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"apellidos" => "Garcias-Ladaria" "email" => array:1 [ 0 => "jgarcila@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "D." "apellidos" => "Ramos Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Saus" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "A." "apellidos" => "Martín-Santiago" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitari Son Espases, Palma de Mallorca, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitari Son Espases, Palma de Mallorca, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hamartoma de músculo liso familiar" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 599 "Ancho" => 900 "Tamanyo" => 78020 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the 8-year-old patient. Multiple hyperpigmented papules with a follicular distribution.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Smooth muscle hamartoma (SMH) is a rare lesion, and is typically congenital, although some cases manifest in the first years of life. Several clinical forms are described: the first and most frequent is characterized by a smooth indurated plaque, which can be skin colored or hyperpigmented with hypertrichosis; while the second manifests as multiple papules with a follicular distribution, without hypertrichosis, occupying a circumscribed area. The less common clinical variant consists of more generalized lesions with prominent skin folds reminiscent of “Michelin baby”. These lesions are predominantly located in the lumbar area, and less commonly on the thighs, arms, face, or mammary region. The condition follows a benign course and the lesions, including hypertrichosis, usually attenuate with age.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">An 8-year-old girl and her 10-year-old sister each presented with an asymptomatic congenital lesion in the right pectoral area (<a class="elsevierStyleCrossRefs" href="#fig0005">Figs. 1 and 2</a>). They were 2 daughters of nonconsanguineous parents and had no other siblings. The patients’ parents reported the absence of any similar lesions in the girls’ relatives, including themselves, their uncles, and their grandparents. Physical examination revealed a plaque composed of small hyperpigmented papules with a follicular distribution. The older sister's lesions had become increasingly flattened in the preceding years, coinciding with puberty.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The younger sister underwent a biopsy at the level of the anterior axillary line. This showed minimal epidermal acanthosis, hyperpigmentation of the basal layer, and proliferation in the reticular dermis of multiple muscle fibers that showed no defined orientation and expressed smooth muscle actin (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Based on these findings, a diagnosis of SMH was established. The older sister's lesions were not biopsied as they appeared practically identical to those of her sister, caused no symptoms, and were located in a cosmetically sensitive location with a high probability of pathological scarring.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Due to morphological overlap, in some cases SMH and Becker nevus (BN) are considered to represent 2 poles on the same spectrum of developmental disorders.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> In our patients, the diagnosis of SMH was based on the papular appearance and the abundance of muscle fibers in the dermis. BN is caused by postzygotic mutations in the β-actin gene (<span class="elsevierStyleItalic">ACTB</span>) that are detected only in dermal smooth muscle fibers.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> These mutations are lethal when expressed in the germ line, and are therefore not heritable.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Mutations in the same <span class="elsevierStyleItalic">ACTB</span> gene have recently been described in SMH.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Two other cases of SMH have been described in siblings, in which, curiously, the location of the lesions also coincided, as in our patients.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6,7</span></a> Several cases of BN have also been published in various members of the same family (familial BN).<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8–11</span></a> Although paradominance has been proposed to explain these cases, the discovery in BN of these mutations, which are dominant and lethal when they occur in the germ line, rules out this mechanism.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Although coincidence cannot be ruled out, the manner in which the clinical presentation is replicated between parents and children and between siblings is indeed striking.</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, we describe the cases of 2 sisters with SMH with coinciding lesions. As also described for other familial cases of hamartoma, coincidence of the same lesion in the same site is unusual, and challenges current understanding of genetic mosaicism.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 599 "Ancho" => 900 "Tamanyo" => 78020 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the 8-year-old patient. Multiple hyperpigmented papules with a follicular distribution.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 599 "Ancho" => 900 "Tamanyo" => 106927 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the patient's sister (10 years of age). The patient's follicular papules had progressively flattened over the preceding years.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 619 "Ancho" => 1250 "Tamanyo" => 214393 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological image of the biopsy performed on the 8-year-old patient. A, Multiple smooth muscle fibers (black arrows) are distributed with no defined orientation in the dermis, beneath a slightly acanthotic epidermis (hematoxylin–eosin, original magnification ×10). B, Fibers stained for smooth muscle actin.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Harper's textbook of pediatric dermatology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P. Hoeger" 1 => "V. Kinsler" 2 => "A. Yan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:4 [ "edicion" => "4th ed." 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año/Mes | Html | Total | |
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2024 Noviembre | 5 | 3 | 8 |
2024 Octubre | 108 | 65 | 173 |
2024 Septiembre | 124 | 32 | 156 |
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2023 Diciembre | 67 | 19 | 86 |
2023 Noviembre | 84 | 47 | 131 |
2023 Octubre | 67 | 41 | 108 |
2023 Septiembre | 89 | 42 | 131 |
2023 Agosto | 54 | 19 | 73 |
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2023 Junio | 64 | 36 | 100 |
2023 Mayo | 57 | 37 | 94 |
2023 Abril | 42 | 27 | 69 |
2023 Marzo | 55 | 25 | 80 |
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2023 Enero | 68 | 44 | 112 |
2022 Diciembre | 70 | 37 | 107 |
2022 Noviembre | 74 | 63 | 137 |
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2022 Septiembre | 81 | 53 | 134 |
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2022 Abril | 19 | 29 | 48 |