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Adverse Cutaneous Reactions to Erlotinib
Efectos Cutáneos Adversos Causados Por Erlotinib
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Pitarch, J. Garde, A. Torrijos, A. Juárez, M.I. Febrer, C. Camps" "autores" => array:6 [ 0 => array:4 [ "nombre" => "G." "apellidos" => "Pitarch" "email" => array:1 [ 0 => "gerardpitarch@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "J." "apellidos" => "Garde" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Torrijos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "A." 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"apellidos" => "Camps" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Consorci Hospital General Universitari de València, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Servicio de Oncología Médica, Consorci Hospital General Universitari de València, Valencia, Spain" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Correspondence: Servicio de Dermatología, Hospital General de Castelló, Avda. Benicàssim s/n, 12004 Castelló de la Plana, Spain." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos Cutáneos Adversos Causados Por Erlotinib" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaAceptado" => "2006-06-19" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec84093" "palabras" => array:5 [ 0 => "erlotinib" 1 => "epidermal growth factor receptor" 2 => "acneiform" 3 => "seborrheic dermatitis" 4 => "paronychia" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec84094" "palabras" => array:5 [ 0 => "erlotinib" 1 => "receptor de factor de crecimiento epidérmico" 2 => "acneiforme" 3 => "dermatitis seborreica" 4 => "paroniquia" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Erlotinib is an inhibitor of human epidermal growth factor approved for treating nonsmall cell lung cancer. The aim of this prospective observational study was to determine the prevalence of adverse cutaneous reactions caused by erlotinib and assess the management of such effects.</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">Eleven patients with lung cancer and 1 with ovarian cancer received erlotinib at a dose of 150<span class="elsevierStyleHsp" style=""></span>mg/d. The prevalence, severity, and time course of the adverse cutaneous reactions were assessed.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The most frequent cutaneous reaction was acneiform eruption (10 cases). The patients were treated with topical erythromycin and clindamycin, or with doxycycline. Also reported were seborrheic dermatitis (5), paronychia (4), xerosis (3), mouth blisters (3), blepharitis (2), cheilitis (1), and fissures on the hands and feet (1). The first reactions to appear were seborrheic dermatitis (9.8 days until onset) and acneiform eruption (11.8 days), whereas the paronychia presented latest (65.3 days). One patient with acneiform eruption and another with paronychia suspended treatment until the lesions improved.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Erlotinib induces adverse effects in most patients treated. Acneiform eruption, seborrheic dermatitis, and paronychia are the most frequently reported reactions and can lead to temporary suspension of erlotinib administration.</p>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El erlotinib es un inhibidor del factor de crecimiento epidérmico humano aprobado en el tratamiento del cáncer de pulmón no microcítico. El objetivo de este estudio prospectivo y observacional es determinar la prevalencia de los efectos cutáneos adversos por erlotinib y su manejo.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Once pacientes con cáncer de pulmón y una con cáncer de ovario fueron tratados con erlotinib en dosis de 150 mg diarios. Se evaluó la prevalencia, la intensidad y la cronología de los efectos cutáneos adversos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">La reacción cutánea más frecuente fue la erupción acneiforme (10 casos). Los pacientes fueron tratados con eritromicina o clindamicina tópicas, o con doxicilina. Los pacientes también desarrollaron dermatitis seborreica (5), paroniquia (4), xerosis (3), aftas orales (3), blefaritis (2), queilitis (1) y fisuras en manos y pies (1). Los efectos adversos más precoces fueron la dermatitis seborreica (9,8 días hasta la aparición) y la erupción acneiforme (11,8 días), mientras que la paroniquia fue el efecto más tardío (65,3 días). Un paciente con erupción acneiforme y otro con paroniquia suspendieron el tratamiento con erlotinib hasta la mejoría de las lesiones.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">El erlotinib produce efectos cutáneos adversos en la gran mayoría de los pacientes tratados. La erupción acneiforme, la dermatitis seborreica y la paroniquia son los efectos más frecuentes, que pueden llevar a interrumpir temporalmente la administración de erlotinib.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:34 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
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| 2021 Diciembre | 22 | 34 | 56 |
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| 2020 Marzo | 22 | 24 | 46 |
| 2020 Febrero | 2 | 8 | 10 |
| 2020 Enero | 0 | 15 | 15 |
| 2019 Diciembre | 0 | 14 | 14 |
| 2019 Noviembre | 0 | 13 | 13 |
| 2019 Octubre | 0 | 7 | 7 |
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| 2018 Diciembre | 0 | 5 | 5 |
| 2018 Noviembre | 0 | 3 | 3 |
| 2018 Octubre | 0 | 1 | 1 |
| 2018 Septiembre | 0 | 3 | 3 |
| 2018 Agosto | 0 | 9 | 9 |
| 2018 Julio | 0 | 8 | 8 |
| 2018 Junio | 0 | 2 | 2 |
| 2018 Mayo | 0 | 10 | 10 |
| 2018 Abril | 0 | 12 | 12 |
| 2018 Marzo | 1 | 7 | 8 |
| 2018 Febrero | 15 | 9 | 24 |
| 2018 Enero | 13 | 21 | 34 |
| 2017 Diciembre | 12 | 12 | 24 |
| 2017 Noviembre | 12 | 14 | 26 |
| 2017 Octubre | 16 | 12 | 28 |
| 2017 Septiembre | 8 | 12 | 20 |
| 2017 Agosto | 16 | 17 | 33 |
| 2017 Julio | 24 | 19 | 43 |
| 2017 Junio | 17 | 15 | 32 |
| 2017 Mayo | 17 | 17 | 34 |
| 2017 Abril | 13 | 28 | 41 |
| 2017 Marzo | 16 | 27 | 43 |
| 2017 Febrero | 19 | 20 | 39 |
| 2017 Enero | 19 | 26 | 45 |
| 2016 Diciembre | 38 | 24 | 62 |
| 2016 Noviembre | 44 | 13 | 57 |
| 2016 Octubre | 32 | 15 | 47 |
| 2016 Septiembre | 36 | 15 | 51 |
| 2016 Agosto | 38 | 25 | 63 |
| 2016 Julio | 41 | 12 | 53 |
| 2016 Junio | 9 | 9 | 18 |
| 2016 Mayo | 8 | 6 | 14 |
| 2016 Abril | 7 | 15 | 22 |
| 2016 Marzo | 5 | 13 | 18 |
| 2016 Febrero | 11 | 12 | 23 |
| 2016 Enero | 9 | 15 | 24 |
| 2015 Diciembre | 8 | 8 | 16 |
| 2015 Noviembre | 11 | 12 | 23 |
| 2015 Octubre | 12 | 15 | 27 |
| 2015 Septiembre | 7 | 18 | 25 |
| 2015 Agosto | 10 | 7 | 17 |
| 2015 Julio | 22 | 13 | 35 |
| 2015 Junio | 32 | 8 | 40 |
| 2015 Mayo | 77 | 12 | 89 |
| 2015 Abril | 47 | 5 | 52 |
| 2015 Marzo | 32 | 10 | 42 |
| 2015 Febrero | 10 | 11 | 21 |
| 2015 Enero | 18 | 9 | 27 |
| 2014 Diciembre | 23 | 5 | 28 |
| 2014 Noviembre | 23 | 10 | 33 |
| 2014 Octubre | 35 | 7 | 42 |
| 2014 Septiembre | 21 | 14 | 35 |
| 2014 Agosto | 33 | 19 | 52 |
| 2014 Julio | 40 | 19 | 59 |
| 2014 Junio | 47 | 9 | 56 |
| 2014 Mayo | 41 | 17 | 58 |
| 2014 Abril | 28 | 7 | 35 |
| 2014 Marzo | 40 | 20 | 60 |
| 2014 Febrero | 31 | 26 | 57 |
| 2014 Enero | 33 | 17 | 50 |
| 2013 Diciembre | 36 | 25 | 61 |
| 2013 Noviembre | 27 | 23 | 50 |
| 2013 Octubre | 29 | 25 | 54 |
| 2013 Septiembre | 33 | 26 | 59 |
| 2013 Agosto | 30 | 38 | 68 |
| 2013 Julio | 40 | 43 | 83 |
| 2013 Junio | 27 | 30 | 57 |
| 2013 Mayo | 22 | 36 | 58 |
| 2013 Abril | 19 | 36 | 55 |
| 2013 Marzo | 28 | 29 | 57 |
| 2013 Febrero | 36 | 15 | 51 |
| 2013 Enero | 11 | 6 | 17 |
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