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        "titulo" => "Measurement Assessment of Minimal Disease Activity In Psoriasis in Spain&#58; A National Cross-Sectional Study"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La psoriasis &#40;Ps&#41;&#44; seg&#250;n la Organizaci&#243;n Mundial de la Salud &#40;OMS&#41;&#44; es una enfermedad cr&#243;nica&#44; no declarable&#44; dolorosa&#44; desfigurante e incapacitante&#44; sin cura y con un importante impacto negativo en la calidad de vida &#40;CdV&#41; del paciente<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A pesar del avance terap&#233;utico algunos pacientes no consiguen blanquear completamente las manifestaciones cut&#225;neas o tienen otros problemas que siguen alterando su CdV<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">2</span></a>&#46; Esto&#44; unido a las diferentes expectativas y prioridades de dermat&#243;logos y pacientes en su control<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">3</span></a>&#44; obliga a hacer modificaciones con el fin de ajustar el tratamiento de forma personalizada y midiendo el resultado obtenido de manera objetiva<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">4&#44;5</span></a> para conseguir un manejo hol&#237;stico de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Las medidas de la afectaci&#243;n de la enfermedad pueden ser objetivas &#40;<span class="elsevierStyleItalic">Psoriasis Activity Skin Index</span> &#91;PASI&#93;&#59; el <span class="elsevierStyleItalic">Body Surface Area</span> &#91;BSA&#93;&#44; o porcentaje de piel afectada&#44;&#59; el <span class="elsevierStyleItalic">Physician Global Assesment</span> &#91;PGA&#93;&#41;&#44; o subjetivas&#44; realizadas por el paciente &#40;<span class="elsevierStyleItalic">Dermatology Life Quality Index</span> &#91;DLQI&#93;&#41;&#59; aunque todas tienen limitaciones intr&#237;nsecas a cada &#237;ndice&#44; como ya se ha comentado<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">El Grupo de Psoriasis &#40;GPs&#41; de la Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a en 2017 dise&#241;&#243; un proyecto para la creaci&#243;n de una medida que valorara conjuntamente entre paciente y dermat&#243;logo la afectaci&#243;n de la enfermedad y se defini&#243; la Actividad M&#237;nima de Enfermedad en Psoriasis &#40;AME&#41;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">7</span></a>&#46; La AME incluye la valoraci&#243;n por parte del dermat&#243;logo del BSA&#44; la presencia o no de localizaci&#243;n especial y la exclusi&#243;n de artritis&#46; Por su parte el paciente punt&#250;a el DLQI y cuantifica la intensidad del picor &#40;0-10&#41;&#44; del eritema &#40;0-10&#41;&#44; de la descamaci&#243;n &#40;0-10&#41; y de la visibilidad &#40;0-10&#41;&#46; Se cumple AME cuando no hay artritis activa&#44; m&#225;s 3 de los siguientes &#237;tems&#58; picor &#8804;<span class="elsevierStyleHsp" style=""></span>1&#47;10&#59; descamaci&#243;n &#8804;<span class="elsevierStyleHsp" style=""></span>2&#47;10&#59; enrojecimiento &#8804; 2&#47;10&#59; visibilidad &#8804;<span class="elsevierStyleHsp" style=""></span>2&#47;10&#59; BSA<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>2&#59; DLQI<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>2 y no hay lesiones en localizaciones especiales&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">El objetivo de nuestro estudio fue describir la situaci&#243;n de la AME en la pr&#225;ctica cl&#237;nica en Espa&#241;a&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material y m&#233;todos</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se realiz&#243; un estudio observacional&#44; transversal y multic&#233;ntrico nacional&#46; Cada regi&#243;n aport&#243; la informaci&#243;n de 10 dermat&#243;logos a trav&#233;s de un coordinador&#46; Los dermat&#243;logos participantes recogieron de forma consecutiva los datos de 5 pacientes con Ps en placas y sin artritis activa&#46; Se recogieron el consentimiento informado&#44; datos epidemiol&#243;gicos y cl&#237;nicos &#40;sexo&#44; edad&#44; situaci&#243;n terap&#233;utica y f&#225;rmaco utilizado&#59; afectaci&#243;n o no de localizaci&#243;n especial&#59; y confirmaci&#243;n de ausencia de artritis activa&#41;&#44; PASI&#44; BSA&#44; DLQI&#59; y valoraci&#243;n de la intensidad de picor&#44; eritema&#44; descamaci&#243;n y visibilidad por parte del paciente&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Los datos fueron introducidos por cada coordinador regional en una <span class="elsevierStyleItalic">web</span> dise&#241;ada <span class="elsevierStyleItalic">ad hoc</span> por la unidad de investigaci&#243;n de la AEDV&#44; encargada del an&#225;lisis&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Se realiz&#243; un an&#225;lisis descriptivo d&#243;nde las variables continuas se expresaron como media y desviaci&#243;n est&#225;ndar &#40;DE&#41;&#44; mediana&#44; primer y tercer cuartil y&#44; m&#225;ximo y m&#237;nimo&#46; Las diferencias se evaluaron mediante la prueba de la t de Student o la prueba de Mann-Whitney&#46; Las variables cualitativas se estimaron con frecuencias absolutas y relativas y las diferencias se evaluaron mediante la prueba de la &#967;<span class="elsevierStyleSup">2</span>&#46; Se realiz&#243; un gr&#225;fico suavizado de la probabilidad de no cumplir criterios AME seg&#250;n PASI para determinar un punto de corte &#243;ptimo&#44; a trav&#233;s de una regresi&#243;n log&#237;stica&#46; Por &#250;ltimo&#44; se realiz&#243; una regresi&#243;n log&#237;stica multivariable ajustada por regi&#243;n&#44; para determinar la asociaci&#243;n entre cumplir criterios de la AME y las diferentes caracter&#237;sticas epidemiol&#243;gicas y cl&#237;nicas&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">El estudio ha sido aprobado por el Comit&#233; &#201;tico de Investigaci&#243;n del Hospital Universitario de Gran Canaria Dr&#46; Negr&#237;n &#40;2022-299-1&#41;&#46; Todos los pacientes dieron su consentimiento para participar en el estudio&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">Participaron 18 coordinadores y 180 dermat&#243;logos de toda Espa&#241;a que recogieron datos de 830 pacientes con Ps vulgar que no presentaban artritis activa&#46; Se obtuvieron datos de las 17 comunidades aut&#243;nomas &#40;excepto Ceuta y Melilla&#41; y de 44 provincias de entre las 50 del pa&#237;s&#44; con diferencias entre las distintas regiones &#40;Catalu&#241;a 124 pacientes&#44; m&#225;ximo&#59; Baleares&#44; 4 pacientes&#44; m&#237;nimo&#41;&#46; De ellos 493 eran varones &#40;59&#44;5&#37;&#41; con una edad media de 51&#44;4 a&#241;os &#40;DE&#58; 14&#44;2 a&#241;os&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">Los valores medios de afectaci&#243;n de enfermedad medidos por el dermat&#243;logo y por el paciente fueron&#58; BSA&#58; 4&#44;7&#59; PASI&#58; 3&#44;5&#59; DLQI&#58; 3&#44;5&#59; picor&#58; 2&#44;9&#59; descamaci&#243;n&#58; 3&#44;2&#59; eritema&#58; 3&#44;1&#59; visibilidad&#58; 3&#44;3 &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">El 61&#44;7&#37; no ten&#237;a lesiones en localizaciones especiales&#44; el 47&#44;8&#37; ten&#237;a picor &#8804;<span class="elsevierStyleHsp" style=""></span>1&#47;10&#44; el 53&#44;9&#37; descamaci&#243;n &#8804;<span class="elsevierStyleHsp" style=""></span>2&#47;10&#44; el 54&#44;2&#37; enrojecimiento &#8804;<span class="elsevierStyleHsp" style=""></span>2&#47;10&#44; el 55&#44;1&#37; visibilidad &#8804;<span class="elsevierStyleHsp" style=""></span>2&#47;10&#44; el 55&#44;4&#37; BSA<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>2&#44; y el 59&#37; DLQI<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>2 &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">M&#225;s de la mitad de los pacientes &#40;491&#59; 59&#44;2&#37;&#41;&#44; no cumpl&#237;an criterio de la AME y encontramos diferencias significativas entre regiones &#40;m&#225;xima frecuencia Asturias&#58; 98&#37; y m&#237;nima Catalu&#241;a&#58; 37&#44;1&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Gr&#225;fico 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">El cumplimiento de la AME mostr&#243; diferencias significativas por sexo y por edad&#46; Los varones presentaban mayor porcentaje de cumplimiento AME &#40;222 pacientes&#44; 45&#44;0&#37; vs&#46; 117 mujeres&#44; 34&#44;8&#37;&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;003&#41;&#44; as&#237; como los pacientes con mayor edad media &#40;52&#44;9 a&#241;os&#44; DE&#58; 14&#44;3&#41; mostraban tambi&#233;n mayor cumplimiento AME que los de menor edad &#40;50&#44;4 a&#241;os&#44; DE&#58; 14&#41; &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;013&#41;&#46; Adem&#225;s&#44; tambi&#233;n se apreciaron diferencias de cumplimiento por sexo entre las distintas regiones &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Gr&#225;fico 1</a>&#41;&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Se observaron diferencias de cumplir la AME en funci&#243;n del tratamiento &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; El tratamiento biol&#243;gico se asoci&#243; a un mayor cumplimiento de la AME frente al tratamiento no biol&#243;gico &#40;59&#44;4 vs&#46; 23&#44;3&#37;&#41;&#46; No se observaron diferencias entre los distintos tratamientos biol&#243;gicos &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;108&#41;&#44; pero s&#237; frente a los no biol&#243;gicos &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41; &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Los s&#237;ntomas subjetivos referidos por los pacientes &#40;picor&#44; descamaci&#243;n&#44; eritema&#44; visibilidad&#41; fueron la mayor causa de no cumplimiento de la AME&#44; principalmente el picor &#62;<span class="elsevierStyleHsp" style=""></span>1 &#40;72&#44;5&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#sec0070">ver material suplementario</a>&#41;&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">Un 23&#37; de pacientes con PASI&#58; 0 &#40;45&#44; 22&#44;3&#37;&#41; no cumpl&#237;an la AME &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#41;&#46; Y por cada incremento en el PASI de una unidad&#44; pr&#225;cticamente se duplicaba el riesgo de no cumplir la AME &#40;con independencia del tratamiento&#41;&#44; OR&#58; 1&#44;84 &#40;IC 95&#37;&#58; 1&#44;61-2&#44;10&#41;&#46; En dicho riesgo&#44; se aprecia un cambio de tendencia a partir de puntuaciones PASI&#58; 5&#44; donde los incrementos no son tan pronunciados &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Gr&#225;fica 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Utilizando un modelo log&#237;stico multivariable&#44; se comprob&#243; que la probabilidad de cumplir&#47;no cumplir la AME implicaba de forma simult&#225;nea el uso de f&#225;rmaco biol&#243;gico&#44; el PASI&#44; la edad&#44; el sexo y la regi&#243;n geogr&#225;fica&#46; De tal forma que&#44; ninguno de ellos en exclusiva &#40;ni siquiera el uso de f&#225;rmaco biol&#243;gico&#41; explicaba las diferencias encontradas &#40;<a class="elsevierStyleCrossRef" href="#tbl0030">tabla 6</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia><p id="par0095" class="elsevierStylePara elsevierViewall">Se puede acceder a los datos a trav&#233;s del visor&#58;</p><p id="par0100" class="elsevierStylePara elsevierViewall"><a href="https://aedv.es/grupos-de-trabajo/psoriasis/visualizador-de-casos-de-proyecto-ame/">https&#58;&#47;&#47;aedv&#46;es&#47;grupos-de-trabajo&#47;psoriasis&#47;visualizador-de-casos-de-proyecto-ame&#47;</a></p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Control de enfermedad al aplicar criterios de la AME&#58; global y por regiones</span><p id="par0105" class="elsevierStylePara elsevierViewall">A pesar de que los valores medios de PASI y BSA reflejan que se incluyeron pacientes con enfermedad leve o bien controlados<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">4</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#44; el cumplimiento de la AME es muy bajo&#58; 491 pacientes &#40;59&#44;2&#37;&#41; no cumplen la AME&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">Tambi&#233;n es clara la diferencia encontrada entre comunidades &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Gr&#225;fico 1</a>&#41;&#46; Catalu&#241;a es la regi&#243;n con mayor cumplimiento de la AME&#44; aunque m&#225;s de un tercio de los pacientes &#40;37&#44;1&#37;&#41; no lo cumplen&#46; El hecho de que para nuestro estudio en esta comunidad se haya encontrado un mayor porcentaje de pacientes en tratamiento biol&#243;gico podr&#237;a favorecer su mayor cumplimiento&#46; Este aspecto&#44; el de mayor o menor dificultad de acceso a determinados f&#225;rmacos biol&#243;gicos&#44; es un hecho conocido&#44; pues algunas comunidades permiten utilizar cualquier f&#225;rmaco biol&#243;gico desde primera l&#237;nea y&#44; sin embargo&#44; otras requieren biosimilar de anti-TNF inicialmente o incluso una determinada secuencia<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">Sin embargo&#44; no es solo el mayor uso de biol&#243;gico el que justifica esa diferencia regional&#44; pues sabemos que adem&#225;s del biol&#243;gico&#44; la edad&#44; el sexo&#44; y el PASI de los pacientes&#44; influyen&#59; pero si incluimos estos factores&#44; siguen existiendo diferencias entre regiones&#44; aunque es cierto que las diferencias regionales tienden a minimizarse &#40;pero no a desaparecer del todo&#41; cuando consideramos estos factores&#46; Tal como se aprecia en la <a class="elsevierStyleCrossRef" href="#tbl0030">tabla 6</a>&#44; al existir diferencias significativas en todos los factores &#40;simult&#225;neamente&#41; implica que todos est&#225;n asociados y que el uso de biol&#243;gico por s&#237; solo no es capaz de explicar las diferencias existentes&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Cumplimiento de la AME por sexo y edad</span><p id="par0120" class="elsevierStylePara elsevierViewall">Las preferencias de tratamiento por parte del paciente tienen un papel importante en la consulta&#46; La edad parece influir en las preferencias de elecci&#243;n de terapia&#44; tanto en t&#243;picos como en biol&#243;gicos&#44; mostrando las personas m&#225;s j&#243;venes mayor inter&#233;s en las probabilidades de beneficio de dicho tratamiento<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">9</span></a>&#46; Sin embargo&#44; nosotros comprobamos que los pacientes de mayor edad son los que m&#225;s cumplen la AME&#44; lo que estar&#237;a acorde con la peor puntuaci&#243;n en escalas de CdV de los m&#225;s j&#243;venes<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">10</span></a>&#44; pero contrastar&#237;a con lo observado en otros estudios en los que parece que los pacientes mayores con problemas cut&#225;neos tienen peor CdV&#44; debido a otros problemas de salud a&#241;adidos<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">En nuestro estudio tambi&#233;n comprobamos que los varones cumplen con mayor frecuencia la AME que las mujeres &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Gr&#225;fico 1</a>&#41;&#46; En otros estudios se ha encontrado que existe una distinci&#243;n por sexos&#44; a favor de las mujeres&#44; en la prescripci&#243;n de f&#225;rmacos biol&#243;gico<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">12</span></a>&#44; tambi&#233;n se sabe que ellas parecen tener mayores puntuaciones de picor<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">13</span></a>&#44; mayor afectaci&#243;n en su CdV<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">14</span></a> y mayor frecuencia de alteraciones del sue&#241;o<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">15</span></a>&#46; Estos par&#225;metros no se encuentran entre las escalas de gravedad utilizadas habitualmente &#40;BSA&#44; PGA&#44; PASI&#41;&#44; por lo que pueden infravalorar la gravedad de la enfermedad en ciertos subgrupos de pacientes&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Cumplimiento de la AME por grupo terap&#233;utico</span><p id="par0130" class="elsevierStylePara elsevierViewall">El uso de f&#225;rmacos m&#225;s eficaces podr&#237;a ser el factor m&#225;s determinante para la consecuci&#243;n de la AME&#46; De hecho&#44; comprobamos en nuestro estudio que el uso de f&#225;rmaco biol&#243;gico&#44; en contra de f&#225;rmacos de s&#237;ntesis qu&#237;mica o fototerapia es el que mayor porcentaje de cumplimiento de la AME asocia&#46; Adem&#225;s&#44; se ha comprobado en pacientes psori&#225;sicos con la medida del <span class="elsevierStyleItalic">Psoriasis Symptoms and Signs Diary</span> &#40;PSSD&#41; que incluye eritema&#44; prurito&#44; dolor y otros s&#237;ntomas&#44; que diversos f&#225;rmacos mejoran estos s&#237;ntomas&#44; si bien no hay comparativos entre f&#225;rmacos a&#250;n que permitan elegir entre unos y otros<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">Sin embargo&#44; no hemos observado diferencias significativas entre los f&#225;rmacos biol&#243;gicos&#44; algo que podr&#237;a deberse a un sesgo de selecci&#243;n por tratarse de un estudio no controlado&#44; en el que seleccionamos en cada paciente el f&#225;rmaco que consideramos que tiene mejor probabilidad de &#233;xito&#59; o a la tendencia a utilizar los f&#225;rmacos biol&#243;gicos con niveles de eficacia m&#225;s pobre en pacientes con mayores probabilidades de &#233;xito &#40;pacientes <span class="elsevierStyleItalic">n&#228;ive</span>&#44; normopeso&#44; poca duraci&#243;n de la enfermedad&#44; baja comorbilidad&#41;&#44; y a la inversa&#44; reservando los f&#225;rmacos de mayor tasa de repuesta para los pacientes m&#225;s complejos&#46; Esto podr&#237;a haber influido en la obtenci&#243;n de resultados m&#225;s positivos &#40;mejores&#41; en el primer grupo y resultados inferiores en el segundo&#44; lo que podr&#237;a haber resultado en tasas de efectividad similares entre ambos grupos<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">17&#8211;20</span></a>&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Sorprende que ning&#250;n paciente en fototerapia consiga la AME&#44; y los altos porcentajes de no consecuci&#243;n de la AME en los que est&#225;n sin tratamiento &#40;80&#44;4&#37;&#41;&#44; o solo con t&#243;picos &#40;88&#44;4&#37;&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Valoraci&#243;n de correlaci&#243;n entre PASI y cumplimiento de la AME</span><p id="par0145" class="elsevierStylePara elsevierViewall">El &#237;ndice PASI es la medida estandar para valorar la gravedad de la Ps&#44; pero no siempre se correlaciona directamente con la percepci&#243;n del paciente<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">7</span></a>&#46; Se recogi&#243; en el estudio con el fin de compararlo con la AME&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">El PASI como medida &#250;nica de gravedad resulta poco precisa especialmente en casos muy leves&#44; con poca &#225;rea afecta&#46; De hecho&#44; en nuestro estudio el 23&#37; de los pacientes con PASI 0 no cumplen criterios de la AME&#46; Adem&#225;s&#44; no tiene en cuenta la localizaci&#243;n de las lesiones&#44; que sabemos puede ser muy limitante para el paciente&#44; como u&#241;as&#44; pliegues&#44; genitales o&#44; palmas y plantas&#46; M&#225;s a&#250;n&#44; el PASI no es una medida lineal ya que cambios del 9 al 10&#37; de &#225;rea afecta en una de las localizaciones hace que se doble la puntuaci&#243;n&#44; sin que haya cambios en otros s&#237;ntomas como el eritema&#44; la infiltraci&#243;n o la descamaci&#243;n<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">21</span></a>&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">En este sentido&#44; es entendible que hasta un 28&#37; de pacientes con PASI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>1 o un 35&#37; de pacientes con PASI<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>2 de nuestro estudio no cumplan criterios de la AME por lo expuesto anteriormente&#44; pero llama la atenci&#243;n el hecho de que un paciente que no tenga lesiones de Ps &#40;PASI 0&#41; ni artritis psori&#225;sica no cumpla criterios de la AME y hablar&#237;a a favor de otros condicionantes&#44; probablemente de origen psicol&#243;gico&#44; que puedan influir en la sensaci&#243;n de enfermedad o podr&#237;a indicar ciertas limitaciones de especificidad en la medici&#243;n para la que est&#225; destinada&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Qu&#233; ha supuesto introducir la medida de la AME</span><p id="par0160" class="elsevierStylePara elsevierViewall">Las manifestaciones subjetivas m&#225;s importantes de la enfermedad son valoradas en la AME por el propio paciente&#44; qui&#233;n define cu&#225;nto de intensas son sus placas&#44; cu&#225;nto descaman&#44; cu&#225;nto pican&#44; cu&#225;nto molestan y cu&#225;nto se ven&#46; La importancia que estos valores tienen para los afectados se ve reflejada en que&#44; de los 491 pacientes del estudio que no cumplen la AME&#44; alrededor del 70&#37; incluye estos s&#237;ntomas subjetivos como motivo de su incumplimiento&#44; siendo el prurito el de mayor porcentaje &#40;72&#44;5&#37;&#41; de los 4 &#40;<a class="elsevierStyleCrossRef" href="#sec0070">ver material suplementario</a>&#41;&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">De hecho&#44; el s&#237;ntoma m&#225;s molesto para los pacientes psori&#225;sicos es el prurito&#44; que est&#225; presente entre el 60 y el 90&#37; de ellos<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">22</span></a>&#46; Este dato coincide con el de un estudio multic&#233;ntrico en el que se evaluaban factores psicol&#243;gicos relacionados con la Ps donde el 69&#44;5&#37; de los pacientes refer&#237;a prurito y&#44; de estos&#44; en casi el 75&#37; era cr&#243;nico<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">23</span></a>&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">La visibilidad de la Ps puede causar rechazo social y conductas de evitaci&#243;n que llegan a condicionar a muchos pacientes<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">24</span></a>&#46; En nuestro estudio 372 pacientes no cumpl&#237;an la AME por este criterio&#44; reforzando la idea que la inclusi&#243;n de estos s&#237;ntomas subjetivos&#44; no recogidos en otros &#237;ndices<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">25&#44;26</span></a>&#44; es importante para valorar la gravedad de la Ps por medio de factores psicol&#243;gicos y sociales que afectan negativamente a la CdV del paciente&#46;</p><p id="par0175" class="elsevierStylePara elsevierViewall">La AME no es la suma de PASI&#44; BSA y DLQI&#44; sino una medida global de la situaci&#243;n cl&#237;nica en la que el paciente y el dermat&#243;logo no ven la necesidad de hacer ninguna modificaci&#243;n terap&#233;utica ni ninguna otra intervenci&#243;n&#44; aportando un valor cualitativo diferente&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">No obstante&#44; y aunque el GPs lo considera de utilidad en el manejo del paciente<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">27</span></a>&#44; a&#250;n no se ha extendido su uso y son pocas las publicaciones que especifican la AME como medida de resultado terap&#233;utico y situaci&#243;n cl&#237;nica del paciente psori&#225;sico<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">28</span></a>&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Limitaciones del estudio</span><p id="par0185" class="elsevierStylePara elsevierViewall">Al tratarse de un estudio nacional es de suponer que la muestra de pacientes obtenida sea heterog&#233;nea por su diversidad geogr&#225;fica&#44; lo que puede influir en las distintas sensibilidades de apreciaci&#243;n de los par&#225;metros subjetivos medidos por el paciente&#44; diferente percepci&#243;n de los s&#237;ntomas en funci&#243;n de diferencias culturales&#44; diferencias de experiencia en manejo de la Ps entre los dermat&#243;logos colaboradores &#40;consulta monogr&#225;fica vs&#46; consulta com&#250;n&#44; urbe vs&#46; rural&#41;&#44; distinto acceso a f&#225;rmacos de mayor efectividad<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">29</span></a>&#44; etc&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Los pacientes no fueron aleatorizados&#44; sino que se reclutaron en pr&#225;ctica cl&#237;nica habitual&#44; en un corto per&#237;odo de tiempo &#40;1-2 d&#237;as&#41; por lo que podr&#237;a haber un sesgo de participaci&#243;n y selecci&#243;n&#44; por reclutamiento de los m&#225;s participativos&#44; o por el azar de los que acudieran a consulta esos d&#237;as&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusiones</span><p id="par0195" class="elsevierStylePara elsevierViewall">Tras aplicar la AME a nivel nacional se comprueba que el cumplimiento es relativamente bajo&#44; con diferencias significativas por sexo&#44; edad&#44; regi&#243;n y tipo de tratamiento utilizado&#44; y s&#237;ntomas referidos por los pacientes&#46; Pero ninguno de estos factores en exclusiva justific&#243; las diferencias encontradas&#46; Tampoco el uso de biol&#243;gico por s&#237; solo es capaz de explicar las diferencias existentes&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">La valoraci&#243;n de la AME frente a PASI supone una mayor aproximaci&#243;n al paciente&#44; al permitirle intervenir en la medici&#243;n de la gravedad de su enfermedad&#44; lo cual podr&#237;a suponer un aumento cualitativo en el manejo de estos pacientes&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">La utilizaci&#243;n de la AME en la pr&#225;ctica cl&#237;nica habitual es f&#225;cil y c&#243;moda y puede aumentar la calidad del manejo del paciente psori&#225;sico al incluir en su medici&#243;n par&#225;metros no contemplados en otras escalas de gravedad de las com&#250;nmente utilizadas hasta ahora&#46; Por tanto&#44; animamos a los dermat&#243;logos que atiendan pacientes con Ps a usar la AME como medida de valoraci&#243;n de su gravedad y como objetivo terap&#233;utico&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Autor&#237;as</span><p id="par0210" class="elsevierStylePara elsevierViewall">G&#46; Carretero Hern&#225;ndez&#58; dise&#241;o del estudio&#44; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n nacional del estudio&#44; primer autor del manuscrito&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">Ara Mart&#237;n&#44; Mariano&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Arag&#243;n&#44; primer autor del manuscrito&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">Armesto Alonso&#44; Susana&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Cantabria&#44; primera autora del manuscrito&#46;</p><p id="par0225" class="elsevierStylePara elsevierViewall">Belinch&#243;n Romero&#44; Isabel&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de resultados&#44; coordinaci&#243;n regional del estudio en Comunidad Valenciana&#44; primera autora del manuscrito&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Eiris Salvado&#44; Noemi&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Andaluc&#237;a&#44; primera autora del manuscrito&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Ferr&#225;n Farr&#233;s&#44; Marta&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Catalu&#241;a&#44; primera autora del manuscrito&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Galache Osuna&#44; Cristina&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Asturias&#44; primera autora del manuscrito&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">Garc&#237;a Bust&#237;nduy&#44; Marta&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Canarias&#44; primera autora del manuscrito&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">Garc&#237;a Latasa de Aran&#237;bar&#44; Javier&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Arag&#243;n&#44; primer autor del manuscrito&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Juli&#225; Manresa&#44; Marc&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Pa&#237;s Vasco&#44; primer autor del manuscrito&#46;</p><p id="par0260" class="elsevierStylePara elsevierViewall">Llamas Velasco&#44; Mar&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Madrid&#44; primera autora del manuscrito&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">L&#243;pez Ferrer&#44; Anna&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Catalu&#241;a&#44; primera autora del manuscrito</p><p id="par0270" class="elsevierStylePara elsevierViewall">Roncero Riesco&#44; M&#243;nica&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Castilla Le&#243;n&#44; primera autora del manuscrito&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">Ruiz Genao&#44; Diana&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Madrid&#44; primera autora del manuscrito&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Ruiz-Villaverde&#44; Ricardo&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Andaluc&#237;a&#44; primer autor del manuscrito&#44;</p><p id="par0285" class="elsevierStylePara elsevierViewall">Salgado Boquete&#44; Laura&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Galicia&#44; primera autora del manuscrito&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Soria Mart&#237;nez&#44; Caridad&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Murcia&#44; primera autora del manuscrito&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Vilarrasa Rull&#44; Eva&#58; obtenci&#243;n de los datos&#44; interpretaci&#243;n de los resultados&#44; coordinaci&#243;n regional del estudio en Catalu&#241;a e Islas Baleares&#44; primera autora del manuscrito&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">Descalzo&#44; MA&#58; an&#225;lisis de los datos&#44; interpretaci&#243;n de los resultados&#44; elaboraci&#243;n del manuscrito&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicto de intereses</span><p id="par0305" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introducci&#243;n</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">El Grupo de Psoriasis de la Academia Espa&#241;ola de Dermatolog&#237;a y Venereolog&#237;a &#40;GPs&#41; dise&#241;o en 2017 la medida Actividad M&#237;nima de Enfermedad en Psoriasis &#40;AME&#41;&#46; Se presentan los resultados de un estudio observacional&#44; transversal y multic&#233;ntrico de la aplicaci&#243;n de esta escala a nivel nacional&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Material y m&#233;todos</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se realiz&#243; un muestreo no aleatorizado&#44; estratificado para alcanzar representaci&#243;n auton&#243;mica y provincial&#44; de pacientes consecutivos con psoriasis &#40;Ps&#41; vulgar sin artritis activa&#46; Se incluyeron 830 pacientes&#58; 493 eran varones &#40;59&#44;5&#37;&#41;&#44; con una edad media de 51&#44;4 a&#241;os &#40;DE<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>14&#44;2&#41;&#44; de todas las autonom&#237;as del pa&#237;s &#40;excepto Ceuta y Melilla&#41; y 44 &#40;88&#37;&#41; de las 50 provincias&#46; Se obtuvo un cuestionario recogiendo datos demogr&#225;ficos&#44; DLQI&#44; valoraci&#243;n subjetiva en escalas de 0 a 10 de picor&#44; eritema&#44; descamaci&#243;n y visibilidad&#59; y el PASI y el BSA del paciente&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">M&#225;s de la mitad no cumpl&#237;an criterio de AME &#40;491&#59; 59&#44;2&#37;&#41;&#44; con diferencia significativa entre regiones&#44; por el sexo y por la edad&#46; Tambi&#233;n hab&#237;a diferencias seg&#250;n el tratamiento realizado &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&#41;&#46; El uso de un medicamento biol&#243;gico se asoci&#243; a un mayor cumplimiento AME frente al uso de otro tipo de medicamentos &#40;59&#44;4 vs&#46; 23&#44;3&#37;&#41;&#46; No se observaron diferencias entre los tratamientos biol&#243;gicos&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El porcentaje global de cumplimiento AME es bajo&#44; con diferencias por la localizaci&#243;n geogr&#225;fica&#44; el sexo&#44; la edad y el f&#225;rmaco utilizado&#44; si bien ninguno de esos factores por separado las justifica&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Introducci&#243;n"
          ]
          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Material y m&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Resultados"
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          3 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Conclusiones"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Introduction</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In 2017&#44; the Spanish Academy of Dermatology and Venereology Psoriasis Working Group &#40;PWG&#41; designed the Minimal Disease Activity &#40;MDA&#41; criteria to determine the level of disease activity&#46; We hereby present the results of an observational&#44; cross-sectional&#44; multicenter study of the nationwide application of these criteria&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Material and methods</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We conducted a non-randomized sampling&#44; stratified to achieve autonomic and provincial representation of consecutive patients with psoriasis &#40;Ps&#41; vulgaris without active arthritis&#46; A total of 830 patients were included&#58; 493 men &#40;59&#46;5&#37;&#41;&#44; with a mean age of 51&#46;4 years &#40;SD&#44; 14&#46;2&#41;&#44; from all autonomous regions of Spain &#40;except for Ceuta and Melilla&#41; and 44 &#40;88&#37;&#41; out of the 50 provinces&#46; A questionnaire was obtained with demographic data&#44; DLQI&#44; subjective assessment&#8212;on a scale from 0 to 10&#8212;of itching&#44; erythema&#44; desquamation&#44; visibility&#44; and the patients&#8217; PASI and BSA&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">More than 50&#37; failed to meet the MDA criteria &#40;491&#59; 59&#46;2&#37;&#41;&#44; with significant differences being reported by region&#44; sex&#44; and age&#46; Additionally&#44; significant differences were reported based on the therapy used &#40;<span class="elsevierStyleItalic">P</span>&#60;&#46;001&#41;&#46; The use of biological therapies was associated with higher MDA compliance compared to other therapies &#40;59&#46;4&#37; vs 23&#46;3&#37;&#41;&#46; No differences were reported among various biological therapies&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">The overall rate of MDA compliance is low&#44; with differences being based on geographic location&#44; sex&#44; age&#44; and drug used&#44; yet none of these factors separately justify them&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0010">Los nombres de los componentes del Grupo de Psoriasis de la AEDV est&#225;n relacionados en el <a class="elsevierStyleCrossRef" href="#sec0070">anexo 1</a>&#46;</p>"
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            "apendice" => "<p id="par0320" class="elsevierStylePara elsevierViewall">Abalde Pintos&#44; Mar&#237;a Teresa&#59; Alfaro Rubio&#44; Alberto&#59; Aparicio Espa&#241;ol&#44; Gloria&#59; Aranegui Arteaga&#44; Beatriz&#59; Arechalde P&#233;rez&#44; Ana&#59; Ar&#243;stegui Aguilar&#44; Jorge&#59; Arrue Michelena&#44; Itrziar&#59; Az&#243;n Masoliver&#44; Antoni&#59; Bajo del Pozo&#44; Cristina&#59; Ballano Ruiz&#44; Adri&#225;n&#59; Baniandr&#233;s Rodr&#237;guez&#44; Ofelia&#59; Blanco Barios&#44; Susana&#59; Bordel G&#243;mez&#44; Mar&#237;a Teresa&#59; Carrascosa Carrillo&#44; Jos&#233; Manuel&#59; Carrizosa Esquivel&#44; Ana Mar&#237;a&#59; Castellano Gonz&#225;lez&#44; Mar&#237;a&#59; Castro Guti&#233;rrez&#44; Beatriz&#59; Concell&#243;n Do&#241;ate&#44; Mar&#237;a Antonia&#59; Conde Taboada&#44; Alberto&#59; Conejero del Mazo&#44; Raquel&#59; Corral de la Calle&#44; Miriam&#59; Corbal&#225;n V&#233;lez&#44; Ra&#250;l&#59; Curc&#243; Botargues&#44; Neus&#59; de la Fuente Meira&#44; Sonia&#59; de las Heras&#44; Cristina&#59; de la Torre Gomar&#44; Francisco&#59; del Alc&#225;zar Viladomi&#250;&#44; Elena&#59; del R&#237;o Gil&#44; Rub&#233;n&#59; Delgado Mucienes&#44; Carmen&#59; Delgado Vicente&#44; Sonsoles&#59; Duarte Ferrera&#44; Miguel&#59; Dur&#225;n Vi&#225;n&#44; Carlos&#59; Escalonilla Garc&#237;a-Patos&#44; Pilar&#59; Fern&#225;ndez Armenteros&#44; Jos&#233; Manuel&#59; Fern&#225;ndez D&#237;az&#44; Mar&#237;a Luisa&#59; Fern&#225;ndez S&#225;nchez&#44; Cristina&#59; Fuentelsaz del Barrio&#44; Mar&#237;a Victoria&#59; Fortu&#241;o Ru&#237;z&#44; Yolanda&#59; Fr&#237;as Iniesta&#44; Jos&#233;&#59; Gal&#225;n Guti&#233;rrez&#44; Manuel&#59; Gallardo Hern&#225;ndez&#44; Fernando&#59; Garc&#237;a Arpa&#44; M&#243;nica&#59; Garc&#237;a Donoso&#44; Carmen&#59; Garc&#237;a Fern&#225;ndez de Villalta&#44; Mar&#237;a Jos&#233;&#59; Garc&#237;a Font&#44; Mer edes&#59; Garc&#237;a Gil&#44; Miguel&#59; Garc&#237;a Mart&#237;nez&#44; Esther&#59; Garc&#237;a S&#225;nchez&#44; Mar&#237;a&#59; Garc&#237;a Souto&#44; Fernando&#59; Garrido Colmenero&#44; Cristina&#59; Gil Faure&#44; Inma&#59; Gil Mateo&#44; Mar&#237;a del Pino&#59; Godoy D&#237;az&#44; Daniel&#59; Godoy Gij&#243;n&#44; Elena&#59; G&#243;mez Avivar&#44; Pilar&#59; G&#243;mez Centeno&#44; Pilar&#59; G&#243;mez de Castro&#44; Celia&#59; G&#243;mez D&#237;ez&#44; Santiago&#59; G&#243;mez Vila&#44; Borja&#59; Gonz&#225;lez Cantero&#44; &#193;lvaro&#59; Gonz&#225;lez Quesada&#44; Alicia&#59; Gonz&#225;lez Villanueva&#44; Iris&#59; Gracia Caza&#241;a&#44; Tamara&#59; Hergueta S&#225;nchez&#44; Julia Paloma&#59; Hern&#225;ndez Hern&#225;ndez&#44; Zaida&#59; Hern&#225;ndez Montoya&#44; Carlos&#59; Hospital Gil&#44; Mercedes&#59; Lacalle Calder&#243;n&#44; Marina&#59; Laso Dosal&#44; Francisco Javier&#59; Lezcano Biosca&#44; Victoria&#59; L&#243;pez &#193;vila&#44; Angel&#59; L&#243;pez Castillo&#44; Daniel&#59; L&#243;pez-Escobar Garc&#237;a-Prendes&#44; Mar&#237;a&#59; L&#243;pez Estebaranz&#44; Jos&#233; Luis&#59; Lorda Esp&#233;s&#44; Marta&#59; Luj&#225;n Rodr&#237;guez&#44; Dunia&#59; Mahiques Santos&#44; Laura&#59; Marcell&#225;n Fern&#225;ndez&#44; Mar&#237;a&#59; M&#225;rquez Henr&#237;quez&#44; Juan&#59; Marqu&#233;s Mart&#237;n&#44; Laura&#59; Marr&#243;n Moya&#44; Servando Eugenio&#59; Mart&#237;n Alcalde&#44; Javier&#59; Mart&#237;n Gonz&#225;lez&#44; Isabel&#59; Mart&#237;n S&#225;ez&#44; Esther&#59; Mart&#237;nez de Espronceda Esquerro&#44; I&#241;igo&#59; Mart&#237;nez de Salinas Quintana&#44; Ana&#59; Mataix Mart&#237;nez&#44; Javier&#59; Matas Nadal&#44; Clara&#59; Mateu Puchades&#44; Almudena&#59; Medina Montalvo&#44; Susana&#59; Men&#233;ndez Garc&#237;a-Estrada&#44; Ana&#59; Miralles Botella&#44; Julia&#59; Mitxelena Eceiza&#44; Yosune&#59; Mollet S&#225;nchez&#44; Jordi&#59; Monte Serrano&#44; Juan&#59; Montes Torres&#44; Andrea&#59; Morales Callaghan&#44; Ana&#59; Morales Larios&#44; Elisa&#59; Morales Moya&#44; Ana Luisa&#59; Moreno Su&#225;rez&#44; F&#225;tima&#59; Mu&#241;oz Santos&#44; Carlos&#59; No P&#233;rez&#44; Nuria&#59; Notario Rosa&#44; Jaume&#59; Ormaetxea P&#233;rez&#44; Nerea&#59; Palacios Garc&#237;a&#44; Laura&#59; Pardo S&#225;nchez&#44; Jos&#233;&#59; P&#233;rez Barrio&#44; Silvia&#59; P&#233;rez Caballero&#44; Jos&#233; Antonio&#59; P&#233;rez Gil&#44; Amalia&#59; P&#233;rez Su&#225;rez&#44; Beatriz&#59; Pestana Eliche&#44; Mar&#237;a&#59; Pousa Mart&#237;nez&#44; Mar&#237;a&#59; Poveda Montoyo&#44; In&#233;s&#59; Prieto Torres&#44; Luc&#237;a&#59; Puebla Tornero&#44; Laura&#44; Puig Sanz&#44; Lluis&#59; Pujol Moncus&#237;&#44; Josep&#59; Ram&#237;rez Andreo&#44; Antonio&#59; Ram&#237;rez Concha&#44; Jos&#233; Mar&#237;a&#59; Ram&#237;rez Santos&#44; Aquilina&#59; Reguero del Cura&#44; Leandra&#59; Requena L&#243;pez&#44; Sheila&#59; Ribera Pibernat&#44; Miquel&#59; Riera Monroig&#44; Josep&#59; R&#237;o Garc&#237;a&#44; Irene&#59; Rivera D&#237;az&#44; Raquel&#59; Rivera Fuentes&#44; Ignacio&#59; Rocamora Dur&#225;n&#44; Vicen&#231;&#59; Rodr&#237;guez Blanco&#44; Sabela&#59; Rodr&#237;guez Freire&#44; Lourdes&#59; Rodr&#237;guez Garc&#237;a&#44; Fernando&#59; Rodr&#237;guez Mart&#237;n&#44; Marina&#59; Rodr&#237;guez Nevado&#44; Isabel&#59; Romero Aguilera&#44; Guillermo&#59; Romero Mate&#44; Alberto&#59; Romero Sillero&#44; Estrella&#59; Ruiz Carrascosa&#44; Jos&#233; Carlos&#59; Ruiz Mart&#237;nez&#44; Javier&#59; Sagrist&#225; Garc&#237;a&#59; Marc&#59; Sa&#237;nz Gaspar&#44; Laura&#59; Salas Mart&#237;nez&#44; Ana&#59; Salleras Redonet&#44; Montserrat&#59; S&#225;nchez Caminero&#44; Prado&#59; S&#225;nchez Largo&#44; Elena&#59; S&#225;nchez P&#233;rez&#44; Javier&#59; S&#225;nchez Salas&#44; Mar&#237;a Pilar&#59; Santos-Juanes Jim&#233;nez&#44; Jorge&#59; Sahuquillo Torralba&#44; Antonio&#59; Segurado Rodr&#237;guez&#44; Agustina&#59; Sidr&#243; Sartos&#44; Miriam&#59; Solanas Trevi&#241;o&#44; Ruth&#59; Su&#225;rez Hern&#225;ndez&#44; Jos&#233;&#59; Taberner Ferrer&#44; Rosa&#59; &#218;beda Clemente&#44; Mar&#237;a Isabel&#59; Urigoitia Ugalde&#44; Peru&#59; V&#225;zquez L&#243;pez&#44; Francisco&#59; Vel&#225;zquez Tarjuelo&#44; Diana&#59; Vidal Sarro&#44; David&#59; Vilar Alejo&#44; Jaime&#59; Villegas Romero&#44; Isabel y Yanguas Barona&#44; Ignacio&#46;</p>"
            "etiqueta" => "Anexo 1"
            "titulo" => "Grupo de Psoriasis de la AEDV en cada regi&#243;n por el correspondiente coordinador regional"
            "identificador" => "sec0070"
          ]
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            "apendice" => "<p id="par0330" class="elsevierStylePara elsevierViewall"><elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>"
            "etiqueta" => "Anexo A"
            "titulo" => "Material adicional"
            "identificador" => "sec0080"
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        "etiqueta" => "Figura 1"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Cumplimiento de la AME por regiones y sexo&#46;</p>"
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        "etiqueta" => "Figura 2"
        "tipo" => "MULTIMEDIAFIGURA"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Probabilidad de no cumplir criterios de la AME seg&#250;n PASI&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total pacientes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">830&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comunidad Aut&#243;noma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Andaluc&#237;a&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arag&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">100&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Asturias&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Baleares&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Canarias&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cantabria&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Castilla y Le&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Castilla-La Mancha&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Catalu&#241;a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">124&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Comunidad Valenciana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Extremadura&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Galicia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Madrid&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">96&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Murcia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Navarra&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pa&#237;s Vasco&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rioja&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sexo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Var&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">493&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mujer&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">336&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad en a&#241;os&#44; media &#40;DE&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#44;4 &#47;14&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3593225.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Datos demogr&#225;ficos</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">DE&#58; Desviaci&#243;n est&#225;ndar</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Media&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">DE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Mediana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Primer cuartil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Tercer cuartil&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Min&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Max&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">BSA &#40;0-100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">827&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">PASI &#40;0-72&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">826&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">44&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">DLQI &#40;0-30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">821&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4&#44;6&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Picor &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">829&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#44;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Eritema &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Visibilidad &#40;0-10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">829&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3593220.png"
              ]
            ]
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        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Descripci&#243;n Cl&#237;nica Global</p>"
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      4 => array:8 [
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        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
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            "detalle" => "Tabla "
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                0 => """
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Porcentaje&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">100&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="3" align="left" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">61&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Si&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">317&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Picor &#8804; 1&#47;10</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">433&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Si&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">396&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Descamaci&#243;n &#8804; 2&#47;10</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">382&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Si&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">446&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">53&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Enrojecimiento &#8804; 2&#47;10</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">380&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Si&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">449&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Visibilidad &#8804; 2&#47;10</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">372&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Si&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">457&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">BSA &#8804; 2</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">369&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">44&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Si&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">458&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">DLQI &#8804; 2</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">337&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">41&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Si&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">484&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">59&#44;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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                0 => "xTab3593222.png"
              ]
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        "descripcion" => array:1 [
          "es" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Valores par&#225;metros criterios AME</p>"
        ]
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        "etiqueta" => "Tabla 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
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          0 => array:3 [
            "identificador" => "at4"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
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          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="4" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cumple AME</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Si</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">N&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#37; &#40;por columna&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tipo tratamiento</span>&#42;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ninguno&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>T&#243;picos&#8224;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sist&#46; cl&#225;sicos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Biol&#243;gicos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Orales &#40;apr&#47;fum&#47;tofa&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Fototerapia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#42;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">No biol&#243;gico vs biol&#243;gico</span>&#42;</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>No biol&#243;gico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Biol&#243;gicos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>&#42;&#42;p&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;001&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " colspan="7" align="left" valign="\n
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                  \t\t\t\t">45&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">326&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PASI&#60;<span class="elsevierStyleHsp" style=""></span>5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">303&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">47&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">331&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">52&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab3593223.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Cumplimiento AME seg&#250;n valor de PASI</p>"
        ]
      ]
      7 => array:8 [
        "identificador" => "tbl0030"
        "etiqueta" => "Tabla 6"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at6"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Prob&#46; AME&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Odds ratio&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; CI LL&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95&#37; CI UL&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p-valor&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Uso Biol&#243;gico&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#44;65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">PASI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;0000&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#44;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;0040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Sexo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;0090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Regi&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;91&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&#44;72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;8690&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&#44;77&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;0150&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;25&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#44;81&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#44;15&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;5660&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9&nbsp;\t\t\t\t\t\t\n
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