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raised reddish lesion that had developed in her left breast over the previous 3 months&#46; She gave no history of trauma and did not describe constitutional symptoms&#46; The lesion had increased in size after the repeated application of mud to the area over 2 months&#46; Treatment with a potent topical corticosteroid &#40;betamethasone valerate&#44; 0&#46;122&#37; wt&#47;wt&#41; was then applied twice daily for a month&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical examination revealed a single erythematous plaque with areas of scarring&#46; A yellowish discharge emanated from multiple openings in an area beneath the left nipple measuring approximately 5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>cm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; On palpation the plaque was firm and indurated and was slightly tender&#59; there was no underlying breast lump&#46; Diascopy findings were nonspecific&#46; Gram stain of the discharge showed the presence of gram-positive cocci and abundant neutrophils&#46; No acid-fast bacilli &#40;AFB&#41; were seen on direct smear&#46; Potassium hydroxide &#40;KOH&#41; mount and fungal culture of skin scrapings and of the discharge was negative&#46; Ultrasonography of the breasts was normal&#44; though a single lymph node of 20<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>8<span class="elsevierStyleHsp" style=""></span>mm with a preserved hilum was observed in the left axilla&#46; Chest X-ray was normal and the Mantoux skin test produced a wheal of 8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mm&#46; Routine blood tests were within normal limits&#46; The patient was treated with oral cefuroxime 500<span class="elsevierStyleHsp" style=""></span>mg twice a day plus topical 2&#37; 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the patient was treated with 250<span class="elsevierStyleHsp" style=""></span>mg of oral terbinafine once daily plus topical 2&#37; sertaconazole cream twice daily&#46; The lesion resolved completely within 8 weeks and there was no evidence of recurrence after 6 months of follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In 1883&#44; Majocchi<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> described a phenomenon in which dermatophytes&#44; which usually remain limited to the stratum corneum&#44; become more aggressive and invade the superficial dermis&#46; Majocchi granuloma typically develops when a dermatophyte infection extends down a hair follicle in the setting of localized immunosuppression &#40;most commonly a potent topical steroid&#41; or systemic immunosuppression&#46; The result is a granulomatous response in the dermis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> The commonly implicated organisms are <span class="elsevierStyleItalic">Trichophyton</span> species &#40;<span class="elsevierStyleItalic">rubrum</span>&#44; <span class="elsevierStyleItalic">mentagrophytes complex</span>&#44; <span class="elsevierStyleItalic">violaceum</span>&#41; as well as some nondermatophyte species such as <span class="elsevierStyleItalic">Aspergillus</span> and <span class="elsevierStyleItalic">Phoma</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> Although historically <span class="elsevierStyleItalic">T&#46; violaceum</span> has been the most commonly identified organism&#44; Majocchi granuloma now a days is usually due to <span class="elsevierStyleItalic">T rubrum</span>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Two clinical forms of Majocchi granuloma&#44; follicular and subcutaneous nodular&#44; have been described&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> The follicular type usually develops after trauma&#44; repeated shaving of hair-bearing areas&#44; or topical corticosteroid treatment&#44; and in cases of long-standing immunosuppression&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;6</span></a> The subcutaneous nodular type occurs in immunocompromised hosts&#46; Our patient developed the follicular type&#44; probably caused by endothrix-type infection due to anthropophilic <span class="elsevierStyleItalic">T&#46; violaceum</span> secondary to the use of a potent topical steroid under occlusion&#44; which could have led to deep penetration of the fungus&#46; In modern medicine&#44; systemic antifungals such as griseofulvin&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> itraconazole&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> and terbinafine<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> are the mainstays of therapy as they are safe and effective&#46; The duration of therapy should be of at least 4&#8211;8 weeks&#44; and treatment should be continued until all lesions have cleared&#46; In the reports in literature&#44; nearly all lesions resolve without scarring within 6 weeks of starting antifungal&#46; The response of Majocchi granuloma to oral terbinafine can be explained on the basis of its pharmacokinetics&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> Terbinafine is the preferred oral therapy for treating Majocchi granuloma not only for its superior efficacy in eliminating dermatophytes&#44; but also because of its greater selectivity for the skin structures involved in Majocchi granuloma and fewer drug interactions than azole antifungals like itraconazole&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> We used terbinafine for its good antidermatophyte activity&#44; adequate penetration into common sites of dermatophyte infection &#40;stratum corneum and the hair follicle&#41;&#44; lower rates of recurrence&#44; low rate of drug interactions &#40;its metabolism does not involve cytochrome P450&#41;&#44; and its cost effectiveness when long-term therapy is warranted to prevent relapse&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> A diagnosis of Majocchi granuloma should always be considered in papular-pustular plaques&#44; especially when the patient describes factors associated with local or systemic immunosuppression&#46; Negative results of KOH examination or fungal culture of skin scrapings or of the purulent discharge do not exclude a diagnosis of Majocchi granuloma&#44; which should be confirmed either by tissue culture or by PAS staining of histopathology samples&#46; Although the detection of fungal spores or hyphae using special stains on histopathology samples will confirm the diagnosis&#44; these structures may sometimes escape detection&#44; as in our case&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> Fungal spores and hyphae are usually detected within hairs or hair follicles and in dermal granulomas&#46; Our inability to detect the fungal elements may have been due to the absence of hair follicles and the poorly defined granulomas in our biopsy specimen&#46; To the best of our knowledge&#44; this is the first reported case of Majocchi granuloma of the breast&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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Case and Research Letter
Majocchi Granuloma of the Breast: A Rare Clinical Entity
Granuloma de Majocchi: Una rara entidad
U. Khanna
Autor para correspondencia
urmi23khanna@gmail.com

Corresponding author.
, T. Kumar Dhali, P. D'Souza, S. Chowdhry
Department of Dermatology, ESIPGIMSR Basaidarapur, New Delhi, 15, India
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raised reddish lesion that had developed in her left breast over the previous 3 months&#46; She gave no history of trauma and did not describe constitutional symptoms&#46; The lesion had increased in size after the repeated application of mud to the area over 2 months&#46; Treatment with a potent topical corticosteroid &#40;betamethasone valerate&#44; 0&#46;122&#37; wt&#47;wt&#41; was then applied twice daily for a month&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinical examination revealed a single erythematous plaque with areas of scarring&#46; A yellowish discharge emanated from multiple openings in an area beneath the left nipple measuring approximately 5<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>4<span class="elsevierStyleHsp" style=""></span>cm &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; On palpation the plaque was firm and indurated and was slightly tender&#59; there was no underlying breast lump&#46; Diascopy findings were nonspecific&#46; Gram stain of the discharge showed the presence of gram-positive cocci and abundant neutrophils&#46; No acid-fast bacilli &#40;AFB&#41; were seen on direct smear&#46; Potassium hydroxide &#40;KOH&#41; mount and fungal culture of skin scrapings and of the discharge was negative&#46; Ultrasonography of the breasts was normal&#44; though a single lymph node of 20<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>8<span class="elsevierStyleHsp" style=""></span>mm with a preserved hilum was observed in the left axilla&#46; Chest X-ray was normal and the Mantoux skin test produced a wheal of 8<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>6<span class="elsevierStyleHsp" style=""></span>mm&#46; Routine blood tests were within normal limits&#46; The patient was treated with oral cefuroxime 500<span class="elsevierStyleHsp" style=""></span>mg twice a day plus topical 2&#37; mupirocin cream but showed no improvement after 2 weeks of treatment&#46; We performed skin biopsy based on a differential diagnosis of hidradenitis suppurativa&#44; lupus vulgaris&#44; or subcutaneous fungal infection&#46; Hematoxylin and eosin staining of the sample revealed a mixed cell&#44; granulomatous inflammatory reaction in the dermis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Ziehl-Neelsen and periodic acid Schiff &#40;PAS&#41; stains to detect AFB and fungi were both negative&#46; Mycobacterial culture of the tissue sample was negative&#44; but fungal culture on Sabouraud dextrose agar with chloramphenicol produced growth of heaped up&#44; folded violaceous colonies of waxy consistency after 3 weeks&#44; suggestive of <span class="elsevierStyleItalic">Trichophyton violaceum</span>&#46; Lactophenol cotton blue mount showed the presence of tangled&#44; irregular branched hyphae with chlamydospores&#46; With a final diagnosis of Majocchi&#39;s granuloma&#44; the patient was treated with 250<span class="elsevierStyleHsp" style=""></span>mg of oral terbinafine once daily plus topical 2&#37; sertaconazole cream twice daily&#46; The lesion resolved completely within 8 weeks and there was no evidence of recurrence after 6 months of follow-up &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">In 1883&#44; Majocchi<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> described a phenomenon in which dermatophytes&#44; which usually remain limited to the stratum corneum&#44; become more aggressive and invade the superficial dermis&#46; Majocchi granuloma typically develops when a dermatophyte infection extends down a hair follicle in the setting of localized immunosuppression &#40;most commonly a potent topical steroid&#41; or systemic immunosuppression&#46; The result is a granulomatous response in the dermis&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> The commonly implicated organisms are <span class="elsevierStyleItalic">Trichophyton</span> species &#40;<span class="elsevierStyleItalic">rubrum</span>&#44; <span class="elsevierStyleItalic">mentagrophytes complex</span>&#44; <span class="elsevierStyleItalic">violaceum</span>&#41; as well as some nondermatophyte species such as <span class="elsevierStyleItalic">Aspergillus</span> and <span class="elsevierStyleItalic">Phoma</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> Although historically <span class="elsevierStyleItalic">T&#46; violaceum</span> has been the most commonly identified organism&#44; Majocchi granuloma now a days is usually due to <span class="elsevierStyleItalic">T rubrum</span>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Two clinical forms of Majocchi granuloma&#44; follicular and subcutaneous nodular&#44; have been described&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> The follicular type usually develops after trauma&#44; repeated shaving of hair-bearing areas&#44; or topical corticosteroid treatment&#44; and in cases of long-standing immunosuppression&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;6</span></a> The subcutaneous nodular type occurs in immunocompromised hosts&#46; Our patient developed the follicular type&#44; probably caused by endothrix-type infection due to anthropophilic <span class="elsevierStyleItalic">T&#46; violaceum</span> secondary to the use of a potent topical steroid under occlusion&#44; which could have led to deep penetration of the fungus&#46; In modern medicine&#44; systemic antifungals such as griseofulvin&#44;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a> itraconazole&#44;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> and terbinafine<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> are the mainstays of therapy as they are safe and effective&#46; The duration of therapy should be of at least 4&#8211;8 weeks&#44; and treatment should be continued until all lesions have cleared&#46; In the reports in literature&#44; nearly all lesions resolve without scarring within 6 weeks of starting antifungal&#46; The response of Majocchi granuloma to oral terbinafine can be explained on the basis of its pharmacokinetics&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> Terbinafine is the preferred oral therapy for treating Majocchi granuloma not only for its superior efficacy in eliminating dermatophytes&#44; but also because of its greater selectivity for the skin structures involved in Majocchi granuloma and fewer drug interactions than azole antifungals like itraconazole&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> We used terbinafine for its good antidermatophyte activity&#44; adequate penetration into common sites of dermatophyte infection &#40;stratum corneum and the hair follicle&#41;&#44; lower rates of recurrence&#44; low rate of drug interactions &#40;its metabolism does not involve cytochrome P450&#41;&#44; and its cost effectiveness when long-term therapy is warranted to prevent relapse&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> A diagnosis of Majocchi granuloma should always be considered in papular-pustular plaques&#44; especially when the patient describes factors associated with local or systemic immunosuppression&#46; Negative results of KOH examination or fungal culture of skin scrapings or of the purulent discharge do not exclude a diagnosis of Majocchi granuloma&#44; which should be confirmed either by tissue culture or by PAS staining of histopathology samples&#46; Although the detection of fungal spores or hyphae using special stains on histopathology samples will confirm the diagnosis&#44; these structures may sometimes escape detection&#44; as in our case&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a> Fungal spores and hyphae are usually detected within hairs or hair follicles and in dermal granulomas&#46; Our inability to detect the fungal elements may have been due to the absence of hair follicles and the poorly defined granulomas in our biopsy specimen&#46; To the best of our knowledge&#44; this is the first reported case of Majocchi granuloma of the breast&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interests</span><p id="par0030" class="elsevierStylePara elsevierViewall">The authors declare no conflict of interest&#46;</p></span></span>"
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