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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Systemic sclerosis is a multisystem disease characterized by skin sclerosis and fibrosis of internal organs secondary to microvascular damage&#46; Diagnosis is often delayed&#44; resulting in advanced disease and organ dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Diffuse depigmentation in a salt and pepper pattern can help in the early diagnosis of certain cases&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> This sign&#44; however&#44; can often be overlooked or confused with other types of dyschromia such as vitiligo&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The salt and pepper sign is a dyschromia associated with progressive systemic sclerosis&#46; It is characterized by vitiligo-like depigmentation with perifollicular pigmentary retention&#44; as the periadnexal capillary network preserves melanogenesis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> This sign is one of the earliest and most frequent findings in progressive systemic sclerosis in patients with Fitzpatrick skin types IV&#44; V&#44; or VI&#44; and it may sometimes be the only manifestation in patients without cutaneous sclerosis plaques &#40;systemic sclerosis sine scleroderma&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;4</span></a> Pigmentary changes in scleroderma have been identified as an early manifestation of systemic damage in up to 30&#37; of patients&#59; most of these patients have pulmonary involvement due to interstitial fibrosis and pulmonary hypertension&#44; which is usually the main cause of mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;5</span></a> The lesions are most often located on the head &#40;forehead&#44; scalp&#44; and retroauricular region&#41;&#44; followed by the neck and the dorsum of the fingers&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Histologic findings of sclerosis in areas of dyschromia are inconsistent&#44; while signs of follicular fibrosis are rare&#46; Other findings are similar to those seen in vitiligo&#58; pigmentary incontinence&#44; a periadnexal lymphocytic infiltrate&#44; and absence of melanocytes at the periphery of the follicle&#46; Biopsy findings in salt and pepper areas are therefore not diagnostic&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The clinical and dermoscopic characteristics of 4 patients with systemic sclerosis and salt and pepper skin are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; A whitish perifollicular halo was seen on dermoscopy in all cases&#46; All the patients met the 2013 diagnostic criteria for progressive systemic sclerosis according to the American College of Rheumatology&#47;European League Against Rheumatism&#44; and they all had lung involvement in imaging studies&#46; Based on these findings&#44; they were referred to the rheumatology department&#44; where they were treated with mycophenolate and systemic corticosteroids&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Because the salt and pepper sign shares clinical features &#40;visible to the naked eye and under Wood&#39;s lamp&#41; and histologic and pathophysiologic characteristics with vitiligo&#44; it is usually diagnosed late&#44; and is often confused with follicular repigmentation in vitiligo&#46; Patients with a delayed diagnosis develop progressive systemic disease&#44; including vascular disease&#44; interstitial lung fibrosis&#44; myocarditis&#44; acute renal failure&#44; lower esophageal incompetence&#44; and arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> More effective techniques &#40;such as dermoscopy&#41; are therefore required for early diagnosis&#46; In patients with vitiligo&#44; dermoscopy shows a pseudo pigment network with ill-defined borders in areas of follicular repigmentation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> All 4 patients whose details are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> had a whitish perifollicular halo on dermoscopy &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; This halo could be a hallmark sign that might be clinically helpful in distinguishing between salt and pepper skin in progressive systemic sclerosis and repigmentation around the hair follicles in vitiligo&#46; Its recognition could therefore help accelerate the diagnosis of severe sclerosis and systemic involvement &#40;mainly pulmonary&#41;&#46; The salt and pepper sign might correspond to early perifollicular fibrosis&#44; similar to that seen in lichen planopilaris&#46; Our findings confirm the usefulness of dermoscopy in clinical dermatology&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic features of perifollicular repigmentation in stable vitiligo&#46; A&#44; Structureless white areas&#44; diffuse pigment network&#44; and perifollicular erythema&#46; B&#44; Perifollicular repigmentation in a pigment network with ill-defined borders&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic features of dyschromia in salt and pepper skin&#46; A&#44; Accentuated pigment network surrounding a whitish perifollicular circle against an achromic background&#46; B&#44; Accentuated pigment network surrounding a uniform whitish perifollicular halo against white areas with telangiectasias&#46;</p>"
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; F&#44; female&#46;</p>"
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            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex&#47;age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Other cutaneous signs of scleroderma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Previous diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dermoscopic findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Systemic findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chest &#40;intermammary cleft&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SclerodactylyMorphea plaques on dorsal aspect of forearms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perifollicular pigmentation with a whitish halo and a white area with a pseudo perifollicular network surrounding a milky red area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary fibrosis&#58; Bilateral patchy&#44; ground glass pattern&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cheeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melasma and confetti-like depigmentation due to hydroquinone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Whitish perifollicular halo surrounded by a pseudo pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Interstitial pulmonary fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Forehead &#40;frontal hairline&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sclerosis plaques on thighsLipodermatosclerosis on right leg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Whitish perifollicular halo surrounded by a pseudo pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Back&#44; midline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Friction melanosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Whitish perifollicular halo surrounded by a pseudo pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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Case and Research Letter
Off-White Perifollicular Halo Around the Salt and Pepper Sign in the Dermoscopic Diagnosis of Systemic Sclerosis and Interstitial Lung Disease
Halo perifolicular blanquecino a la dermatoscopia del signo de sal y pimienta en el diagnóstico de esclerosis sistémica y enfermedad pulmonar intersticial
A.A. Hernández Collazoa,
Autor para correspondencia
adameckderma@gmail.com

Corresponding author.
, M.H. Capilla Garcíab, F. Barba Hernándezc, R. Quiñones Venegasd
a Dermatología, Nuevo Hospital “Miguel Hidalgo” y Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico
b Facultad de Medicina, Universidad Autónoma de Aguascalientes, Aguascalientes, Mexico
c Medicina Interna, Hospital ABC, Ciudad de México, Mexico
d Instituto Dermatológico de Jalisco “Dr. José Barba Rubio”, Mexico
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Systemic sclerosis is a multisystem disease characterized by skin sclerosis and fibrosis of internal organs secondary to microvascular damage&#46; Diagnosis is often delayed&#44; resulting in advanced disease and organ dysfunction&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">1</span></a> Diffuse depigmentation in a salt and pepper pattern can help in the early diagnosis of certain cases&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> This sign&#44; however&#44; can often be overlooked or confused with other types of dyschromia such as vitiligo&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The salt and pepper sign is a dyschromia associated with progressive systemic sclerosis&#46; It is characterized by vitiligo-like depigmentation with perifollicular pigmentary retention&#44; as the periadnexal capillary network preserves melanogenesis &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> This sign is one of the earliest and most frequent findings in progressive systemic sclerosis in patients with Fitzpatrick skin types IV&#44; V&#44; or VI&#44; and it may sometimes be the only manifestation in patients without cutaneous sclerosis plaques &#40;systemic sclerosis sine scleroderma&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0050"><span class="elsevierStyleSup">3&#44;4</span></a> Pigmentary changes in scleroderma have been identified as an early manifestation of systemic damage in up to 30&#37; of patients&#59; most of these patients have pulmonary involvement due to interstitial fibrosis and pulmonary hypertension&#44; which is usually the main cause of mortality&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">2&#44;5</span></a> The lesions are most often located on the head &#40;forehead&#44; scalp&#44; and retroauricular region&#41;&#44; followed by the neck and the dorsum of the fingers&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Histologic findings of sclerosis in areas of dyschromia are inconsistent&#44; while signs of follicular fibrosis are rare&#46; Other findings are similar to those seen in vitiligo&#58; pigmentary incontinence&#44; a periadnexal lymphocytic infiltrate&#44; and absence of melanocytes at the periphery of the follicle&#46; Biopsy findings in salt and pepper areas are therefore not diagnostic&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The clinical and dermoscopic characteristics of 4 patients with systemic sclerosis and salt and pepper skin are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; A whitish perifollicular halo was seen on dermoscopy in all cases&#46; All the patients met the 2013 diagnostic criteria for progressive systemic sclerosis according to the American College of Rheumatology&#47;European League Against Rheumatism&#44; and they all had lung involvement in imaging studies&#46; Based on these findings&#44; they were referred to the rheumatology department&#44; where they were treated with mycophenolate and systemic corticosteroids&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Because the salt and pepper sign shares clinical features &#40;visible to the naked eye and under Wood&#39;s lamp&#41; and histologic and pathophysiologic characteristics with vitiligo&#44; it is usually diagnosed late&#44; and is often confused with follicular repigmentation in vitiligo&#46; Patients with a delayed diagnosis develop progressive systemic disease&#44; including vascular disease&#44; interstitial lung fibrosis&#44; myocarditis&#44; acute renal failure&#44; lower esophageal incompetence&#44; and arthritis&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">2</span></a> More effective techniques &#40;such as dermoscopy&#41; are therefore required for early diagnosis&#46; In patients with vitiligo&#44; dermoscopy shows a pseudo pigment network with ill-defined borders in areas of follicular repigmentation &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a> All 4 patients whose details are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> had a whitish perifollicular halo on dermoscopy &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; This halo could be a hallmark sign that might be clinically helpful in distinguishing between salt and pepper skin in progressive systemic sclerosis and repigmentation around the hair follicles in vitiligo&#46; Its recognition could therefore help accelerate the diagnosis of severe sclerosis and systemic involvement &#40;mainly pulmonary&#41;&#46; The salt and pepper sign might correspond to early perifollicular fibrosis&#44; similar to that seen in lichen planopilaris&#46; Our findings confirm the usefulness of dermoscopy in clinical dermatology&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0025" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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        ]
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Dermoscopic features of dyschromia in salt and pepper skin&#46; A&#44; Accentuated pigment network surrounding a whitish perifollicular circle against an achromic background&#46; B&#44; Accentuated pigment network surrounding a uniform whitish perifollicular halo against white areas with telangiectasias&#46;</p>"
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          "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; F&#44; female&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex&#47;age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Location&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Other cutaneous signs of scleroderma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Previous diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dermoscopic findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Systemic findings&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Chest &#40;intermammary cleft&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">SclerodactylyMorphea plaques on dorsal aspect of forearms&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Perifollicular pigmentation with a whitish halo and a white area with a pseudo perifollicular network surrounding a milky red area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary fibrosis&#58; Bilateral patchy&#44; ground glass pattern&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cheeks&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Melasma and confetti-like depigmentation due to hydroquinone&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Whitish perifollicular halo surrounded by a pseudo pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Interstitial pulmonary fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Forehead &#40;frontal hairline&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sclerosis plaques on thighsLipodermatosclerosis on right leg&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Whitish perifollicular halo surrounded by a pseudo pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">F&#47;42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Back&#44; midline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">None&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Friction melanosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Whitish perifollicular halo surrounded by a pseudo pigment network&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Pulmonary fibrosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Clinical and Dermoscopic Characteristics in Patients With Progressive Systemic Sclerosis and Salt and Pepper Skin&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
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            0 => array:3 [
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                          "etal" => false
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                  "contribucion" => array:1 [
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                            0 => "K&#46;K&#46; Solanki"
                            1 => "C&#46; Hor"
                            2 => "W&#46;S&#46; Chang"
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                            0 => "A&#46; Singh"
                            1 => "S&#46; Ambujam"
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                        0 => array:2 [
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                          "autores" => array:6 [
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                            1 => "S&#46; Jordan"
                            2 => "N&#46; Graf"
                            3 => "J&#46; de Oliveira Pena"
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                            5 => "Y&#46; Allanore"
                          ]
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                            0 => "M&#46; Gonin"
                            1 => "J&#46;C&#46; Gerster"
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                      "titulo" => "Dermoscopy in vitiligo&#58; diagnosis and beyond"
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                          "etal" => false
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                            0 => "A&#46; Kumar Jha"
                            1 => "S&#46; Sonthalia"
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