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she developed cutaneous lesions on the trunk&#46; On the physical examination she presented three patches&#58; one on each breast&#44; and one on the left inframammary fold &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These lesions had a shiny white color with a discrete lilaceous ring&#46; To the touch&#44; they presented as clearly atrophic&#46; She reported occasional itching but no other symptoms&#46; The patient had a past medical history of morphea 8 years before &#40;histologically diagnosed&#41;&#44; having been treated with topical corticosteroids and oral methotrexate&#44; with remission of the disease for more than 6 years&#46; Postinflammatory hyperpigmentation was not detected&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A skin biopsy of one of the patches was performed&#46; Histological examination demonstrated findings of lichen sclerosus with underlying morphea &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Nivolumab was stopped after 6 months of treatment because of the lack of efficacy in oncological terms&#46; In subsequent visits to our clinics&#44; the patient showed improvement of her cutaneous lesions&#44; without any topical or systemic treatment&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Relapse of morphea has been described in 50&#37; of patients in the first 2 years after diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In the presented case&#44; more than 6 years had passed since the last exacerbation of morphea&#44; and this episode of relapsing happened only 2 weeks after initiating Nivolumab&#46; Although natural evolution of the disease may have played a role&#44; we considered Nivolumab as a possible trigger&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Many other medications have been associated with the development of morphea&#46; The formation of autoantibodies and subsequent microvasculature injury has been proposed in the pathogenesis of these cases of drug-induced morphea&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In different clinical trials&#44; anti-PD1 therapies such as Pembrolizumab or Nivolumab showed a relatively safe profile&#44; with a low incidence of major adverse effects &#40;drug-related grade 3 or 4 toxic effects only in 14&#37; of the patients&#41;&#44; being those related with pneumonitis the most severe of them&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> These adverse reactions related with immune-checkpoints inhibitors have been named as immune-related adverse events &#40;irAEs&#41;&#46; When focusing on the skin irAEs&#44; non-specficic macular papular rash and pruritus have been described as the most common ones&#46; Interestingly&#44; vitiligo has also been reported&#44; but only in patients with melanoma&#46; Urticaria&#44; alopecia and mucosal involvement are other frequently described skin irAEs&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The exacerbation of preexisting autoimune disorders related to immunotherapies has also been reported&#46; These disorders include psoriasis&#44; sarcoidosis&#44; bullous pemphigoid and subacute lupus erythematosus&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#8211;7</span></a> To the best of our knowledge&#44; this would be the first case of morphea relapsing due to any cancer immunotherapy treatment&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; attending to the nature of this kind of immunotherapies&#44; totally different from traditional chemotherapy&#44; dermatologists should be aware not only of their typical irAEs&#44; but also of the possibility of exacerbation or relapse of previously controlled skin diseases&#44; especially immune-related ones&#46; This will probably represent a new challenge for dermatologists in the future&#44; as these treatments are being used more and more often&#46; More experience is needed in order to conclude the exact relation of cancer immunotherapy and the relapse of these diseases&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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                        "link" => array:1 [
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                      "titulo" => "Dermatologic complications of anti-PD-1&#47;PD-L1 immune checkpoint antibodies"
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                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
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                  ]
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              ]
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                        "link" => array:1 [
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                        "paginaFinal" => "228"
                        "link" => array:1 [
                          0 => array:2 [
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Case and Research Letter
Relapse of morphea during Nivolumab therapy for lung adenocarcinoma
Recaída de morfea durante tratamiento con Nivolumab en adenocarcinoma de pulmón
A. Alegre-Sánchez
Autor para correspondencia
adrian.alegresanchez@gmail.com

Corresponding author.
, P. Fonda-Pascual, D. Saceda-Corralo, E. de las Heras-Alonso
Dermatology Service, Ramon y Cajal Hospital, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Nivolumab is a Programmed Death-1 &#40;PD1&#41; receptor &#40;PD-1&#41; inhibitor&#44; first approved as cancer immune-checkpoint inhibitor therapy for stage IV malignant melanoma&#44; with recent indications in different tumors such as non-small cell lung cancer&#44; prostate cancer&#44; renal-cell cancer or ovarian cancer&#46; A wide variety of skin reactions have been described associated to cancer immunotherapy&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;7</span></a> We present a case of morphea relapsing during Nivolumab treatment&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 65 year-old woman came to our clinic referred by the Oncology department of our hospital&#46; She was being followed due to a stage IV lung adenocarcinoma for which she had received different therapies&#46; Just 2 months after initiating treatment with Nivolumab &#40;3<span class="elsevierStyleHsp" style=""></span>mg&#47;kg every 2 weeks&#41;&#44; she developed cutaneous lesions on the trunk&#46; On the physical examination she presented three patches&#58; one on each breast&#44; and one on the left inframammary fold &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; These lesions had a shiny white color with a discrete lilaceous ring&#46; To the touch&#44; they presented as clearly atrophic&#46; She reported occasional itching but no other symptoms&#46; The patient had a past medical history of morphea 8 years before &#40;histologically diagnosed&#41;&#44; having been treated with topical corticosteroids and oral methotrexate&#44; with remission of the disease for more than 6 years&#46; Postinflammatory hyperpigmentation was not detected&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A skin biopsy of one of the patches was performed&#46; Histological examination demonstrated findings of lichen sclerosus with underlying morphea &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Nivolumab was stopped after 6 months of treatment because of the lack of efficacy in oncological terms&#46; In subsequent visits to our clinics&#44; the patient showed improvement of her cutaneous lesions&#44; without any topical or systemic treatment&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Relapse of morphea has been described in 50&#37; of patients in the first 2 years after diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> In the presented case&#44; more than 6 years had passed since the last exacerbation of morphea&#44; and this episode of relapsing happened only 2 weeks after initiating Nivolumab&#46; Although natural evolution of the disease may have played a role&#44; we considered Nivolumab as a possible trigger&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Many other medications have been associated with the development of morphea&#46; The formation of autoantibodies and subsequent microvasculature injury has been proposed in the pathogenesis of these cases of drug-induced morphea&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In different clinical trials&#44; anti-PD1 therapies such as Pembrolizumab or Nivolumab showed a relatively safe profile&#44; with a low incidence of major adverse effects &#40;drug-related grade 3 or 4 toxic effects only in 14&#37; of the patients&#41;&#44; being those related with pneumonitis the most severe of them&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> These adverse reactions related with immune-checkpoints inhibitors have been named as immune-related adverse events &#40;irAEs&#41;&#46; When focusing on the skin irAEs&#44; non-specficic macular papular rash and pruritus have been described as the most common ones&#46; Interestingly&#44; vitiligo has also been reported&#44; but only in patients with melanoma&#46; Urticaria&#44; alopecia and mucosal involvement are other frequently described skin irAEs&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The exacerbation of preexisting autoimune disorders related to immunotherapies has also been reported&#46; These disorders include psoriasis&#44; sarcoidosis&#44; bullous pemphigoid and subacute lupus erythematosus&#46;<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">5&#8211;7</span></a> To the best of our knowledge&#44; this would be the first case of morphea relapsing due to any cancer immunotherapy treatment&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; attending to the nature of this kind of immunotherapies&#44; totally different from traditional chemotherapy&#44; dermatologists should be aware not only of their typical irAEs&#44; but also of the possibility of exacerbation or relapse of previously controlled skin diseases&#44; especially immune-related ones&#46; This will probably represent a new challenge for dermatologists in the future&#44; as these treatments are being used more and more often&#46; More experience is needed in order to conclude the exact relation of cancer immunotherapy and the relapse of these diseases&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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                    0 => array:2 [
                      "titulo" => "Safety&#44; activity&#44; and immune correlates of anti-PD-1 antibody in cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;L&#46; Topalian"
                            1 => "F&#46;S&#46; Hodi"
                            2 => "J&#46;R&#46; Brahmer"
                            3 => "S&#46;N&#46; Gettinger"
                            4 => "D&#46;C&#46; Smith"
                            5 => "D&#46;F&#46; McDermott"
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                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2012"
                        "volumen" => "366"
                        "paginaInicial" => "2443"
                        "paginaFinal" => "2454"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22658127"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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              "identificador" => "bib0060"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:3 [
                  "comentario" => "quiz 237&#8211;8"
                  "contribucion" => array:1 [
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                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            1 => "B&#46; Macdonald"
                            2 => "L&#46;E&#46; Golitz"
                            3 => "P&#46; LoRusso"
                            4 => "A&#46; Sekulic"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2014.07.033"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2015"
                        "volumen" => "72"
                        "paginaInicial" => "221"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25592339"
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                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Dermatologic complications of anti-PD-1&#47;PD-L1 immune checkpoint antibodies"
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                        0 => array:2 [
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                          "autores" => array:6 [
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                            1 => "N&#46; Meyer"
                            2 => "L&#46; Lamant"
                            3 => "E&#46; Vigarios"
                            4 => "J&#46; Mazieres"
                            5 => "J&#46;P&#46; Delord"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1097/CCO.0000000000000290"
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                        "tituloSerie" => "Curr Opin Oncol"
                        "fecha" => "2016"
                        "volumen" => "28"
                        "paginaInicial" => "254"
                        "paginaFinal" => "263"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27136138"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0070"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Characterisation and management of dermatologic adverse events to agents targeting the PD-1 receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "V&#46;R&#46; Belum"
                            1 => "B&#46; Benhuri"
                            2 => "M&#46;A&#46; Postow"
                            3 => "M&#46;D&#46; Hellmann"
                            4 => "A&#46;M&#46; Lesokhin"
                            5 => "N&#46;H&#46; Segal"
                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.ejca.2016.02.010"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Cancer"
                        "fecha" => "2016"
                        "volumen" => "60"
                        "paginaInicial" => "12"
                        "paginaFinal" => "25"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27043866"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ipilimumab therapy in patients with &#38;advanced melanoma and preexisting autoimmune disorders"
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                            0 => "D&#46;B&#46; Johnson"
                            1 => "R&#46;J&#46; Sullivan"
                            2 => "P&#46;A&#46; Ott"
                            3 => "M&#46;S&#46; Carlino"
                            4 => "N&#46;I&#46; Khushalani"
                            5 => "F&#46; Ye"
                          ]
                        ]
                      ]
                    ]
                  ]
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                        "fecha" => "2016"
                        "volumen" => "2"
                        "paginaInicial" => "234"
                        "paginaFinal" => "240"
                        "link" => array:1 [
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                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
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                    0 => array:2 [
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                            3 => "K&#46; Kabashima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                    ]
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                ]
              ]
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              "identificador" => "bib0085"
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                            3 => "T&#46; Yamamoto"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-2212"
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                        "paginaInicial" => "259"
                        "paginaFinal" => "260"
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                          0 => array:2 [
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Información del artículo
ISSN: 00017310
Idioma original: Inglés
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2022 Noviembre 34 35 69
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2022 Enero 46 46 92
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2021 Noviembre 33 46 79
2021 Octubre 45 53 98
2021 Septiembre 36 38 74
2021 Agosto 38 42 80
2021 Julio 29 39 68
2021 Junio 42 40 82
2021 Mayo 36 38 74
2021 Abril 69 76 145
2021 Marzo 66 39 105
2021 Febrero 78 37 115
2021 Enero 43 28 71
2020 Diciembre 40 28 68
2020 Noviembre 24 24 48
2020 Octubre 30 23 53
2020 Septiembre 41 18 59
2020 Agosto 35 28 63
2020 Julio 27 14 41
2020 Junio 32 35 67
2020 Mayo 32 10 42
2020 Abril 30 21 51
2020 Marzo 32 29 61
2020 Febrero 9 0 9
2020 Enero 4 0 4
2019 Diciembre 4 0 4
2019 Noviembre 2 0 2
2019 Septiembre 4 0 4
2019 Agosto 4 0 4
2019 Julio 4 0 4
2019 Junio 4 0 4
2019 Mayo 6 0 6
2019 Abril 2 3 5
2019 Febrero 4 0 4
2019 Enero 1 2 3
2018 Diciembre 2 0 2
2018 Noviembre 2 0 2
2018 Septiembre 2 0 2
2018 Julio 1 0 1
2018 Junio 0 1 1
2018 Mayo 1 0 1
2018 Abril 2 0 2
2018 Marzo 1 0 1
2018 Febrero 30 2 32
2018 Enero 28 7 35
2017 Diciembre 41 15 56
2017 Noviembre 15 11 26
2017 Octubre 6 9 15
2017 Septiembre 11 10 21
2017 Agosto 12 10 22
2017 Julio 10 15 25
2017 Junio 22 15 37
2017 Mayo 10 25 35
2017 Abril 29 28 57
2017 Marzo 14 37 51
2017 Febrero 18 51 69
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