Controversies in dermatology
Recent Data on the Risk of Malignancy in Congenital Melanocytic Nevi: The Continuing Debate on Treatment
Últimos Datos Sobre el Riesgo de Malignización de Los Nevus Melanocíticos Congénitos: el Debate Sobre el Tratamiento Continúa
A. Hernández
, A. Torrelo
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ahernandez@aedv.es
Correspondence: Dermatología, Hospital del Niño Jesús, Avda. Menéndez Pelayo, 65, 28009 Madrid, Spain.
Correspondence: Dermatología, Hospital del Niño Jesús, Avda. Menéndez Pelayo, 65, 28009 Madrid, Spain.
Servicio de Dermatología, Hospital del Niño Jesús, Madrid, Spain
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"apellidos" => "Hernández" "email" => array:1 [ 0 => "ahernandez@aedv.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Torrelo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Dermatología, Hospital del Niño Jesús, Madrid, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Dermatología, Hospital del Niño Jesús, Avda. Menéndez Pelayo, 65, 28009 Madrid, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Últimos Datos Sobre el Riesgo de Malignización de Los Nevus Melanocíticos Congénitos: el Debate Sobre el Tratamiento Continúa" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2007-09-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84144" "palabras" => array:3 [ 0 => "congenital melanocytic nevus" 1 => "melanoma" 2 => "risk" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84143" "palabras" => array:3 [ 0 => "nevus melanocítico congénito" 1 => "melanoma" 2 => "riesgo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Congenital melanocytic nevi (CMN) have traditionally been considered a risk factor for the appearance of melanoma, but the true incidence of malignancy is unknown. Although various studies have attempted to quantify it, the results are highly variable and it is difficult to decide on the best therapeutic approach to take. Consequently, for some time the management of CMN has depended more on personal experience than on clear scientific evidence. The most recent studies performed in large patient series indicate that the risk of malignancy in CMN is much lower than expected and mainly affects large lesions involving the axial midline. In addition, it appears that a number of melanomas develop on the site of partially or completely excised lesions, or even away from the CMN itself, making the appropriateness of prophylactic surgery increasingly doubtful.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Los nevus melanocíticos congénitos (NMC) se han considerado tradicionalmente un factor de riesgo para la aparición de melanoma, pero se desconoce la verdadera incidencia de la malignización. Aunque numerosos trabajos han tratado de cuantificarla, los resultados son muy dispares y resulta difícil decidir qué actitud terapéutica es la más adecuada. Por este motivo, durante mucho tiempo el manejo de los NMC ha dependido más de la experiencia personal que de una auténtica evidencia científica. Los últimos estudios realizados en series amplias de pacientes reflejan que el riesgo de malignización de los NMC es mucho más bajo de lo que se creía, y afecta principalmente a lesiones de gran tamaño localizadas sobre el axis. Además, parece que un considerable número de melanomas se desarrolla sobre lesiones parcial o totalmente extirpadas, e incluso fuera del propio NMC, por lo que la necesidad de la cirugía profiláctica es cada vez más controvertida.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Congenital nevocytic nevi and malignant melanomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.W. Kopf" 1 => "R.S. Bart" 2 => "P. 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 6 | 29 | 35 |
| 2024 Octubre | 68 | 144 | 212 |
| 2024 Septiembre | 54 | 107 | 161 |
| 2024 Agosto | 95 | 174 | 269 |
| 2024 Julio | 67 | 155 | 222 |
| 2024 Junio | 76 | 171 | 247 |
| 2024 Mayo | 53 | 157 | 210 |
| 2024 Abril | 68 | 111 | 179 |
| 2024 Marzo | 70 | 120 | 190 |
| 2024 Febrero | 68 | 52 | 120 |
| 2024 Enero | 49 | 53 | 102 |
| 2023 Diciembre | 43 | 43 | 86 |
| 2023 Noviembre | 67 | 42 | 109 |
| 2023 Octubre | 45 | 44 | 89 |
| 2023 Septiembre | 48 | 44 | 92 |
| 2023 Agosto | 52 | 43 | 95 |
| 2023 Julio | 45 | 58 | 103 |
| 2023 Junio | 47 | 36 | 83 |
| 2023 Mayo | 45 | 73 | 118 |
| 2023 Abril | 45 | 31 | 76 |
| 2023 Marzo | 56 | 29 | 85 |
| 2023 Febrero | 35 | 26 | 61 |
| 2023 Enero | 40 | 44 | 84 |
| 2022 Diciembre | 30 | 46 | 76 |
| 2022 Noviembre | 26 | 30 | 56 |
| 2022 Octubre | 17 | 22 | 39 |
| 2022 Septiembre | 22 | 56 | 78 |
| 2022 Agosto | 27 | 47 | 74 |
| 2022 Julio | 18 | 52 | 70 |
| 2022 Junio | 27 | 54 | 81 |
| 2022 Mayo | 30 | 54 | 84 |
| 2022 Abril | 32 | 47 | 79 |
| 2022 Marzo | 37 | 60 | 97 |
| 2022 Febrero | 26 | 24 | 50 |
| 2022 Enero | 24 | 37 | 61 |
| 2021 Diciembre | 25 | 32 | 57 |
| 2021 Noviembre | 26 | 40 | 66 |
| 2021 Octubre | 41 | 47 | 88 |
| 2021 Septiembre | 24 | 45 | 69 |
| 2021 Agosto | 20 | 27 | 47 |
| 2021 Julio | 24 | 29 | 53 |
| 2021 Junio | 38 | 33 | 71 |
| 2021 Mayo | 28 | 30 | 58 |
| 2021 Abril | 67 | 56 | 123 |
| 2021 Marzo | 71 | 26 | 97 |
| 2021 Febrero | 64 | 26 | 90 |
| 2021 Enero | 47 | 15 | 62 |
| 2020 Diciembre | 34 | 15 | 49 |
| 2020 Noviembre | 16 | 13 | 29 |
| 2020 Octubre | 12 | 10 | 22 |
| 2020 Septiembre | 26 | 16 | 42 |
| 2020 Agosto | 33 | 17 | 50 |
| 2020 Julio | 23 | 6 | 29 |
| 2020 Junio | 22 | 17 | 39 |
| 2020 Mayo | 16 | 17 | 33 |
| 2020 Abril | 23 | 19 | 42 |
| 2020 Marzo | 31 | 19 | 50 |
| 2020 Febrero | 5 | 4 | 9 |
| 2020 Enero | 0 | 8 | 8 |
| 2019 Diciembre | 0 | 7 | 7 |
| 2019 Noviembre | 0 | 3 | 3 |
| 2019 Octubre | 0 | 5 | 5 |
| 2019 Septiembre | 0 | 5 | 5 |
| 2019 Agosto | 0 | 2 | 2 |
| 2019 Julio | 0 | 16 | 16 |
| 2019 Junio | 0 | 15 | 15 |
| 2019 Mayo | 0 | 82 | 82 |
| 2019 Abril | 0 | 23 | 23 |
| 2019 Marzo | 0 | 10 | 10 |
| 2019 Febrero | 0 | 4 | 4 |
| 2019 Enero | 0 | 3 | 3 |
| 2018 Diciembre | 0 | 9 | 9 |
| 2018 Noviembre | 0 | 5 | 5 |
| 2018 Septiembre | 0 | 12 | 12 |
| 2018 Agosto | 0 | 15 | 15 |
| 2018 Julio | 0 | 16 | 16 |
| 2018 Junio | 0 | 11 | 11 |
| 2018 Mayo | 0 | 5 | 5 |
| 2018 Abril | 0 | 14 | 14 |
| 2018 Marzo | 1 | 2 | 3 |
| 2018 Febrero | 9 | 7 | 16 |
| 2018 Enero | 21 | 14 | 35 |
| 2017 Diciembre | 14 | 15 | 29 |
| 2017 Noviembre | 17 | 26 | 43 |
| 2017 Octubre | 16 | 6 | 22 |
| 2017 Septiembre | 17 | 14 | 31 |
| 2017 Agosto | 30 | 19 | 49 |
| 2017 Julio | 28 | 9 | 37 |
| 2017 Junio | 29 | 29 | 58 |
| 2017 Mayo | 25 | 17 | 42 |
| 2017 Abril | 26 | 17 | 43 |
| 2017 Marzo | 21 | 16 | 37 |
| 2017 Febrero | 20 | 22 | 42 |
| 2017 Enero | 25 | 20 | 45 |
| 2016 Diciembre | 43 | 20 | 63 |
| 2016 Noviembre | 25 | 21 | 46 |
| 2016 Octubre | 25 | 31 | 56 |
| 2016 Septiembre | 26 | 11 | 37 |
| 2016 Agosto | 24 | 18 | 42 |
| 2016 Julio | 24 | 9 | 33 |
| 2016 Junio | 6 | 10 | 16 |
| 2016 Mayo | 6 | 4 | 10 |
| 2016 Abril | 11 | 11 | 22 |
| 2016 Marzo | 2 | 14 | 16 |
| 2016 Febrero | 9 | 13 | 22 |
| 2016 Enero | 8 | 15 | 23 |
| 2015 Diciembre | 6 | 7 | 13 |
| 2015 Noviembre | 14 | 9 | 23 |
| 2015 Octubre | 5 | 14 | 19 |
| 2015 Septiembre | 1 | 12 | 13 |
| 2015 Agosto | 8 | 6 | 14 |
| 2015 Julio | 35 | 12 | 47 |
| 2015 Junio | 31 | 9 | 40 |
| 2015 Mayo | 65 | 16 | 81 |
| 2015 Abril | 35 | 16 | 51 |
| 2015 Marzo | 29 | 4 | 33 |
| 2015 Febrero | 15 | 12 | 27 |
| 2015 Enero | 27 | 21 | 48 |
| 2014 Diciembre | 20 | 5 | 25 |
| 2014 Noviembre | 28 | 17 | 45 |
| 2014 Octubre | 45 | 14 | 59 |
| 2014 Septiembre | 41 | 14 | 55 |
| 2014 Agosto | 41 | 18 | 59 |
| 2014 Julio | 60 | 25 | 85 |
| 2014 Junio | 49 | 17 | 66 |
| 2014 Mayo | 51 | 12 | 63 |
| 2014 Abril | 52 | 19 | 71 |
| 2014 Marzo | 41 | 20 | 61 |
| 2014 Febrero | 21 | 17 | 38 |
| 2014 Enero | 38 | 15 | 53 |
| 2013 Diciembre | 36 | 19 | 55 |
| 2013 Noviembre | 23 | 18 | 41 |
| 2013 Octubre | 24 | 20 | 44 |
| 2013 Septiembre | 30 | 29 | 59 |
| 2013 Agosto | 17 | 22 | 39 |
| 2013 Julio | 23 | 49 | 72 |
| 2013 Junio | 25 | 26 | 51 |
| 2013 Mayo | 25 | 18 | 43 |
| 2013 Abril | 23 | 17 | 40 |
| 2013 Marzo | 43 | 20 | 63 |
| 2013 Febrero | 24 | 12 | 36 |
| 2013 Enero | 13 | 3 | 16 |
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