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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Vitiligo is the most common acquired form of skin dyschromia and impacts the quality of life of affected individuals&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">1&#44;2</span></a> Cosmetic camouflage is a therapeutic alternative that can be used to improve skin appearance and hence quality of life in patients with skin dyschromia&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">3</span></a> Several studies have demonstrated the effectiveness of this approach&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">An uncontrolled quasi-experimental study of patients with facial vitiligo treated at the Dr&#46; Ladislao de la Pascua dermatology center&#44; Mexico City&#44; between July 2017 and May 2019&#44; evaluated the impact of cosmetic camouflage on patient quality of life using generic and specific scales&#46; The study was approved by relevant ethics and research committees and all study participants provided written informed consent&#46; Adult vitiligo patients with spots in the facial region were recruited&#44; regardless of the clinical variety and extent of the disease&#46; Those with other concomitant dermatological diseases affecting the face&#44; psychiatric diseases &#40;depression and anxiety&#41;&#44; and&#47;or allergies to cosmetics were excluded&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Quality of life was assessed using disease-specific &#40;vitiligo quality-of-life index &#91;VitiQol&#93;&#41; and generic &#40;Dermatology Life Quality Index &#91;DLQI&#93;&#44; EuroQol-5 Dimension &#91;EQ5D&#93;&#44; and the Short Form Health Survey &#91;SF36&#93;&#41; scales at the initial visit &#40;V1&#41; and at weeks 8 &#40;V2&#41; and 16 &#40;V3&#41; of the study&#46; Validated Mexican Spanish versions of all scales were used&#46; For normally distributed data&#44; a repeated measures analysis of variance &#40;ANOVA&#41; test was used to compare the scores of the quality-of-life questionnaires&#46; In all other cases&#44; the Friedman test was used&#46; Statistical significance was set at <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Participants were instructed how to use cosmetic camouflage in a workshop led by a professional makeup artist&#46; The product used was Dermablend &#40;Vichy Laboratories&#41;&#46; The authors received no financial compensation for the use of this protocol and Vichy M&#233;xico was not involved in the study design or execution&#44; or the statistical analysis&#46; All participants were instructed to apply cosmetic camouflage for 16 weeks&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A total of 45 vitiligo patients with facial involvement were recruited&#46; Of these&#44; 42 completed 2 study visits and 38 completed the 3 scheduled visits&#46; The sociodemographic variables of the study population are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Significant changes in post- versus pre-intervention quality-of-life scores in the different questionnaires are shown in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; In the DLQI questionnaire&#44; a significant change in the effect of vitiligo on quality of life was observed for 27 &#40;64&#46;3&#37;&#41; patients&#58; quality-of-life improvements were observed in 1 category for 18 &#40;66&#46;7&#37;&#41; patients&#44; 2 categories for 6 &#40;22&#46;2&#37;&#41; patients&#44; and 3 categories for 3 &#40;11&#46;1&#37;&#41; patients&#46; These findings were similar to those of Ogenage et al&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">4</span></a> In our study&#44; the use of cosmetic camouflage was associated with a positive change in quality of life that was evident within the first 8 weeks of intervention and&#44; according to the results of the post hoc analysis&#44; persisted until the end of the study &#40;except for some categories of the SF36 questionnaire&#41;&#46; These findings reflect a change that occurred shortly after beginning the intervention&#44; as reported in similar studies in pediatric populations&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">6</span></a> The specific scale used to measure quality of life in our study was the ViTiQol score&#44; for which significant differences were observed after versus before the intervention&#46; Our study is the first to use this instrument to evaluate the effect of interventions in vitiligo patients and revealed a significant correlation &#40;<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; between the DLQI and ViTiQol questionnaire findings&#44; in line with a previous validation study performed in a Mexican population&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">7</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">Analysis of the other study variables &#40;sex&#44; age&#44; educational level&#44; and occupation&#41; revealed no significant differences that were maintained at the end of the study&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">In conclusion&#44; despite the study&#39;s limitations &#40;including a predominantly female study population&#44; the lack of a control group&#44; and the absence of comparison with another intervention to improve quality of life&#41;&#44; our findings demonstrate an improvement in quality of life in vitiligo patients who used cosmetic camouflage &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; This intervention proved to be fast and safe&#44; with adequate adherence and good patient satisfaction&#44; and therefore represents a valid option as a therapeutic supplement for vitiligo&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0040" class="elsevierStylePara elsevierViewall">Dermablend products were donated by Vichy M&#233;xico&#46; The authors did not receive any financial compensation for the study protocol used&#46; Vichy M&#233;xico was not involved in the study design or execution&#44; or in the statistical analysis&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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                  \t\t\t\t">21 &#40;46&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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    "bibliografia" => array:2 [
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                            0 => "K&#46; Ezzedine"
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                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(14)60763-7"
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                        "tituloSerie" => "Lancet"
                        "fecha" => "2015"
                        "volumen" => "386"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25596811"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interventions for vitiligo"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46; Me"
                            1 => "A&#46; Dm"
                            2 => "B&#46;U&#46;G&#46; Cw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cochrane Library"
                        "fecha" => "2015"
                        "paginaInicial" => "1"
                        "paginaFinal" => "48"
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            2 => array:3 [
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                0 => array:2 [
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                        0 => array:2 [
                          "etal" => false
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