "R. Righi" 3 => "P. Granata" 4 => "E. Minelli" 5 => "M. Salvadore" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet Cytogenet" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "136" "paginaFinal" => "143" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10748294" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Nonrandom karyotypic features in squamous cell carcinomas of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Jin" 1 => "C. Martins" 2 => "C. Jin" 3 => "L. Salemark" 4 => "N. Jonsson" 5 => "B. Persson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genes Chromosomes Cancer" "fecha" => "1999" "volumen" => "26" "paginaInicial" => "295" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10534764" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Jumping translocation of chromosome 14 in a skin squamous cell carcinoma from xeroderma pigmentosum patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Aledo" 1 => "A. Aurias" 2 => "B. Chretein" 3 => "B. Dutrillaux" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Cancer Genet Cytogenet" "fecha" => "1988" "volumen" => "33" "paginaInicial" => "29" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3164238" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clonal cytogenetic evolution in a squamous cell carcinoma of the skin from a xeroderma pigmentosum patient" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Worsham" 1 => "T.E. Carey" 2 => "M.S. Benninger" 3 => "K.M. Gasser" 4 => "W. Kelker" 5 => "R.J. Zarbo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Genes Chromosomes Cancer" "fecha" => "1993" "volumen" => "7" "paginaInicial" => "158" "paginaFinal" => "164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7687869" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Trisomy 7 in keratoacanthoma and squamous cell carcinoma detected by fluorescence in situ hybridization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.C. Cheville" 1 => "C. Bromley" 2 => "Z.B. Argenyi" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Cutan Pathol" "fecha" => "1995" "volumen" => "22" "paginaInicial" => "546" "paginaFinal" => "550" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8835173" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deletion monitoring in skin tumors by interphase-FISH using band-specific DNA probes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Döbler" 1 => "J. Schuh" 2 => "F. Kiesewetter" 3 => "H. Schell" 4 => "T. Liehr" 5 => "E. Gebhart" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Oncol" "fecha" => "1999" "volumen" => "14" "paginaInicial" => "571" "paginaFinal" => "576" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10024693" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Kallioniemi" 1 => "O.P. Kallioniemi" 2 => "D. Sudar" 3 => "D. Rutovitz" 4 => "J.W. Gray" 5 => "F. Waldman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Science" "fecha" => "1992" "volumen" => "28" "paginaInicial" => "818" "paginaFinal" => "821" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromosomal aberrations in squamous cell carcinoma and solar keratoses revealed by comparative genomic hybridization" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K.J. Ashton" 1 => "S.R. Weinstein" 2 => "D.J. Maguire" 3 => "L.R. Griffiths" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.139.7.876" "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "2003" "volumen" => "139" "paginaInicial" => "876" "paginaFinal" => "882" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12873882" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genome-wide detection of chromosomal imbalances in tumors using BAC microarrays" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.W. Cai" 1 => "J.H. Mao" 2 => "C.W. Chow" 3 => "S. Damani" 4 => "A. Balmain" 5 => "A. Bradley" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/nbt0402-393" "Revista" => array:7 [ "tituloSerie" => "Nat Biotechnol" "fecha" => "2002" "volumen" => "20" "paginaInicial" => "393" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11923847" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442209701395" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microarray-based comparative genomic hybridization and its applications in human genetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Oostlander" 1 => "G. Meijer" 2 => "B. Ylstra" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clin Genet" "fecha" => "2004" "volumen" => "66" "paginaInicial" => "448" "paginaFinal" => "495" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.E. Brash" 1 => "J.A. Rudolph" 2 => "J.A. Simon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Proc Natl Acad Sci US" "fecha" => "1991" "volumen" => "88" "paginaInicial" => "10124" "paginaFinal" => "10128" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic change in actinic keratoses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "I. Rehman" 1 => "M. Takata" 2 => "Y.-Y. Wu" 3 => "J.L. Rees" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Oncogene" "fecha" => "1996" "volumen" => "12" "paginaInicial" => "2483" "paginaFinal" => "2490" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8700506" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular profiling of transformed and metastatic murine squamous carcinoma cells by differential display and cDNA microarray reveals altered expression of multiple genes related to growth, apoptosis, angiogenesis, and the NF-kB signal pathway" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Dong" 1 => "E. Loukinova" 2 => "Z. Chen" 3 => "L. Gangi" 4 => "T.I. Chanturita" 5 => "E.T. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Cancer Res" "fecha" => "2001" "volumen" => "15" "paginaInicial" => "4797" "paginaFinal" => "4798" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel proteasome inhibitor PS-341 inhibits activation of NF-kB, cell survival, tumor growth and angiogenesis in squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.B. Sunwoo" 1 => "Z. Chen" 2 => "G. Dong" 3 => "N. Yeh" 4 => "C.C. Bancroft" 5 => "E. Sausville" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2001" "volumen" => "7" "paginaInicial" => "1419" "paginaFinal" => "1428" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11350913" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mutational analysis of CDKN2A genes in patients with squamous cell carcinoma of the skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Z. Saridaki" 1 => "T. Liloglou" 2 => "A. Zafiropoulos" 3 => "E. Koumantaki" 4 => "O. Zoras" 5 => "D.A. Spandidos" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2003" "volumen" => "148" "paginaInicial" => "638" "paginaFinal" => "648" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12752119" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1474442207701783" "estado" => "S300" "issn" => "14744422" ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic imbalances in 26 cases of penile squamous cell carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Alves" 1 => "A. Heller" 2 => "W. Fiedler" 3 => "M.M. Campos" 4 => "U. Claussen" 5 => "A.A. Ornellas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/gcc.1117" "Revista" => array:6 [ "tituloSerie" => "Genes Chromosomes Cancer" "fecha" => "2001" "volumen" => "31" "paginaInicial" => "48" "paginaFinal" => "53" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11284035" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000009900000003/v1_201304241428/S1578219008702324/v1_201304241428/en/main.assets" "Apartado" => array:4 [ "identificador" => "6155" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Articles" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000009900000003/v1_201304241428/S1578219008702324/v1_201304241428/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219008702324?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 3 | 10 | 13 |
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| 2023 Septiembre | 42 | 37 | 79 |
| 2023 Agosto | 33 | 42 | 75 |
| 2023 Julio | 44 | 54 | 98 |
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| 2023 Mayo | 32 | 23 | 55 |
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| 2023 Febrero | 25 | 15 | 40 |
| 2023 Enero | 27 | 34 | 61 |
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| 2022 Agosto | 12 | 14 | 26 |
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| 2022 Abril | 36 | 40 | 76 |
| 2022 Marzo | 43 | 53 | 96 |
| 2022 Febrero | 17 | 30 | 47 |
| 2022 Enero | 18 | 39 | 57 |
| 2021 Diciembre | 18 | 41 | 59 |
| 2021 Noviembre | 21 | 39 | 60 |
| 2021 Octubre | 29 | 42 | 71 |
| 2021 Septiembre | 35 | 44 | 79 |
| 2021 Agosto | 29 | 21 | 50 |
| 2021 Julio | 18 | 27 | 45 |
| 2021 Junio | 12 | 28 | 40 |
| 2021 Mayo | 52 | 35 | 87 |
| 2021 Abril | 44 | 34 | 78 |
| 2021 Marzo | 63 | 22 | 85 |
| 2021 Febrero | 59 | 25 | 84 |
| 2021 Enero | 28 | 17 | 45 |
| 2020 Diciembre | 25 | 15 | 40 |
| 2020 Noviembre | 19 | 14 | 33 |
| 2020 Octubre | 23 | 15 | 38 |
| 2020 Septiembre | 22 | 11 | 33 |
| 2020 Agosto | 26 | 14 | 40 |
| 2020 Julio | 18 | 6 | 24 |
| 2020 Junio | 23 | 29 | 52 |
| 2020 Mayo | 27 | 18 | 45 |
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| 2020 Marzo | 26 | 30 | 56 |
| 2020 Febrero | 5 | 5 | 10 |
| 2020 Enero | 0 | 9 | 9 |
| 2019 Diciembre | 0 | 7 | 7 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 3 | 3 |
| 2019 Septiembre | 0 | 21 | 21 |
| 2019 Agosto | 0 | 2 | 2 |
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| 2019 Mayo | 1 | 51 | 52 |
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| 2019 Marzo | 0 | 3 | 3 |
| 2019 Febrero | 0 | 8 | 8 |
| 2019 Enero | 0 | 1 | 1 |
| 2018 Diciembre | 0 | 6 | 6 |
| 2018 Febrero | 7 | 6 | 13 |
| 2018 Enero | 12 | 11 | 23 |
| 2017 Diciembre | 17 | 7 | 24 |
| 2017 Noviembre | 10 | 5 | 15 |
| 2017 Octubre | 14 | 7 | 21 |
| 2017 Septiembre | 10 | 3 | 13 |
| 2017 Agosto | 8 | 6 | 14 |
| 2017 Julio | 20 | 2 | 22 |
| 2017 Junio | 22 | 12 | 34 |
| 2017 Mayo | 10 | 2 | 12 |
| 2017 Abril | 12 | 5 | 17 |
| 2017 Marzo | 13 | 3 | 16 |
| 2017 Febrero | 12 | 6 | 18 |
| 2017 Enero | 13 | 10 | 23 |
| 2016 Diciembre | 17 | 8 | 25 |
| 2016 Noviembre | 18 | 19 | 37 |
| 2016 Octubre | 24 | 28 | 52 |
| 2016 Septiembre | 25 | 5 | 30 |
| 2016 Agosto | 22 | 4 | 26 |
| 2016 Julio | 24 | 7 | 31 |
| 2016 Junio | 17 | 3 | 20 |
| 2016 Mayo | 7 | 5 | 12 |
| 2016 Abril | 7 | 6 | 13 |
| 2016 Marzo | 3 | 7 | 10 |
| 2016 Febrero | 5 | 10 | 15 |
| 2016 Enero | 15 | 1 | 16 |
| 2015 Diciembre | 10 | 0 | 10 |
| 2015 Noviembre | 18 | 2 | 20 |
| 2015 Octubre | 14 | 1 | 15 |
| 2015 Septiembre | 7 | 6 | 13 |
| 2015 Agosto | 13 | 2 | 15 |
| 2015 Julio | 43 | 9 | 52 |
| 2015 Junio | 56 | 7 | 63 |
| 2015 Mayo | 80 | 13 | 93 |
| 2015 Abril | 36 | 9 | 45 |
| 2015 Marzo | 29 | 16 | 45 |
| 2015 Febrero | 11 | 11 | 22 |
| 2015 Enero | 27 | 9 | 36 |
| 2014 Diciembre | 29 | 7 | 36 |
| 2014 Noviembre | 20 | 14 | 34 |
| 2014 Octubre | 40 | 18 | 58 |
| 2014 Septiembre | 30 | 12 | 42 |
| 2014 Agosto | 34 | 22 | 56 |
| 2014 Julio | 39 | 22 | 61 |
| 2014 Junio | 62 | 14 | 76 |
| 2014 Mayo | 49 | 25 | 74 |
| 2014 Abril | 36 | 14 | 50 |
| 2014 Marzo | 47 | 21 | 68 |
| 2014 Febrero | 40 | 11 | 51 |
| 2014 Enero | 40 | 20 | 60 |
| 2013 Diciembre | 53 | 17 | 70 |
| 2013 Noviembre | 20 | 14 | 34 |
| 2013 Octubre | 29 | 14 | 43 |
| 2013 Septiembre | 29 | 21 | 50 |
| 2013 Agosto | 26 | 38 | 64 |
| 2013 Julio | 35 | 35 | 70 |
| 2013 Junio | 27 | 20 | 47 |
| 2013 Mayo | 27 | 17 | 44 |
| 2013 Abril | 33 | 19 | 52 |
| 2013 Marzo | 31 | 21 | 52 |
| 2013 Febrero | 31 | 16 | 47 |
| 2013 Enero | 15 | 6 | 21 |
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