Estadísticas

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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La introducci&#243;n de la inmunoterapia ha supuesto un gran avance en el manejo de los pacientes con carcinoma de c&#233;lulas de Merkel &#40;CCM&#41; metast&#225;sico&#46; Realizamos un estudio observacional retrospectivo de 14 casos de CCM metast&#225;sico tratados con avelumab&#46; La tasa de respuesta fue del 57&#37;&#44; con una respuesta completa del 29&#37; y una respuesta parcial del 29&#37;&#46; El f&#225;rmaco fue efectivo en el 83&#37; &#40;5&#47;6&#41; de los pacientes que presentaron una &#250;nica localizaci&#243;n metast&#225;sica&#44; pero la enfermedad progres&#243; en el 75&#37; &#40;3&#47;4&#41; de los pacientes con met&#225;stasis &#243;seas&#46; No se detectaron efectos adversos graves en ninguno de los pacientes&#46; No se relacionaron la expresi&#243;n de PD1-L&#44; la presencia de poliomavirus del CCM &#40;MCPyV&#41;&#44; ni la alteraci&#243;n del &#237;ndice neutr&#243;lilo-linfocito &#40;NLR&#41; con la respuesta al tratamiento&#46; Avelumab es efectivo y seguro en el CCM en estadios avanzados&#44; con una posible influencia del n&#250;mero y la localizaci&#243;n de las met&#225;stasis en su efectividad&#46;</p></span>"
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