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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Blastic plasmacytoid dendritic cell neoplasm &#40;BPDCN&#41; is a rare and aggressive hematodermic neoplasm usually involving the skin&#46; In this retrospective case series&#44; 10 cases of BPDCN were identified&#44; 90&#37; of which had skin involvement and exhibited predominantly violaceous nodules and&#47;or bruise-like plaques&#46; Skin lesions showed diffuse or nodular dermal-based infiltrates of intermediate sized blasts with a grenz zone&#46; Tumor immunophenotyping was CD4&#40;&#43;&#41;&#44; CD56&#40;&#43;&#41;&#44; CD123&#40;&#43;&#41; and CD303&#40;&#43;&#41;&#46; The most frequently mutated genes according to targeted next-generation sequencing were TET2 &#40;3&#47;7&#41; and NRAS &#40;2&#47;7&#41;&#46; Multiagent chemotherapy &#40;CT&#41; was administered as first-line therapy&#44; and a total of 5 patients underwent allogenic hematopoietic stem cell transplantation &#40;allo-HSCT&#41;&#46; Better outcomes were observed in younger patients and those treated with acute lymphoblastic leukemia &#40;ALL&#41;-like CT followed by allo-HSCT&#46; This study shows the clinical range of cutaneous lesions of BPDCN&#46; Despite the absence of a gold standard therapy&#44; patients treated with myeloablative intensive regimens and allo-HSCT seem to have a more favorable prognosis&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La neoplasia bl&#225;stica de c&#233;lulas dendr&#237;ticas plasmocitoides &#40;NBCDP&#41;&#44; es una neoplasia hematod&#233;rmica poco frecuente y agresiva&#46; En esta serie de casos retrospectiva&#44; se identificaron 10 casos de NBCDP&#44; con un 90 &#37; de afectaci&#243;n de la piel&#44; present&#225;ndose predominantemente como n&#243;dulos viol&#225;ceos y&#47;o placas hematoma-like&#46; Las lesiones cut&#225;neas mostraban infiltrados d&#233;rmicos difusos o nodulares de blastos de tama&#241;o intermedio con zona de grenz&#46; El inmunofenotipado fue CD4&#40;&#43;&#41;&#44; CD56&#40;&#43;&#41;&#44; CD123&#40;&#43;&#41; y CD303&#40;&#43;&#41;&#46; Los genes mutados m&#225;s frecuentes fuerton TET2 &#40;3&#47;7&#41; y NRAS &#40;2&#47;7&#41;&#46; Se administr&#243; multi-quimioterapia &#40;QT&#41; como tratamiento de primera l&#237;nea&#44; y cinco pacientes se sometieron a trasplante alog&#233;nico de progenitores hematopoy&#233;ticas &#40;alo-TPH&#41;&#46; Se observaron mejores resultados en pacientes m&#225;s j&#243;venes y aquellos tratados con QT similar a la leucemia linfobl&#225;stica aguda &#40;LLA&#41; seguida de alo-TPH&#46; Este estudio muestra el rango cl&#237;nico de las lesiones cut&#225;neas de NBCDP&#46; A pesar de no haber un <span class="elsevierStyleItalic">gold-standard</span> terap&#233;utico&#44; los reg&#237;menes de QT mieloablativos y alo-TPH parecen tener un pron&#243;stico m&#225;s favorable&#46;</p></span>"
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