se ha leído el artículo
array:24 [ "pii" => "S0001731023001643" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.02.011" "estado" => "S300" "fechaPublicacion" => "2023-04-01" "aid" => "3410" "copyright" => "AEDV" "copyrightAnyo" => "2022" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2023;114:T308-T317" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S0001731023000029" "issn" => "00017310" "doi" => "10.1016/j.ad.2023.01.002" "estado" => "S300" "fechaPublicacion" => "2023-04-01" "aid" => "3352" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2023;114:318-26" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Revisión</span>" "titulo" => "MPOX (antes viruela del mono): revisión de los aspectos clínicos, epidemiológicos, diagnósticos y terapéuticos más relevantes para el dermatólogo" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:3 [ 0 => "es" 1 => "es" 2 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "318" "paginaFinal" => "326" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mpox — Formerly Monkey Pox — in Dermatology: A Review of Epidemiologic Features, Clinical Presentation, Diagnosis, and Treatment" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0015" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 1038 "Ancho" => 1333 "Tamanyo" => 135511 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Català, J. Riera, I. Fuertes" "autores" => array:3 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Català" ] 1 => array:2 [ "nombre" => "J." "apellidos" => "Riera" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Fuertes" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0015"></elsevierMultimedia></p></span>" ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023000029?idApp=UINPBA000044" "url" => "/00017310/0000011400000004/v1_202304111712/S0001731023000029/v1_202304111712/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0001731022010511" "issn" => "00017310" "doi" => "10.1016/j.ad.2022.11.009" "estado" => "S300" "fechaPublicacion" => "2023-04-01" "aid" => "3335" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2023;114:308-17" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">REVISIÓN</span>" "titulo" => "Haptenos, proteínas y dermatitis atópica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "308" "paginaFinal" => "317" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Haptens, Proteins, and Atopic Dermatitis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 596 "Ancho" => 1505 "Tamanyo" => 145695 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Dermatitis de contacto por proteínas a carne de pollo. A) Eccema crónico de manos. B) Resultado positivo del <span class="elsevierStyleItalic">prick-prick</span> con carne de pollo.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Amat-Samaranch, J.F. Silvestre Salvador" "autores" => array:2 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Amat-Samaranch" ] 1 => array:2 [ "nombre" => "J.F." "apellidos" => "Silvestre Salvador" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022010511?idApp=UINPBA000044" "url" => "/00017310/0000011400000004/v1_202304111712/S0001731022010511/v1_202304111712/es/main.assets" ] "asociados" => array:1 [ 0 => array:18 [ "pii" => "S0001731022010511" "issn" => "00017310" "doi" => "10.1016/j.ad.2022.11.009" "estado" => "S300" "fechaPublicacion" => "2023-04-01" "aid" => "3335" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Actas Dermosifiliogr. 2023;114:308-17" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">REVISIÓN</span>" "titulo" => "Haptenos, proteínas y dermatitis atópica" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "308" "paginaFinal" => "317" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Haptens, Proteins, and Atopic Dermatitis" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 596 "Ancho" => 1505 "Tamanyo" => 145695 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Dermatitis de contacto por proteínas a carne de pollo. A) Eccema crónico de manos. B) Resultado positivo del <span class="elsevierStyleItalic">prick-prick</span> con carne de pollo.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "V. Amat-Samaranch, J.F. Silvestre Salvador" "autores" => array:2 [ 0 => array:2 [ "nombre" => "V." "apellidos" => "Amat-Samaranch" ] 1 => array:2 [ "nombre" => "J.F." "apellidos" => "Silvestre Salvador" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022010511?idApp=UINPBA000044" "url" => "/00017310/0000011400000004/v1_202304111712/S0001731022010511/v1_202304111712/es/main.assets" ] ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review</span>" "titulo" => " Haptens, Proteins, and Atopic Dermatitis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "T308" "paginaFinal" => "T317" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "V. Amat-Samaranch, J.F. Silvestre Salvador" "autores" => array:2 [ 0 => array:4 [ "nombre" => "V." "apellidos" => "Amat-Samaranch" "email" => array:1 [ 0 => "vamat@clinic.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "J.F." "apellidos" => "Silvestre Salvador" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Clínic de Barcelona, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario de Alicante, Alicante, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Haptenos, proteínas y dermatitis atópica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 809 "Ancho" => 1755 "Tamanyo" => 208136 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Adult atopic dermatitis aggravated by contact allergy to fragrances in a 74-year-old man. (A and B) Eczema affecting the posterior trunk and right arm. (C) Results of patch testing with the GEIDAC standard series at 48<span class="elsevierStyleHsp" style=""></span>hours: fragrance mix I+++ and fragrance mix II+++. (D) Patch test results (fragrance series) at 96<span class="elsevierStyleHsp" style=""></span>hours: geraniol++ and citral++. Partial control of AD was achieved with avoidance measures.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Atopic dermatitis (AD) is a chronic skin disease comprising a skin barrier defect combined with an impaired immune response in genetically predisposed individuals and in which exposure to external environmental agents play a key role.<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">1,2</span></a> Impairment of the skin barrier facilitates the penetration of microbial agents, irritants, and allergens, including both haptens and proteins.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Co-occurrence of AD and irritant contact dermatitis is very frequent and widely accepted. Furthermore, many cases of allergic contact dermatitis (ACD) involve patients with pre-existing irritant contact dermatitis. Following this line of reasoning, patients with AD should be more prone to ACD. However, the opposite has traditionally been stated, namely, that ACD is less common in atopic patients. Given that ACD depends on a mainly type 1 helper T cell (T<span class="elsevierStyleInf">H</span>1) response, it was believed that the predominance of the T<span class="elsevierStyleInf">H</span>2 response in atopic patients in some way “protected” them from sensitization to haptens and accounted for the less frequent sensitization observed.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">3</span></a> However, in our daily practice, we see many patients with AD who experience ACD as a complication.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The role of protein allergy in patients with specific atopic diseases, such as asthma, rhinitis, eosinophilic esophagitis, and food allergy, is well known.<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">4</span></a> Protein contact dermatitis (PCD) is also widely accepted and is found to be more frequent in atopic patients with chronic hand eczema. It usually occurs in the workplace after exposure to animal or plant proteins. However, the involvement of proteins in exacerbations of AD or the role of immunotherapy as treatment of AD are more controversial topics.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In the present article, we aim to provide an update that covers the latest advances in pathophysiology, symptoms, and treatment that have made it possible to better understand the highly complex relationship between AD, haptens, and proteins.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Atopic Dermatitis and Haptens</span><p id="par0025" class="elsevierStylePara elsevierViewall">Worldwide, 15%–20% of children and 1%–10% of adults are affected by AD.<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">1,2</span></a> The clinical presentations vary considerably, although they generally include eczema. The clinical manifestations also vary with age and may occur as flare-ups or be persistent. AD is often associated with high levels of serum immunoglobulin (Ig) E, a personal or family history of type 1 hypersensitivity reactions, allergic rhinitis, and asthma. Diagnosis is based on symptoms,<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">5</span></a> and diagnostic criteria that could prove useful in more complicated cases have been reported.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">ACD is a delayed hypersensitivity reaction to contact allergens, normally low-molecular-weight substances (haptens) that can cross the skin barrier. Clinically, it presents as eczema, thus hampering differentiation between AD and ACD.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">7</span></a> Histology is not useful for differentiation, since both conditions have a similar histologic pattern. In acute flares, we observed a predominance of spongiosis and vesiculation, whereas in the chronic forms, the predominant pattern is one of acanthosis with hyperkeratosis and, to a lesser extent, spongiosis. Patch testing is the gold standard approach for diagnosis of ACD<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">8,9</span></a> and must be performed in the case of a patient with chronic eczema in whom we wish to distinguish between AD, ACD, and AD complicated by ACD.</p><p id="par0035" class="elsevierStylePara elsevierViewall">As for the pathophysiology of ACD, it was initially thought that the patient presented with predominantly T<span class="elsevierStyleInf">H</span>1-driven inflammatory polarization.<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">10</span></a> However, in healthy patients, inflammatory polarization after sensitization has been shown to be diverse, with cytokine-producing effector lymphocytes of various types: type 1 (interferon [IFN] γ, tumor necrosis factor [TNF]), type 17 (interleukin [IL] 17), type 22 (IL-22), and type 2 (IL-4, IL-5, IL-9, IL-13).<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">10</span></a> Variability in polarization seems to be associated with the type of allergen and its ability to activate specific pathways in innate immunity, although other factors that have yet to be determined may be involved. For example, nickel is a potent inducer of the T<span class="elsevierStyleInf">H</span>1, T<span class="elsevierStyleInf">H</span>17, and T<span class="elsevierStyleInf">H</span>22 pathways, whereas fragrances and rubbers show more T<span class="elsevierStyleInf">H</span>2 activity, with less participation of T<span class="elsevierStyleInf">H</span>1 and T<span class="elsevierStyleInf">H</span>17.<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">11</span></a></p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Prevalence of Allergic Contact Dermatitis in Patients With Atopic Dermatitis</span><p id="par0040" class="elsevierStylePara elsevierViewall">Despite the initial proposal of an inverse association between AD and ACD, the co-occurrence of both diseases leads us to believe that there may by a positive relationship between the two. The skin barrier function defect and increased transepidermal water loss leave patients with AD more predisposed to irritant contact dermatitis,<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">12</span></a> which increases the likelihood of allergen penetration.<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">13,14</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Patients with AD were traditionally thought to experience fewer T<span class="elsevierStyleInf">H</span>1-mediated type 4 hypersensitivity reactions owing to T<span class="elsevierStyleInf">H</span>2 polarization. This notion was reinforced by studies showing the inability to sensitize patients with AD after repeated exposure to dinitrochlorobenzene (DNCB).<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">15</span></a> Recently, Newel et al.<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">16</span></a> compared the clinical and immunological response to sensitization to DNCB in healthy individuals and atopic patients. The authors found that healthy patients had a stronger clinical response to exposure to DNCB, with polarization of the inflammatory response toward T<span class="elsevierStyleInf">H</span>1. Patients with AD, on the other hand, had a lesser clinical response to exposure to DNCB, with polarization of the inflammatory response toward T<span class="elsevierStyleInf">H</span>2 and a greater percentage of IL-10 than the controls. In other words, DNCB is in fact capable of producing sensitization in patients with AD, albeit via the T<span class="elsevierStyleInf">H</span>2 pathway and with less intense symptoms.</p><p id="par0050" class="elsevierStylePara elsevierViewall">The prevalence of ACD in patients with AD has been assessed in different populations using retrospective studies, which conclude that atopic patients are equally or more predisposed to ACD than the general population. One systematic review showed a significantly greater prevalence of ACD induced by at least 1 allergen in atopic pediatric patients than in nonatopic pediatric patients (46.6% and 41.7%, respectively).<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">17</span></a> Another systematic review and meta-analysis of 74 studies found no statistically significant differences in the prevalence of ACD between patients with and without AD.<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">18</span></a> Furthermore, an increased rate of positive results was observed in patients with severe DA; the authors attribute this finding to the fact that it is mainly patients with severe disease who are referred for testing.<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">18</span></a> Other studies have shown that the prevalence of ACD is higher in patients with mild AD than in those with severe AD,<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">19,20</span></a> and it has been postulated that this phenomenon arises because patients with severe AD have a higher challenge threshold for contact sensitization.<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">18</span></a> Also in support of a positive relationship between AD and ACD is the finding that polysensitization (≥3 allergens) is more frequent in atopic patients than in healthy individuals (28.7% vs. 14.5%, <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>.002).<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">14</span></a> Daily clinical practice shows that both entities are associated, with AD frequently seen to be exacerbated by ACD (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Patch Tests in Atopic Dermatitis: When to Perform Them and How to Interpret the Results</span><p id="par0055" class="elsevierStylePara elsevierViewall">Patch testing is highly recommended in patients clinically suspected of having AD, in patients with an atypical or changing distribution of dermatitis, and in therapy-resistant AD. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the recommendations put forward by the Expert Panel of the American Contact Dermatitis Society at their meeting in Denver in 2014.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">In our opinion, patients with AD (both children and adults) are candidates for patch testing at least once in their lifetime. However, in some patients with severe AD, or eczema affecting the arms and back, it is not always possible to perform patch tests under optimal conditions. Performing patch testing in the context of a flare-up of AD can diminish or increase the response (owing to irritation), leading to false-negative or false-positive results.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">21</span></a> In these cases, patch testing should be performed where possible, and the results should be interpreted with caution.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">22</span></a> Readings may also be altered in patients receiving immunosuppressive treatment; therefore, doses should be reduced as much as possible and the readings should be taken late (7–10 days) to avoid false-negatives.<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">21,23</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">It is important to remember that patients with AD have a greater tendency toward irritative responses that could be interpreted as false positives. Occlusion of patches and application of surgical tape for 48<span class="elsevierStyleHsp" style=""></span>hours, especially in hot regions or during summer, can lead to irritation and folliculitis. In addition, the concentration used in standard series for some allergens, especially metals (chrome and cobalt), fragrances, formaldehyde, and lanolin, can cause irritation in patients with more sensitive skin.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">21</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Furthermore, in patients with AD, the allergic response can be weaker and shorter. The gradual increase in response over a period of days in allergic reactions (crescendo pattern) is not as frequent in atopic patients; therefore, positive results must be observed carefully, even those of weak intensity, in the first reading.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">21</span></a> This altered or attenuated inflammatory response in AD is thought to be associated with differences in the activation pathways of the innate immune system.<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">16</span></a> Patients with AD and ACD have a lower number of dendritic cells (CD1a<span class="elsevierStyleSup">+</span>, CD1C<span class="elsevierStyleSup">+</span>) and langerin-positive Langerhans cells, thus potentially supporting the theory that antigen presentation is deficient in atopic patients owing to the absence of dendritic cells in the setting of a massive entry of allergens via the skin.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">24</span></a> This altered response can also be explained by the differential expression in the pathways involved in allergic sensitization. Increased expression of the T<span class="elsevierStyleInf">H</span>17 and T<span class="elsevierStyleInf">H</span>2 inflammatory pathways in AD could attenuate the T<span class="elsevierStyleInf">H</span>1 pathway, possibly leading to a less intense allergic response.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">24</span></a> Moreover, increased anti-inflammatory chemokine levels (e.g., IL-10) may also play a role in this altered response.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">24</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">In summary, patch testing should be performed in patients with AD, although the timing and interpretation of the tests may be complicated. <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> provides a series of points that should be taken into consideration when performing patch tests on affected patients.<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">21</span></a></p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Allergens Involved in Patients With Allergic Contact Dermatitis and Atopic Dermatitis</span><p id="par0080" class="elsevierStylePara elsevierViewall">Most of the allergens involved in ACD in atopic patients (both children and adults) are present in their topical medication or in their cosmetic or personal care products,<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">44</span></a> many of which are classed as hypoallergenic.<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">18,25,26</span></a> The risk factors for becoming sensitized to one's own products are onset of AD before 6 months of age, high IgE value, and moderate-severe AD.<a class="elsevierStyleCrossRef" href="#bib0455"><span class="elsevierStyleSup">26</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall">Many studies report a higher frequency of sensitization to allergens such as fragrances, plants, antiseptics, corticosteroids, topical antibiotics, and surfactants than in the healthy population.<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">26–36</span></a><a class="elsevierStyleCrossRefs" href="#tbl0015">Tables 3 and 4</a> show the most common allergens in adults and children with AD.<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">26,35,36</span></a> Nickel sulfate is the most common allergen in patients with AD and in the general population, although various studies have reported sensitization rates that are lower than, higher than, or similar to those reported for the healthy population.<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">18,35,37</span></a> Many studies have found an increase in sensitization to sesquiterpene lactones in atopic patients, although in most cases the relevance of this finding is unknown.<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">35</span></a></p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0090" class="elsevierStylePara elsevierViewall">Atopic patients are less frequently sensitized to potent allergens (methylchloroisothiazolinone, cobalt, and potassium dichromate) than the general population<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">27</span></a>; in contrast, they are more frequently sensitized to weak allergens (e.g., propylene glycol, eugenol, vanilla, parabens).<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">28</span></a> Weak allergens are thought to be capable of producing more frequent sensitization in AD owing to the disruption of the skin barrier, which favors penetration and immunologic imbalance.<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">28</span></a> Potent allergens are capable of sensitizing healthy patients via the T<span class="elsevierStyleInf">H</span>1 pathway, although the immunologic imbalance in AD seems to induce “hyporeactivity”, resulting in a diminished response.<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">24,28</span></a> Greater sensitization to haptens via the T<span class="elsevierStyleInf">H</span>2 pathway (e.g., fragrances and rubbers) than via the T<span class="elsevierStyleInf">H</span>1 pathway could also account for these differences in sensitization in AD.</p><p id="par0095" class="elsevierStylePara elsevierViewall">Patch tests should include, at least, the standard Spanish or European series (TRUE test may be insufficient) and the patient's own products (i.e., both personal care products and topical treatments).<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">21</span></a> Patch testing should not be performed with rinse-off products owing to the irritation they can induce.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">5</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Dupilumab: Efficacy in the Treatment of ACD and Effect on Patch Testing</span><p id="par0100" class="elsevierStylePara elsevierViewall">Dupilumab was recently approved for the treatment of moderate to severe AD.<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">38</span></a> It has also been used for the treatment of ACD, although the results have been inconsistent. A recent systematic review of 47 patients with ACD treated with dupilumab found clearance of ACD in 9 cases, partial improvement in 31, no improvement in 4, and worsening in 3.<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">39</span></a> It has been postulated that dupilumab could be useful for the treatment of ACD caused by T<span class="elsevierStyleInf">H</span>2-mediated allergens, since improvements in the symptoms of ACD caused by allergens such as fragrances, rubbers, and textile dyes have been observed.<a class="elsevierStyleCrossRefs" href="#bib0520"><span class="elsevierStyleSup">39–41</span></a> In contrast, dupilumab could exacerbate ACD caused by allergens that act via the T<span class="elsevierStyleInf">H</span>1 pathway, with reports of cases involving methylisothiazolinone, formaldehyde releasers, and phenylguanidines.<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">42</span></a> Other studies found no statistically significant differences in the response to dupilumab in atopic patients with and without ACD.<a class="elsevierStyleCrossRefs" href="#bib0540"><span class="elsevierStyleSup">43,44</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">In summary, there is considerable variation in the response to dupilumab in ACD, and outcomes that are independent of the allergen and the T<span class="elsevierStyleInf">H</span> pathway are thought to be involved. The variability in the results found in clinical practice cannot be explained solely by the different inflammation patterns generated by the allergens, as argued by some authors.<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">45</span></a> The rigid division of allergens into those that sensitize via the T<span class="elsevierStyleInf">H</span>1 pathway or the T<span class="elsevierStyleInf">H</span>2 pathway may be insufficient. In the polarization toward a specific pathway, in addition to the characteristics of the allergen itself, patient-related factors may play a role, as seen in the more marked tendency toward T<span class="elsevierStyleInf">H</span>2-mediated reactions in atopic patients. It may be that the immunologic context in which sensitization occurs (e.g., during a flare-up of AD) plays a role in polarization toward T<span class="elsevierStyleInf">H</span>1 or T<span class="elsevierStyleInf">H</span>2. Furthermore, the improvement in the skin barrier brought about by dupilumab could improve symptoms irrespective of the pathway involved. Dupilumab could be proposed as an option in cases where it is impossible to avoid the allergen and the dermatitis is severe.<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">46</span></a> In addition, it should be considered in atopic patients with concomitant ACD owing to its effect on the underlying disease.<a class="elsevierStyleCrossRef" href="#bib0555"><span class="elsevierStyleSup">46</span></a></p><p id="par0110" class="elsevierStylePara elsevierViewall">The effect of dupilumab on the results of patch tests is also being assessed. A study analyzing the results of patch tests before, during, and after treatment with dupilumab found that of the 144 allergens tested before and after, 17 lost positivity after treatment, including fragrances and balsam of Peru, which are known to polarize toward T<span class="elsevierStyleInf">H</span>2.<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">39</span></a> In contrast, a recent retrospective study in which patch tests were performed before and after treatment found that positive results persisted in 51.2% of patients (64/125) and a loss of positivity in only 10.4% (13/125).<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">43</span></a> The allergens for which positivity was lost included emulsifiers, fragrances, metals, sunscreens, medications, resins, and preservatives. Almost three-quarters (73.1%) of the positive results with fragrances before treatment remained unchanged in the posttreatment tests. The authors concluded that dupilumab did not seem to have a major impact on the results of the tests.<a class="elsevierStyleCrossRef" href="#bib0540"><span class="elsevierStyleSup">43</span></a> However, since the results were inconclusive in 38.4% of cases, we believe that the drug's ability to modify the results of patch tests remains doubtful.</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Atopic Dermatitis and Proteins</span><p id="par0115" class="elsevierStylePara elsevierViewall">Proteins are a recognized allergen in type 1 hypersensitivity reactions, which manifest on the skin as wheals, angioedema, or both. Traditionally, proteins were not associated with eczema lesions, since their high molecular weight meant that they were not considered capable of crossing the skin barrier and causing a type 4 reaction. PCD was first described some decades ago as a condition comprising both type 1 and type 4 reactions. The condition facilitated our understanding of how food and environmental proteins play a role in specific exacerbations of AD, in both children and adults.</p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Protein Contact Dermatitis</span><p id="par0120" class="elsevierStylePara elsevierViewall">PCD is a type 1 and type 4 hypersensitivity reaction. Patients present with pruritus immediately after exposure to the allergen and subsequently develop eczematous lesions. The conditions can manifest as contact urticaria-type lesions, followed by eczematous lesions at the same site.<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">47</span></a> The lesions most commonly affect the hands and forearms. Patients generally have chronic hand eczema and are atopic (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Most cases are occupational and involve contact with plants or animals (workers who handle foodstuffs). It is important to rule out oral symptoms on contact with the foods (oral allergy syndrome), since patients could experience anaphylaxis on ingestion.<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">48</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0125" class="elsevierStylePara elsevierViewall">The diagnosis of PCD is based on prick testing, which involves applying a drop of the study allergen on the forearm and puncturing the skin with a lancet. A positive histamine control is always recommended (this should produce a wheal measuring<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>mm), with a negative saline control. The reading is taken at 15<span class="elsevierStyleHsp" style=""></span>minutes, and a reaction is considered positive if it generates a wheal measuring<span class="elsevierStyleHsp" style=""></span>≥<span class="elsevierStyleHsp" style=""></span>3<span class="elsevierStyleHsp" style=""></span>mm.<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">49</span></a> Since application of previously prepared food extracts usually generates false negatives, prick-prick testing should be performed with fresh foods.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">22</span></a> Given that the reaction is a type 1 and type 4 hypersensitivity reaction, late readings should be taken.</p><p id="par0130" class="elsevierStylePara elsevierViewall">In our opinion, the term PCD could also be used for generalized exacerbations or in those with an airborne pattern of AD in patients sensitized to proteins (with a positive prick test result).</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Proteins and Exacerbations of Atopic Dermatitis</span><p id="par0135" class="elsevierStylePara elsevierViewall">In patients with AD, skin barrier defects enable proteins to penetrate the epidermis despite their high molecular weight. Here, they interact with local inflammatory cells to trigger a type 1 and type 4 hypersensitivity reaction.<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">50</span></a> Antigen-presenting cells in the epidermis and dermis display higher surface expression of the high-affinity IgE receptor (FcɛRI). After capturing proteins, they migrate to the lymph nodes, where they induce a T<span class="elsevierStyleInf">H</span>2- and B cell-specific lymphocyte response, with production of specific IgE.<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">51</span></a> This would explain both the hypersensitivity reactions and the co-occurrence of urticaria-like and eczematous lesions.</p><p id="par0140" class="elsevierStylePara elsevierViewall">Foods are the most common allergens in atopic pediatric patients. Children are sensitized during the first months of life, when foods are introduced into their diet. Food penetrates the body percutaneously in the context of perioral eczema.<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">52</span></a> Therefore, both pediatricians and parents should be taught to treat perioral eczema appropriately until it is fully controlled with topical corticosteroids. Up to one-third of atopic children experience worsening of their dermatitis because of exposure to food, with the most common culprits being egg, milk, and wheat.<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">53</span></a> PCD to foods should be suspected in children who experience generalized or severe flare-ups of their AD triggered by exposure to food. Therefore, a full history should be taken with the parents.</p><p id="par0145" class="elsevierStylePara elsevierViewall">Aeroallergens are more frequent in adults, with the most common being dust mites, animal dander, pollens, and cockroach.<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">50</span></a> Aeroallergens can also worsen AD through their inherent proteolytic ability, which aggravates alteration of the barrier function (they also act as irritants or pseudoallergens).<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">50</span></a> PCD should be suspected in atopic adults who develop eczema with an airborne pattern in areas such as the face (involvement of the eyelids), neck (involvement of the retroauricular area), and exposed areas of the upper limbs and skin folds (involvement of the axillae and cubital fossa) (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>).<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">22</span></a> In adults, PCD induced by food is less common, although some allergens, such as carrot, hazelnut, and celery, are involved in cross-reactions with aeroallergens and can trigger flare-ups in pollen-sensitized patients.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">22</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0150" class="elsevierStylePara elsevierViewall">Diagnosis of PCD in atopic patients should be based on the prick test when there is clinical suspicion. However, this approach should not be used indiscriminately, and clinical relevance should always be established, since many patients are sensitized to aeroallergens and foods. In other words, sensitization is not synonymous with involvement.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">22</span></a> The atopy patch test was initially put forward as a useful diagnostic method, although it does not currently form part of the recommendations set out in clinical practice guidelines.<a class="elsevierStyleCrossRefs" href="#bib0430"><span class="elsevierStyleSup">21,22</span></a> The test involves applying proteins such as foods, dust mite, animal dander, or pollen on the skin, followed by an assessment of the eczematous reaction between 24 and 72<span class="elsevierStyleHsp" style=""></span>hours. It has not proven possible to standardize the test, which makes it difficult to differentiate between results indicating irritation and results indicating allergy (especially to dust mites). Determination of serum specific IgE may also be useful, although a negative result does not rule out the diagnosis.<a class="elsevierStyleCrossRef" href="#bib0565"><span class="elsevierStyleSup">48</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">As for treatment, allergen avoidance has been shown to improve symptoms, although it is insufficient to stop exacerbations of AD owing to the multifactorial nature of the disease.<a class="elsevierStyleCrossRef" href="#bib0595"><span class="elsevierStyleSup">54</span></a> In fact, only half of adults sensitized to ≥1 food see an improvement in their symptoms by removing the food from their diet.<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">22</span></a> In children, removal of the food that causes flare-ups of AD may lead to a clinical improvement in the skin lesions, although it can induce IgE-mediated allergy.<a class="elsevierStyleCrossRef" href="#bib0600"><span class="elsevierStyleSup">55</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Specific immunotherapy is indicated for the treatment of allergic asthma, allergic rhinoconjunctivitis, and hymenoptera venom allergy. It is not currently indicated for treatment of AD. No satisfactory results have been obtained with respect to preventing flare-ups of AD in protein-sensitized patients,<a class="elsevierStyleCrossRefs" href="#bib0435"><span class="elsevierStyleSup">22,54</span></a> probably because immunotherapy was started with the aim of preventing all the exacerbations the patient experiences and not only to obtain a partial improvement in AD. The main allergen studied is dust mite.<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">56</span></a> The results of different trials and meta-analyses are very inconsistent, concluding that scientific evidence in favor of immunotherapy is insufficient to recommend it as a general approach in the treatment of atopic patients.<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">57</span></a> However, European AD guidelines recommend considering immunotherapy in selected patients, namely, those with proven sensitization (prick test or serum specific IgE) and flare-ups of AD triggered by exposure to the allergen (mainly dust mite, birch pollen, and grasses).<a class="elsevierStyleCrossRefs" href="#bib0610"><span class="elsevierStyleSup">57–59</span></a> In contrast with European guidelines, American guidelines do not recommend immunotherapy for treatment of AD.<a class="elsevierStyleCrossRef" href="#bib0625"><span class="elsevierStyleSup">60</span></a> Before starting immunotherapy, it is recommended to wait until AD is controlled. It should not be indicated if the patient is receiving immunosuppressive therapy, although it seems that it can be introduced if the patient is receiving dupilumab or tralokinumab.<a class="elsevierStyleCrossRef" href="#bib0630"><span class="elsevierStyleSup">61</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Omalizumab is approved for treatment of allergic asthma, chronic rhinosinusitis with nasal polyps, and chronic spontaneous urticaria.<a class="elsevierStyleCrossRef" href="#bib0635"><span class="elsevierStyleSup">62</span></a> Its use in AD has not yielded sufficiently satisfactory results.<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">63</span></a> However, it is currently being investigated for use in the treatment of food allergy, in which it seems to be effective when administered in monotherapy and in combination with oral immunotherapy.<a class="elsevierStyleCrossRefs" href="#bib0635"><span class="elsevierStyleSup">62,64</span></a> Ligelizumab is also under study for the treatment of food allergy.<a class="elsevierStyleCrossRef" href="#bib0650"><span class="elsevierStyleSup">65</span></a></p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusion</span><p id="par0170" class="elsevierStylePara elsevierViewall">AD is a complex disease with a multifactorial nature. ACD and PCD are allergic diseases that can co-occur with AD and lead to exacerbations. Clinicians should be aware of both conditions and the appropriate diagnostic procedure in order to avoid causative allergens and improve control of the underlying disease. New treatments for AD with specific targets on the T<span class="elsevierStyleInf">H</span>2 pathway could prove useful for treating specific cases of associated ACD, although they could also modify the results of diagnostic tests.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Funding</span><p id="par0175" class="elsevierStylePara elsevierViewall">The authors declare that no funding was received for the present article.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflicts of Interest</span><p id="par0180" class="elsevierStylePara elsevierViewall">The authors declare they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1882214" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1631420" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1882215" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1631419" "titulo" => "Palabras clave" ] 4 => array:3 [ "identificador" => "sec0005" "titulo" => "Atopic Dermatitis and Haptens" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0010" "titulo" => "Prevalence of Allergic Contact Dermatitis in Patients With Atopic Dermatitis" ] 1 => array:2 [ "identificador" => "sec0015" "titulo" => "Patch Tests in Atopic Dermatitis: When to Perform Them and How to Interpret the Results" ] 2 => array:2 [ "identificador" => "sec0020" "titulo" => "Allergens Involved in Patients With Allergic Contact Dermatitis and Atopic Dermatitis" ] 3 => array:2 [ "identificador" => "sec0025" "titulo" => "Dupilumab: Efficacy in the Treatment of ACD and Effect on Patch Testing" ] ] ] 5 => array:3 [ "identificador" => "sec0030" "titulo" => "Atopic Dermatitis and Proteins" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Protein Contact Dermatitis" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Proteins and Exacerbations of Atopic Dermatitis" ] ] ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Conclusion" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Funding" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflicts of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2022-08-30" "fechaAceptado" => "2022-11-15" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1631420" "palabras" => array:5 [ 0 => "Atopic dermatitis" 1 => "Contact dermatitis" 2 => "Patch test" 3 => "Dupilumab" 4 => "Prick test" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1631419" "palabras" => array:5 [ 0 => "Dermatitis atópica" 1 => "Dermatitis de contacto" 2 => "Epicutáneas" 3 => "Dupilumab" 4 => "<span class="elsevierStyleItalic">Prick test</span>" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Atopic dermatitis is a chronic inflammatory disease that is multifactorial in nature. Allergic contact dermatitis and protein contact dermatitis are allergic conditions that may occur in the context of atopic dermatitis and be the cause of exacerbations. Although the prevalence of allergic contact dermatitis is similar in atopic patients and the general population, these 2 conditions are frequently associated because atopic inflammation disrupts the skin barrier. Skin tests are therefore recommended in atopic individuals. Dupilumab could be useful for treating allergic contact dermatitis if it is mediated by type 2 helper T cells but could exacerbate inflammation if mediated by T<span class="elsevierStyleInf">H</span>1 cells: further study is needed before conclusions can be drawn. Although the mechanism by which exposure to environmental proteins exacerbates atopic dermatitis remains under discussion, such exacerbations are routinely seen in clinical practice. Prick testing is recommended in symptomatic atopic dermatitis. When prick-test findings are positive, patients should be advised to avoid the culprit substances.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La dermatitis atópica (DA) es una enfermedad inflamatoria crónica multifactorial. La dermatitis de contacto alérgica (DCA) y la dermatitis de contacto por proteínas (DCP) son patologías alérgicas que pueden ser comórbidas a la DA y ser causa de algunas de las exacerbaciones. Aunque la DCA tiene una prevalencia similar en pacientes atópicos que en la población general, debemos considerarla una comorbilidad frecuente en la DA por la disrupción de la barrera cutánea. Por ello, se recomienda la realización de pruebas epicutáneas a los pacientes atópicos. Dupilumab podría ser útil para el tratamiento de la DCA mediada por vía Th2 y exacerbar aquellas que ocurren por vía Th1, aunque se precisan más estudios para establecer conclusiones. El mecanismo por el que la exposición a proteínas ambientales produce exacerbaciones en la DA es controvertido, pero es un fenómeno habitual en la práctica clínica diaria. Se recomienda estudio mediante <span class="elsevierStyleItalic">prick test</span> a pacientes con clínica sugestiva y recomendar conductas evitativas ante pacientes sintomáticos y pruebas positivas.</p></span>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 809 "Ancho" => 1755 "Tamanyo" => 208136 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Adult atopic dermatitis aggravated by contact allergy to fragrances in a 74-year-old man. (A and B) Eczema affecting the posterior trunk and right arm. (C) Results of patch testing with the GEIDAC standard series at 48<span class="elsevierStyleHsp" style=""></span>hours: fragrance mix I+++ and fragrance mix II+++. (D) Patch test results (fragrance series) at 96<span class="elsevierStyleHsp" style=""></span>hours: geraniol++ and citral++. Partial control of AD was achieved with avoidance measures.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 596 "Ancho" => 1505 "Tamanyo" => 145695 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Protein contact dermatitis caused by chicken meat. (A) Chronic hand eczema. (B) Positive prick-prick result with chicken meat.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1099 "Ancho" => 1505 "Tamanyo" => 192418 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Adult atopic dermatitis exacerbated by allergic contact dermatitis caused by airborne cat dander protein. (A) Eczematous dermatitis with an airborne pattern. (B and C) Disseminated eczema on the posterior trunk, buttocks, and intergluteal cleft.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">Abbreviations</span>: ACD, allergic contact dermatitis; AD, atopic dermatitis.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. AD that worsens, changes its distribution, does not respond to topical treatment or emollients, or flares up immediately after suspension of topical treatment \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2. Atypical distribution of AD lesions or pattern suggestive of ACD: pattern mainly affecting the face and neck, hand and foot involvement, involvement mainly of the eyelids or perioral region/cheilitis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3. Refractory hand eczema in the workplace \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4. Onset of AD in adolescents or adults with no childhood history of AD \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5. Patients with severe AD before starting immunosuppressive therapy \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">When to Consider Patch Testing in Atopic Patients.</p>" ] ] 4 => array:8 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at2" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. Irritant reactions are common, especially to metals (chrome and cobalt), fragrances, formaldehyde, and lanolin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2. The patient's own rinse-off products can cause irritant reactions, especially if not appropriately diluted \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3. The crescendo pattern between readings is not as common in patients with atopic dermatitis \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4. Applying the patches during a flare-up of atopic dermatitis can diminish the response, leading to false negatives. The risk of increased skin irritation is also higher \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5. Immunosuppressive treatment can induce false negatives; therefore, testing should be performed without the drug or at the smallest dose possible. If the drug cannot be suspended, testing should be repeated at a later date, when the disease is controlled and the drug can be suspended \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6. Greater susceptibility to changes in climate, with the possibility of more irritant responses during hotter periods \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Interpretation of Patch Test Results in Patients with Atopic Dermatitis.</p>" ] ] 5 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at3" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nickel sulfate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fragrance mix I \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Methyisothiazolinone and methylchloroisothiazolinone \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Balsam of Peru \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Thiomersal \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cobalt chloride \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Potassium dichromate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ethylenediamine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Paraphenylenediamine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Formaldehyde \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neomycin sulfate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Colophony \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Thiuram mix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Budesonide \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Black rubber mix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Benzocaine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4-<span class="elsevierStyleItalic">tert</span>-Butylphenol \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Paraben mix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Quaternium 15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mercapto mix \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Most Common Allergens in Adults With Atopic Dermatitis.</p>" ] ] 6 => array:8 [ "identificador" => "tbl0020" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at4" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nickel sulfate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fragrance mix I \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Balsam of Peru \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bacitracin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Formaldehyde \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cocamidopropyl betaine \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Propylene glycol \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Wool alcohols \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lanolin \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bronopol \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Neomycin sulfate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Quaternium 15 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Colophony \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tixocortol-21-pivalate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Methylisothiazolinone and methylchloroisothiazolinone \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cobalt \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fragrance mix II \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Potassium dichromate \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Compositae mix \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Parthenolide \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Most Frequent Allergens in Pediatric Patients With Atopic Dermatitis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:65 [ 0 => array:3 [ "identificador" => "bib0330" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global variations in prevalence of eczema symptoms in children from ISAAC phase three" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "ISAAC Phase Three Study Group" "etal" => false "autores" => array:5 [ 0 => "J.A. Odhiambo" 1 => "H.C. Williams" 2 => "T.O. Clayton" 3 => "C.F. Robertson" 4 => "M.I. Asher" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2009.10.009" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2009" "volumen" => "124" "paginaInicial" => "1251" "paginaFinal" => "1258e23" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20004783" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0335" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adult eczema prevalence and associations with asthma and other health and demographic factors: a US population-based study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.I. Silverberg" 1 => "J.M. Hanifin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2013.08.031" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2013" "volumen" => "132" "paginaInicial" => "1132" "paginaFinal" => "1138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24094544" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0340" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact dermatitis in atopic dermatitis children – past, present, and future" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Borok" 1 => "C. Matiz" 2 => "A. Goldenberg" 3 => "S.E. Jacob" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s12016-018-8711-2" "Revista" => array:7 [ "tituloSerie" => "Clin Rev Allergy Immunol" "fecha" => "2019" "volumen" => "56" "paginaInicial" => "86" "paginaFinal" => "98" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30225535" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508520347582" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0345" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comorbidities and the impact of atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "J.I. Silverberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.anai.2019.04.020" "Revista" => array:6 [ "tituloSerie" => "Ann Allergy Asthma Immunol" "fecha" => "2019" "volumen" => "123" "paginaInicial" => "144" "paginaFinal" => "151" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31034875" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0350" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role and diagnosis of allergic contact dermatitis in patients with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.L. Owen" 1 => "P.P. Vakharia" 2 => "J.I. Silverberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s40257-017-0340-7" "Revista" => array:6 [ "tituloSerie" => "Am J Clin Dermatol" "fecha" => "2018" "volumen" => "19" "paginaInicial" => "293" "paginaFinal" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29305764" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0355" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atopic dermatitis: a review of current diagnostic criteria and a proposed update to management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Reynolds" 1 => "J. Gorelick" 2 => "M. Bruno" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Drugs Dermatol" "fecha" => "2020" "volumen" => "19" "paginaInicial" => "244" "paginaFinal" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32550689" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0360" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "European Society of Contact Dermatitis guideline for diagnostic patch testing – recommendations on best practice" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.D. Johansen" 1 => "K. Aalto-Korte" 2 => "T. Agner" 3 => "K.E. Andersen" 4 => "A. Bircher" 5 => "M. Bruze" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.12432" "Revista" => array:7 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2015" "volumen" => "73" "paginaInicial" => "195" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26179009" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827819307585" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0365" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic features of atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.M. Hanifin" 1 => "G. Rajka" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555924447" "Revista" => array:5 [ "tituloSerie" => "Acta Dermatoever" "fecha" => "1980" "numero" => "Suppl. 92" "paginaInicial" => "44" "paginaFinal" => "47" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0370" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis: patient diagnosis and evaluation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.M. Mowad" 1 => "B. Anderson" 2 => "P. Scheinman" 3 => "S. Pootongkam" 4 => "S. Nedorost" 5 => "B. Brod" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2015.02.1139" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2016" "volumen" => "74" "paginaInicial" => "1029" "paginaFinal" => "1040" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27185421" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0375" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.L. Scheinman" 1 => "M. Vocanson" 2 => "J.P. Thyssen" 3 => "J.D. Johansen" 4 => "R.L. Nixon" 5 => "K. Dear" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/s41572-021-00271-4" "Revista" => array:5 [ "tituloSerie" => "Nat Rev Dis Primers" "fecha" => "2021" "volumen" => "7" "paginaInicial" => "38" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34045488" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0380" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Dhingra" 1 => "A. Shemer" 2 => "J. Correa da Rosa" 3 => "M. Rozenblit" 4 => "J. Fuentes-Duculan" 5 => "J.K. Gittler" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2014.03.009" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2014" "volumen" => "134" "paginaInicial" => "362" "paginaFinal" => "372" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24768652" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0385" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of contact dermatitis in patients with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Aquino" 1 => "L. Fonacier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaip.2014.05.004" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol Pract" "fecha" => "2014" "volumen" => "2" "paginaInicial" => "382" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25017524" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0390" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact dermatitis considerations in atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C.W. Rundle" 1 => "D. Bergman" 2 => "A. Goldenberg" 3 => "S.E. Jacob" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2017.03.009" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2017" "volumen" => "35" "paginaInicial" => "367" "paginaFinal" => "374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28709567" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0395" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis to personal care products and topical medications in adults with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Rastogi" 1 => "K.R. Patel" 2 => "V. Singam" 3 => "J.I. Silverberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2018.07.017" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2018" "volumen" => "79" "paginaInicial" => "1028" "paginaFinal" => "1033.e6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30053491" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0400" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact sensitivity to dinitrochlorobenzene is impaired in atopic subjects. Controversy revisited" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Rees" 1 => "P.S. Friedmann" 2 => "J.N. Matthews" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1990" "volumen" => "126" "paginaInicial" => "1173" "paginaFinal" => "1175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2396834" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0405" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sensitization via healthy skin programs Th2 responses in individuals with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Newell" 1 => "M.E. Polak" 2 => "J. Perera" 3 => "C. Owen" 4 => "P. Boyd" 5 => "C. Pickard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/jid.2013.148" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2013" "volumen" => "133" "paginaInicial" => "2372" "paginaFinal" => "2380" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23528819" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0410" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact allergy in children with atopic dermatitis: a systematic review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.B. Simonsen" 1 => "J.D. Johansen" 2 => "M. Deleuran" 3 => "C.G. Mortz" 4 => "M. Sommerlund" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.15628" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2017" "volumen" => "177" "paginaInicial" => "395" "paginaFinal" => "405" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28470762" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0415" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between atopic dermatitis and contact sensitization: a systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.R. Hamann" 1 => "D. Hamann" 2 => "A. Egeberg" 3 => "J.D. Johansen" 4 => "J. Silverberg" 5 => "J.P. Thyssen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2017.02.001" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2017" "volumen" => "77" "paginaInicial" => "70" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28392290" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S002604952030319X" "estado" => "S300" "issn" => "00260495" ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0420" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A longitudinal study of contact sensitivity in patients with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Uehara" 1 => "T. Sawai" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archderm.1989.01670150056006" "Revista" => array:7 [ "tituloSerie" => "Arch Dermatol" "fecha" => "1989" "volumen" => "125" "paginaInicial" => "366" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2522294" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508514004478" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0425" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patch testing, tuberculin testing and sensitization with dinitrochlorobenzene and nitrosodimethylanilini of patients with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M. Forsbeck" 1 => "A. Hovmark" 2 => "E. Skog" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/0001555556135138" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "1976" "volumen" => "56" "paginaInicial" => "135" "paginaFinal" => "138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/58522" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0430" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pragmatic approach to patch testing atopic dermatitis patients: clinical recommendations based on expert consensus opinion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.K. Chen" 1 => "S.E. Jacob" 2 => "S.T. Nedorost" 3 => "J.M. Hanifin" 4 => "E.L. Simpson" 5 => "M. Boguniewicz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DER.0000000000000208" "Revista" => array:5 [ "tituloSerie" => "Dermatitis" "fecha" => "2016" "volumen" => "27" "paginaInicial" => "186" "paginaFinal" => "192" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0435" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atopic dermatitis in adults: a diagnostic challenge" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.F. Silvestre Salvador" 1 => "D. Romero-Pérez" 2 => "B. Encabo-Durán" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.18176/jiaci.0138" "Revista" => array:6 [ "tituloSerie" => "J Investig Allergol Clin Immunol" "fecha" => "2017" "volumen" => "27" "paginaInicial" => "78" "paginaFinal" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28071589" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0440" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of immunomodulatory agents on patch testing: expert opinion 2012" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.F. Fowler" 1 => "H.I. Maibach" 2 => "M. Zirwas" 3 => "J.S. Taylor" 4 => "J.G. Dekoven" 5 => "D. Sasseville" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DER.0b013e318275969f" "Revista" => array:6 [ "tituloSerie" => "Dermatitis" "fecha" => "2012" "volumen" => "23" "paginaInicial" => "301" "paginaFinal" => "303" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23169220" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0445" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patients with atopic dermatitis have attenuated and distinct contact hypersensitivity responses to common allergens in skin" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Correa da Rosa" 1 => "D. Malajian" 2 => "A. Shemer" 3 => "M. Rozenblit" 4 => "N. Dhingra" 5 => "T. Czarnowicki" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2014.11.017" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2015" "volumen" => "135" "paginaInicial" => "712" "paginaFinal" => "720" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25583101" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0450" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consumer preferences, product characteristics, and potentially allergenic ingredients in best-selling moisturizers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Xu" 1 => "M. Kwa" 2 => "M.E. Lohman" 3 => "R. Evers-Meltzer" 4 => "J.I. Silverberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2017.3046" "Revista" => array:6 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2017" "volumen" => "153" "paginaInicial" => "1099" "paginaFinal" => "1105" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28877310" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0455" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence and risk factors for allergic contact dermatitis to topical treatment in atopic dermatitis: a study in 641 children" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. Mailhol" 1 => "V. Lauwers-Cances" 2 => "F. Rancé" 3 => "C. Paul" 4 => "F. Giordano-Labadie" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2008.01890.x" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2009" "volumen" => "64" "paginaInicial" => "801" "paginaFinal" => "806" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19183418" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0460" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pediatric contact dermatitis registry data on contact allergy in children with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.E. Jacob" 1 => "M. McGowan" 2 => "N.B. Silverberg" 3 => "J.L. Pelletier" 4 => "L. Fonacier" 5 => "N. Mousdicas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2016.6136" "Revista" => array:7 [ "tituloSerie" => "JAMA Dermatol" "fecha" => "2017" "volumen" => "153" "paginaInicial" => "765" "paginaFinal" => "770" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28241280" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508520301372" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0465" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflamed skin predisposes to sensitization to less potent allergens" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N. Kohli" 1 => "S. Nedorost" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2016.03.010" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2016" "volumen" => "75" "paginaInicial" => "312" "paginaFinal" => "3170" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27287247" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0470" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to surfactants" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C.N. Shaughnessy" 1 => "D. Malajian" 2 => "D.V. Belsito" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2013.12.009" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2014" "volumen" => "70" "paginaInicial" => "704" "paginaFinal" => "708" "itemHostRev" => array:3 [ "pii" => "S0168827820301264" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0475" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sensitization patterns in Compositae-allergic patients with current or past atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "E. Paulsen" 1 => "K.E. Andersen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.12035" "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2013" "volumen" => "68" "paginaInicial" => "277" "paginaFinal" => "285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23601063" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0480" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Positive patch test reactions to lanolin: cross-sectional data from the north american contact dermatitis group, 1994–2006" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Warshaw" 1 => "D.D. Nelsen" 2 => "H.I. Maibach" 3 => "J.G. Marks" 4 => "K.A. Zug" 5 => "J.S. Taylor" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatitis" "fecha" => "2009" "volumen" => "20" "paginaInicial" => "79" "paginaFinal" => "88" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19426613" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0485" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of and factors influencing sensitization to corticosteroids in a Danish patch test population" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D. Vind-Kezunovic" 1 => "J.D. Johansen" 2 => "B.C. Carlsen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1600-0536.2011.01898.x" "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2011" "volumen" => "64" "paginaInicial" => "325" "paginaFinal" => "329" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21457277" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0490" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Contact sensitivity in patients with recalcitrant atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Tamagawa-Mineoka" 1 => "K. Masuda" 2 => "S. Ueda" 3 => "N. Nakamura" 4 => "E. Hotta" 5 => "J. Hattori" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1346-8138.12866" "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "2015" "volumen" => "42" "paginaInicial" => "720" "paginaFinal" => "722" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25808093" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0495" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D. Malajian" 1 => "D.V. Belsito" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2013.03.012" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2013" "volumen" => "69" "paginaInicial" => "232" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23583066" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1542356516308618" "estado" => "S300" "issn" => "15423565" ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0500" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergic contact dermatitis in atopic individuals: results of a 30-year retrospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Y. Teo" 1 => "J.P. McFadden" 2 => "I.R. White" 3 => "M. Lynch" 4 => "P. Banerjee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.13363" "Revista" => array:6 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2019" "volumen" => "81" "paginaInicial" => "409" "paginaFinal" => "416" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31347185" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0505" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of atopy in the prevalence of contact sensitization: the experience of a Greek referral center" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Tagka" 1 => "G.I. Lambrou" 2 => "E. Nicolaidou" 3 => "S.G. Gregoriou" 4 => "A. Katsarou-Katsari" 5 => "D. Rigopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2020/3946084" "Revista" => array:5 [ "tituloSerie" => "Dermatol Res Pract" "fecha" => "2020" "volumen" => "2020" "paginaInicial" => "3946084" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33133180" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0510" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Filaggrin is a predominant member of the denaturation-resistant nickel-binding proteome of human epidermis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Ross-Hansen" 1 => "O. Østergaard" 2 => "J.T. Tanassi" 3 => "J.P. Thyssen" 4 => "J.D. Johansen" 5 => "T. Menné" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/jid.2013.445" "Revista" => array:6 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2014" "volumen" => "134" "paginaInicial" => "1164" "paginaFinal" => "1166" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24157460" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0515" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Ficha tecnica Dupixent 300<span class="elsevierStyleHsp" style=""></span>mg solucion inyectable en jeringa precargada. Available from: <a target="_blank" href="https://cima.aemps.es/cima/dochtml/ft/1171229006/FT_1171229006.html">https://cima.aemps.es/cima/dochtml/ft/1171229006/FT_1171229006.html</a> [accessed 12.6.22]." ] ] ] 38 => array:3 [ "identificador" => "bib0520" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of dupilumab on allergic contact dermatitis and patch testing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.E. Jo" 1 => "A. Mufti" 2 => "M. Sachdeva" 3 => "M. Pratt" 4 => "J. Yeung" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2021.02.044" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2021" "volumen" => "84" "paginaInicial" => "1772" "paginaFinal" => "1776" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33617912" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673617306475" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0525" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dupilumab use in allergic contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.C. Machler" 1 => "C.T. Sung" 2 => "E. Darwin" 3 => "S.E. Jacob" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2018.07.043" "Revista" => array:7 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2019" "volumen" => "80" "paginaInicial" => "280" "paginaFinal" => "281.e1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30092326" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508513002175" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0530" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A case series of dupilumab-treated allergic contact dermatitis patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "A.M. Goldminz" 1 => "P.L. Scheinman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dth.12701" "Revista" => array:5 [ "tituloSerie" => "Dermatol Ther" "fecha" => "2018" "volumen" => "31" "paginaInicial" => "e12701" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30246906" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0535" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blocking type 2 inflammation by dupilumab does not control classic (type 1-driven) allergic contact dermatitis in chronic hand eczema" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.N. Crepy" 1 => "A. Nosbaum" 2 => "L. Bensefa-Colas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/cod.13266" "Revista" => array:7 [ "tituloSerie" => "Contact Dermatitis" "fecha" => "2019" "volumen" => "81" "paginaInicial" => "145" "paginaFinal" => "147" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30851059" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827820303998" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0540" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The impact of dupilumab on patch testing and the prevalence of comorbid allergic contact dermatitis in recalcitrant atopic dermatitis: a retrospective chart review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Raffi" 1 => "R. Suresh" 2 => "N. Botto" 3 => "J.E. Murase" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2019.09.028" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2020" "volumen" => "82" "paginaInicial" => "132" "paginaFinal" => "138" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31562940" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0545" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A retrospective review of dupilumab for atopic dermatitis patients with allergic contact dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "N. Chipalkatti" 1 => "N. Lee" 2 => "P. Zancanaro" 3 => "N. Dumont" 4 => "C. Kachuk" 5 => "D. Rosmarin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2018.12.048" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2019" "volumen" => "80" "paginaInicial" => "1166" "paginaFinal" => "1167" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30630024" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0550" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Variable impact of dupilumab on patch testing results and allergic contact dermatitis in adults with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Stout" 1 => "J.I. Silverberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2019.03.020" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2019" "volumen" => "81" "paginaInicial" => "157" "paginaFinal" => "162" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30885752" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0555" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dupilumab for allergic contact dermatitis and implications for patch testing: Irreconcilable differences" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Shah" 1 => "E.C. Milam" 2 => "K.I. Lo Sicco" 3 => "D.E. Cohen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2020.05.036" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol" "fecha" => "2020" "volumen" => "83" "paginaInicial" => "e215" "paginaFinal" => "e216" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32417419" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0560" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Food-related contact dermatitis, contact urticaria, and atopy patch test with food" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Walter" 1 => "M. Seegräber" 2 => "A. Wollenberg" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s12016-018-8687-y" "Revista" => array:6 [ "tituloSerie" => "Clin Rev Allergy Immunol" "fecha" => "2019" "volumen" => "56" "paginaInicial" => "19" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29881951" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0565" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protein contact dermatitis: review of 27 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Hernández-Bel" 1 => "J. de la Cuadra" 2 => "R. García" 3 => "V. Alegre" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2011.02.005" "Revista" => array:7 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2011" "volumen" => "102" "paginaInicial" => "336" "paginaFinal" => "343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21497331" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0140673619330417" "estado" => "S300" "issn" => "01406736" ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0570" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Practical guide to skin prick tests in allergy to aeroallergens" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. Bousquet" 1 => "L. Heinzerling" 2 => "C. Bachert" 3 => "N.G. Papadopoulos" 4 => "P.J. Bousquet" 5 => "P.G. Burney" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1398-9995.2011.02728.x" "Revista" => array:7 [ "tituloSerie" => "Allergy" "fecha" => "2012" "volumen" => "67" "paginaInicial" => "18" "paginaFinal" => "24" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22050279" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827819302831" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0575" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of airborne proteins in atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S.G. Hostetler" 1 => "B. Kaffenberger" 2 => "T. Hostetler" 3 => "M.J. Zirwas" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Aesthet Dermatol" "fecha" => "2010" "volumen" => "3" "paginaInicial" => "22" "paginaFinal" => "31" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21203352" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0580" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "FcepsilonRI engagement of Langerhans cell-like dendritic cells and inflammatory dendritic epidermal cell-like dendritic cells induces chemotactic signals and different T-cell phenotypes in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Novak" 1 => "R. Valenta" 2 => "B. Bohle" 3 => "S. Laffer" 4 => "J. Haberstok" 5 => "S. Kraft" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2004.02.005" "Revista" => array:6 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2004" "volumen" => "113" "paginaInicial" => "949" "paginaFinal" => "957" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15131579" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0585" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epicutaneous sensitization to food allergens in atopic dermatitis: What do we know?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E.H. Tham" 1 => "M. Rajakulendran" 2 => "B.W. Lee" 3 => "H.P.S. Van Bever" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/pai.13127" "Revista" => array:6 [ "tituloSerie" => "Pediatr Allergy Immunol" "fecha" => "2020" "volumen" => "31" "paginaInicial" => "7" "paginaFinal" => "18" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31541586" "web" => "Medline" ] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0590" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The atopy patch test (APT) – a useful tool for the diagnosis of food allergy in children with atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B. Niggemann" 1 => "S. Reibel" 2 => "U. Wahn" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1034/j.1398-9995.2000.00464.x" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2000" "volumen" => "55" "paginaInicial" => "281" "paginaFinal" => "285" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10753020" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0595" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mite allergy and atopic dermatitis: is there a clear link? (Review)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.S. Bumbacea" 1 => "S.L. Corcea" 2 => "S. Ali" 3 => "L.C. Dinica" 4 => "I.S. Fanfaret" 5 => "D. Boda" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3892/etm.2020.9120" "Revista" => array:7 [ "tituloSerie" => "Exp Ther Med" "fecha" => "2020" "volumen" => "20" "paginaInicial" => "3554" "paginaFinal" => "3560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32905207" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0168827819306506" "estado" => "S300" "issn" => "01688278" ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0600" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Controversies in allergy: food testing and dietary avoidance in atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R.G. Robison" 1 => "A.M. Singh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaip.2018.11.006" "Revista" => array:7 [ "tituloSerie" => "J Allergy Clin Immunol Pract" "fecha" => "2019" "volumen" => "7" "paginaInicial" => "35" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30501976" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508515005995" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0605" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Analysis of the long-term efficacy and safety of subcutaneous immunotherapy for atopic dermatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Zhou" 1 => "S. Chen" 2 => "Z. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2500/aap.2021.42.200126" "Revista" => array:5 [ "tituloSerie" => "Allergy Asthma Proc" "fecha" => "2021" "volumen" => "42" "paginaInicial" => "e47" "paginaFinal" => "e54" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0610" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Allergen immunotherapy and atopic dermatitis: the good, the bad, and the unknown" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Rizk" 1 => "M. Rodenas" 2 => "A. De Benedetto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11882-019-0893-z" "Revista" => array:5 [ "tituloSerie" => "Curr Allergy Asthma Rep" "fecha" => "2019" "volumen" => "19" "paginaInicial" => "57" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31776678" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0615" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: Part I" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Wollenberg" 1 => "S. Barbarot" 2 => "T. Bieber" 3 => "S. Christen-Zaech" 4 => "M. Deleuran" 5 => "A. Fink-Wagner" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.14891" "Revista" => array:7 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2018" "volumen" => "32" "paginaInicial" => "657" "paginaFinal" => "682" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29676534" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1542356518300107" "estado" => "S300" "issn" => "15423565" ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0620" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Wollenberg" 1 => "S. Christen-Zäch" 2 => "A. Taieb" 3 => "C. Paul" 4 => "J.P. Thyssen" 5 => "M. de Bruin-Weller" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.16892" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2020" "volumen" => "34" "paginaInicial" => "2717" "paginaFinal" => "2744" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33205485" "web" => "Medline" ] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0625" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current guidelines for the evaluation and management of atopic dermatitis: a comparison of the Joint Task Force Practice Parameter and American Academy of Dermatology guidelines" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.F. Eichenfield" 1 => "J. Ahluwalia" 2 => "A. Waldman" 3 => "J. Borok" 4 => "J. Udkoff" 5 => "M. Boguniewicz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaci.2017.01.009" "Revista" => array:7 [ "tituloSerie" => "J Allergy Clin Immunol" "fecha" => "2017" "volumen" => "139" "numero" => "4S" "paginaInicial" => "S49" "paginaFinal" => "S57" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28390477" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0630" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical contraindications to allergen immunotherapy: an EAACI position paper" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C. Pitsios" 1 => "P. Demoly" 2 => "M.B. Bilò" 3 => "R. Gerth van Wijk" 4 => "O. Pfaar" 5 => "G.J. Sturm" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/all.12638" "Revista" => array:6 [ "tituloSerie" => "Allergy" "fecha" => "2015" "volumen" => "70" "paginaInicial" => "897" "paginaFinal" => "909" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25913519" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0635" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Omalizumab as monotherapy for food allergy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "S. Arasi" 1 => "M. Mennini" 2 => "A. Cafarotti" 3 => "A. Fiocchi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ACI.0000000000000744" "Revista" => array:6 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2021" "volumen" => "21" "paginaInicial" => "286" "paginaFinal" => "291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33769312" "web" => "Medline" ] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0640" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Targeting immunoglobulin E in atopic dermatitis: a review of the existing evidence" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Wollenberg" 1 => "S.F. Thomsen" 2 => "J.P. Lacour" 3 => "X. Jaumont" 4 => "S. Lazarewicz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.waojou.2021.100519" "Revista" => array:5 [ "tituloSerie" => "World Allergy Organ J" "fecha" => "2021" "volumen" => "14" "paginaInicial" => "100519" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/33815652" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0645" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Update on omalizumab in allergen immunotherapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.A. Dantzer" 1 => "R.A. Wood" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/ACI.0000000000000781" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Allergy Clin Immunol" "fecha" => "2021" "volumen" => "21" "paginaInicial" => "559" "paginaFinal" => "568" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/34419967" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508518347589" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0650" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The rationale for development of ligelizumab in food allergy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.A. Wood" 1 => "R.S. Chinthrajah" 2 => "A. Eggel" 3 => "I. Bottoli" 4 => "A. Gautier" 5 => "M. Woisetschlaeger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.waojou.2022.100690" "Revista" => array:5 [ "tituloSerie" => "World Allergy Organ J" "fecha" => "2022" "volumen" => "15" "paginaInicial" => "100690" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/36185545" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000011400000004/v1_202304111712/S0001731023001643/v1_202304111712/en/main.assets" "Apartado" => array:4 [ "identificador" => "6210" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Revisiones" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011400000004/v1_202304111712/S0001731023001643/v1_202304111712/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731023001643?idApp=UINPBA000044" ]
año/Mes | Html | Total | |
---|---|---|---|
2024 Noviembre | 15 | 5 | 20 |
2024 Octubre | 164 | 77 | 241 |
2024 Septiembre | 167 | 59 | 226 |
2024 Agosto | 182 | 90 | 272 |
2024 Julio | 144 | 65 | 209 |
2024 Junio | 153 | 76 | 229 |
2024 Mayo | 118 | 60 | 178 |
2024 Abril | 124 | 53 | 177 |
2024 Marzo | 99 | 57 | 156 |
2024 Febrero | 62 | 44 | 106 |
2024 Enero | 90 | 37 | 127 |
2023 Diciembre | 144 | 37 | 181 |
2023 Noviembre | 109 | 44 | 153 |
2023 Octubre | 105 | 65 | 170 |
2023 Septiembre | 104 | 49 | 153 |
2023 Agosto | 103 | 30 | 133 |
2023 Julio | 122 | 55 | 177 |
2023 Junio | 121 | 47 | 168 |
2023 Mayo | 108 | 49 | 157 |
2023 Abril | 268 | 55 | 323 |
2023 Marzo | 146 | 106 | 252 |
2023 Febrero | 2 | 5 | 7 |