array:25 [
  "pii" => "S0001731022008134"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2022.09.015"
  "estado" => "S300"
  "fechaPublicacion" => "2022-11-01"
  "aid" => "3217"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2022;113:T991-T994"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731022004719"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.02.029"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "3074"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:995-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Two Track Biologic Therapy for Concurrent Chronic Spontaneous Urticaria and Psoriasis Vulgaris in One Patient"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "995"
          "paginaFinal" => "996"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Terapia biol&#243;gica de dos v&#237;as para urticaria espont&#225;nea cr&#243;nica concurrente con psoriasis vulgar en un paciente"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Benko, B&#46; Hrvatin Stancic, T&#46; Lunder"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Benko"
            ]
            1 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Hrvatin Stancic"
            ]
            2 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Lunder"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022004719?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000010/v1_202211300529/S0001731022004719/v1_202211300529/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731021003306"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.01.015"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "2763"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:991-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICO-CL&#205;NICA</span>"
      "titulo" => "Coexistencia de vit&#237;ligo y alopecia frontal fibrosante&#58; caso cl&#237;nico y an&#225;lisis de su fisiopatolog&#237;a"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "991"
          "paginaFinal" => "994"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Coexistence of vitiligo and frontal fibrosing alopecia&#58; A case report and analysis of its physiopathology"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1349
              "Ancho" => 1300
              "Tamanyo" => 194669
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A y C</span>&#41; Regresi&#243;n de la l&#237;nea capilar frontal con p&#233;rdida de unidades foliculares&#44; eritema y escama perifolicular&#44; carencia de cejas&#46; M&#225;culas acr&#243;micas en la misma distribuci&#243;n&#46; Signo capilar &#250;nico &#40;flecha negra&#41; <span class="elsevierStyleBold">B&#41;</span> Fluorescencia con l&#225;mpara de Wood&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Trujillo-Gaviria, D&#46; G&#243;mez-Osorio, J&#46;D&#46; Ruiz-Restrepo, O&#46;J&#46; Valencia-Ocampo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Trujillo-Gaviria"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "G&#243;mez-Osorio"
            ]
            2 => array:2 [
              "nombre" => "J&#46;D&#46;"
              "apellidos" => "Ruiz-Restrepo"
            ]
            3 => array:2 [
              "nombre" => "O&#46;J&#46;"
              "apellidos" => "Valencia-Ocampo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021003306?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000010/v1_202211300529/S0001731021003306/v1_202211300529/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S0001731021003306"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2021.01.015"
      "estado" => "S300"
      "fechaPublicacion" => "2022-11-01"
      "aid" => "2763"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2022;113:991-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICO-CL&#205;NICA</span>"
        "titulo" => "Coexistencia de vit&#237;ligo y alopecia frontal fibrosante&#58; caso cl&#237;nico y an&#225;lisis de su fisiopatolog&#237;a"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "991"
            "paginaFinal" => "994"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Coexistence of vitiligo and frontal fibrosing alopecia&#58; A case report and analysis of its physiopathology"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1349
                "Ancho" => 1300
                "Tamanyo" => 194669
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A y C</span>&#41; Regresi&#243;n de la l&#237;nea capilar frontal con p&#233;rdida de unidades foliculares&#44; eritema y escama perifolicular&#44; carencia de cejas&#46; M&#225;culas acr&#243;micas en la misma distribuci&#243;n&#46; Signo capilar &#250;nico &#40;flecha negra&#41; <span class="elsevierStyleBold">B&#41;</span> Fluorescencia con l&#225;mpara de Wood&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Trujillo-Gaviria, D&#46; G&#243;mez-Osorio, J&#46;D&#46; Ruiz-Restrepo, O&#46;J&#46; Valencia-Ocampo"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Trujillo-Gaviria"
              ]
              1 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "G&#243;mez-Osorio"
              ]
              2 => array:2 [
                "nombre" => "J&#46;D&#46;"
                "apellidos" => "Ruiz-Restrepo"
              ]
              3 => array:2 [
                "nombre" => "O&#46;J&#46;"
                "apellidos" => "Valencia-Ocampo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021003306?idApp=UINPBA000044"
      "url" => "/00017310/0000011300000010/v1_202211300529/S0001731021003306/v1_202211300529/es/main.assets"
    ]
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => " Coexistence of Vitiligo and Frontal Fibrosing Alopecia&#58; A Case Report and Analysis of Its Physiopathology"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T991"
        "paginaFinal" => "T994"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Trujillo-Gaviria, D&#46; G&#243;mez-Osorio, J&#46;D&#46; Ru&#237;z-Restrepo, O&#46;J&#46; Valencia-Ocampo"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Trujillo-Gaviria"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "G&#243;mez-Osorio"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;D&#46;"
            "apellidos" => "Ru&#237;z-Restrepo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "O&#46;J&#46;"
            "apellidos" => "Valencia-Ocampo"
            "email" => array:1 [
              0 => "oscar.valencia@udea.edu.co"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Dermatology Resident&#44; Universidad de Antioquia&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Dermatopatologist&#44; Professor of the Dermatology Section&#44; Universidad de Antioquia&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Dermatologist&#44; Professor of the Dermatology Section&#44; Universidad de Antioquia&#44; CIDERM Investigation Group&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Coexistencia de vit&#237;ligo y alopecia frontal fibrosante&#58; caso cl&#237;nico y an&#225;lisis de su fisiopatolog&#237;a"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1301
            "Ancho" => 1301
            "Tamanyo" => 228323
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#8211;C&#44; Evaluation at 6 months of treatment revealed evidence of repigmentation in some areas&#44; reduced erythema&#44; and growth of new hair follicles&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vitiligo is the most common depigmentation disorder&#44; affecting 0&#46;5&#8211;1&#37; of the world&#39;s population&#46; Frontal fibrosing alopecia &#40;FFA&#41; is a recently described scarring alopecia that mostly affects postmenopausal women and whose incidence has been increasing gradually during the last decade&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The most widely accepted theory for the pathophysiology of vitiligo is that it is caused by the convergence of genetic factors&#44; autoimmunity&#44; oxidative stress&#44; and neurotoxicity&#44; among others&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> In the case of FFA&#44; the pathogenic model taking shape includes genetic factors&#44; activation of the innate immune system&#44; elimination of epithelial stem cells&#44; activation of epithelial-mesenchymal transition&#44; and hormonal factors&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> While vitiligo and FFA occur together infrequently&#44; an understanding of the underlying pathophysiological events can provide new clues as to treatment of FFA&#44; which&#44; to date&#44; has been considered a progressive disease that responds poorly to available treatment options&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Presentation</span><p id="par0015" class="elsevierStylePara elsevierViewall">We present the case of a 60-year-old woman with a family history of systemic lupus erythematosus &#40;sister&#41; and a 2-year personal history of depigmented lesions mainly affecting the forehead&#44; eyebrows&#44; and thorax&#46; She also had a 1-year history of alopecia&#46; The dermatology examination revealed achromic macules with involvement of the frontal and temporal areas&#44; eyebrows&#44; and thorax&#46; The lesions on the scalp followed the hairline&#46; Recession of the frontal hairline was observed&#44; with loss of follicular units and scarring accompanied by occasional erythematous papules and perifollicular scaling&#46; Wood lamp examination showed clearly delimited depigmented areas emitting a bright blue-whitish fluorescent light &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Dermoscopy revealed moderate perifollicular scaling and erythema&#44; with isolated hairs&#46; We performed 2 skin biopsies&#46; Histopathology revealed damage to the basement layer of the hair follicles&#44; with abundant necrotic keratinocytes&#44; in association with lamellar fibrosis&#44; fibrosis in the adjacent dermis&#44; and an inflammatory mononuclear infiltrate in the follicular infundibulum&#46; Staining with Fontana-Masson&#44; S100&#44; and Melan-A was negative for melanocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; thus confirming the diagnosis of FFA and vitiligo co-occurring in the same lesion&#46; The Vitiligo Extent Score &#40;VES&#41; was 1&#46;1031 and the Frontal Fibrosing Alopecia Severity Score &#40;FFASS&#41; was 11&#46;6&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The patient received treatment with corticosteroids &#40;triamcinolone acetonide&#44; 2<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#47;mo for 3<span class="elsevierStyleHsp" style=""></span>months&#41;&#44; excimer laser &#40;308<span class="elsevierStyleHsp" style=""></span>nm&#41; twice weekly until minimal erythema with a fluence of 550<span class="elsevierStyleHsp" style=""></span>mJ&#47;cm<span class="elsevierStyleSup">2</span> was reached &#40;total of 30 sessions&#41;&#44; and application of tacrolimus 0&#46;1&#37; ointment twice daily&#46; After 6 months of treatment&#44; repigmentation was visible in some areas&#44; the eczema and inflammation had partly resolved&#44; and new hair follicles had grown&#44; with a VES of 0&#46;665 and an FFASS of 10&#46;1&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">FFA is a type of scarring alopecia that is characterized by continuous and progressive recession of the frontotemporal hairline and frequent involvement of the eyebrows&#46; It was first described in menopausal White Australian women&#44; although it is increasingly reported in males and persons from other countries and races&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> It is caused by a lymphocytic infiltrate affecting the frontotemporal hairline&#44; thus leading to chronic inflammation of the hair follicle and subsequent scarring alopecia&#46; It has been associated with the influence of hormones during the menopause and many diseases&#44; such as autoimmune disorders &#40;e&#46;g&#46;&#44; hypothyroidism and vitiligo&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The literature contains 7 reports of FFA and vitiligo co-occurring at the same site &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; with most cases affecting White patients&#46; Here&#44; we report the case of co-occurrence of both conditions in which the pigmentation disorder preceded alopecia by 1 year&#46; The various hypotheses put forward to explain the pathophysiologic phenomenon include cytotoxic CD8 lymphocyte activity &#40;common to both diseases&#41;&#44; Koebner phenomenon &#40;which can lead to FFA at sites previously affected by vitiligo&#41;&#44; and the actinic damage caused by exposure of depigmented areas of skin to sunlight&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The patient was a constant user of hair dyes&#44; which may have triggered both diseases&#46; Phenol is a common component of depigmenting agents&#46; Its structure is similar to that of tyrosine&#44; thus enabling it to inhibit melanogenesis and generating an inflammatory response&#44; with the subsequent autoimmunity and destruction of melanocytes that is observed in vitiligo&#46; Furthermore&#44; contact with these chemicals can lead to exposure to normally hidden follicular antigens&#44; which can be detected and attacked by the cellular immune system&#46; Prolonged stimulation of the inflammatory response could account for the resulting destruction of the hair follicles in FFA&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> Understanding these immunologic mechanisms could prove useful for the treatment of patients with both diseases&#46; Cohort studies are necessary to calculate the risk of FFA and vitiligo in populations exposed to topical chemical products&#44; such as hair dyes&#46; We think these chemical hair care products should be avoided by patients with vitiligo affecting the hairline of the scalp&#44; although this recommendation should be validated in studies&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Case Presentation"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Discussion"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of Interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1350
            "Ancho" => 1300
            "Tamanyo" => 202148
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and C&#44; Recession of the frontal hairline with loss of follicular units&#44; erythema&#44; and perifollicular scale&#46; Note the loss of eyebrow hair&#46; Achromic macules following the same pattern&#46; Lonely hair sign &#40;black arrow&#41;&#46; B&#44; Wood lamp showing fluorescence&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1301
            "Ancho" => 1301
            "Tamanyo" => 228323
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#8211;C&#44; Evaluation at 6 months of treatment revealed evidence of repigmentation in some areas&#44; reduced erythema&#44; and growth of new hair follicles&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1219
            "Ancho" => 1251
            "Tamanyo" => 304386
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology revealed vacuolization of the basement layer&#44; abundant necrotic keratinocytes &#40;black arrow&#41;&#44; dermal lamellar fibrosis &#40;red arrow&#41;&#44; and moderate inflammatory mononuclear cell infiltration &#40;blue arrow&#41;&#46; B&#44; Fontana&#8211;Masson staining was negative for melanocytes&#46; C&#44; Melan-A immunohistochemical staining was negative for melanocytes&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Article&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Race&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">History of vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">History of autoimmune disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">D&#237;az and Miteva&#44; 2019<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hispanic origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Katoulis et al&#46;&#44; 2016<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case study</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypothyroidism&#47;morphea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Miteva et al&#46;&#44; 2011<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case series</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypothyroidism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypothyroidism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hispanic origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Cases of Co-occurrence of Frontal Fibrosing Alopecia and Vitiligo&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Vitiligo y vitamina D"
                      "tituloTraducido" => "&#91;&#91;nll&#93;Vitiligo and vitamin D"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Villegas"
                            1 => "C&#46;M&#46; Zuluaga"
                            2 => "L&#46; Javier"
                            3 => "M&#46; Albis"
                            4 => "&#211;&#46; Jairo"
                            5 => "V&#46; Ocampo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Asoc Colomb Dermatol"
                        "fecha" => "2019"
                        "volumen" => "1"
                        "paginaInicial" => "36"
                        "paginaFinal" => "51"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia&#58; an update on the hypothesis of pathogenesis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Tavakolpour"
                            1 => "H&#46;R&#46; Mahmoudi"
                            2 => "R&#46; Abedini"
                            3 => "K&#46;K&#46; Hesari"
                            4 => "A&#46; Kiani"
                            5 => "M&#46; Daneshpazhooh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijwd.2018.11.003"
                      "Revista" => array:2 [
                        "tituloSerie" => "Int J Women&#39;s Dermatol"
                        "fecha" => "2018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia&#58; a review of 60 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Macdonald"
                            1 => "C&#46; Clark"
                            2 => "S&#46; Holmes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2011.12.038"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Dermatol"
                        "fecha" => "2012"
                        "volumen" => "67"
                        "paginaInicial" => "955"
                        "paginaFinal" => "961"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia&#58; demographic and clinical characteristics of 490 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Kanti"
                            1 => "A&#46; Constantinou"
                            2 => "P&#46; Reygagne"
                            3 => "A&#46; Vogt"
                            4 => "J&#46; Kottner"
                            5 => "U&#46; Blume-Peytavi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2019"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peripilar &#8220;guttate&#8221; hypopigmentation of the scalp and idiopathic guttate hypomelanosis in frontal fibrosing alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;A&#46; Diaz"
                            1 => "M&#46; Miteva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ski Appendage Disord"
                        "fecha" => "2019"
                        "volumen" => "5"
                        "paginaInicial" => "100"
                        "paginaFinal" => "103"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia and vitiligo&#58; coexistence or true association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Katoulis"
                            1 => "K&#46; Diamanti"
                            2 => "D&#46; Sgouros"
                            3 => "A&#46;I&#46; Liakou"
                            4 => "A&#46; Alevizou"
                            5 => "E&#46; Bozi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ski Appendage Disord"
                        "fecha" => "2016"
                        "volumen" => "2"
                        "paginaInicial" => "152"
                        "paginaFinal" => "155"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia occurring on scalp vitiligo&#58; report of four cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Miteva"
                            1 => "C&#46; Aber"
                            2 => "F&#46; Torres"
                            3 => "A&#46; Tosti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2011.10382.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "165"
                        "paginaInicial" => "445"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21517796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Active life expectancy in the older us population&#44; 1982&#8211;2011&#58; black&#8211;white differences persisted"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;A&#46; Freedman"
                            1 => "B&#46;C&#46; Spillman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Health Aff"
                        "fecha" => "2016"
                        "volumen" => "35"
                        "paginaInicial" => "1351"
                        "paginaFinal" => "1358"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011300000010/v1_202211300529/S0001731022008134/v1_202211300529/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6143"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011300000010/v1_202211300529/S0001731022008134/v1_202211300529/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022008134?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Coexistence of Vitiligo and Frontal Fibrosing Alopecia: A Case Report and Analysis of Its Physiopathology
Coexistencia de vitíligo y alopecia frontal fibrosante: caso clínico y análisis de su fisiopatología
L. Trujillo-Gaviriaa, D. Gómez-Osorioa, J.D. Ruíz-Restrepob, O.J. Valencia-Ocampoc,
Autor para correspondencia
oscar.valencia@udea.edu.co

Corresponding author.
a Dermatology Resident, Universidad de Antioquia, Medellín, Colombia
b Dermatopatologist, Professor of the Dermatology Section, Universidad de Antioquia, Medellín, Colombia
c Dermatologist, Professor of the Dermatology Section, Universidad de Antioquia, CIDERM Investigation Group, Medellín, Colombia
Leído
4280
Veces
se ha leído el artículo
1139
Total PDF
3141
Total HTML
Compartir estadísticas
 array:25 [
  "pii" => "S0001731022008134"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2022.09.015"
  "estado" => "S300"
  "fechaPublicacion" => "2022-11-01"
  "aid" => "3217"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2022;113:T991-T994"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731022004719"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.02.029"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "3074"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:995-6"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
      "titulo" => "Two Track Biologic Therapy for Concurrent Chronic Spontaneous Urticaria and Psoriasis Vulgaris in One Patient"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "995"
          "paginaFinal" => "996"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Terapia biol&#243;gica de dos v&#237;as para urticaria espont&#225;nea cr&#243;nica concurrente con psoriasis vulgar en un paciente"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46; Benko, B&#46; Hrvatin Stancic, T&#46; Lunder"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "M&#46;"
              "apellidos" => "Benko"
            ]
            1 => array:2 [
              "nombre" => "B&#46;"
              "apellidos" => "Hrvatin Stancic"
            ]
            2 => array:2 [
              "nombre" => "T&#46;"
              "apellidos" => "Lunder"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022004719?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000010/v1_202211300529/S0001731022004719/v1_202211300529/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731021003306"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2021.01.015"
    "estado" => "S300"
    "fechaPublicacion" => "2022-11-01"
    "aid" => "2763"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:991-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICO-CL&#205;NICA</span>"
      "titulo" => "Coexistencia de vit&#237;ligo y alopecia frontal fibrosante&#58; caso cl&#237;nico y an&#225;lisis de su fisiopatolog&#237;a"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "991"
          "paginaFinal" => "994"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Coexistence of vitiligo and frontal fibrosing alopecia&#58; A case report and analysis of its physiopathology"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 1349
              "Ancho" => 1300
              "Tamanyo" => 194669
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A y C</span>&#41; Regresi&#243;n de la l&#237;nea capilar frontal con p&#233;rdida de unidades foliculares&#44; eritema y escama perifolicular&#44; carencia de cejas&#46; M&#225;culas acr&#243;micas en la misma distribuci&#243;n&#46; Signo capilar &#250;nico &#40;flecha negra&#41; <span class="elsevierStyleBold">B&#41;</span> Fluorescencia con l&#225;mpara de Wood&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "L&#46; Trujillo-Gaviria, D&#46; G&#243;mez-Osorio, J&#46;D&#46; Ruiz-Restrepo, O&#46;J&#46; Valencia-Ocampo"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "L&#46;"
              "apellidos" => "Trujillo-Gaviria"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "G&#243;mez-Osorio"
            ]
            2 => array:2 [
              "nombre" => "J&#46;D&#46;"
              "apellidos" => "Ruiz-Restrepo"
            ]
            3 => array:2 [
              "nombre" => "O&#46;J&#46;"
              "apellidos" => "Valencia-Ocampo"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021003306?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000010/v1_202211300529/S0001731021003306/v1_202211300529/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S0001731021003306"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2021.01.015"
      "estado" => "S300"
      "fechaPublicacion" => "2022-11-01"
      "aid" => "2763"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2022;113:991-4"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICO-CL&#205;NICA</span>"
        "titulo" => "Coexistencia de vit&#237;ligo y alopecia frontal fibrosante&#58; caso cl&#237;nico y an&#225;lisis de su fisiopatolog&#237;a"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "991"
            "paginaFinal" => "994"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Coexistence of vitiligo and frontal fibrosing alopecia&#58; A case report and analysis of its physiopathology"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1349
                "Ancho" => 1300
                "Tamanyo" => 194669
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A y C</span>&#41; Regresi&#243;n de la l&#237;nea capilar frontal con p&#233;rdida de unidades foliculares&#44; eritema y escama perifolicular&#44; carencia de cejas&#46; M&#225;culas acr&#243;micas en la misma distribuci&#243;n&#46; Signo capilar &#250;nico &#40;flecha negra&#41; <span class="elsevierStyleBold">B&#41;</span> Fluorescencia con l&#225;mpara de Wood&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "L&#46; Trujillo-Gaviria, D&#46; G&#243;mez-Osorio, J&#46;D&#46; Ruiz-Restrepo, O&#46;J&#46; Valencia-Ocampo"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "L&#46;"
                "apellidos" => "Trujillo-Gaviria"
              ]
              1 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "G&#243;mez-Osorio"
              ]
              2 => array:2 [
                "nombre" => "J&#46;D&#46;"
                "apellidos" => "Ruiz-Restrepo"
              ]
              3 => array:2 [
                "nombre" => "O&#46;J&#46;"
                "apellidos" => "Valencia-Ocampo"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021003306?idApp=UINPBA000044"
      "url" => "/00017310/0000011300000010/v1_202211300529/S0001731021003306/v1_202211300529/es/main.assets"
    ]
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => " Coexistence of Vitiligo and Frontal Fibrosing Alopecia&#58; A Case Report and Analysis of Its Physiopathology"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T991"
        "paginaFinal" => "T994"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "L&#46; Trujillo-Gaviria, D&#46; G&#243;mez-Osorio, J&#46;D&#46; Ru&#237;z-Restrepo, O&#46;J&#46; Valencia-Ocampo"
        "autores" => array:4 [
          0 => array:3 [
            "nombre" => "L&#46;"
            "apellidos" => "Trujillo-Gaviria"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "G&#243;mez-Osorio"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "J&#46;D&#46;"
            "apellidos" => "Ru&#237;z-Restrepo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:4 [
            "nombre" => "O&#46;J&#46;"
            "apellidos" => "Valencia-Ocampo"
            "email" => array:1 [
              0 => "oscar.valencia@udea.edu.co"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Dermatology Resident&#44; Universidad de Antioquia&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Dermatopatologist&#44; Professor of the Dermatology Section&#44; Universidad de Antioquia&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Dermatologist&#44; Professor of the Dermatology Section&#44; Universidad de Antioquia&#44; CIDERM Investigation Group&#44; Medell&#237;n&#44; Colombia"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Coexistencia de vit&#237;ligo y alopecia frontal fibrosante&#58; caso cl&#237;nico y an&#225;lisis de su fisiopatolog&#237;a"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1301
            "Ancho" => 1301
            "Tamanyo" => 228323
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#8211;C&#44; Evaluation at 6 months of treatment revealed evidence of repigmentation in some areas&#44; reduced erythema&#44; and growth of new hair follicles&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vitiligo is the most common depigmentation disorder&#44; affecting 0&#46;5&#8211;1&#37; of the world&#39;s population&#46; Frontal fibrosing alopecia &#40;FFA&#41; is a recently described scarring alopecia that mostly affects postmenopausal women and whose incidence has been increasing gradually during the last decade&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The most widely accepted theory for the pathophysiology of vitiligo is that it is caused by the convergence of genetic factors&#44; autoimmunity&#44; oxidative stress&#44; and neurotoxicity&#44; among others&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">1</span></a> In the case of FFA&#44; the pathogenic model taking shape includes genetic factors&#44; activation of the innate immune system&#44; elimination of epithelial stem cells&#44; activation of epithelial-mesenchymal transition&#44; and hormonal factors&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">2</span></a> While vitiligo and FFA occur together infrequently&#44; an understanding of the underlying pathophysiological events can provide new clues as to treatment of FFA&#44; which&#44; to date&#44; has been considered a progressive disease that responds poorly to available treatment options&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">3</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Presentation</span><p id="par0015" class="elsevierStylePara elsevierViewall">We present the case of a 60-year-old woman with a family history of systemic lupus erythematosus &#40;sister&#41; and a 2-year personal history of depigmented lesions mainly affecting the forehead&#44; eyebrows&#44; and thorax&#46; She also had a 1-year history of alopecia&#46; The dermatology examination revealed achromic macules with involvement of the frontal and temporal areas&#44; eyebrows&#44; and thorax&#46; The lesions on the scalp followed the hairline&#46; Recession of the frontal hairline was observed&#44; with loss of follicular units and scarring accompanied by occasional erythematous papules and perifollicular scaling&#46; Wood lamp examination showed clearly delimited depigmented areas emitting a bright blue-whitish fluorescent light &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Dermoscopy revealed moderate perifollicular scaling and erythema&#44; with isolated hairs&#46; We performed 2 skin biopsies&#46; Histopathology revealed damage to the basement layer of the hair follicles&#44; with abundant necrotic keratinocytes&#44; in association with lamellar fibrosis&#44; fibrosis in the adjacent dermis&#44; and an inflammatory mononuclear infiltrate in the follicular infundibulum&#46; Staining with Fontana-Masson&#44; S100&#44; and Melan-A was negative for melanocytes &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#44; thus confirming the diagnosis of FFA and vitiligo co-occurring in the same lesion&#46; The Vitiligo Extent Score &#40;VES&#41; was 1&#46;1031 and the Frontal Fibrosing Alopecia Severity Score &#40;FFASS&#41; was 11&#46;6&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The patient received treatment with corticosteroids &#40;triamcinolone acetonide&#44; 2<span class="elsevierStyleHsp" style=""></span>mg&#47;mL&#47;mo for 3<span class="elsevierStyleHsp" style=""></span>months&#41;&#44; excimer laser &#40;308<span class="elsevierStyleHsp" style=""></span>nm&#41; twice weekly until minimal erythema with a fluence of 550<span class="elsevierStyleHsp" style=""></span>mJ&#47;cm<span class="elsevierStyleSup">2</span> was reached &#40;total of 30 sessions&#41;&#44; and application of tacrolimus 0&#46;1&#37; ointment twice daily&#46; After 6 months of treatment&#44; repigmentation was visible in some areas&#44; the eczema and inflammation had partly resolved&#44; and new hair follicles had grown&#44; with a VES of 0&#46;665 and an FFASS of 10&#46;1&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0030" class="elsevierStylePara elsevierViewall">FFA is a type of scarring alopecia that is characterized by continuous and progressive recession of the frontotemporal hairline and frequent involvement of the eyebrows&#46; It was first described in menopausal White Australian women&#44; although it is increasingly reported in males and persons from other countries and races&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">4</span></a> It is caused by a lymphocytic infiltrate affecting the frontotemporal hairline&#44; thus leading to chronic inflammation of the hair follicle and subsequent scarring alopecia&#46; It has been associated with the influence of hormones during the menopause and many diseases&#44; such as autoimmune disorders &#40;e&#46;g&#46;&#44; hypothyroidism and vitiligo&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">The literature contains 7 reports of FFA and vitiligo co-occurring at the same site &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#44; with most cases affecting White patients&#46; Here&#44; we report the case of co-occurrence of both conditions in which the pigmentation disorder preceded alopecia by 1 year&#46; The various hypotheses put forward to explain the pathophysiologic phenomenon include cytotoxic CD8 lymphocyte activity &#40;common to both diseases&#41;&#44; Koebner phenomenon &#40;which can lead to FFA at sites previously affected by vitiligo&#41;&#44; and the actinic damage caused by exposure of depigmented areas of skin to sunlight&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">6</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">The patient was a constant user of hair dyes&#44; which may have triggered both diseases&#46; Phenol is a common component of depigmenting agents&#46; Its structure is similar to that of tyrosine&#44; thus enabling it to inhibit melanogenesis and generating an inflammatory response&#44; with the subsequent autoimmunity and destruction of melanocytes that is observed in vitiligo&#46; Furthermore&#44; contact with these chemicals can lead to exposure to normally hidden follicular antigens&#44; which can be detected and attacked by the cellular immune system&#46; Prolonged stimulation of the inflammatory response could account for the resulting destruction of the hair follicles in FFA&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a> Understanding these immunologic mechanisms could prove useful for the treatment of patients with both diseases&#46; Cohort studies are necessary to calculate the risk of FFA and vitiligo in populations exposed to topical chemical products&#44; such as hair dyes&#46; We think these chemical hair care products should be avoided by patients with vitiligo affecting the hairline of the scalp&#44; although this recommendation should be validated in studies&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:4 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Case Presentation"
        ]
        1 => array:2 [
          "identificador" => "sec0010"
          "titulo" => "Discussion"
        ]
        2 => array:2 [
          "identificador" => "sec0015"
          "titulo" => "Conflicts of Interest"
        ]
        3 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 1350
            "Ancho" => 1300
            "Tamanyo" => 202148
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A and C&#44; Recession of the frontal hairline with loss of follicular units&#44; erythema&#44; and perifollicular scale&#46; Note the loss of eyebrow hair&#46; Achromic macules following the same pattern&#46; Lonely hair sign &#40;black arrow&#41;&#46; B&#44; Wood lamp showing fluorescence&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1301
            "Ancho" => 1301
            "Tamanyo" => 228323
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A&#8211;C&#44; Evaluation at 6 months of treatment revealed evidence of repigmentation in some areas&#44; reduced erythema&#44; and growth of new hair follicles&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1219
            "Ancho" => 1251
            "Tamanyo" => 304386
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A&#44; Histopathology revealed vacuolization of the basement layer&#44; abundant necrotic keratinocytes &#40;black arrow&#41;&#44; dermal lamellar fibrosis &#40;red arrow&#41;&#44; and moderate inflammatory mononuclear cell infiltration &#40;blue arrow&#41;&#46; B&#44; Fontana&#8211;Masson staining was negative for melanocytes&#46; C&#44; Melan-A immunohistochemical staining was negative for melanocytes&#46;</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Article&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Study type&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Age&#44; y&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Race&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">History of vitiligo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">History of autoimmune disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">D&#237;az and Miteva&#44; 2019<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">5</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case study&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hispanic origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Katoulis et al&#46;&#44; 2016<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">8</span></a></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="2" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case study</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypothyroidism&#47;morphea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="7" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Miteva et al&#46;&#44; 2011<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">7</span></a></td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " rowspan="4" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Case series</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypothyroidism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">White&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypothyroidism&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hispanic origin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Cases of Co-occurrence of Frontal Fibrosing Alopecia and Vitiligo&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:8 [
            0 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:3 [
                      "titulo" => "Vitiligo y vitamina D"
                      "tituloTraducido" => "&#91;&#91;nll&#93;Vitiligo and vitamin D"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Villegas"
                            1 => "C&#46;M&#46; Zuluaga"
                            2 => "L&#46; Javier"
                            3 => "M&#46; Albis"
                            4 => "&#211;&#46; Jairo"
                            5 => "V&#46; Ocampo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Rev Asoc Colomb Dermatol"
                        "fecha" => "2019"
                        "volumen" => "1"
                        "paginaInicial" => "36"
                        "paginaFinal" => "51"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia&#58; an update on the hypothesis of pathogenesis and treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "S&#46; Tavakolpour"
                            1 => "H&#46;R&#46; Mahmoudi"
                            2 => "R&#46; Abedini"
                            3 => "K&#46;K&#46; Hesari"
                            4 => "A&#46; Kiani"
                            5 => "M&#46; Daneshpazhooh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijwd.2018.11.003"
                      "Revista" => array:2 [
                        "tituloSerie" => "Int J Women&#39;s Dermatol"
                        "fecha" => "2018"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia&#58; a review of 60 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Macdonald"
                            1 => "C&#46; Clark"
                            2 => "S&#46; Holmes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2011.12.038"
                      "Revista" => array:5 [
                        "tituloSerie" => "J Am Dermatol"
                        "fecha" => "2012"
                        "volumen" => "67"
                        "paginaInicial" => "955"
                        "paginaFinal" => "961"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia&#58; demographic and clinical characteristics of 490 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "V&#46; Kanti"
                            1 => "A&#46; Constantinou"
                            2 => "P&#46; Reygagne"
                            3 => "A&#46; Vogt"
                            4 => "J&#46; Kottner"
                            5 => "U&#46; Blume-Peytavi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2019"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Peripilar &#8220;guttate&#8221; hypopigmentation of the scalp and idiopathic guttate hypomelanosis in frontal fibrosing alopecia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46;A&#46; Diaz"
                            1 => "M&#46; Miteva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ski Appendage Disord"
                        "fecha" => "2019"
                        "volumen" => "5"
                        "paginaInicial" => "100"
                        "paginaFinal" => "103"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia and vitiligo&#58; coexistence or true association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;C&#46; Katoulis"
                            1 => "K&#46; Diamanti"
                            2 => "D&#46; Sgouros"
                            3 => "A&#46;I&#46; Liakou"
                            4 => "A&#46; Alevizou"
                            5 => "E&#46; Bozi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ski Appendage Disord"
                        "fecha" => "2016"
                        "volumen" => "2"
                        "paginaInicial" => "152"
                        "paginaFinal" => "155"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frontal fibrosing alopecia occurring on scalp vitiligo&#58; report of four cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Miteva"
                            1 => "C&#46; Aber"
                            2 => "F&#46; Torres"
                            3 => "A&#46; Tosti"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2011.10382.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "165"
                        "paginaInicial" => "445"
                        "paginaFinal" => "447"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21517796"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Active life expectancy in the older us population&#44; 1982&#8211;2011&#58; black&#8211;white differences persisted"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46;A&#46; Freedman"
                            1 => "B&#46;C&#46; Spillman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Health Aff"
                        "fecha" => "2016"
                        "volumen" => "35"
                        "paginaInicial" => "1351"
                        "paginaFinal" => "1358"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011300000010/v1_202211300529/S0001731022008134/v1_202211300529/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6143"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011300000010/v1_202211300529/S0001731022008134/v1_202211300529/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022008134?idApp=UINPBA000044"
]
Información del artículo
ISSN: 00017310
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 16 16 32
2024 Octubre 118 56 174
2024 Septiembre 150 37 187
2024 Agosto 149 59 208
2024 Julio 89 45 134
2024 Junio 94 67 161
2024 Mayo 88 47 135
2024 Abril 90 35 125
2024 Marzo 77 41 118
2024 Febrero 88 37 125
2024 Enero 138 33 171
2023 Diciembre 169 36 205
2023 Noviembre 109 34 143
2023 Octubre 221 59 280
2023 Septiembre 117 28 145
2023 Agosto 122 23 145
2023 Julio 172 42 214
2023 Junio 115 29 144
2023 Mayo 132 34 166
2023 Abril 85 26 111
2023 Marzo 108 40 148
2023 Febrero 92 27 119
2023 Enero 98 60 158
2022 Diciembre 213 72 285
2022 Noviembre 196 54 250
2022 Octubre 95 102 197
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?