Mecanismo de acción de ustekinumab y su relevancia en la patogénesis de la psoriasis. Impacto en el sistema inmune
Mechanism of Action of Ustekinumab and its Relevance in the Pathogenesisof Psoriasis. Impact on the Immune System
J.M. Carrascosa
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Servei de Dermatologia. Hospital Universitari Germans Trias i Pujol. Universitat Autònoma de Barcelona. Badalona.Barcelona. España
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Hospital Universitari Germans Trias i Pujol. Universitat Autònoma de Barcelona. Badalona.Barcelona. España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Mechanism of Action of Ustekinumab and its Relevance in the Pathogenesisof Psoriasis. Impact on the Immune System" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec85081" "palabras" => array:4 [ 0 => "Ustekinumab" 1 => "Th17" 2 => "IL-12/23" 3 => "Psoriasis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec85082" "palabras" => array:3 [ 0 => "Ustekinumab: TH17" 1 => "IL-12/23" 2 => "Psoriasis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La psoriasis es un proceso inflamatorio crónico en el que participan de forma conjunta la inmunidad innata y la adquirida. Los queratinocitos serán la primera diana a través de la liberación de péptidos antimicrobianos tales como la catelicidina LL37, que a través de la formación de agregados con el ADN del individuo permite la activación de diversas poblaciones de células dendríticas. En este modelo, algunas poblaciones linfocitarias no descritas previamente en la psoriasis, como las células dendríticas mieloides CD11<span class="elsevierStyleSup">+</span> y los linfocitos Th17, desempeñan un papel fundamental en la patogenia de las lesiones. Asimismo, la vía de las interleucinas 12/23, que permite la diferenciación y proliferación clonal de las subpoblaciones linfocitarias Th1 y Th17, implicadas de forma prioritaria en la génesis de la placa psoriásica, representa un punto clave no sólo como nexo entre la inmunidad innata y la adquirida, sino también como diana terapéutica, demostrada ya en la práctica clínica por ustekinumab.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Psoriasis is a chronic inflammatory disorder mediated by elements of both the innate and the adaptive immune system. The first cells involved in the inflammatory response are keratinocytes. These release antimicrobial peptides, such as cathelicidin LL37, which subsequently form complexes with self DNA, enabling the activation of different dendritic cell populations. It is now considered that lymphocyte subsets that have only recently been implicated in psoriasis, such as CD11<span class="elsevierStyleSup">+</span> dendritic cells and T<span class="elsevierStyleInf">H</span>17 cells, play a key role in the pathogenesis of psoriatic lesions. The interleukin 12/23 pathway enables the differentiation and clonal expansion of T<span class="elsevierStyleInf">H</span>1 and T<span class="elsevierStyleInf">H</span>17 cells, 2 types of helper T cells that have an essential role in the formation of psoriatic plaques. This pathway not only acts as a bridge between the innate and adaptive immune system, but is also an important therapeutic target, as has been demonstrated clinically with ustekinumab.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:36 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Noviembre | 11 | 7 | 18 |
| 2024 Octubre | 106 | 26 | 132 |
| 2024 Septiembre | 103 | 27 | 130 |
| 2024 Agosto | 87 | 47 | 134 |
| 2024 Julio | 61 | 26 | 87 |
| 2024 Junio | 87 | 35 | 122 |
| 2024 Mayo | 56 | 33 | 89 |
| 2024 Abril | 71 | 26 | 97 |
| 2024 Marzo | 60 | 33 | 93 |
| 2024 Febrero | 50 | 27 | 77 |
| 2024 Enero | 48 | 31 | 79 |
| 2023 Diciembre | 45 | 18 | 63 |
| 2023 Noviembre | 69 | 33 | 102 |
| 2023 Octubre | 58 | 17 | 75 |
| 2023 Septiembre | 53 | 32 | 85 |
| 2023 Agosto | 43 | 23 | 66 |
| 2023 Julio | 58 | 72 | 130 |
| 2023 Junio | 34 | 57 | 91 |
| 2023 Mayo | 7 | 15 | 22 |
| 2023 Abril | 41 | 23 | 64 |
| 2023 Marzo | 40 | 27 | 67 |
| 2023 Febrero | 42 | 21 | 63 |
| 2023 Enero | 53 | 35 | 88 |
| 2022 Diciembre | 46 | 23 | 69 |
| 2022 Noviembre | 39 | 31 | 70 |
| 2022 Octubre | 55 | 35 | 90 |
| 2022 Septiembre | 36 | 42 | 78 |
| 2022 Agosto | 49 | 41 | 90 |
| 2022 Julio | 33 | 42 | 75 |
| 2022 Junio | 34 | 34 | 68 |
| 2022 Mayo | 37 | 38 | 75 |
| 2022 Abril | 32 | 35 | 67 |
| 2022 Marzo | 36 | 50 | 86 |
| 2022 Febrero | 25 | 25 | 50 |
| 2022 Enero | 44 | 40 | 84 |
| 2021 Diciembre | 62 | 47 | 109 |
| 2021 Noviembre | 62 | 43 | 105 |
| 2021 Octubre | 77 | 58 | 135 |
| 2021 Septiembre | 68 | 38 | 106 |
| 2021 Agosto | 49 | 34 | 83 |
| 2021 Julio | 37 | 42 | 79 |
| 2021 Junio | 37 | 33 | 70 |
| 2021 Mayo | 27 | 57 | 84 |
| 2021 Abril | 96 | 66 | 162 |
| 2021 Marzo | 57 | 29 | 86 |
| 2021 Febrero | 29 | 34 | 63 |
| 2021 Enero | 30 | 23 | 53 |
| 2020 Diciembre | 45 | 25 | 70 |
| 2020 Noviembre | 20 | 15 | 35 |
| 2020 Octubre | 27 | 20 | 47 |
| 2020 Septiembre | 26 | 14 | 40 |
| 2020 Agosto | 32 | 18 | 50 |
| 2020 Julio | 29 | 13 | 42 |
| 2020 Junio | 29 | 26 | 55 |
| 2020 Mayo | 28 | 42 | 70 |
| 2020 Abril | 27 | 14 | 41 |
| 2020 Marzo | 24 | 23 | 47 |
| 2020 Febrero | 1 | 5 | 6 |
| 2020 Enero | 0 | 3 | 3 |
| 2019 Diciembre | 0 | 1 | 1 |
| 2019 Noviembre | 0 | 5 | 5 |
| 2019 Octubre | 0 | 9 | 9 |
| 2019 Septiembre | 0 | 10 | 10 |
| 2019 Agosto | 0 | 6 | 6 |
| 2019 Julio | 0 | 25 | 25 |
| 2019 Junio | 0 | 46 | 46 |
| 2019 Mayo | 1 | 148 | 149 |
| 2019 Abril | 0 | 46 | 46 |
| 2019 Marzo | 0 | 9 | 9 |
| 2019 Febrero | 0 | 10 | 10 |
| 2019 Enero | 0 | 7 | 7 |
| 2018 Diciembre | 1 | 10 | 11 |
| 2018 Noviembre | 1 | 29 | 30 |
| 2018 Octubre | 0 | 1 | 1 |
| 2018 Septiembre | 0 | 8 | 8 |
| 2018 Agosto | 0 | 30 | 30 |
| 2018 Julio | 0 | 13 | 13 |
| 2018 Junio | 0 | 6 | 6 |
| 2018 Mayo | 0 | 7 | 7 |
| 2018 Abril | 0 | 4 | 4 |
| 2018 Marzo | 2 | 13 | 15 |
| 2018 Febrero | 22 | 11 | 33 |
| 2018 Enero | 20 | 8 | 28 |
| 2017 Diciembre | 28 | 14 | 42 |
| 2017 Noviembre | 30 | 12 | 42 |
| 2017 Octubre | 48 | 11 | 59 |
| 2017 Septiembre | 41 | 17 | 58 |
| 2017 Agosto | 33 | 19 | 52 |
| 2017 Julio | 32 | 6 | 38 |
| 2017 Junio | 33 | 35 | 68 |
| 2017 Mayo | 32 | 14 | 46 |
| 2017 Abril | 36 | 37 | 73 |
| 2017 Marzo | 38 | 23 | 61 |
| 2017 Febrero | 39 | 18 | 57 |
| 2017 Enero | 29 | 21 | 50 |
| 2016 Diciembre | 36 | 15 | 51 |
| 2016 Noviembre | 45 | 19 | 64 |
| 2016 Octubre | 66 | 35 | 101 |
| 2016 Septiembre | 85 | 52 | 137 |
| 2016 Agosto | 51 | 24 | 75 |
| 2016 Julio | 30 | 20 | 50 |
| 2016 Junio | 4 | 16 | 20 |
| 2016 Mayo | 0 | 16 | 16 |
| 2016 Abril | 0 | 1 | 1 |
| 2016 Marzo | 5 | 3 | 8 |
| 2016 Febrero | 0 | 5 | 5 |
| 2016 Enero | 0 | 17 | 17 |
| 2015 Diciembre | 3 | 19 | 22 |
| 2015 Noviembre | 3 | 28 | 31 |
| 2015 Octubre | 1 | 18 | 19 |
| 2015 Septiembre | 3 | 12 | 15 |
| 2015 Agosto | 2 | 8 | 10 |
| 2015 Julio | 20 | 2 | 22 |
| 2015 Junio | 28 | 12 | 40 |
| 2015 Mayo | 49 | 29 | 78 |
| 2015 Abril | 38 | 12 | 50 |
| 2015 Marzo | 44 | 15 | 59 |
| 2015 Febrero | 36 | 15 | 51 |
| 2015 Enero | 31 | 17 | 48 |
| 2014 Diciembre | 26 | 12 | 38 |
| 2014 Noviembre | 31 | 18 | 49 |
| 2014 Octubre | 36 | 23 | 59 |
| 2014 Septiembre | 0 | 1 | 1 |
| 2014 Agosto | 2 | 0 | 2 |
| 2014 Julio | 1 | 0 | 1 |
| 2014 Mayo | 2 | 0 | 2 |
| 2014 Abril | 1 | 0 | 1 |
| 2014 Febrero | 0 | 1 | 1 |
| 2014 Enero | 0 | 1 | 1 |
| 2013 Octubre | 1 | 0 | 1 |
| 2013 Septiembre | 1 | 2 | 3 |
| 2013 Junio | 1 | 2 | 3 |
| 2013 Mayo | 1 | 1 | 2 |
| 2013 Marzo | 1 | 1 | 2 |
| 2013 Febrero | 0 | 1 | 1 |
| 2013 Enero | 0 | 1 | 1 |
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