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Evolución durante el embarazo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 559 "Ancho" => 906 "Tamanyo" => 51853 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance image. Oval umbilical skin lesion showing intense contrast uptake in contact with the abdominal muscles.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Endometriosis is a gynecological condition characterized by glands and/or endometrial stroma located outside the uterine cavity; it affects approximately 10% of women of reproductive age.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> It mostly occurs in the pelvic cavity, but can also affect extragenital locations, including the skin.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Umbilical endometriosis accounts for less than 1% of all cases of extragenital endometriosis.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2,3</span></a> The umbilicus is the most common site for cutaneous endometriosis (40% of all cases).</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Report</span><p id="par0015" class="elsevierStylePara elsevierViewall">A 29-year-old nulliparous women, a current smoker, presented with umbilical lesions of 2 years’ duration. The lesions were not painful, but she described cyclic bleeding during menstruation. She denied dysmenorrhea, dyspareunia, and infertility, and there was no history of abdominal surgery.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Physical examination revealed several reddish-brown lesions that were nonreducible and painless on palpation (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Histologic examination of a biopsy specimen showed endometrial glands lined by a pseudostratified cylindrical epithelium and extravasated red blood cells (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A). Immunohistochemical staining was positive for CD10, confirming the presence of ectopic endometrial stroma<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a> (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>B).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Subsequent gynecological evaluation including ultrasound and cervical cytology ruled out genital disease.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The patient also underwent abdominal magnetic resonance imaging (MRI), which revealed a well-defined oval skin lesion showing intense contrast uptake in the umbilical region. The lesion was touching but did not invade the underlying abdominal muscles (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). No other foci of endometriosis were observed.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Surgical excision was considered during follow-up, but the patient became pregnant and the surgery was postponed. The lesions remained stable during pregnancy and resolved spontaneously several days after delivery (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B–D). No recurrences or new lesions have occurred during 2 years of follow-up.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0045" class="elsevierStylePara elsevierViewall">Umbilical endometriosis accounts for between 0.4% and 4% of all endometriosis cases.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> Secondary umbilical endometriosis is more common than primary umbilical endometriosis and is associated with surgical scars following abdominal surgery. Patients with the primary form of this disease do not have a prior surgical history.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Umbilical endometriosis usually affects women in their third decade of life and typically presents as an asymptomatic or painful red-violaceous nodule that exhibits cyclic bleeding during menstruation.</p><p id="par0055" class="elsevierStylePara elsevierViewall">A tentative diagnosis is usually based on clinical findings and confirmed by histology. Apart from endometrial glands and stroma, histology may also show hemosiderin deposits, inflammatory changes, and marked mitotic activity. Immunostaining with CD10, which is positive in the endometrial interstitium, is useful when glands are not seen on histology.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">4</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">The differential diagnosis should include cutaneous metastases, melanoma, seborrheic keratosis, pyogenic granuloma, and keloids.</p><p id="par0065" class="elsevierStylePara elsevierViewall">Imaging tests such as ultrasound, computed tomography, and MRI are useful for ruling out involvement of other organs and establishing lesion depth.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Surgical excision is the treatment of choice. Hormone therapy can be used in patients with systemic disease or before surgery to try to reduce the size of lesions.</p><p id="par0075" class="elsevierStylePara elsevierViewall">In relation to the effect of pregnancy on umbilical endometriosis, Razzi et al.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> published the case of a woman whose lesions resolved spontaneously 2 months after biopsy, at 24 weeks’ gestation. Wiegratz et al.,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> by contrast, described a patient with a 2-year history of primary umbilical endometriosis whose nodules enlarged progressively during pregnancy and whose bleeding changed from cyclic to continuous. The woman underwent surgery before the pregnancy reached full term. Our patient's lesions remained stable during pregnancy, although they protruded more as the belly grew. The bleeding stopped during pregnancy and the lesions resolved spontaneously several days after delivery.</p><p id="par0080" class="elsevierStylePara elsevierViewall">Pregnancy has conventionally been believed to have a beneficial effect on endometriosis, and some patients have even been advised to become pregnant as part of their treatment plan. In a recent review, however, Leeners et al.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a> concluded that there was insufficient evidence to expect pregnancy to reduce the number or size of endometriosis lesions.</p><p id="par0085" class="elsevierStylePara elsevierViewall">There is also insufficient evidence to predict the effects of pregnancy on umbilical endometriosis based on the 3 cases described to date.</p><p id="par0090" class="elsevierStylePara elsevierViewall">We have described, to our knowledge, the third case of umbilical endometriosis in a pregnant woman. The patient's lesions remained stable during pregnancy and resolved spontaneously after birth. More cases are required to determine the effects of pregnancy on umbilical endometriosis.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0095" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Case Report" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Discussion" ] 2 => array:2 [ "identificador" => "sec0015" "titulo" => "Conflicts of Interest" ] 3 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 937 "Ancho" => 1255 "Tamanyo" => 175407 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Lesions before pregnancy. B, Lesions at week 24 of pregnancy. C, Lesions at week 35 of pregnancy. D, Lesions 3 months after delivery.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 941 "Ancho" => 1255 "Tamanyo" => 375399 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Endometrial glands in the dermis (hematoxylin–eosin, original magnification ×4). B, Positive staining with CD10 in the endometrial interstitium (original magnification ×4).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 559 "Ancho" => 906 "Tamanyo" => 51853 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Magnetic resonance image. Oval umbilical skin lesion showing intense contrast uptake in contact with the abdominal muscles.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:9 [ 0 => array:3 [ "identificador" => "bib0050" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of endometriosis and its comorbidities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "F. Parazzini" 1 => "G. Esposito" 2 => "L. Tozzi" 3 => "S. Noli" 4 => "S. 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año/Mes | Html | Total | |
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2024 Noviembre | 22 | 8 | 30 |
2024 Octubre | 138 | 47 | 185 |
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2023 Diciembre | 147 | 39 | 186 |
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2022 Diciembre | 171 | 66 | 237 |
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