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      "titulo" => "Ustekinumab en la artritis psoriásica y la enfermedad de Crohn"
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        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Ustekinumab es un anticuerpo monoclonal humano anti interleucina 12 y 23&#46; En los ensayos cl&#237;nicos pivotales qued&#243; probada su eficacia y seguridad a nivel de la psoriasis en placas moderada-severa&#46; Asimismo&#44; cabe destacar que en dichos ensayos se utiliz&#243; tambi&#233;n el &#237;ndice de severidad de psoriasis ungueal para evaluar su efectividad en la psoriasis ungueal&#46; Los pacientes tratados en el ensayo PHOENIX 1 &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>545&#41; mostraron que las lesiones ungueales mejoraron de forma progresiva hasta la semana 52&#44; si bien en la semana 12&#44; despu&#233;s de dos dosis de ustekinumab&#44; la mediana de la mejor&#237;a de las puntuaciones NASPI respecto al valor basal fue del 25&#37;&#44; llegando al 50&#37; en la semana 24&#46; Por otro lado&#44; desde su reciente incorporaci&#243;n&#44; ustekinumab tambi&#233;n se ha empleado en otras formas de psoriasis &#40;pustulosa&#44; palmo-plantar&#44; eritrod&#233;rmica&#41; y tambi&#233;n en otras enfermedades &#40;pitiriasis rubra pilaris&#44; hidradenitis supurativa y dermatitis at&#243;pica&#41;&#46;</p>"
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