Case and Research Letters
Symmetrical Drug-Related Intertriginous Flexural Exanthema Induced by the Pfizer/BioNTech Comirnaty COVID-19 Vaccine
Exantema intertriginoso y flexural simétrico por fármacos inducido por la vacuna COVID-19 Comirnaty (Pfizer/BioNTech)
N.M. Román Mendoza
, L. Luna Bastante, A. Sánchez Gilo, F.J. Vicente Martin
Autor para correspondencia
Servicio de Dermatología y Venereología, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain
Leído
4806
Vecesse ha leído el artículo
835
Total PDF
3971
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S0001731023008621" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.10.029" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "3721" "copyright" => "AEDV" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:T94-T96" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0001731023004751" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.01.016" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "3535" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:97-101" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>" "titulo" => "Immune-Mediated Adverse Effects in the Immunotherapy Treatment of Patients With Metastatic Melanoma Versus Adjuvant Regimen: A Study in a Daily Practice Setting" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "97" "paginaFinal" => "101" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Efectos adversos inmunomediados en el tratamiento con inmunoterapia de pacientes con melanoma metastásico vs régimen de adyuvancia: estudio de práctica real" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L. Martos-Cabrera, T. Gallego, A. Fernandez-Galván, P. Rodríguez-Jiménez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "L." "apellidos" => "Martos-Cabrera" ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Gallego" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Fernandez-Galván" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Rodríguez-Jiménez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023004751?idApp=UINPBA000044" "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023004751/v1_202401030514/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0001731023004209" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.05.019" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "3517" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:94-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Exantema intertriginoso y flexural simétrico por fármacos inducido por la vacuna COVID-19 Comirnaty (Pfizer/BioNTech)" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "94" "paginaFinal" => "96" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Symmetrical Drug-Related Intertriginous Flexural Exanthema Induced by the Pfizer/BioNTech Comirnaty COVID-19 Vaccine" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 420 "Ancho" => 1007 "Tamanyo" => 72687 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A)<span class="elsevierStyleHsp" style=""></span>Infiltrado inflamatorio perivascular superficial de predominio linfocítico con algún eosinófilo (círculo). B)<span class="elsevierStyleHsp" style=""></span>Eritema inguinal bilateral, bordes bien definidos, no fisuración.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "N.M. Román Mendoza, L. Luna Bastante, A. Sánchez Gilo, F.J. Vicente Martin" "autores" => array:4 [ 0 => array:2 [ "nombre" => "N.M." "apellidos" => "Román Mendoza" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Luna Bastante" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sánchez Gilo" ] 3 => array:2 [ "nombre" => "F.J." "apellidos" => "Vicente Martin" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023004209?idApp=UINPBA000044" "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023004209/v1_202401030514/es/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S0001731023004209" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.05.019" "estado" => "S300" "fechaPublicacion" => "2024-01-01" "aid" => "3517" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2024;115:94-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científico-clínica</span>" "titulo" => "Exantema intertriginoso y flexural simétrico por fármacos inducido por la vacuna COVID-19 Comirnaty (Pfizer/BioNTech)" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "94" "paginaFinal" => "96" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Symmetrical Drug-Related Intertriginous Flexural Exanthema Induced by the Pfizer/BioNTech Comirnaty COVID-19 Vaccine" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 420 "Ancho" => 1007 "Tamanyo" => 72687 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A)<span class="elsevierStyleHsp" style=""></span>Infiltrado inflamatorio perivascular superficial de predominio linfocítico con algún eosinófilo (círculo). B)<span class="elsevierStyleHsp" style=""></span>Eritema inguinal bilateral, bordes bien definidos, no fisuración.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "N.M. Román Mendoza, L. Luna Bastante, A. Sánchez Gilo, F.J. Vicente Martin" "autores" => array:4 [ 0 => array:2 [ "nombre" => "N.M." "apellidos" => "Román Mendoza" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Luna Bastante" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sánchez Gilo" ] 3 => array:2 [ "nombre" => "F.J." "apellidos" => "Vicente Martin" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023004209?idApp=UINPBA000044" "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023004209/v1_202401030514/es/main.assets" ] ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => " Symmetrical Drug-Related Intertriginous Flexural Exanthema Induced by the Pfizer/BioNTech Comirnaty COVID-19 Vaccine" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor,</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T94" "paginaFinal" => "T96" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "N.M. Román Mendoza, L. Luna Bastante, A. Sánchez Gilo, F.J. Vicente Martin" "autores" => array:4 [ 0 => array:4 [ "nombre" => "N.M." "apellidos" => "Román Mendoza" "email" => array:1 [ 0 => "nellyromanmendoza@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Luna Bastante" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Sánchez Gilo" ] 3 => array:2 [ "nombre" => "F.J." "apellidos" => "Vicente Martin" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología y Venereología, Hospital Universitario Rey Juan Carlos, Móstoles, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Exantema intertriginoso y flexural simétrico por fármacos inducido por la vacuna COVID-19 Comirnaty (Pfizer/BioNTech)" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 316 "Ancho" => 756 "Tamanyo" => 47320 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A,<span class="elsevierStyleHsp" style=""></span>Mainly lymphocytic superficial perivascular inflammatory infiltrate with occasional eosinophils (circle). B,<span class="elsevierStyleHsp" style=""></span>Bilateral inguinal erythema with well-defined borders and no fissuring.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">An 82-year-old man with a history of dyslipidemia, diabetes mellitus, and chronic ischemic heart disease developed a pinkish macular exanthema. The rash was pruriginous and without scaling or epidermal detachment and had appeared some weeks earlier. It initially affected the groin before extending posteriorly to the flanks and the back. The patient had changed his brand of esomeprazole 1 month earlier. Esomeprazole was withdrawn because of suspected toxicoderma, and topical treatment was prescribed with methylprednisolone aceponate cream 1<span class="elsevierStyleHsp" style=""></span>mg/g. The patient's lesions resolved in 1 week. The laboratory workup revealed mild eosinophilia, and a skin biopsy showed a mainly lymphocytic superficial perivascular inflammatory infiltrate with mild edema, mild vascular ectasia, and occasional eosinophils (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1A</a>). Prick testing was performed with both brands of esomeprazole, as was a challenge test. The results were negative. The lesions did not reappear when the patient reinitiated treatment with esomeprazole.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Five months later, the patient attended for recurrence of the lesions (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1B</a>). Of note, he had received his third dose of the COVID-19 vaccine Comirnaty 48<span class="elsevierStyleHsp" style=""></span>hours before onset of symptoms. On further questioning, he reported that the previous episode had occurred 72<span class="elsevierStyleHsp" style=""></span>hours after receiving the second dose of Comirnaty.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Given the suspicion of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) associated with administration of Comirnaty, prick testing was completed with the Comirnaty vaccine and with polyethylene glycol (PEG), and patch tests were performed with the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group, metals, special metals from the Martí Tor series, cosmetics, acrylates, and PEG. The results were negative in all cases. Challenge testing with the vaccine was not performed given the recent administration of the third dose. The patient received topical treatment with clobetasol cream 0.5<span class="elsevierStyleHsp" style=""></span>mg/g, and the lesions resolved 4<span class="elsevierStyleHsp" style=""></span>weeks later.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Based on the clinical and histopathological characteristics of the lesions, the temporal relationship with the administration of the vaccine, and the absence of other causes that could account for the clinical picture and considering the causality criteria of Naranjo<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a>, the patient was diagnosed with “probable” SDRIFE induced by Comirnaty.</p><p id="par0025" class="elsevierStylePara elsevierViewall">SDRIFE, which was previously known as baboon syndrome, is a type of systemic contact dermatitis. It manifests as symmetric erythematous exanthema that mainly affects the buttocks, genitals, and skinfolds on the extremities. It occurs when a person who is sensitized to a contact allergen is exposed systemically (transcutaneous, transmucosal, intravenous, intramuscular, oral, inhalation). It is a benign condition, with no manifestations of systemic toxicity and a good prognosis after withdrawal of the causative agent.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Ten cases of SDRIFE caused by COVID-19 vaccine have been published: 5 with Comirnaty,<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3–6</span></a> 2 with CoronaVac,<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6,7</span></a> and 3 with Vaxzevria/ChAdOx1 nCoV-19 (AstraZeneca-Oxford)<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8–10</span></a> (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The symptoms appear during the first few hours after exposure and up to several weeks later.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> In 7 cases, exanthema appeared after the second dose. No signs or symptoms of systemic involvement were observed in any cases.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">Histopathologic findings for SDRIFE are nonspecific,<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,4,7</span></a> and we see superficial perivascular lymphohistiocytic infiltrates that may include neutrophils or eosinophils.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Spongiosis may or may not be present.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Cases of SDRIFE caused by vaccines whose components included thiomersal have been reported. Thiomersal was not a component of the COVID-19 vaccines reported. The adjuvant of Comirnaty studied as a possible cause was PEG.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Patch testing was performed in 4 of the cases of SDRIFE caused by COVID-19 vaccine described above,<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,6,10</span></a> with a positive result for nickel in one.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Prick testing yielded a negative result in 3 patients.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6,10</span></a> Patch testing and prick testing can yield negative results, probably owing to poorer systemic absorption of the drugs when they are administered transcutaneously. Intradermal testing with the vaccine was positive in 1 case, although this positive response may have been the consequence of a local immune response in a patient who has already received the vaccine.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Challenge testing yields positive results in most cases of SDRIFE.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Challenge testing with COVID-19 vaccine has not been reported. All the patients responded well to topical or oral corticosteroids, with resolution of the skin lesions after a few weeks.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Cases of SDRIFE due to COVID-19 vaccine have been reported since the worldwide roll-out of the vaccination program. We report the case of a patient who developed SDRIFE after his second and third doses of the Comirnaty vaccine.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 316 "Ancho" => 756 "Tamanyo" => 47320 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A,<span class="elsevierStyleHsp" style=""></span>Mainly lymphocytic superficial perivascular inflammatory infiltrate with occasional eosinophils (circle). B,<span class="elsevierStyleHsp" style=""></span>Bilateral inguinal erythema with well-defined borders and no fissuring.</p>" ] ] 1 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: DIF, direct immunofluorescence; F, female; M, male.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Vaccine \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age, y \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dose \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Onset \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Analysis \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Biopsy \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Skin tests \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comirnaty<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Eosinophilia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vacuolar interface dermatitis. Mild spongiosisDIF negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comirnaty<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Eosinophilic spongiosisDIF negative \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">YesMild nickel<span class="elsevierStyleHsp" style=""></span>+ \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comirnaty<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Third \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Leukocytosis Neutrophilia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Superficial perivascular lymphocytic infiltrate with eosinophils \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comirnaty<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">65 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">? \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Comirnaty<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative patch/prick test results.Positive intradermal test results \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CoronaVac<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative patch/prick/intradermal test results \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">CoronaVac<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">? \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Elevated renal profile parameters \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hyperkeratosis, acanthosis, spongiosis, lymphohistiocytic perivascular infiltration, extravasation of erythrocytes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vaxzevria<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mild leukocytosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vaxzevria<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Vaxzevria<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Second \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 d \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Negative prick/intradermal test results \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab3424691.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Symmetrical Drug-Related Intertriginous Flexural Exanthema Reported After COVID-19 Vaccination.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A method for estimating the probability of adverse drug reactions" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.A. Naranjo" 1 => "U. Busto" 2 => "E.M. Sellers" 3 => "P. Sandor" 4 => "I. Ruiz" 5 => "E.A. Roberts" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1038/clpt.1981.154" "Revista" => array:6 [ "tituloSerie" => "Clin Pharmacol Ther." "fecha" => "1981" "volumen" => "30" "paginaInicial" => "239" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7249508" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1038/clpt.1981.154" "WWW" => array:1 [ "link" => "https://doi.org/10.1038/clpt.1981.154" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0060" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The baboon syndrome: Systemically-induced allergic contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "K.E. Andersen" 1 => "N. Hjorth" 2 => "T. Menné" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Contact Dermatitis." "fecha" => "1984" "volumen" => "10" "paginaInicial" => "97" "paginaFinal" => "100" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1111/j.1600-0536.1984.tb00343.x" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0065" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic drug-related intertriginous and flexural exanthema induced by the Pfizer-BioNTech COVID-19 vaccine: A report of 2 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Hai" 1 => "H. Shawa" 2 => "P. Kim-Lim" 3 => "J.Z. Wang" 4 => "M. Vy" 5 => "M.A. Fung" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jdcr.2021.10.016" "Revista" => array:6 [ "tituloSerie" => "JAAD Case Rep." "fecha" => "2021" "volumen" => "18" "paginaInicial" => "57" "paginaFinal" => "60" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34722840" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jdcr.2021.10.016" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.jdcr.2021.10.016" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0070" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case of symmetrical drug-related intertriginous and flexural exanthema-like eruption associated with Pfizer COVID-19 vaccination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Manaa" 1 => "M. Ziv" 2 => "J. Krausz" 3 => "R.P. Dodiuk-Gad" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/dth.15546" "Revista" => array:5 [ "tituloSerie" => "Dermatol Ther." "fecha" => "2022" "volumen" => "35" "paginaInicial" => "e15546" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35485220" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/dth.15546" "WWW" => array:1 [ "link" => "https://doi.org/10.1111/dth.15546" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0075" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous adverse reactions associated with SARS-CoV-2 vaccines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "F. Bellinato" 1 => "M. Maurelli" 2 => "P. Gisondi" 3 => "G. Girolomoni" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3390/jcm10225344" "Revista" => array:5 [ "tituloSerie" => "J Clin Med." "fecha" => "2021" "volumen" => "10" "paginaInicial" => "5344" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34830627" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3390/jcm10225344" "WWW" => array:1 [ "link" => "https://doi.org/10.3390/jcm10225344" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0080" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Symmetrical drug-related intertriginous and flexural exanthema-like eruption after COVID-19 vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "I. Lahouel" 1 => "N. Ben Salah" 2 => "N. Ben Fadhel" 3 => "F. Chahed" 4 => "N. Ouni" 5 => "H. Belhadjali" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/jdv.18108" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2022" "volumen" => "36" "paginaInicial" => "e597" "paginaFinal" => "e599" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35344627" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/jdv.18108" "WWW" => array:1 [ "link" => "https://doi.org/10.1111/jdv.18108" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0085" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic drug-related intertriginous and flexural exanthema like eruption after CoronaVac vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O.M. Orenay" 1 => "I. Balta" 2 => "D. Yigit" 3 => "M. Eksioglu" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/jdv.17454" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2021" "volumen" => "35" "paginaInicial" => "e634" "paginaFinal" => "e635" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34138472" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/jdv.17454" "WWW" => array:1 [ "link" => "https://doi.org/10.1111/jdv.17454" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0090" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Symmetrical drug-related intertriginous and flexural exanthema like eruption associated with COVID-19 vaccination" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.N. Lim" 1 => "G. Wylie" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/ced.14898" "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol." "fecha" => "2022" "volumen" => "47" "paginaInicial" => "175" "paginaFinal" => "176" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34399001" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/ced.14898" "WWW" => array:1 [ "link" => "https://doi.org/10.1111/ced.14898" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0095" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Symmetric drug-related intertriginous and flexural exanthema-like eruption related to coronavirus disease 2019 vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.K. Hong" 1 => "S.H. Shin" 2 => "K.H. Yoo" 3 => "K. Li" 4 => "S.J. Seo" ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/cod.14092" "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis." "fecha" => "2022" "volumen" => "87" "paginaInicial" => "91" "paginaFinal" => "93" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/35243643" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/cod.14092" "WWW" => array:1 [ "link" => "https://doi.org/10.1111/cod.14092" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0100" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic drug-related intertriginous and flexural exanthema-like eruption after Oxford-AstraZeneca COVID-19 vaccine" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Di Bona" 1 => "A. Miniello" 2 => "E. Nettis" ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Clin Mol Allergy." "fecha" => "2022" "volumen" => "20" "paginaInicial" => "13" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1186/s12948-022-00179-8" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000011500000001/v1_202401030514/S0001731023008621/v1_202401030514/en/main.assets" "Apartado" => array:4 [ "identificador" => "6160" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas científico-clínicas" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011500000001/v1_202401030514/S0001731023008621/v1_202401030514/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023008621?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 20 | 11 | 31 |
| 2024 Octubre | 195 | 60 | 255 |
| 2024 Septiembre | 206 | 56 | 262 |
| 2024 Agosto | 294 | 73 | 367 |
| 2024 Julio | 293 | 49 | 342 |
| 2024 Junio | 180 | 58 | 238 |
| 2024 Mayo | 224 | 51 | 275 |
| 2024 Abril | 138 | 51 | 189 |
| 2024 Marzo | 252 | 53 | 305 |
| 2024 Febrero | 232 | 62 | 294 |
| 2024 Enero | 1234 | 69 | 1303 |
| 2023 Diciembre | 535 | 85 | 620 |
| 2023 Noviembre | 168 | 157 | 325 |
Mostrar todo
