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however&#44; SU is often unresponsive to them&#46; Other treatment options are leukotriene receptor antagonists&#44; UV-hardening&#44; cyclosporine A&#44; antimalarial drugs&#44; plasmapheresis and intravenous immunoglobulin &#40;IVIG&#41;&#46; Efficacy of these treatments is usually partial or transient and may induce several unwanted effects&#44; i&#46;e&#46; anaphylaxis&#44; immunosuppression and malignancy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Omalizumab is a humanized monoclonal IgG1-kappa antibody against IgE recently approved by the US Food and Drug Administration and the European Medicines Agency for antihistamine refractory patients with chronic spontaneous urticaria &#40;CSU&#41; who are at least 12 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Omalizumab binds to free IgE with a greater affinity than IgE itself binds to the high-affinity Fc¿RI receptors present on basophils&#46; Thus&#44; it reduces the availability of free IgE for binding and promotes down-regulation of Fc¿RI on the surface of mast cells and basophils preventing IgE-mediated histamine release&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">We report a case of a previously healthy 21 year-old Caucasian female with a 4-year history of erythema&#44; intense itch&#44; swelling and hives after minimal sun exposure even through window glass&#46; No history of asthma or food allergy was reported&#46; Phototest performed on the patient&#39;s back &#40;Waldman&#174; UV 181 UVA and Waldman&#174; UV 800 broad band UVB&#41; was positive for UVA&#44; minimal urticarial dose 7<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; and showed no reaction to UVB &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Visible light was not tested&#46; IgE serum levels were elevated &#40;294<span class="elsevierStyleHsp" style=""></span>kU&#47;L&#41; and other blood test determinations fell within normal limits&#59; cell count&#44; porphirins&#44; antinuclear antibodies&#44; liver and renal function panel&#44; and serum triptase&#46; She was diagnosed with Solar Urticaria &#40;SU&#41; induced by UVA&#44; and partially achieved to control symptoms with antihistamines &#40;Fexofenadine hydrochloride 180<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41; and broad-spectrum sunscreens&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Three years after diagnosis&#44; her SU became unresponsive to first-line treatment with antihistamines&#44; even updosing up to 4-fold&#46; Her quality of life&#44; as assessed by the Dermatology Quality of Life Index &#40;DLQI 21&#41; was seriously affected by SU&#46; Thus&#44; after careful consideration we decided to try experimental therapy with omalizumab&#46; Following approval from our institution ethics committee for exceptional medical treatments&#44; an initial dose of 300<span class="elsevierStyleHsp" style=""></span>mg of omalizumab was administered in April 2015&#44; and antihistamines were gradually discontinued&#46; Subsequent doses of 300<span class="elsevierStyleHsp" style=""></span>mg were administered monthly&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient reported a complete relief of symptoms within one day of the administration of the first dose &#40;DLQI 0&#41;&#46; She remained asymptomatic during the Spanish summer and no side effects were noted&#46; However&#44; a delay of omalizumab administration of one week brought back mild urticaria on one occasion&#46; We repeated the phototest six months later to check treatment response and no reaction occurred to either UVA or UVB spectrum &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; One year later&#44; she is still on omalizumab and the effect is sustained&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Treatment of SU with omalizumab is still off-label&#59; however&#44; management of SU with omalizumab has been proved effective on several occasions<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#8211;9</span></a> and promising clinical results have recently been published&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">On a recently published phase-II multicentric study&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> the response rate of SU to omalizumab appeared close to the mean proportion of patients with CSU achieving a urticarial activity score over 7 days of 6 or less with the same dose of omalizumab&#44; and&#59; similar to what is observed in CSU&#44; the improvement in solar urticaria was rapidly lost when omalizumab was stopped&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Omalizumab seems to be a new well-tolerated effective agent in the treatment of severe SU and might be soon included in SU treatment guidelines as a third-line therapy in the same way it is done with CSU&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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Case and Research Letter
Refractory solar urticaria successfully treated with omalizumab with normalization of phototest
Urticaria solar refractaria tratada satisfactoriamente con omalizumab y normalización del fototest
A. Combalia
Autor para correspondencia
andreacombalia@gmail.com

Corresponding author.
, C. Fernández-Sartorio, P. Aguilera
Dermatology Department, Hospital Clínic de Barcelona, Barcelona, Spain
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however&#44; SU is often unresponsive to them&#46; Other treatment options are leukotriene receptor antagonists&#44; UV-hardening&#44; cyclosporine A&#44; antimalarial drugs&#44; plasmapheresis and intravenous immunoglobulin &#40;IVIG&#41;&#46; Efficacy of these treatments is usually partial or transient and may induce several unwanted effects&#44; i&#46;e&#46; anaphylaxis&#44; immunosuppression and malignancy&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Omalizumab is a humanized monoclonal IgG1-kappa antibody against IgE recently approved by the US Food and Drug Administration and the European Medicines Agency for antihistamine refractory patients with chronic spontaneous urticaria &#40;CSU&#41; who are at least 12 years of age&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Omalizumab binds to free IgE with a greater affinity than IgE itself binds to the high-affinity Fc¿RI receptors present on basophils&#46; Thus&#44; it reduces the availability of free IgE for binding and promotes down-regulation of Fc¿RI on the surface of mast cells and basophils preventing IgE-mediated histamine release&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">We report a case of a previously healthy 21 year-old Caucasian female with a 4-year history of erythema&#44; intense itch&#44; swelling and hives after minimal sun exposure even through window glass&#46; No history of asthma or food allergy was reported&#46; Phototest performed on the patient&#39;s back &#40;Waldman&#174; UV 181 UVA and Waldman&#174; UV 800 broad band UVB&#41; was positive for UVA&#44; minimal urticarial dose 7<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#44; and showed no reaction to UVB &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Visible light was not tested&#46; IgE serum levels were elevated &#40;294<span class="elsevierStyleHsp" style=""></span>kU&#47;L&#41; and other blood test determinations fell within normal limits&#59; cell count&#44; porphirins&#44; antinuclear antibodies&#44; liver and renal function panel&#44; and serum triptase&#46; She was diagnosed with Solar Urticaria &#40;SU&#41; induced by UVA&#44; and partially achieved to control symptoms with antihistamines &#40;Fexofenadine hydrochloride 180<span class="elsevierStyleHsp" style=""></span>mg&#47;day&#41; and broad-spectrum sunscreens&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Three years after diagnosis&#44; her SU became unresponsive to first-line treatment with antihistamines&#44; even updosing up to 4-fold&#46; Her quality of life&#44; as assessed by the Dermatology Quality of Life Index &#40;DLQI 21&#41; was seriously affected by SU&#46; Thus&#44; after careful consideration we decided to try experimental therapy with omalizumab&#46; Following approval from our institution ethics committee for exceptional medical treatments&#44; an initial dose of 300<span class="elsevierStyleHsp" style=""></span>mg of omalizumab was administered in April 2015&#44; and antihistamines were gradually discontinued&#46; Subsequent doses of 300<span class="elsevierStyleHsp" style=""></span>mg were administered monthly&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The patient reported a complete relief of symptoms within one day of the administration of the first dose &#40;DLQI 0&#41;&#46; She remained asymptomatic during the Spanish summer and no side effects were noted&#46; However&#44; a delay of omalizumab administration of one week brought back mild urticaria on one occasion&#46; We repeated the phototest six months later to check treatment response and no reaction occurred to either UVA or UVB spectrum &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; One year later&#44; she is still on omalizumab and the effect is sustained&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Treatment of SU with omalizumab is still off-label&#59; however&#44; management of SU with omalizumab has been proved effective on several occasions<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3&#8211;9</span></a> and promising clinical results have recently been published&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">On a recently published phase-II multicentric study&#44;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> the response rate of SU to omalizumab appeared close to the mean proportion of patients with CSU achieving a urticarial activity score over 7 days of 6 or less with the same dose of omalizumab&#44; and&#59; similar to what is observed in CSU&#44; the improvement in solar urticaria was rapidly lost when omalizumab was stopped&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Omalizumab seems to be a new well-tolerated effective agent in the treatment of severe SU and might be soon included in SU treatment guidelines as a third-line therapy in the same way it is done with CSU&#46;</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0050" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest&#46;</p></span></span>"
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Información del artículo
ISSN: 00017310
Idioma original: Inglés
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