Case reports
Waldenström Macroglobulinemia Associated With Cutaneous Lesions and Type I Cryoglobulinemia
Macroglobulinemia de Waldenström Asociada a Lesiones Cutáneas y Crioglobulinemia Tipo IA
J. del Olmoa, A. Españaa,
, M.A. Idoateb, C. Panizoc
Autor para correspondencia
aespana@unav.es
Correspondence: Departamento de Dermatología, Clínica Universitaria de Navarra, Facultat de Medicina, Universidad de Navarra, Apartado 4209 31080 Pamplona, Navarra, Spain.
Correspondence: Departamento de Dermatología, Clínica Universitaria de Navarra, Facultat de Medicina, Universidad de Navarra, Apartado 4209 31080 Pamplona, Navarra, Spain.
a Departamento de Dermatología, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain
b Departamento de Anatomía Patológica, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain
c Departamento de Hematología, Clínica Universitaria de Navarra,Facultad de Medicina, Universidad de Navarra, Pamplona, Navarra, Spain
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Patients with this disease show elevated serum levels and tissue deposition of monoclonal immunoglobulin (Ig) M produced by these aberrant cells. We present the case of a patient with Waldenström macroglobulinemia who suffered cutaneous lesions resulting from deposition of #k light chains of IgM and clinical manifestations secondary to associated type I cryoglobulinemia. We discuss the different pathological cutaneous processes caused by IgM in Waldenström macroglobulinemia.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La macroglobulinemia de Waldenström (MW) es una discrasia sanguínea caracterizada por la proliferación monoclonal de células linfoplasmocitarias en la médula ósea, ganglios linfáticos y bazo. Estos pacientes tienen niveles elevados en suero y depósito en tejidos de la inmunoglobulina (Ig) M, de tipo monoclonal, producida por estas células aberrantes. Presentamos el caso de un paciente afecto de MW, con lesiones cutáneas debidas al depósito de cadenas ligeras Kappa de IgM y con manifestaciones clínicas secundarias a la crioglobulinemia tipo I que el paciente tenía asociada. Discutimos los distintos proceso patológicos cutáneos provocados por la IgM en la MW.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Waldenström's macroglobulinemia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "T.F. Deuel" 1 => "P. Davis" 2 => "L.V. 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| año/Mes | Html | Total | |
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| 2015 Octubre | 4 | 4 | 8 |
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| 2015 Febrero | 18 | 20 | 38 |
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| 2014 Diciembre | 35 | 26 | 61 |
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| 2014 Octubre | 27 | 20 | 47 |
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| 2014 Agosto | 54 | 18 | 72 |
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| 2014 Marzo | 42 | 22 | 64 |
| 2014 Febrero | 38 | 26 | 64 |
| 2014 Enero | 33 | 30 | 63 |
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| 2013 Agosto | 30 | 36 | 66 |
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| 2013 Mayo | 38 | 52 | 90 |
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