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"apellidos" => "Puig" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0001731014004219" "doi" => "10.1016/j.ad.2014.10.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731014004219?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219015000505?idApp=UINPBA000044" "url" => "/15782190/0000010600000003/v3_202209240641/S1578219015000505/v3_202209240641/en/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S0001731014004165" "issn" => "00017310" "doi" => "10.1016/j.ad.2014.07.006" "estado" => "S300" "fechaPublicacion" => "2015-04-01" "aid" => "1057" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2015;106:158-67" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 3942 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 1352 "PDF" => 2587 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Revisión</span>" "titulo" => "Histopatología de las alopecias. 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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "155" "paginaFinal" => "157" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "T. Torres, L. Puig" "autores" => array:2 [ 0 => array:4 [ "nombre" => "T." "apellidos" => "Torres" "email" => array:1 [ 0 => "tiagotorres2002@hotmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0005" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Puig" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Department of Dermatology, Centro Hospitalar do Porto, Portugal" "etiqueta" => "a" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Portugal" "etiqueta" => "b" "identificador" => "aff0005" ] 2 => array:3 [ "entidad" => "Department of Dermatology, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Objetivos terapéuticos en la psoriasis: ¿debería ser la respuesta PASI90 la norma asistencial?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Psoriasis is a chronic, immune-mediated inflammatory disorder affecting 2–3% of general population, being both physically and emotionally debilitating.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">Due to the rapid advances in the understanding of psoriasis pathogenesis, several targeted medications, aiming specific components of the immune system, have been and are currently being developed.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> These biologic therapies are a major technological advancement over traditional immunosuppressive medications and have revolutionized the treatment of psoriasis. Currently available biologic agents for psoriasis treatment have shown to be very effective, even long-term, with a favorable safety profile.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The most widely used instrument for objective measurement of psoriasis severity and extension is the Psoriasis Area and Severity Index (PASI), which was developed in 1978.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Even though it has a number of limitations (non-linearity because of the surface score, notorious floor effect and poor sensitivity to change for relatively small areas of involvement, lack of ponderation of the different qualities of the lesions and functional impairment associated with lesions involving visible areas, such as, the hands, feet, nails or genital areas and reduced reproducibility due to the variability associated to the determination of BSA<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>), PASI has been considered the gold standard of psoriasis severity scale for decades.</p><p id="par0020" class="elsevierStylePara elsevierViewall">A 75% reduction in the PASI score with respect to baseline (PASI 75) is the current standard of response assessment used for primary endpoints in most clinical trials of psoriasis and it has been considered the treatment goal for moderate to severe psoriasis in a recent European consensus.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">However, not so long ago, some authors considered PASI 75 to be too stringent, placing potentially useful therapies at risk of failing to demonstrate efficacy, and PASI 50 to represent a clinically significant change for psoriasis patients and a better primary endpoint.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> This may have been true in an era of less effective drugs but, in the current status of biologic treatment, more ambitious outcome measures must be chose.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Although PASI 75 response is commonly used as the primary efficacy endpoint in clinical trials of biologics, PASI 90 and even PASI 100 response rates are commonly reported and are becoming important secondary endpoints. As is often the case, technological/therapeutic advances precede and eventually determine changes in therapeutic paradigms.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The efficacy showed by the IL-17 inhibitors (both IL-17A and IL-17 receptor subunit A inhibitors) in phase II and phase III clinical trials, which bears the promise of achieving PASI 90 response or better in the majority of patients, may make us rethink this issue again.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Methotrexate showed, in the randomized controlled comparative trials of infliximab and adalimumab, a 16 and 26-week PASI 90 response between 14–19.1% and 14.9%, respectively.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Considering biologic therapy, the week-12 PASI 90 rate in publish randomized trials of efalizumab, one of the first biologic agents approved for psoriasis and later withdrawn, was between 4–12%,<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> while the results of a 3-year continuous dosing study, showed a PASI 90 response of 24.5%.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">The anti-TNFα therapies show better results, with the monoclonal antibodies infliximab and adalimumab showing a higher response rate than the soluble TNFα receptor etanercept in clinical trials. In a recently published meta-analysis the efficacy of biologics in the treatment of moderate-to-severe plaque psoriasis based on the available randomized controlled trials has been estimated.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> The probability of achieving a PASI 90 response at the primary endpoint time is 19.3% (95% CI: 16.6–22.0) for etanercept at week 12, 36.5% (95% CI: 25.7–47.4) for adalimumab at week 16 and 49.5% (95% CI: 45.6–53.4) for infliximab at week 10. At week 24 the probability of achieving a PASI 90 response is 27.8% (95% CI: 23.6–31.9), 45.7% (95% CI: 42.1–49.3) and 50.6% (95% CI: 45.3–55.9) respectively for etanercept, adalimumab and infliximab.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In the long term, the reported PASI 90 response in the open-label extension studies RESTORE and REVEAL was 45% for infliximab at week 50 and 50% for adalimumab at 3 years.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">13,14</span></a> Regarding ustekinumab, the latest biologic agent approved for treatment of moderate to severe psoriasis, the results observed in the phase III clinical trials were similar to the response rates observed with the anti-TNFα monoclonal antibodies. In the same meta-analysis, the probability of achieving a PASI 90 response at week 12 and 24 is 47.2% (95% CI: 42.6–51.8) and 58.2% (95% CI: 53.7–62.8) respectively for the 45<span class="elsevierStyleHsp" style=""></span>mg dose.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> In the long-term efficacy analyze of ustekinumab in patients treated for up to 5 years in the PHOENIX 1 study, the 5-year PASI 90 response rate reported was 39.7%.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Looking to the recently published results of phase II and phase III randomized trials of secukinumab, ixekizumab (both anti-IL-17A monoclonal antibodies) and brodalumab (anti-IL-17 receptor subunit A monoclonal antibody) PASI 90 and PASI 100 response rates are impressive. In the phase II, randomized, double-blind, placebo-controlled, dose-ranging study of brodalumab, a PASI 90 and PASI 100 response was observed in 75% and 62%, respectively of the patients in the 210<span class="elsevierStyleHsp" style=""></span>mg group at week 12.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> In the 48-week open-label extension of the phase II trial, 86% and 64% of the patients achieved, respectively, PASI 90 and PASI 100 at week 48<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a>. Concerning the phase II, double-blind, placebo-controlled trial with ixekizumab at 12 weeks, the percentage of patients with PASI 90 and PASI 100 response was 71% and 39% respectively, in the group of patients treated with 150<span class="elsevierStyleHsp" style=""></span>mg and 59% and 38% respectively in the 75<span class="elsevierStyleHsp" style=""></span>mg group.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">18</span></a> In the open-label extension, with a dose of 120<span class="elsevierStyleHsp" style=""></span>mg every 4 week, 79% and 57% achieved a PASI 90 and PASI 100 response after 52 weeks.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> In the phase II, randomized, double-blind, placebo-controlled dose-ranging study of secukinumab the 12-week PASI 90 response in the 150<span class="elsevierStyleHsp" style=""></span>mg group was 52%.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> In the phase III FIXTURE study, comparing two doses of secukinumab (300<span class="elsevierStyleHsp" style=""></span>mg and 150<span class="elsevierStyleHsp" style=""></span>mg) with etanercept and placebo, the 12-week PASI 90 and PASI 100 response in the 300<span class="elsevierStyleHsp" style=""></span>mg secukinumab group was 54% and 24% respectively.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> At week 52, 65% of the patients treated with secukinumab 300<span class="elsevierStyleHsp" style=""></span>mg monthly had a PASI 90 response.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> In other phase III study, the ERASURE study, the 12-week PASI 90 and PASI 100 response was 59.2% and 28.6% respectively. At week 52, nearly 60% of the patients treated with secukinumab 300<span class="elsevierStyleHsp" style=""></span>mg monthly had a PASI 90 response.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a></p><p id="par0060" class="elsevierStylePara elsevierViewall">These results are in fact very promising, but confirmation both from further clinical trials and particularly daily clinical practice is necessary.</p><p id="par0065" class="elsevierStylePara elsevierViewall">PASI 90 may represent the best meaningful clinical response, instead of PASI 75, particularly in patients with very severe psoriasis. Considering patients with PASI above 20 (as seen in most studies in moderate to severe psoriasis), a PASI 75 response would associate to an absolute PASI around 5, compatible with a PGA score of 2, usually considered mild psoriasis (mild plaque elevation, light red coloration, predomination of fine scale). However PASI 90 response would equate to a PASI around 2, compatible with a PGA of 0/1 (almost clear). In this sense, PASI 90 response probably better reflects a “clear”/“almost clear” status than PASI 75.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> Moreover, it is well known that reduction in PASI predicts a reduction in DLQI with a good correlation. A recent systematic review showed that a PASI 75 response was associated with a considerably higher mean DLQI change (9.36) than a PASI 50–75 response (6.12).<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> The difference between both groups was 3.24, higher than 3.2, the value considered clinically meaningful according to the proposed minimal clinically important difference for the DLQI in psoriasis.<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">23,24</span></a> This data suggests that there is a true quality-of-life benefit associated with higher levels of psoriasis clearance, and that higher PASI reductions (for instance PASI 90) may probably determine even better quality-of-life benefits. As a matter of fact, combining data from two adalimumab trials, the PASI 100 and PASI 90 to <100 groups demonstrated a >10-point decrease in DLQI total scores at week 16, and these changes were statistically significantly greater than those observed for the PASI 75 to <90 group and the other PASI response groups (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001).<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">The ultimate goal of psoriasis treatment is the complete clearance of all skin lesions and symptoms, however, when pushing the response rate so high, safety concerns must be considered. The immunomodulatory/immunosuppressive effects of these agents should not be forgotten and holding the balance is the key. Nevertheless the safety data on these new agents is reassuring, appointing to a favorable safety profile. The expected favorable safety/efficacy ratio of the IL-17 inhibitors is probably related to the selective mechanism of action of these new drugs, as a lower blockade in the inflammatory cascade may result in less immunosuppression and consequently in less risks of infection and malignancy, while maintaining a high efficacy through selectively acting at the level of this key effector cytokine.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall">The psoriasis treatment paradigm has changed with the advent of biologics. The treatment advancements we have seen with these agents make us believe that achieving clearance or near-clearance of psoriasis will be possible. If in the past, a PASI 50 and 75 response was possibly sufficient enough and the PASI 90 achievement just a mirage, maybe sooner than many expected, clinicians will be disappointed if a PASI 90 response is not achieved.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflict of interest</span><p id="par0080" class="elsevierStylePara elsevierViewall">Dr. T. Torres has participated in clinical trial sponsored by Abbvie, Amgen and Novartis and has received honoraria for acting as a consultant and/or as a speaker at events sponsored by Abbvie, Janssen, MSD and Pfizer.</p><p id="par0085" class="elsevierStylePara elsevierViewall">Prof. L. Puig has participated in clinical trials sponsored by Abbvie, Amgen, Lilly, Merck, Novartis, Pfizer España, and VBL and has received honoraria for acting as a consultant and as a speaker at events sponsored by Abbvie, Merck, Janssen, Merck, Novartis, and Pfizer.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflict of interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Psoriasis: epidemiology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.E. Gudjonsson" 1 => "J.T. 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2024 Mayo | 72 | 56 | 128 |
2024 Abril | 78 | 59 | 137 |
2024 Marzo | 62 | 49 | 111 |
2024 Febrero | 51 | 49 | 100 |
2024 Enero | 67 | 63 | 130 |
2023 Diciembre | 73 | 67 | 140 |
2023 Noviembre | 59 | 97 | 156 |
2023 Octubre | 79 | 86 | 165 |
2023 Septiembre | 59 | 87 | 146 |
2023 Agosto | 70 | 64 | 134 |
2023 Julio | 113 | 88 | 201 |
2023 Junio | 103 | 58 | 161 |
2023 Mayo | 107 | 73 | 180 |
2023 Abril | 87 | 62 | 149 |
2023 Marzo | 145 | 50 | 195 |
2023 Febrero | 84 | 71 | 155 |
2023 Enero | 67 | 82 | 149 |
2022 Diciembre | 81 | 89 | 170 |
2022 Noviembre | 88 | 113 | 201 |
2022 Octubre | 73 | 84 | 157 |
2022 Septiembre | 65 | 97 | 162 |
2022 Agosto | 76 | 88 | 164 |
2022 Julio | 62 | 102 | 164 |
2022 Junio | 68 | 91 | 159 |
2022 Mayo | 86 | 126 | 212 |
2022 Abril | 79 | 132 | 211 |
2022 Marzo | 82 | 147 | 229 |
2022 Febrero | 59 | 92 | 151 |
2022 Enero | 89 | 116 | 205 |
2021 Diciembre | 61 | 81 | 142 |
2021 Noviembre | 39 | 120 | 159 |
2021 Octubre | 59 | 148 | 207 |
2021 Septiembre | 54 | 128 | 182 |
2021 Agosto | 49 | 100 | 149 |
2021 Julio | 56 | 115 | 171 |
2021 Junio | 64 | 91 | 155 |
2021 Mayo | 53 | 55 | 108 |
2021 Abril | 141 | 133 | 274 |
2021 Marzo | 111 | 53 | 164 |
2021 Febrero | 70 | 44 | 114 |
2021 Enero | 67 | 45 | 112 |
2020 Diciembre | 67 | 39 | 106 |
2020 Noviembre | 49 | 45 | 94 |
2020 Octubre | 55 | 45 | 100 |
2020 Septiembre | 92 | 31 | 123 |
2020 Agosto | 77 | 54 | 131 |
2020 Julio | 22 | 52 | 74 |
2020 Junio | 30 | 65 | 95 |
2020 Mayo | 45 | 57 | 102 |
2020 Abril | 24 | 31 | 55 |
2020 Marzo | 25 | 43 | 68 |
2020 Febrero | 6 | 32 | 38 |
2020 Enero | 5 | 19 | 24 |
2019 Diciembre | 8 | 31 | 39 |
2019 Noviembre | 4 | 10 | 14 |
2019 Octubre | 0 | 38 | 38 |
2019 Septiembre | 8 | 33 | 41 |
2019 Agosto | 4 | 11 | 15 |
2019 Julio | 7 | 34 | 41 |
2019 Junio | 6 | 45 | 51 |
2019 Mayo | 3 | 140 | 143 |
2019 Abril | 2 | 92 | 94 |
2019 Marzo | 6 | 26 | 32 |
2019 Febrero | 1 | 27 | 28 |
2019 Enero | 1 | 7 | 8 |
2018 Diciembre | 1 | 13 | 14 |
2018 Noviembre | 0 | 6 | 6 |
2018 Octubre | 5 | 2 | 7 |
2018 Septiembre | 2 | 19 | 21 |
2018 Agosto | 0 | 70 | 70 |
2018 Julio | 0 | 40 | 40 |
2018 Junio | 0 | 38 | 38 |
2018 Mayo | 0 | 69 | 69 |
2018 Abril | 1 | 54 | 55 |
2018 Marzo | 4 | 33 | 37 |
2018 Febrero | 26 | 44 | 70 |
2018 Enero | 31 | 41 | 72 |
2017 Diciembre | 25 | 32 | 57 |
2017 Noviembre | 25 | 40 | 65 |
2017 Octubre | 42 | 38 | 80 |
2017 Septiembre | 18 | 35 | 53 |
2017 Agosto | 37 | 45 | 82 |
2017 Julio | 32 | 50 | 82 |
2017 Junio | 32 | 67 | 99 |
2017 Mayo | 29 | 39 | 68 |
2017 Abril | 27 | 74 | 101 |
2017 Marzo | 11 | 77 | 88 |
2017 Febrero | 13 | 46 | 59 |
2017 Enero | 10 | 29 | 39 |
2016 Diciembre | 40 | 29 | 69 |
2016 Noviembre | 14 | 42 | 56 |
2016 Octubre | 19 | 61 | 80 |
2016 Septiembre | 1 | 33 | 34 |
2016 Agosto | 1 | 34 | 35 |
2016 Julio | 15 | 20 | 35 |
2016 Junio | 21 | 8 | 29 |
2016 Mayo | 16 | 8 | 24 |
2016 Abril | 18 | 4 | 22 |
2016 Marzo | 13 | 5 | 18 |
2016 Febrero | 11 | 13 | 24 |
2016 Enero | 16 | 8 | 24 |
2015 Diciembre | 13 | 6 | 19 |
2015 Noviembre | 11 | 9 | 20 |
2015 Octubre | 11 | 12 | 23 |
2015 Septiembre | 1 | 16 | 17 |
2015 Agosto | 0 | 12 | 12 |
2015 Julio | 16 | 2 | 18 |
2015 Junio | 6 | 3 | 9 |
2015 Mayo | 7 | 1 | 8 |
2015 Abril | 8 | 22 | 30 |