Estadísticas

 array:22 [
  "pii" => "S0001731012700029"
  "issn" => "00017310"
  "doi" => "10.1016/S0001-7310(12)70002-9"
  "estado" => "S300"
  "fechaPublicacion" => "2012-10-01"
  "aid" => "70002"
  "copyright" => "Academia Española de Dermatología y Venereología"
  "copyrightAnyo" => "2012"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Actas Dermosifiliogr. 2012;103 Supl 2:1-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1784
    "formatos" => array:2 [
      "HTML" => 1012
      "PDF" => 772
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0001731012700030"
    "issn" => "00017310"
    "doi" => "10.1016/S0001-7310(12)70003-0"
    "estado" => "S300"
    "fechaPublicacion" => "2012-10-01"
    "aid" => "70003"
    "copyright" => "Academia Española de Dermatología y Venereología"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Actas Dermosifiliogr. 2012;103 Supl 2:7-15"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2317
      "formatos" => array:2 [
        "HTML" => 1150
        "PDF" => 1167
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Mecanismo de acción de ustekinumab y su relevancia en la patogénesis de la psoriasis. Impacto en el sistema inmune"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "7"
          "paginaFinal" => "15"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Mechanism of Action of Ustekinumab and its Relevance in the Pathogenesisof Psoriasis. Impact on the Immune System"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J.M. Carrascosa"
          "autores" => array:1 [
            0 => array:2 [
              "nombre" => "J.M."
              "apellidos" => "Carrascosa"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012700030?idApp=UINPBA000044"
    "url" => "/00017310/00000103000000S2/v1_201304241722/S0001731012700030/v1_201304241722/es/main.assets"
  ]
  "es" => array:12 [
    "idiomaDefecto" => true
    "titulo" => "Ustekinumab. Introducción. Estructura química. Farmacocinética e inmunogenicidad"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "1"
        "paginaFinal" => "6"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "E. Daudén"
        "autores" => array:1 [
          0 => array:3 [
            "nombre" => "E."
            "apellidos" => "Daudén"
            "email" => array:1 [
              0 => "estebandauden@medynet.com"
            ]
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Servicio de Dermatología. Hospital Universitario de la Princesa. Madrid. España"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Ustekinumab. Introduction. Chemical Structure. Pharmacokinetics and immunogenicity"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "PalabrasClave" => array:2 [
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec85078"
          "palabras" => array:7 [
            0 => "Ustekinumab"
            1 => "Interleucina 12"
            2 => "Interleucina 23"
            3 => "Terapia biológica"
            4 => "Psoriasis"
            5 => "Enfermedad de Crohn"
            6 => "Farmacocinética"
          ]
        ]
      ]
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec85079"
          "palabras" => array:7 [
            0 => "Ustekinumab"
            1 => "Interleukin 12"
            2 => "Interleukin 23"
            3 => "Biologic therapy"
            4 => "Psoriasis"
            5 => "Crohn disease"
            6 => "Pharmacokinetics"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presenta el contenido de esta monograf&#237;a sobre el conocimiento actual del ustekinumab&#44; especialmente en relaci&#243;n con la psoriasis pero tambi&#233;n en otras indicaciones&#46; Se describe su estructura qu&#237;mica&#44; el proceso de obtenci&#243;n&#44; se analizan los datos farmacocin&#233;ticos &#40;absorci&#243;n&#44; distribuci&#243;n&#44; metabolismo&#44; eliminaci&#243;n&#41;&#44; sus interacciones y se revisa la informaci&#243;n relativa a la inmunogenicidad de la mol&#233;cula&#46;</p>"
      ]
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">This chapter opens with a brief introduction to the content of this supplement summarizing our current knowledge of ustekinumab with a particular focus on psoriasis but also including other indications&#46; In addition to describing the chemical structure and the process used to produce this biologic agent&#44; the chapter analyzes the drug&#39;s pharmacokinetic profile &#40;absorption&#44; distribution&#44; metabolism&#44; and excretion&#41; and interactions with other drugs&#46; A review of the information relating to the immunogenicity of the molecule is also included&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:24 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "F&#46;O&#46; Nestle"
                            1 => "D&#46;H&#46; Kaplan"
                            2 => "J&#46; Barker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMra0804595"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2009"
                        "volumen" => "361"
                        "paginaInicial" => "496"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19641206"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "National Psoriasis Foundation National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Kimball"
                            1 => "D&#46; Gladman"
                            2 => "J&#46;M&#46; Gelfand"
                            3 => "K&#46; Gordon"
                            4 => "E&#46;J&#46; Horn"
                            5 => "N&#46;J&#46; Korman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2008.01.006"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2008"
                        "volumen" => "58"
                        "paginaInicial" => "1031"
                        "paginaFinal" => "1042"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18313171"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Psoriasis is common&#44; carries a substantial burden even when not extensive&#44; and is associated with widespread treatment dissatisfaction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46;S&#46; Stern"
                            1 => "T&#46; Nijsten"
                            2 => "S&#46;R&#46; Feldman"
                            3 => "D&#46;J&#46; Margolis"
                            4 => "T&#46; Rolstad"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1046/j.1087-0024.2003.09102.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Investig Dermatol Symp Proc"
                        "fecha" => "2004"
                        "volumen" => "9"
                        "paginaInicial" => "136"
                        "paginaFinal" => "139"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15083780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:1 [
                  "referenciaCompleta" => "Ustekinumab SPC&#46; &#40;Acceso en Ago 2011&#41;&#46; Disponible en&#58; <a class="elsevierStyleInterRef" href="http://www.emea.europe.eu/humandocs/PDFs/EPAR/stelara/H-958-PI-en.pdf">http&#58;&#47;&#47;www&#46;emea&#46;europe&#46;eu&#47;humandocs&#47;PDFs&#47;EPAR&#47;stelara&#47;H-958-PI-en&#46;pdf</a>&#41;&#46;"
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A randomized trial of ustekinumab&#44; a human interleukin-12&#47;23 monoclonal antibody&#44; in patients with moderate-to-severe Crohn&#39;s disease"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Ustekinumab Crohn&#39;s Disease Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "W&#46;J&#46; Sandborn"
                            1 => "B&#46;G&#46; Feagan"
                            2 => "R&#46;N&#46; Fedorak"
                            3 => "E&#46; Scherl"
                            4 => "M&#46;R&#46; Fleisher"
                            5 => "S&#46; Katz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1053/j.gastro.2008.07.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Gastroenterology"
                        "fecha" => "2008"
                        "volumen" => "135"
                        "paginaInicial" => "1130"
                        "paginaFinal" => "1141"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18706417"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ustekinumab&#44; a human interleukin-12&#47;23 monoclonal antibody&#44; for psoriatic arthritis&#58; randomized&#44; double-blind&#44; placebo-controlled&#44; crossover trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Gottlieb"
                            1 => "A&#46; Menter"
                            2 => "A&#46; Mendelsohn"
                            3 => "Y&#46;K&#46; Shen"
                            4 => "S&#46; Li"
                            5 => "C&#46; Guzzo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(09)60140-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2009"
                        "volumen" => "373"
                        "paginaInicial" => "633"
                        "paginaFinal" => "640"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19217154"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A phase I trial of an interleukin-12&#47;23 monoclonal antibody in relapsing multiple sclerosis"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Multiple Sclerosis Investigators"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "L&#46;H&#46; Kasper"
                            1 => "D&#46; Everitt"
                            2 => "T&#46;P&#46; Leist"
                            3 => "K&#46;A&#46; Ryan"
                            4 => "M&#46;A&#46; Mascelli"
                            5 => "K&#46; Johnson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1185/030079906X120931"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Res Opin"
                        "fecha" => "2006"
                        "volumen" => "22"
                        "paginaInicial" => "1671"
                        "paginaFinal" => "1678"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16968570"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Repeated subcutaneous injections of IL12&#47;23 p40 neutralising antibody&#44; ustekinumab&#44; in patients with relapsing-remitting multiple sclerosis&#58; a phase II&#44; double-blind&#44; placebo-controlled&#44; randomized&#44; dose-ranging study"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "Ustekinumab MS Investigators"
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46;M&#46; Segal"
                            1 => "C&#46;S&#46; Constantinescu"
                            2 => "A&#46; Raychaudhuri"
                            3 => "L&#46; Kim"
                            4 => "R&#46; Fidelus-Gort"
                            5 => "L&#46;H&#46; Kasper"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S1474-4422(08)70173-X"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet Neurol"
                        "fecha" => "2008"
                        "volumen" => "7"
                        "paginaInicial" => "796"
                        "paginaFinal" => "804"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18703004"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "High-avidity human IgG kappa monoclonal antibodies from a novel strain of minilocus transgenic mice"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D&#46;M&#46; Fishwild"
                            1 => "S&#46;L&#46; O&#8217;Donnell"
                            2 => "T&#46; Bengoechea"
                            3 => "D&#46;V&#46; Hudson"
                            4 => "F&#46; Harding"
                            5 => "S&#46;L&#46; Bernhard"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nbt0796-845"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Biotechnol"
                        "fecha" => "1996"
                        "volumen" => "14"
                        "paginaInicial" => "845"
                        "paginaFinal" => "851"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9631008"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Development of the IL-12&#47;23 antagonist ustekinumab in psoriasis&#58; past&#44; present&#44; and future perspectives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N&#46; Yeilding"
                            1 => "P&#46; Szapary"
                            2 => "C&#46; Brodmerkel"
                            3 => "J&#46; Benson"
                            4 => "M&#46; Plotnick"
                            5 => "H&#46; Zhou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1749-6632.2011.05963.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann N Y Acad Sci"
                        "fecha" => "2011"
                        "volumen" => "1222"
                        "paginaInicial" => "30"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21434940"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Therapeutic targeting of the IL-12&#47;23 pathways&#58; generation and characterization of ustekinumab"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J&#46;M&#46; Benson"
                            1 => "C&#46;W&#46; Sachs"
                            2 => "G&#46; Treacy"
                            3 => "H&#46; Zhou"
                            4 => "C&#46;E&#46; Pendley"
                            5 => "C&#46;M&#46; Brodmerkel"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1038/nbt.1903"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nat Biotechnol"
                        "fecha" => "2011"
                        "volumen" => "29"
                        "paginaInicial" => "615"
                        "paginaFinal" => "624"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21747388"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population pharmacokinetic modeling of ustekinumab&#44; a human monoclonal antibody targeting IL-12&#47;23p40&#44; in patients with moderate to severe plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Zhu"
                            1 => "C&#46; Hu"
                            2 => "M&#46; Lu"
                            3 => "S&#46; Liao"
                            4 => "J&#46;C&#46; Marini"
                            5 => "J&#46; Yohrling"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0091270008329556"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol"
                        "fecha" => "2009"
                        "volumen" => "49"
                        "paginaInicial" => "162"
                        "paginaFinal" => "175"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19179295"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population pharmacokinetics of ustekinumab in patients with active psoriatic arthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Y&#46;W&#46; Zhu"
                            1 => "A&#46; Mendelsohn"
                            2 => "C&#46; Pendley"
                            3 => "H&#46;M&#46; Davis"
                            4 => "H&#46; Zhou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Clin Pharmacol Ther"
                        "fecha" => "2010"
                        "volumen" => "48"
                        "paginaInicial" => "830"
                        "paginaFinal" => "846"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21084039"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ustekinumab for the treatment of plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Reich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Expert Rev Dermatol"
                        "fecha" => "2009"
                        "volumen" => "4"
                        "paginaInicial" => "443"
                        "paginaFinal" => "453"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A phase 1&#44; double-blind&#44; placebo-controlled study evaluating single subcutaneous administrations of a human interleukin-12&#47;23 monoclonal antibody in subjects with plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Gottlieb"
                            1 => "K&#46;D&#46; Cooper"
                            2 => "T&#46;S&#46; McCormick"
                            3 => "E&#46; Toichi"
                            4 => "D&#46;E&#46; Everitt"
                            5 => "B&#46; Frederick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1185/030079907X182112"
                      "Revista" => array:6 [
                        "tituloSerie" => "Curr Med Res Opin"
                        "fecha" => "2007"
                        "volumen" => "23"
                        "paginaInicial" => "1081"
                        "paginaFinal" => "1092"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17519075"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transcytosis and catabolism of antibody"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46; Ghetie"
                            1 => "E&#46;S&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1385/IR:25:2:097"
                      "Revista" => array:6 [
                        "tituloSerie" => "Immunol Res"
                        "fecha" => "2002"
                        "volumen" => "25"
                        "paginaInicial" => "97"
                        "paginaFinal" => "113"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11999172"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Impact of weight on the efficacy and safety of ustekinumab in patients with moderate to severe psoriasis&#58; rationale for dosing recommendations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Lebwohl"
                            1 => "N&#46; Yeilding"
                            2 => "P&#46; Szapary"
                            3 => "Y&#46; Wang"
                            4 => "S&#46; Li"
                            5 => "Y&#46; Zhu"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jaad.2009.11.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Am Acad Dermatol"
                        "fecha" => "2010"
                        "volumen" => "63"
                        "paginaInicial" => "571"
                        "paginaFinal" => "579"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20599293"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population-based assessments of clinical drug-drug interactions&#58; qualitative indices or quantitative measures&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46; Zhou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/0091270006294278"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Pharmacol"
                        "fecha" => "2006"
                        "volumen" => "46"
                        "paginaInicial" => "1268"
                        "paginaFinal" => "1289"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17050792"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk-based strategy for the assessment of pharmacokinetic drug-drug interactions for therapeutic monoclonal antibodies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "H&#46; Zhou"
                            1 => "H&#46;M&#46; Davis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.drudis.2009.05.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Drug Discov Today"
                        "fecha" => "2009"
                        "volumen" => "14"
                        "paginaInicial" => "891"
                        "paginaFinal" => "898"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19520183"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of ustekinumab&#44; a human interleukin-12&#47;23 monoclonal antibody&#44; in patients with psoriasis&#58; 76-week results from a randomized&#44; double-blind&#44; placebo-controlled trial &#40;PHOENIX 1&#41;"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "PHOENIX 1 study investigators"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;L&#46; Leonardi"
                            1 => "A&#46;B&#46; Kimball"
                            2 => "K&#46;A&#46; Papp"
                            3 => "N&#46; Yeilding"
                            4 => "C&#46; Guzzo"
                            5 => "Y&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(08)60725-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2008"
                        "volumen" => "371"
                        "paginaInicial" => "1665"
                        "paginaFinal" => "1674"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18486739"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Efficacy and safety of ustekinumab&#44; a human interleukin-12&#47;23 monoclonal antibody&#44; in patients with psoriasis&#58; 52-week results from a randomized&#44; double-blind&#44; placebo-controlled trial &#40;PHOENIX 2&#41;"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "PHOENIX 2 study investigators"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "K&#46;A&#46; Papp"
                            1 => "R&#46;G&#46; Langley"
                            2 => "M&#46; Lebwohl"
                            3 => "G&#46;G&#46; Krueger"
                            4 => "P&#46; Szapary"
                            5 => "N&#46; Yeilding"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0140-6736(08)60726-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "2008"
                        "volumen" => "371"
                        "paginaInicial" => "1675"
                        "paginaFinal" => "1684"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18486740"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "ACCEPT Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;E&#46; Griffiths"
                            1 => "B&#46;E&#46; Strober"
                            2 => "P&#46; Van de Kerkhof"
                            3 => "V&#46; Ho"
                            4 => "R&#46; Fidelus-Gort"
                            5 => "N&#46; Yeilding"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa0810652"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2010"
                        "volumen" => "362"
                        "paginaInicial" => "118"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20071701"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A phase I study evaluating the safety&#44; pharmacokinetics&#44; and clinical response of a human IL-12 p40 antibody in subjects with plaque psoriasis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "C&#46;L&#46; Kauffman"
                            1 => "N&#46; Aria"
                            2 => "E&#46; Toichi"
                            3 => "T&#46;S&#46; McCormick"
                            4 => "K&#46;D&#46; Cooper"
                            5 => "A&#46;B&#46; Gottlieb"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.0022-202X.2004.23448.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2004"
                        "volumen" => "123"
                        "paginaInicial" => "1037"
                        "paginaFinal" => "1044"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15610511"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A human interleukin-12&#47;23 monoclonal antibody for the treatment of psoriasis"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "CNTO 1275 Psoriasis Study Group"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;G&#46; Krueger"
                            1 => "R&#46;G&#46; Langley"
                            2 => "C&#46; Leonardi"
                            3 => "N&#46; Yeilding"
                            4 => "C&#46; Guzzo"
                            5 => "Y&#46; Wang"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJMoa062382"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "2007"
                        "volumen" => "356"
                        "paginaInicial" => "580"
                        "paginaFinal" => "592"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17287478"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/00017310/00000103000000S2/v1_201304241722/S0001731012700029/v1_201304241722/es/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/00017310/00000103000000S2/v1_201304241722/S0001731012700029/v1_201304241722/es/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012700029?idApp=UINPBA000044"
]