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1</a>A and B&#41;&#46; On the perineum&#44; a well-demarcated erosion with a whitish&#44; exudative surface was seen&#44; in addition to painful&#44; oozing&#44; raised erythematous plaques with a verrucous surface on the inguinal folds &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41; and right axilla&#46; The complete skin examination also revealed two small flaccid blisters and an erosion on the back and a superficial erosion on the left lower tarsal conjunctiva&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histological examination of one of the flaccid blisters on the back revealed an intraepidermal blister and suprabasal acantholysis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#44; as well as a dense epidermal and dermal inflammatory infiltrate&#44; rich in neutrophils and eosinophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; Histological examination of the left inguinal vegetating plaque showed identical findings&#44; in addition to pseudoepitheliomatous epidermal hyperplasia &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; Direct immunofluorescence of perilesional skin showed intercellular staining of the epidermis by immunoglobulin &#40;Ig&#41; G deposits &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>D&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A diagnosis of pemphigus vegetans was established&#46; The patient was treated with systemic prednisolone 60<span class="elsevierStyleHsp" style=""></span>mg&#47;d &#40;1 mg&#47;kg&#47;day&#41; with a slow taper&#44; azathioprine 150<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and topical tacrolimus 1<span class="elsevierStyleHsp" style=""></span>mg&#47;g ointment on the lips&#46; The cutaneous and mucosal lesions regressed completely in two months and the patient was kept on azathioprine 150<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Pemphigus vegetans is a rare variant of pemphigus vulgaris&#44; and is thought to represent a reactive response of the skin to the autoimmune insult of pemphigus vulgaris&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It is characterized by flaccid blisters that erupt into erosions and eventually form papillomatous vegetations&#44; especially in intertriginous areas and on the scalp or face&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Involvement of the vermilion border of the lips is a clinical hallmark of oral involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The tongue may show cerebriform-like changes&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The exuberant cobblestone pattern of the lips and oral mucosa associated with marked weight loss in the current case highlights the importance of oral manifestations of pemphigus vegetans&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Suprabasal acantholysis is an early histopathological finding in pemphigus vulgaris and pemphigus vegetans&#46; With time&#44; the lesions acquire a verrucous and hyperkeratotic appearance and biopsy samples from pemphigus vegetans may exhibit epidermal hyperplasia&#44; papillomatosis&#44; and intraepidermal eosinophilic abscesses&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a> Presence of an eosinophilic response&#44; formation of microabscesses&#44; and extent of vesiculation have been proposed as possible histopathological features for distinguishing pemphigus vegetans from pemphigus vulgaris&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Direct immunofluorescence usually shows deposits of IgG and possibly C3 on the surface of keratinocytes&#46; Circulating intercellular antibodies against desmogleins&#44; generally of the IgG class&#44; are detected in most patients by indirect immunofluorescence&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The patient described in this report had elevated titers of both anti-desmoglein 3 &#40;&#62;200<span class="elsevierStyleHsp" style=""></span>RU&#47;mL&#41; and anti-desmoglein 1 antibodies &#40;142<span class="elsevierStyleHsp" style=""></span>RU&#47;mL&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The clinical differential diagnosis should include Hayley&#8211;Hayley disease&#44; IgA pemphigus&#44; and paraneoplastic pemphigus&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> while the histological differential diagnosis should include pemphigus vulgaris&#44; Hayley&#8211;Hayley disease&#44; Darier disease&#44; and Grover disease&#46; Pyodermatitis-pyostomatitis vegetans can clinically and histopathologically resemble pemphigus vegetans and only indirect and direct immunofluorescence studies can accurately distinguish between these two entities&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span>"
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Case and research letter
Cobblestone mouth: An exuberant oral presentation of pemphigus vegetans
Una boca en empedrado: una presentación oral exuberante de pénfigo vegetante
P. Mendes-Bastos
Autor para correspondencia
Pmendesbastos@gmail.com

Corresponding author.
, C. Amaro, C. Fernandes
Department of Dermatology and Venereology, Hospital de Curry Cabral, Centro Hospitalar de Lisboa Central, Portugal
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        "titulo" => "Una boca en empedrado&#58; una presentaci&#243;n oral exuberante de p&#233;nfigo vegetante"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#44; B&#41; Painful white verrucous papules&#44; fissures&#44; erosions&#44; and crusts on the vermillion border of the lips and the hard palate &#40;cobblestone pattern&#41;&#59; sulci and gyri on the dorsum of the tongue &#40;cerebriform tongue&#41;&#46; &#169; Oozing&#44; raised erythematous plaques with a verrucous surface on the inguinal folds&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 45-year-old woman presented with a 4-month history of painful erosions on the oral mucosa and lips&#44; and reported a weight loss of 12<span class="elsevierStyleHsp" style=""></span>kg due to difficulties in eating&#46; Over the past 2 months she had noticed painful exudative erosions on the inguinal folds and perineum as well as erythematous conjunctiva and easy tearing&#46; She had been prescribed several systemic and topical medications&#44; but her condition had progressively worsened&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">On physical examination&#44; the surfaces of the vermillion border of the lips&#44; the gums&#44; and the hard palate had multiple white verrucous papules&#44; fissures&#44; erosions&#44; and crusts forming a cobblestone pattern&#46; The dorsum of the tongue had sulci and gyri that gave it a cerebriform appearance &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A and B&#41;&#46; On the perineum&#44; a well-demarcated erosion with a whitish&#44; exudative surface was seen&#44; in addition to painful&#44; oozing&#44; raised erythematous plaques with a verrucous surface on the inguinal folds &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>C&#41; and right axilla&#46; The complete skin examination also revealed two small flaccid blisters and an erosion on the back and a superficial erosion on the left lower tarsal conjunctiva&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Histological examination of one of the flaccid blisters on the back revealed an intraepidermal blister and suprabasal acantholysis &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A&#41;&#44; as well as a dense epidermal and dermal inflammatory infiltrate&#44; rich in neutrophils and eosinophils &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>B&#41;&#46; Histological examination of the left inguinal vegetating plaque showed identical findings&#44; in addition to pseudoepitheliomatous epidermal hyperplasia &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41;&#46; Direct immunofluorescence of perilesional skin showed intercellular staining of the epidermis by immunoglobulin &#40;Ig&#41; G deposits &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>D&#41;&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">A diagnosis of pemphigus vegetans was established&#46; The patient was treated with systemic prednisolone 60<span class="elsevierStyleHsp" style=""></span>mg&#47;d &#40;1 mg&#47;kg&#47;day&#41; with a slow taper&#44; azathioprine 150<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#44; and topical tacrolimus 1<span class="elsevierStyleHsp" style=""></span>mg&#47;g ointment on the lips&#46; The cutaneous and mucosal lesions regressed completely in two months and the patient was kept on azathioprine 150<span class="elsevierStyleHsp" style=""></span>mg&#47;d&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Pemphigus vegetans is a rare variant of pemphigus vulgaris&#44; and is thought to represent a reactive response of the skin to the autoimmune insult of pemphigus vulgaris&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It is characterized by flaccid blisters that erupt into erosions and eventually form papillomatous vegetations&#44; especially in intertriginous areas and on the scalp or face&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Involvement of the vermilion border of the lips is a clinical hallmark of oral involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The tongue may show cerebriform-like changes&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The exuberant cobblestone pattern of the lips and oral mucosa associated with marked weight loss in the current case highlights the importance of oral manifestations of pemphigus vegetans&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Suprabasal acantholysis is an early histopathological finding in pemphigus vulgaris and pemphigus vegetans&#46; With time&#44; the lesions acquire a verrucous and hyperkeratotic appearance and biopsy samples from pemphigus vegetans may exhibit epidermal hyperplasia&#44; papillomatosis&#44; and intraepidermal eosinophilic abscesses&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a> Presence of an eosinophilic response&#44; formation of microabscesses&#44; and extent of vesiculation have been proposed as possible histopathological features for distinguishing pemphigus vegetans from pemphigus vulgaris&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Direct immunofluorescence usually shows deposits of IgG and possibly C3 on the surface of keratinocytes&#46; Circulating intercellular antibodies against desmogleins&#44; generally of the IgG class&#44; are detected in most patients by indirect immunofluorescence&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> The patient described in this report had elevated titers of both anti-desmoglein 3 &#40;&#62;200<span class="elsevierStyleHsp" style=""></span>RU&#47;mL&#41; and anti-desmoglein 1 antibodies &#40;142<span class="elsevierStyleHsp" style=""></span>RU&#47;mL&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The clinical differential diagnosis should include Hayley&#8211;Hayley disease&#44; IgA pemphigus&#44; and paraneoplastic pemphigus&#44;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> while the histological differential diagnosis should include pemphigus vulgaris&#44; Hayley&#8211;Hayley disease&#44; Darier disease&#44; and Grover disease&#46; Pyodermatitis-pyostomatitis vegetans can clinically and histopathologically resemble pemphigus vegetans and only indirect and direct immunofluorescence studies can accurately distinguish between these two entities&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span>"
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