Letter to the Editor
Comment on: Late-Onset Acquired Generalized Lipodystrophy with Muscle Involvement
Comentario a: Lipodistrofia generalizada adquirida de inicio tardío y con afectación muscular
Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India
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Sahoo, S.K. Kamalnathan" "autores" => array:2 [ 0 => array:4 [ "nombre" => "J.P." "apellidos" => "Sahoo" "email" => array:1 [ 0 => "jppgi@yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "S.K." "apellidos" => "Kamalnathan" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Endocrinology, Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), India" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Comentario a: Lipodistrofia generalizada adquirida de inicio tardío y con afectación muscular" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">After reading the interesting case report by Llamas-Velasco et al.,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> we would like to add a comment.</p><p id="par0010" class="elsevierStylePara elsevierViewall">The authors described a case of acquired generalized lipodystrophy (AGL) with muscle involvement. The index patient with AGL had normal muscle strength and biopsy report. The evidence of muscle involvement were the presence of high creatine kinase levels and a myopathic pattern on electromyography.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Furthermore, the patient had hypothyroidism with dyslipidemia for which she was receiving levothyroxine and fenofibrate. The authors do not mention neither the dose for these 2 drugs nor the effectiveness of the levothyroxine supplementation (the results of serum thyroid stimulating hormone level). High serum creatine kinase levels and a myopathic pattern on electromyography have been reported in patients with hypothyroidism and also in such patients when they are receiving hypolipidemic therapy (fenofibrate) even in the absence of clinical evidence of muscular involvement.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,3</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:3 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Late-onset acquired generalized lipodystrophy with muscle involvement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Llamas-Velasco" 1 => "E. Daudén" 2 => "G. Martínez-Peñas" 3 => "A. García-Diez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ad.2011.08.006" "Revista" => array:6 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2012" "volumen" => "103" "paginaInicial" => "729" "paginaFinal" => "732" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22188950" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neuromuscular findings in thyroid dysfunction: a prospective clinical and electrodiagnostic study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R.F. Duyff" 1 => "J. Van den Bosch" 2 => "D.M. Laman" 3 => "B.J. van Loon" 4 => "W.H. Linssen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Neurol Neurosurg Psychiatry" "fecha" => "2000" "volumen" => "68" "paginaInicial" => "750" "paginaFinal" => "755" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10811699" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rhabdomyolysis associated with fibrate therapy: review of 76 published cases and a new case report" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Wu" 1 => "Y. Song" 2 => "H. Li" 3 => "J. Chen" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00228-009-0723-7" "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Pharmacol" "fecha" => "2009" "volumen" => "65" "paginaInicial" => "1169" "paginaFinal" => "1174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19756555" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/00017310/0000010400000007/v1_201308270831/S0001731013001518/v1_201308270831/en/main.assets" "Apartado" => array:4 [ "identificador" => "6182" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Cartas al Director" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00017310/0000010400000007/v1_201308270831/S0001731013001518/v1_201308270831/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731013001518?idApp=UINPBA000044" ]
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