array:25 [
  "pii" => "S0001731022002903"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2020.08.040"
  "estado" => "S300"
  "fechaPublicacion" => "2022-05-01"
  "aid" => "3004"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2022;113:T524-T525"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731021004312"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2020.08.030"
    "estado" => "S300"
    "fechaPublicacion" => "2022-05-01"
    "aid" => "2821"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:526-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICO-CL&#205;NICA</span>"
      "titulo" => "Cirug&#237;a microgr&#225;fica de Mohs en el carcinoma epidermoide de la unidad ungueal"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "526"
          "paginaFinal" => "528"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Mohs Micrographic Surgery in Squamous Cell Carcinoma of the Nail Unit"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 917
              "Ancho" => 1300
              "Tamanyo" => 204333
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentaci&#243;n cl&#237;nica del carcinoma epidermoide ungueal&#46; Placas eritematodescamativas &#40;A y B&#41; y tejido similar a granulaci&#243;n &#40;C&#41; de localizaci&#243;n periungueal&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Garc&#237;a-Zamora, R&#46; Mi&#241;ano Medrano, F&#46;J&#46; Vicente-Mart&#237;n, F&#46; Pinedo Moraleda, E&#46; Garc&#237;a-Garc&#237;a, J&#46;L&#46; L&#243;pez-Estebaranz"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Garc&#237;a-Zamora"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Mi&#241;ano Medrano"
            ]
            2 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Vicente-Mart&#237;n"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Pinedo Moraleda"
            ]
            4 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Garc&#237;a-Garc&#237;a"
            ]
            5 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "L&#243;pez-Estebaranz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004312?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000005/v1_202206110542/S0001731021004312/v1_202206110542/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731021004555"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2020.08.033"
    "estado" => "S300"
    "fechaPublicacion" => "2022-05-01"
    "aid" => "2838"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:524-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => "Hamartoma de m&#250;sculo liso familiar"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "524"
          "paginaFinal" => "525"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Familial Smooth Muscle Hamartoma"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 599
              "Ancho" => 900
              "Tamanyo" => 78020
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen cl&#237;nica de la paciente de 8 a&#241;os&#46; Se observan m&#250;ltiples p&#225;pulas hiperpigmentadas de distribuci&#243;n folicular&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Garcias-Ladaria, D&#46; Ramos Rodr&#237;guez, C&#46; Saus, A&#46; Mart&#237;n-Santiago"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Garcias-Ladaria"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Ramos Rodr&#237;guez"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Saus"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;n-Santiago"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004555?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000005/v1_202206110542/S0001731021004555/v1_202206110542/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S0001731021004555"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2020.08.033"
      "estado" => "S300"
      "fechaPublicacion" => "2022-05-01"
      "aid" => "2838"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2022;113:524-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Hamartoma de m&#250;sculo liso familiar"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "524"
            "paginaFinal" => "525"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Familial Smooth Muscle Hamartoma"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 599
                "Ancho" => 900
                "Tamanyo" => 78020
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen cl&#237;nica de la paciente de 8 a&#241;os&#46; Se observan m&#250;ltiples p&#225;pulas hiperpigmentadas de distribuci&#243;n folicular&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Garcias-Ladaria, D&#46; Ramos Rodr&#237;guez, C&#46; Saus, A&#46; Mart&#237;n-Santiago"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Garcias-Ladaria"
              ]
              1 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Ramos Rodr&#237;guez"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Saus"
              ]
              3 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Mart&#237;n-Santiago"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004555?idApp=UINPBA000044"
      "url" => "/00017310/0000011300000005/v1_202206110542/S0001731021004555/v1_202206110542/es/main.assets"
    ]
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => " Familial Smooth Muscle Hamartoma"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T524"
        "paginaFinal" => "T525"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Garcias-Ladaria, D&#46; Ramos Rodr&#237;guez, C&#46; Saus, A&#46; Mart&#237;n-Santiago"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "Garcias-Ladaria"
            "email" => array:1 [
              0 => "jgarcila@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Ramos Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Saus"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Mart&#237;n-Santiago"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitari Son Espases&#44; Palma de Mallorca&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitari Son Espases&#44; Palma de Mallorca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Hamartoma de m&#250;sculo liso familiar"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 599
            "Ancho" => 900
            "Tamanyo" => 78020
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the 8-year-old patient&#46; Multiple hyperpigmented papules with a follicular distribution&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Smooth muscle hamartoma &#40;SMH&#41; is a rare lesion&#44; and is typically congenital&#44; although some cases manifest in the first years of life&#46; Several clinical forms are described&#58; the first and most frequent is characterized by a smooth indurated plaque&#44; which can be skin colored or hyperpigmented with hypertrichosis&#59; while the second manifests as multiple papules with a follicular distribution&#44; without hypertrichosis&#44; occupying a circumscribed area&#46; The less common clinical variant consists of more generalized lesions with prominent skin folds reminiscent of &#8220;Michelin baby&#8221;&#46; These lesions are predominantly located in the lumbar area&#44; and less commonly on the thighs&#44; arms&#44; face&#44; or mammary region&#46; The condition follows a benign course and the lesions&#44; including hypertrichosis&#44; usually attenuate with age&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">An 8-year-old girl and her 10-year-old sister each presented with an asymptomatic congenital lesion in the right pectoral area &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; They were 2 daughters of nonconsanguineous parents and had no other siblings&#46; The patients&#8217; parents reported the absence of any similar lesions in the girls&#8217; relatives&#44; including themselves&#44; their uncles&#44; and their grandparents&#46; Physical examination revealed a plaque composed of small hyperpigmented papules with a follicular distribution&#46; The older sister&#39;s lesions had become increasingly flattened in the preceding years&#44; coinciding with puberty&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The younger sister underwent a biopsy at the level of the anterior axillary line&#46; This showed minimal epidermal acanthosis&#44; hyperpigmentation of the basal layer&#44; and proliferation in the reticular dermis of multiple muscle fibers that showed no defined orientation and expressed smooth muscle actin &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Based on these findings&#44; a diagnosis of SMH was established&#46; The older sister&#39;s lesions were not biopsied as they appeared practically identical to those of her sister&#44; caused no symptoms&#44; and were located in a cosmetically sensitive location with a high probability of pathological scarring&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Due to morphological overlap&#44; in some cases SMH and Becker nevus &#40;BN&#41; are considered to represent 2 poles on the same spectrum of developmental disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> In our patients&#44; the diagnosis of SMH was based on the papular appearance and the abundance of muscle fibers in the dermis&#46; BN is caused by postzygotic mutations in the &#946;-actin gene &#40;<span class="elsevierStyleItalic">ACTB</span>&#41; that are detected only in dermal smooth muscle fibers&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> These mutations are lethal when expressed in the germ line&#44; and are therefore not heritable&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Mutations in the same <span class="elsevierStyleItalic">ACTB</span> gene have recently been described in SMH&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Two other cases of SMH have been described in siblings&#44; in which&#44; curiously&#44; the location of the lesions also coincided&#44; as in our patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;7</span></a> Several cases of BN have also been published in various members of the same family &#40;familial BN&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;11</span></a> Although paradominance has been proposed to explain these cases&#44; the discovery in BN of these mutations&#44; which are dominant and lethal when they occur in the germ line&#44; rules out this mechanism&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Although coincidence cannot be ruled out&#44; the manner in which the clinical presentation is replicated between parents and children and between siblings is indeed striking&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; we describe the cases of 2 sisters with SMH with coinciding lesions&#46; As also described for other familial cases of hamartoma&#44; coincidence of the same lesion in the same site is unusual&#44; and challenges current understanding of genetic mosaicism&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 599
            "Ancho" => 900
            "Tamanyo" => 78020
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the 8-year-old patient&#46; Multiple hyperpigmented papules with a follicular distribution&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 599
            "Ancho" => 900
            "Tamanyo" => 106927
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the patient&#39;s sister &#40;10 years of age&#41;&#46; The patient&#39;s follicular papules had progressively flattened over the preceding years&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 619
            "Ancho" => 1250
            "Tamanyo" => 214393
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological image of the biopsy performed on the 8-year-old patient&#46; A&#44; Multiple smooth muscle fibers &#40;black arrows&#41; are distributed with no defined orientation in the dermis&#44; beneath a slightly acanthotic epidermis &#40;hematoxylin&#8211;eosin&#44; original magnification &#215;10&#41;&#46; B&#44; Fibers stained for smooth muscle actin&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Harper&#39;s textbook of pediatric dermatology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Hoeger"
                            1 => "V&#46; Kinsler"
                            2 => "A&#46; Yan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "4th ed&#46;"
                        "fecha" => "2020"
                        "editorial" => "Wiley-Blackwell"
                        "editorialLocalizacion" => "Hoboken&#44; NJ"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weedon&#39;s skin pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;W&#46; Patterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "4th ed&#46;"
                        "fecha" => "2016"
                        "editorial" => "Churchill-Livingston"
                        "editorialLocalizacion" => "London"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Postzygotic mutations in beta- actin are associated with Becker&#39;s nevus and Becker&#39;s nevus syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;D&#46; Cai"
                            1 => "B&#46;K&#46; Sun"
                            2 => "A&#46; Chiang"
                            3 => "A&#46; Rogers"
                            4 => "L&#46; Bernet"
                            5 => "B&#46; Cheng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2017"
                        "volumen" => "137"
                        "paginaInicial" => "1795e8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Becker&#39;s nevus and lethal beta-actin mutations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Happle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jid.2017.04.003"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2017"
                        "volumen" => "137"
                        "paginaInicial" => "1619"
                        "paginaFinal" => "1621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28625464"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022202X18323601"
                          "estado" => "S300"
                          "issn" => "0022202X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-zygotic ACTB mutations underlie congenital smooth muscle hamartomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Atzmony"
                            1 => "N&#46; Ugwu"
                            2 => "T&#46;D&#46; Zaki"
                            3 => "R&#46;J&#46; Antaya"
                            4 => "K&#46;A&#46; Choate"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/cup.13683"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2020"
                        "volumen" => "47"
                        "paginaInicial" => "681"
                        "paginaFinal" => "685"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32170967"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple familial smooth muscle hamartomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Gualandri"
                            1 => "S&#46; Cambiaghi"
                            2 => "E&#46; Ermacora"
                            3 => "G&#46; Tadini"
                            4 => "R&#46; Gianotti"
                            5 => "R&#46; Caputo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1525-1470.2001.018001017.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2001"
                        "volumen" => "18"
                        "paginaInicial" => "17"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11207964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple congenital familial smooth muscle hamartoma in two siblings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Garc&#237;a-Gav&#237;n"
                            1 => "L&#46; P&#233;rez-P&#233;rez"
                            2 => "F&#46; Allegue"
                            3 => "A&#46; P&#233;rez-Pedrosa"
                            4 => "J&#46;A&#46; Ort&#237;z-Rey"
                            5 => "A&#46; Zulaica"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2012"
                        "volumen" => "18"
                        "paginaInicial" => "7"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial Becker&#39;s nevus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;F&#46; Fretzin"
                            1 => "D&#46; Whitney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0190-9622(85)80107-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1985"
                        "volumen" => "12"
                        "paginaInicial" => "589"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3989022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial Becker&#39;s nevus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Panizzon"
                            1 => "U&#46;W&#46; Schnyder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Dermatologica"
                        "fecha" => "1988"
                        "volumen" => "176"
                        "paginaInicial" => "275e6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial Becker&#39;s nevus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;C&#46; Jain"
                            1 => "B&#46;K&#46; Fisher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1989"
                        "volumen" => "28"
                        "paginaInicial" => "263e4"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital Becker&#39;s nevus with a familial association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;E&#46; Book"
                            1 => "A&#46;T&#46; Glass"
                            2 => "T&#46;A&#46; Laude"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.1997.tb00985.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "1997"
                        "volumen" => "14"
                        "paginaInicial" => "373"
                        "paginaFinal" => "375"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9336809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011300000005/v1_202206110542/S0001731022002903/v1_202206110542/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "92870"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas &#47; Case and Research Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011300000005/v1_202206110542/S0001731022002903/v1_202206110542/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022002903?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Familial Smooth Muscle Hamartoma
Hamartoma de músculo liso familiar
J. Garcias-Ladariaa,
Autor para correspondencia
jgarcila@gmail.com

Corresponding author.
, D. Ramos Rodrígueza, C. Sausb, A. Martín-Santiagoa
a Servicio de Dermatología, Hospital Universitari Son Espases, Palma de Mallorca, Spain
b Servicio de Anatomía Patológica, Hospital Universitari Son Espases, Palma de Mallorca, Spain
Leído
3690
Veces
se ha leído el artículo
1311
Total PDF
2379
Total HTML
Compartir estadísticas
 array:25 [
  "pii" => "S0001731022002903"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2020.08.040"
  "estado" => "S300"
  "fechaPublicacion" => "2022-05-01"
  "aid" => "3004"
  "copyright" => "AEDV"
  "copyrightAnyo" => "2021"
  "documento" => "simple-article"
  "crossmark" => 1
  "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
  "subdocumento" => "crp"
  "cita" => "Actas Dermosifiliogr. 2022;113:T524-T525"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731021004312"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2020.08.030"
    "estado" => "S300"
    "fechaPublicacion" => "2022-05-01"
    "aid" => "2821"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:526-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CARTA CIENT&#205;FICO-CL&#205;NICA</span>"
      "titulo" => "Cirug&#237;a microgr&#225;fica de Mohs en el carcinoma epidermoide de la unidad ungueal"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "526"
          "paginaFinal" => "528"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Mohs Micrographic Surgery in Squamous Cell Carcinoma of the Nail Unit"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 917
              "Ancho" => 1300
              "Tamanyo" => 204333
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Presentaci&#243;n cl&#237;nica del carcinoma epidermoide ungueal&#46; Placas eritematodescamativas &#40;A y B&#41; y tejido similar a granulaci&#243;n &#40;C&#41; de localizaci&#243;n periungueal&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "E&#46; Garc&#237;a-Zamora, R&#46; Mi&#241;ano Medrano, F&#46;J&#46; Vicente-Mart&#237;n, F&#46; Pinedo Moraleda, E&#46; Garc&#237;a-Garc&#237;a, J&#46;L&#46; L&#243;pez-Estebaranz"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Garc&#237;a-Zamora"
            ]
            1 => array:2 [
              "nombre" => "R&#46;"
              "apellidos" => "Mi&#241;ano Medrano"
            ]
            2 => array:2 [
              "nombre" => "F&#46;J&#46;"
              "apellidos" => "Vicente-Mart&#237;n"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Pinedo Moraleda"
            ]
            4 => array:2 [
              "nombre" => "E&#46;"
              "apellidos" => "Garc&#237;a-Garc&#237;a"
            ]
            5 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "L&#243;pez-Estebaranz"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004312?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000005/v1_202206110542/S0001731021004312/v1_202206110542/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731021004555"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2020.08.033"
    "estado" => "S300"
    "fechaPublicacion" => "2022-05-01"
    "aid" => "2838"
    "copyright" => "AEDV"
    "documento" => "simple-article"
    "crossmark" => 1
    "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
    "subdocumento" => "crp"
    "cita" => "Actas Dermosifiliogr. 2022;113:524-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => "Hamartoma de m&#250;sculo liso familiar"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "524"
          "paginaFinal" => "525"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Familial Smooth Muscle Hamartoma"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 599
              "Ancho" => 900
              "Tamanyo" => 78020
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen cl&#237;nica de la paciente de 8 a&#241;os&#46; Se observan m&#250;ltiples p&#225;pulas hiperpigmentadas de distribuci&#243;n folicular&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46; Garcias-Ladaria, D&#46; Ramos Rodr&#237;guez, C&#46; Saus, A&#46; Mart&#237;n-Santiago"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Garcias-Ladaria"
            ]
            1 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Ramos Rodr&#237;guez"
            ]
            2 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Saus"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Mart&#237;n-Santiago"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004555?idApp=UINPBA000044"
    "url" => "/00017310/0000011300000005/v1_202206110542/S0001731021004555/v1_202206110542/es/main.assets"
  ]
  "asociados" => array:1 [
    0 => array:19 [
      "pii" => "S0001731021004555"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2020.08.033"
      "estado" => "S300"
      "fechaPublicacion" => "2022-05-01"
      "aid" => "2838"
      "copyright" => "AEDV"
      "documento" => "simple-article"
      "crossmark" => 1
      "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/"
      "subdocumento" => "crp"
      "cita" => "Actas Dermosifiliogr. 2022;113:524-5"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:1 [
        "total" => 0
      ]
      "es" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
        "titulo" => "Hamartoma de m&#250;sculo liso familiar"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "524"
            "paginaFinal" => "525"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Familial Smooth Muscle Hamartoma"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figura 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 599
                "Ancho" => 900
                "Tamanyo" => 78020
              ]
            ]
            "descripcion" => array:1 [
              "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Imagen cl&#237;nica de la paciente de 8 a&#241;os&#46; Se observan m&#250;ltiples p&#225;pulas hiperpigmentadas de distribuci&#243;n folicular&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46; Garcias-Ladaria, D&#46; Ramos Rodr&#237;guez, C&#46; Saus, A&#46; Mart&#237;n-Santiago"
            "autores" => array:4 [
              0 => array:2 [
                "nombre" => "J&#46;"
                "apellidos" => "Garcias-Ladaria"
              ]
              1 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Ramos Rodr&#237;guez"
              ]
              2 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Saus"
              ]
              3 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Mart&#237;n-Santiago"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731021004555?idApp=UINPBA000044"
      "url" => "/00017310/0000011300000005/v1_202206110542/S0001731021004555/v1_202206110542/es/main.assets"
    ]
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => " Familial Smooth Muscle Hamartoma"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#58;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "T524"
        "paginaFinal" => "T525"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46; Garcias-Ladaria, D&#46; Ramos Rodr&#237;guez, C&#46; Saus, A&#46; Mart&#237;n-Santiago"
        "autores" => array:4 [
          0 => array:4 [
            "nombre" => "J&#46;"
            "apellidos" => "Garcias-Ladaria"
            "email" => array:1 [
              0 => "jgarcila@gmail.com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Ramos Rodr&#237;guez"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Saus"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Mart&#237;n-Santiago"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Servicio de Dermatolog&#237;a&#44; Hospital Universitari Son Espases&#44; Palma de Mallorca&#44; Spain"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Anatom&#237;a Patol&#243;gica&#44; Hospital Universitari Son Espases&#44; Palma de Mallorca&#44; Spain"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Hamartoma de m&#250;sculo liso familiar"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 599
            "Ancho" => 900
            "Tamanyo" => 78020
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the 8-year-old patient&#46; Multiple hyperpigmented papules with a follicular distribution&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Smooth muscle hamartoma &#40;SMH&#41; is a rare lesion&#44; and is typically congenital&#44; although some cases manifest in the first years of life&#46; Several clinical forms are described&#58; the first and most frequent is characterized by a smooth indurated plaque&#44; which can be skin colored or hyperpigmented with hypertrichosis&#59; while the second manifests as multiple papules with a follicular distribution&#44; without hypertrichosis&#44; occupying a circumscribed area&#46; The less common clinical variant consists of more generalized lesions with prominent skin folds reminiscent of &#8220;Michelin baby&#8221;&#46; These lesions are predominantly located in the lumbar area&#44; and less commonly on the thighs&#44; arms&#44; face&#44; or mammary region&#46; The condition follows a benign course and the lesions&#44; including hypertrichosis&#44; usually attenuate with age&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">An 8-year-old girl and her 10-year-old sister each presented with an asymptomatic congenital lesion in the right pectoral area &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">Figs&#46; 1 and 2</a>&#41;&#46; They were 2 daughters of nonconsanguineous parents and had no other siblings&#46; The patients&#8217; parents reported the absence of any similar lesions in the girls&#8217; relatives&#44; including themselves&#44; their uncles&#44; and their grandparents&#46; Physical examination revealed a plaque composed of small hyperpigmented papules with a follicular distribution&#46; The older sister&#39;s lesions had become increasingly flattened in the preceding years&#44; coinciding with puberty&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The younger sister underwent a biopsy at the level of the anterior axillary line&#46; This showed minimal epidermal acanthosis&#44; hyperpigmentation of the basal layer&#44; and proliferation in the reticular dermis of multiple muscle fibers that showed no defined orientation and expressed smooth muscle actin &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Based on these findings&#44; a diagnosis of SMH was established&#46; The older sister&#39;s lesions were not biopsied as they appeared practically identical to those of her sister&#44; caused no symptoms&#44; and were located in a cosmetically sensitive location with a high probability of pathological scarring&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Due to morphological overlap&#44; in some cases SMH and Becker nevus &#40;BN&#41; are considered to represent 2 poles on the same spectrum of developmental disorders&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> In our patients&#44; the diagnosis of SMH was based on the papular appearance and the abundance of muscle fibers in the dermis&#46; BN is caused by postzygotic mutations in the &#946;-actin gene &#40;<span class="elsevierStyleItalic">ACTB</span>&#41; that are detected only in dermal smooth muscle fibers&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> These mutations are lethal when expressed in the germ line&#44; and are therefore not heritable&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Mutations in the same <span class="elsevierStyleItalic">ACTB</span> gene have recently been described in SMH&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Two other cases of SMH have been described in siblings&#44; in which&#44; curiously&#44; the location of the lesions also coincided&#44; as in our patients&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6&#44;7</span></a> Several cases of BN have also been published in various members of the same family &#40;familial BN&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;11</span></a> Although paradominance has been proposed to explain these cases&#44; the discovery in BN of these mutations&#44; which are dominant and lethal when they occur in the germ line&#44; rules out this mechanism&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Although coincidence cannot be ruled out&#44; the manner in which the clinical presentation is replicated between parents and children and between siblings is indeed striking&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; we describe the cases of 2 sisters with SMH with coinciding lesions&#46; As also described for other familial cases of hamartoma&#44; coincidence of the same lesion in the same site is unusual&#44; and challenges current understanding of genetic mosaicism&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0035" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:2 [
        0 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
        ]
        1 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:3 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 599
            "Ancho" => 900
            "Tamanyo" => 78020
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the 8-year-old patient&#46; Multiple hyperpigmented papules with a follicular distribution&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 599
            "Ancho" => 900
            "Tamanyo" => 106927
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Clinical image of the patient&#39;s sister &#40;10 years of age&#41;&#46; The patient&#39;s follicular papules had progressively flattened over the preceding years&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 619
            "Ancho" => 1250
            "Tamanyo" => 214393
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Histological image of the biopsy performed on the 8-year-old patient&#46; A&#44; Multiple smooth muscle fibers &#40;black arrows&#41; are distributed with no defined orientation in the dermis&#44; beneath a slightly acanthotic epidermis &#40;hematoxylin&#8211;eosin&#44; original magnification &#215;10&#41;&#46; B&#44; Fibers stained for smooth muscle actin&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Harper&#39;s textbook of pediatric dermatology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46; Hoeger"
                            1 => "V&#46; Kinsler"
                            2 => "A&#46; Yan"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "4th ed&#46;"
                        "fecha" => "2020"
                        "editorial" => "Wiley-Blackwell"
                        "editorialLocalizacion" => "Hoboken&#44; NJ"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Weedon&#39;s skin pathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;W&#46; Patterson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:4 [
                        "edicion" => "4th ed&#46;"
                        "fecha" => "2016"
                        "editorial" => "Churchill-Livingston"
                        "editorialLocalizacion" => "London"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0065"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Postzygotic mutations in beta- actin are associated with Becker&#39;s nevus and Becker&#39;s nevus syndrome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "E&#46;D&#46; Cai"
                            1 => "B&#46;K&#46; Sun"
                            2 => "A&#46; Chiang"
                            3 => "A&#46; Rogers"
                            4 => "L&#46; Bernet"
                            5 => "B&#46; Cheng"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2017"
                        "volumen" => "137"
                        "paginaInicial" => "1795e8"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Becker&#39;s nevus and lethal beta-actin mutations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Happle"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jid.2017.04.003"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2017"
                        "volumen" => "137"
                        "paginaInicial" => "1619"
                        "paginaFinal" => "1621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28625464"
                            "web" => "Medline"
                          ]
                        ]
                        "itemHostRev" => array:3 [
                          "pii" => "S0022202X18323601"
                          "estado" => "S300"
                          "issn" => "0022202X"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0075"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Post-zygotic ACTB mutations underlie congenital smooth muscle hamartomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Atzmony"
                            1 => "N&#46; Ugwu"
                            2 => "T&#46;D&#46; Zaki"
                            3 => "R&#46;J&#46; Antaya"
                            4 => "K&#46;A&#46; Choate"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/cup.13683"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Cutan Pathol"
                        "fecha" => "2020"
                        "volumen" => "47"
                        "paginaInicial" => "681"
                        "paginaFinal" => "685"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32170967"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple familial smooth muscle hamartomas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L&#46; Gualandri"
                            1 => "S&#46; Cambiaghi"
                            2 => "E&#46; Ermacora"
                            3 => "G&#46; Tadini"
                            4 => "R&#46; Gianotti"
                            5 => "R&#46; Caputo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1525-1470.2001.018001017.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "2001"
                        "volumen" => "18"
                        "paginaInicial" => "17"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11207964"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Multiple congenital familial smooth muscle hamartoma in two siblings"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Garc&#237;a-Gav&#237;n"
                            1 => "L&#46; P&#233;rez-P&#233;rez"
                            2 => "F&#46; Allegue"
                            3 => "A&#46; P&#233;rez-Pedrosa"
                            4 => "J&#46;A&#46; Ort&#237;z-Rey"
                            5 => "A&#46; Zulaica"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Dermatol Online J"
                        "fecha" => "2012"
                        "volumen" => "18"
                        "paginaInicial" => "7"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0090"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial Becker&#39;s nevus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;F&#46; Fretzin"
                            1 => "D&#46; Whitney"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0190-9622(85)80107-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "1985"
                        "volumen" => "12"
                        "paginaInicial" => "589"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3989022"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial Becker&#39;s nevus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "R&#46; Panizzon"
                            1 => "U&#46;W&#46; Schnyder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Dermatologica"
                        "fecha" => "1988"
                        "volumen" => "176"
                        "paginaInicial" => "275e6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Familial Becker&#39;s nevus"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46;C&#46; Jain"
                            1 => "B&#46;K&#46; Fisher"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "1989"
                        "volumen" => "28"
                        "paginaInicial" => "263e4"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Congenital Becker&#39;s nevus with a familial association"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46;E&#46; Book"
                            1 => "A&#46;T&#46; Glass"
                            2 => "T&#46;A&#46; Laude"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1525-1470.1997.tb00985.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Pediatr Dermatol"
                        "fecha" => "1997"
                        "volumen" => "14"
                        "paginaInicial" => "373"
                        "paginaFinal" => "375"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9336809"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000011300000005/v1_202206110542/S0001731022002903/v1_202206110542/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "92870"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas &#47; Case and Research Letter"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000011300000005/v1_202206110542/S0001731022002903/v1_202206110542/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731022002903?idApp=UINPBA000044"
]
Información del artículo
ISSN: 00017310
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 5 3 8
2024 Octubre 108 65 173
2024 Septiembre 124 32 156
2024 Agosto 143 71 214
2024 Julio 90 40 130
2024 Junio 100 45 145
2024 Mayo 80 49 129
2024 Abril 79 42 121
2024 Marzo 82 56 138
2024 Febrero 64 42 106
2024 Enero 68 40 108
2023 Diciembre 67 19 86
2023 Noviembre 84 47 131
2023 Octubre 67 41 108
2023 Septiembre 89 42 131
2023 Agosto 54 19 73
2023 Julio 74 47 121
2023 Junio 64 36 100
2023 Mayo 57 37 94
2023 Abril 42 27 69
2023 Marzo 55 25 80
2023 Febrero 54 28 82
2023 Enero 68 44 112
2022 Diciembre 70 37 107
2022 Noviembre 74 63 137
2022 Octubre 77 40 117
2022 Septiembre 81 53 134
2022 Agosto 87 51 138
2022 Julio 77 40 117
2022 Junio 95 53 148
2022 Mayo 81 48 129
2022 Abril 19 29 48
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?