Resident's Forum
RF – Resistance to Permethrin in Scabies Treatment: Does It Really Exist?
FR – ¿Existe una resistencia real al tratamiento de la escabiosis con permetrina?
J.P. Velasco-Amador, A. Prados-Carmona, R. Ruiz-Villaverde
Autor para correspondencia
Servicio de Dermatología, Hospital Universitario San Cecilio, Inst. Invest. Biosanitaria IBS Granada, Granada, Spain
Leído
8146
Vecesse ha leído el artículo
3087
Total PDF
5059
Total HTML
Compartir estadísticas
array:24 [ "pii" => "S0001731023002892" "issn" => "00017310" "doi" => "10.1016/j.ad.2022.05.046" "estado" => "S300" "fechaPublicacion" => "2023-05-01" "aid" => "3451" "copyright" => "AEDV" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2023;114:T433-T434" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S000173102200895X" "issn" => "00017310" "doi" => "10.1016/j.ad.2022.05.027" "estado" => "S300" "fechaPublicacion" => "2023-05-01" "aid" => "3263" "copyright" => "AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2023;114:435-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Dermatoscopia práctica</span>" "titulo" => "Pápulas peneanas de aparición progresiva" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "435" "paginaFinal" => "436" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Progressively Appearing Papules on the Penis" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 895 "Ancho" => 1005 "Tamanyo" => 152632 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Hallazgos histológicos de la biopsia efectuada con sacabocados. Tinción de hematoxilina-eosina.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Martin-Gorgojo, A. Comunión-Artieda, F.J. Bru-Gorraiz" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Martin-Gorgojo" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Comunión-Artieda" ] 2 => array:2 [ "nombre" => "F.J." "apellidos" => "Bru-Gorraiz" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173102200895X?idApp=UINPBA000044" "url" => "/00017310/0000011400000005/v2_202306061222/S000173102200895X/v2_202306061222/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0001731022010572" "issn" => "00017310" "doi" => "10.1016/j.ad.2022.05.036" "estado" => "S300" "fechaPublicacion" => "2023-05-01" "aid" => "3341" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2023;114:433-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">FORO PARA RESIDENTES</span>" "titulo" => "FR - ¿Existe una resistencia real al tratamiento de la escabiosis con permetrina?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "433" "paginaFinal" => "434" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RF - Resistance to Permethrin in Scabies Treatment: Does It Really Exist?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.P. Velasco-Amador, A. Prados-Carmona, R. Ruiz-Villaverde" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Velasco-Amador" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Prados-Carmona" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022010572?idApp=UINPBA000044" "url" => "/00017310/0000011400000005/v2_202306061222/S0001731022010572/v2_202306061222/es/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S0001731022010572" "issn" => "00017310" "doi" => "10.1016/j.ad.2022.05.036" "estado" => "S300" "fechaPublicacion" => "2023-05-01" "aid" => "3341" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2023;114:433-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">FORO PARA RESIDENTES</span>" "titulo" => "FR - ¿Existe una resistencia real al tratamiento de la escabiosis con permetrina?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "433" "paginaFinal" => "434" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "RF - Resistance to Permethrin in Scabies Treatment: Does It Really Exist?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.P. Velasco-Amador, A. Prados-Carmona, R. Ruiz-Villaverde" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Velasco-Amador" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Prados-Carmona" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022010572?idApp=UINPBA000044" "url" => "/00017310/0000011400000005/v2_202306061222/S0001731022010572/v2_202306061222/es/main.assets" ] ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Resident's Forum</span>" "titulo" => " RF – Resistance to Permethrin in Scabies Treatment: Does It Really Exist?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T433" "paginaFinal" => "T434" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.P. Velasco-Amador, A. Prados-Carmona, R. Ruiz-Villaverde" "autores" => array:3 [ 0 => array:2 [ "nombre" => "J.P." "apellidos" => "Velasco-Amador" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Prados-Carmona" ] 2 => array:4 [ "nombre" => "R." "apellidos" => "Ruiz-Villaverde" "email" => array:1 [ 0 => "ismenios@hotmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital Universitario San Cecilio, Inst. Invest. Biosanitaria IBS Granada, Granada, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "FR – ¿Existe una resistencia real al tratamiento de la escabiosis con permetrina?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Scabies is a highly contagious skin infestation caused by the <span class="elsevierStyleItalic">Sarcoptes scabiei</span> mite. It is generally transmitted through direct, prolonged, skin-to-skin contact, and its incidence increased following the COVID-19 pandemic and home confinement measures.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> The first-line treatment for scabies is 5% topical permethrin cream, which is applied from head to toe and washed off after 8 to 12 hours. This treatment is repeated after 7 to 14 days. Cure rates of up to 98% have been described for this regimen,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> but recent months have seen an increase in unsatisfactory responses to treatment.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Treatment failure has generally been attributed to various causes, including incorrect application of the cream, failure to simultaneously treat coinhabitants, and insufficient disinfection of the environment. An increasing number of dermatologists, however, after ruling out the above errors and achieving cure with other topical treatments, such as sulfur-containing petroleum jelly and sodium benzoate, are suggesting that <span class="elsevierStyleItalic">S. scabiei</span> may be developing true resistance to permethrin.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In 2018, Sunderkötter et al.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> warned of an increase in scabies cases in Germany. Among the possible causes they mentioned was permethrin resistance, as patients did not respond as quickly as they had done in previous years. In 2020, Meyersburg et al.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> described reduced scabies mite susceptibility to permethrin in Austria and called for evaluation of alternative treatment options. In 2021, several Italian working groups also recorded a loss of effectiveness for permethrin. They reported that almost two-thirds of patients in whom the drug had failed responded to another topical treatment, suggesting specific resistance to permethrin; they also excluded lack of compliance as the reason for this lower response.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> The different mechanisms proposed for resistance to permethrin among <span class="elsevierStyleItalic">S. scabiei</span> mites include increased glutathione-S-transferase activity, increased expression of ATP-dependent transporters (e.g., multidrug-resistant protein), and sodium channel mutations.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> These circumstances have required dermatologists to resort more frequently to other first-line drugs, such as oral ivermectin and benzyl benzoate in 25% solution. Other options are topical ivermectin 1% and even 6%–33% sulfur-containing petroleum jelly,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> since resistance to ivermectin has also been described.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">5</span></a> Recent months have seen the emergence of new therapies, such as spinosad 0.9%, a neurotoxin recently approved by the US Food and Drug Administration for the topical treatment of scabies.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The above reports point to the same issue – that the scabies mite is developing increasing resistance to permethrin – and suggest the need to reconsider its recommendation as a first-line treatment in clinical practice guidelines and to assess other options that are showing greater effectiveness.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1648608" "palabras" => array:5 [ 0 => "Scabies" 1 => "<span class="elsevierStyleItalic">Sarcoptes scabiei</span>" 2 => "Permethrin" 3 => "Treatment" 4 => "Epidemic" ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0040" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:3 [ "titulo" => "FR – Epidemia de sarna en el contexto de la pandemia de COVID-19" "tituloTraducido" => "Scabies outbreak during the COVID-19 lockdown" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.A. Cerro" 1 => "A. Navarro-Bielsa" 2 => "A.M. Palma" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2020.11.028" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2022" "volumen" => "113" "paginaInicial" => "516" "paginaFinal" => "518" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34785819" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0045" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increase of scabies in Germany and development of resistant mites? Evidence and consequences" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Sunderkötter" 1 => "A. Aebischer" 2 => "M. Neufeld" 3 => "C. Löser" 4 => "A. Kreuter" 5 => "R. Bialek" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ddg.13706_g" "Revista" => array:6 [ "tituloSerie" => "J Dtsch Dermatol Ges" "fecha" => "2018" "volumen" => "17" "paginaInicial" => "15" "paginaFinal" => "23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30615283" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0050" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Loss of efficacy of topical 5% permethrin for treating scabies: an Austrian single-center study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Meyersburg" 1 => "A. Kaiser" 2 => "J.W. Bauer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Dermatolog Treat" "fecha" => "2020" "volumen" => "4" "paginaInicial" => "1" "paginaFinal" => "4" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0055" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scabies is becoming less sensitive to permethrin therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Balestri" 1 => "M. Magnano" 2 => "S.D. Infusino" 3 => "L. Rizzoli" 4 => "C.R. Girardelli" 5 => "G. Rech" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.17538" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2021" "volumen" => "35" "paginaInicial" => "e889" "paginaFinal" => "e891" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34310767" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0060" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Scabies in the age of increasing drug resistance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Khalil" 1 => "O. Abbas" 2 => "A.G. Kibbi" 3 => "M. Kurban" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pntd.0005920" "Revista" => array:5 [ "tituloSerie" => "PLoS Negl Trop Dis" "fecha" => "2017" "volumen" => "11" "paginaInicial" => "e0005920" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29190303" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0065" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European guideline for the management of scabies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.M. Salavastru" 1 => "O. Chosidow" 2 => "M.J. Boffa" 3 => "M. Janier" 4 => "G.S. Tiplica" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.14351" "Revista" => array:7 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2017" "volumen" => "31" "paginaInicial" => "1248" "paginaFinal" => "1253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28639722" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0959804916323085" "estado" => "S300" "issn" => "09598049" ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0070" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spinosad at 0.9% in the treatment of scabies: efficacy results from 2 multicenter, randomized, double-blind, vehicle-controlled studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.C. Seiler" 1 => "R.C. Keech" 2 => "J.L. Aker" 3 => "W. Miller" 4 => "C. Belcher" 5 => "K.W. Mettert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2021.07.074" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2022" "volumen" => "86" "paginaInicial" => "97" "paginaFinal" => "103" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34391812" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000011400000005/v2_202306061222/S0001731023002892/v2_202306061222/en/main.assets" "Apartado" => array:4 [ "identificador" => "34907" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Foro de Residentes" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011400000005/v2_202306061222/S0001731023002892/v2_202306061222/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023002892?idApp=UINPBA000044" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 14 | 27 | 41 |
| 2024 Octubre | 386 | 280 | 666 |
| 2024 Septiembre | 415 | 279 | 694 |
| 2024 Agosto | 351 | 412 | 763 |
| 2024 Julio | 312 | 324 | 636 |
| 2024 Junio | 240 | 257 | 497 |
| 2024 Mayo | 212 | 333 | 545 |
| 2024 Abril | 156 | 246 | 402 |
| 2024 Marzo | 207 | 224 | 431 |
| 2024 Febrero | 170 | 122 | 292 |
| 2024 Enero | 249 | 75 | 324 |
| 2023 Diciembre | 383 | 74 | 457 |
| 2023 Noviembre | 589 | 57 | 646 |
| 2023 Octubre | 431 | 83 | 514 |
| 2023 Septiembre | 237 | 44 | 281 |
| 2023 Agosto | 201 | 46 | 247 |
| 2023 Julio | 192 | 61 | 253 |
| 2023 Junio | 118 | 42 | 160 |
| 2023 Mayo | 152 | 60 | 212 |
| 2023 Abril | 44 | 41 | 85 |
Mostrar todo
