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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 34-year-old woman with no remarkable past medical history presented with a slow-growing asymptomatic lesion on her right buttock that had been present for 20 years&#46; Physical examination revealed a well-defined&#44; round&#44; bluish plaque with a diameter of 15<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Polarized light dermoscopy showed global multichromatic pigmentation &#40;blue&#44; red&#44; white&#41;&#44; dotted and irregular linear vessels&#44; bright white lines&#44; and structureless bluish-white and reddish areas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Nonpolarized dermoscopy showed a homogeneous blue pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Histologic examination of a skin biopsy specimen showed a preserved epidermis with superficial parakeratosis and&#44; in the deep reticular dermis&#44; a dense proliferation of round dendritic melanocytes with darkly pigmented melanophages &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Skin biopsy confirmed a diagnosis of cellular blue nevus&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Blue nevi are benign lesions composed of a proliferation of dendritic melanocytes in the dermis&#46; They can be congenital or acquired and present clinically as solitary or multiple papules&#44; nodules&#44; or plaques with a blue&#44; gray-blue&#44; or bluish-brown color&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a> Onset is typically in childhood&#44; adolescence&#44; or early adulthood&#46; Most lesions are located on the face&#44; scalp&#44; extremities&#44; and buttocks&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Blue nevi can mimic both melanocytic and nonmelanocytic lesions&#44; including melanoma&#44; cutaneous melanoma metastases&#44; Spitz&#47;Reed nevus&#44; and basal cell carcinoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The hallmark nonpolarized dermoscopic feature is a homogeneous blue pattern without a pigment network or any other distinctive structures&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a> Less frequently&#44; this global pattern may also have a diffuse blackish or brown color&#44; or a combination of 2 colors &#40;dichromatic pattern&#41; such as blue-brown&#44; blue-black&#44; or blue-gray&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> Multichromatic pigmentation with a combination of blue&#44; brown&#44; white&#44; black&#44; red&#44; and&#47;or gray is uncommon and has been reported in just 15&#46;8&#37; of blue nevi&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Vascular structures &#40;polymorphous&#44; dotted&#44; comma&#44; irregular linear&#44; and arborizing vessels&#41; are rare local findings&#46; Some case series have shown these features to be significantly associated with the global multichromatic pattern&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Presence of hypopigmented white areas&#44; which histologically correspond to dermal fibrosis&#44; is another uncommon local feature&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Bright white lines&#44; visualized only under polarized light&#44; are not pathognomonic and have not been linked to blue nevus in any of the reports identified&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Observation of a solitary lesion present since childhood in a young patient with no personal or family history of melanoma combined with a homogeneous blue pattern seen on dermoscopy is strongly suggestive of a diagnosis of blue nevus&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> Melanoma&#44; however&#44; cannot be ruled out when dermoscopy shows a bluish lesion with multichromatic pigmentation and other local criteria&#44; such as vessels&#46; In such cases&#44; surgical excision is mandatory&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; we have presented a case of cellular blue nevus in which polarized light dermoscopy showed the uncommon global multichromatic pattern and the bright white lines associated with this benign entity&#46; Based on these findings&#44; the differential diagnosis is broad&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of Interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Practical Dermoscopy
Solitary Blue Plaque: Beyond the Homogeneous Blue Pattern
Placa azul solitaria: más allá del patrón azul homogéneo
A. Alonzo Caldarelli
Autor para correspondencia
agostina.ac3@gmail.com

Corresponding author.
, P. Johana Barba
Práctica Privada, La Plata, Argentina
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Report</span><p id="par0005" class="elsevierStylePara elsevierViewall">A 34-year-old woman with no remarkable past medical history presented with a slow-growing asymptomatic lesion on her right buttock that had been present for 20 years&#46; Physical examination revealed a well-defined&#44; round&#44; bluish plaque with a diameter of 15<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">Polarized light dermoscopy showed global multichromatic pigmentation &#40;blue&#44; red&#44; white&#41;&#44; dotted and irregular linear vessels&#44; bright white lines&#44; and structureless bluish-white and reddish areas &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Nonpolarized dermoscopy showed a homogeneous blue pattern &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Histologic examination of a skin biopsy specimen showed a preserved epidermis with superficial parakeratosis and&#44; in the deep reticular dermis&#44; a dense proliferation of round dendritic melanocytes with darkly pigmented melanophages &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">What Is Your Diagnosis&#63;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Diagnosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Skin biopsy confirmed a diagnosis of cellular blue nevus&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Comment</span><p id="par0035" class="elsevierStylePara elsevierViewall">Blue nevi are benign lesions composed of a proliferation of dendritic melanocytes in the dermis&#46; They can be congenital or acquired and present clinically as solitary or multiple papules&#44; nodules&#44; or plaques with a blue&#44; gray-blue&#44; or bluish-brown color&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a> Onset is typically in childhood&#44; adolescence&#44; or early adulthood&#46; Most lesions are located on the face&#44; scalp&#44; extremities&#44; and buttocks&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">2&#44;3</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Blue nevi can mimic both melanocytic and nonmelanocytic lesions&#44; including melanoma&#44; cutaneous melanoma metastases&#44; Spitz&#47;Reed nevus&#44; and basal cell carcinoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">The hallmark nonpolarized dermoscopic feature is a homogeneous blue pattern without a pigment network or any other distinctive structures&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a> Less frequently&#44; this global pattern may also have a diffuse blackish or brown color&#44; or a combination of 2 colors &#40;dichromatic pattern&#41; such as blue-brown&#44; blue-black&#44; or blue-gray&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a> Multichromatic pigmentation with a combination of blue&#44; brown&#44; white&#44; black&#44; red&#44; and&#47;or gray is uncommon and has been reported in just 15&#46;8&#37; of blue nevi&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Vascular structures &#40;polymorphous&#44; dotted&#44; comma&#44; irregular linear&#44; and arborizing vessels&#41; are rare local findings&#46; Some case series have shown these features to be significantly associated with the global multichromatic pattern&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">1&#8211;3</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Presence of hypopigmented white areas&#44; which histologically correspond to dermal fibrosis&#44; is another uncommon local feature&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">Bright white lines&#44; visualized only under polarized light&#44; are not pathognomonic and have not been linked to blue nevus in any of the reports identified&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Observation of a solitary lesion present since childhood in a young patient with no personal or family history of melanoma combined with a homogeneous blue pattern seen on dermoscopy is strongly suggestive of a diagnosis of blue nevus&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">3</span></a> Melanoma&#44; however&#44; cannot be ruled out when dermoscopy shows a bluish lesion with multichromatic pigmentation and other local criteria&#44; such as vessels&#46; In such cases&#44; surgical excision is mandatory&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">1</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">In conclusion&#44; we have presented a case of cellular blue nevus in which polarized light dermoscopy showed the uncommon global multichromatic pattern and the bright white lines associated with this benign entity&#46; Based on these findings&#44; the differential diagnosis is broad&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conflicts of Interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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