Images in Dermatology
Melanocytic Nevus in Subacute Lupus Erythematosus: An Unexpected Association
Nevus melanocítico en lupus eritematoso subagudo: una asociación inesperada
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Ríos-Martín" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Machuca-Aguado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "T." "apellidos" => "Benítez Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:4 [ "nombre" => "J.J." "apellidos" => "Ríos-Martín" "email" => array:1 [ 0 => "jjrios@us.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Anatomía Patológica, Hospital Universitario Virgen Macarena, Sevilla, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Dermatología, Hospital Universitario Virgen Macarena, Sevilla, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Nevus melanocítico en lupus eritematoso subagudo: una asociación inesperada" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 655 "Ancho" => 901 "Tamanyo" => 200163 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 61-year-old woman with no remarkable past history presented with slightly raised, annular erythematous macules of approximately 3 months’ duration on the neckline and dorsal surface of the arms.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Skin biopsy of 1 of the lesions revealed 2 findings: interface dermatitis and an intradermal melanocytic nevus (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). The interface dermatitis was characterized by vacuolar changes, a perivascular lymphocytic inflammatory infiltrate, and interstitial mucin deposition (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). The intradermal nevus was composed of amelanotic epithelioid melanocytes accompanied by a focal lymphocytic inflammatory infiltrate. The melanocytes had abundant eosinophilic cytoplasm with well-defined borders and mild nuclear pleomorphism (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The histologic diagnosis was an intradermal melanocytic nevus co-occurring with subacute lupus erythematosus.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Although melanocytic nevi are known to co-occur with inflammatory disorders such as eczema (Meyerson nevus), psoriasis, and lichen sclerosus, few cases have been described, and this is the first report of co-occurrence with lupus erythematosus.</p><p id="par0025" class="elsevierStylePara elsevierViewall">This finding is important as it may indicate that inflammatory conditions can lead to morphologic changes in a benign proliferation that simulate melanoma. 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