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resident in Spain for more than 5 years&#44; presented with a very long history of dystrophic toenails&#46; She had been diagnosed with onychomycosis caused by <span class="elsevierStyleItalic">Aspergillus</span> spp&#46; and treated with several topical antifungal agents with no improvement&#46; On examination&#44; she presented thickened&#44; opaque nail plates with a yellow or brown discoloration and cracked surfaces &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Significant scaling was observed around the nails&#44; between the toes&#44; and on the soles&#46; Her fingernails were unaffected&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Nail clippings and periungual skin swabs confirmed <span class="elsevierStyleItalic">S&#46; dimidiatum</span> on microscopy and cycloheximide-free agar mycological culture&#46; No dermatophytes were found&#44; but colonies of <span class="elsevierStyleItalic">Aspergillus</span> spp&#46; 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and protected from light for 3<span class="elsevierStyleHsp" style=""></span>h&#44; as previously described&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> When the dressing was removed&#44; the nails were cleaned with 70&#37; ethanol and irradiated using a 635<span class="elsevierStyleHsp" style=""></span>nm light emitting diode lamp &#40;Aktilite<span class="elsevierStyleSup">&#174;</span>&#44; 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#46; No side effects were observed during or after treatment&#46; The same procedure was repeated 1 week later and every 2 weeks thereafter&#46; Microbiological cultures became negative after the third session&#46; A total of 4 sessions were administered&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical improvement was noticed after 2 months&#46; Four months later&#44; the patient was clinically and microbiologically cured according to the standard criteria &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; After 6 months of follow-up&#44; cultures became positive in 1 of the 2 nails&#44; but the nails remained clinically cured and there was no evidence under microscopy of nail penetration&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Infection with <span class="elsevierStyleItalic">S&#46; dimidiatum</span> accounts for under 1&#37; of cases of onychomycosis and seldom responds to amorolfine or terbinafine&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Recently&#44; an intermittent posaconazole regimen has been proposed to treat superficial <span class="elsevierStyleItalic">S&#46; dimidiatum</span> infection&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; all of these drugs are expensive and can have significant adverse effects&#46; Moreover&#44; there is little or no evidence of their effectiveness in this setting&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Fewer than 50 cases of onychomycosis treated with aminolevulinic acid or methyl-aminolevulinate PDT have been reported and most of these were caused by dermatophytes&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;8</span></a> Our group obtained good results with methyl-aminolevulinate&#44; using one protocol based on the one previously reported by Piraccini et al&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> In localized mycosis&#44; the therapeutic effect of PDT is twofold&#58; the treatment directly kills the fungus and also reinforces the fungicidal effect by stimulating host immune cells&#44; especially neutrophils&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although in previous cases<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> we have successfully used a protocol with a 2-week interval between sessions&#44; in this case we made some modifications&#46; We reduced the interval between the first and second sessions to 1 week in an attempt to reduce the recovery capacity of the fungus&#46; The results of <span class="elsevierStyleItalic">in vitro</span> experiments with dermatophytes suggest that reducing the interval between PDT sessions will improve the fungicidal effect&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Microbiological diagnosis of onychomycosis is difficult&#59; in fact up to 90&#37; of the cases microbiologically diagnosed the first laboratory result may be negative&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> In our case&#44; however&#44; it is unlikely that the culture results after PDT were false negatives because no antimicrobial substances were present in the medium used&#46; Another problem associated with onychomycosis in general&#44; and <span class="elsevierStyleItalic">Scytalidium</span> infection in particular&#44; is that recurrence is frequent&#46; In this patient we observed microbiological reappearance of the fungus without clinical recurrence&#46; A possible solution for recalcitrant cases might be periodic administration of PDT or a combination of PDT with an antifungal drug over a period of time&#46;</p></span>"
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Case and Research Letter
Photodynamic Therapy With Methyl-aminolevulinate can be Useful in the Management of Scytalidium Infections
La terapia fotodinámica con metilaminolevulinato puede ser útil en el manejo de las infecciones por Scytalidium
C. Aspiroza,b,
Autor para correspondencia
caspirozs@gmail.com

Corresponding author.
, B. Fortuño-Cebamanosa, A. Rezustab,c, Y. Gilaberteb,d
a Unidad de Microbiología, Hospital Royo Villanova, Zaragoza, Spain
b Instituto de Ciencias de la Salud de Aragón, Zaragoza, Spain
c Servicio de Microbiología, Hospital Universitario Miguel Servet, Zaragoza, Universidad de Zaragoza, Spain
d Unidad de Dermatología, Hospital San Jorge, Huesca, Spain
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resident in Spain for more than 5 years&#44; presented with a very long history of dystrophic toenails&#46; She had been diagnosed with onychomycosis caused by <span class="elsevierStyleItalic">Aspergillus</span> spp&#46; and treated with several topical antifungal agents with no improvement&#46; On examination&#44; she presented thickened&#44; opaque nail plates with a yellow or brown discoloration and cracked surfaces &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Significant scaling was observed around the nails&#44; between the toes&#44; and on the soles&#46; Her fingernails were unaffected&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Nail clippings and periungual skin swabs confirmed <span class="elsevierStyleItalic">S&#46; dimidiatum</span> on microscopy and cycloheximide-free agar mycological culture&#46; No dermatophytes were found&#44; but colonies of <span class="elsevierStyleItalic">Aspergillus</span> spp&#46; were seen on Sabouraud plates from 1 of the 2 affected toenails&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Bearing in mind the failure of previous antifungal treatments and the lack of any effective treatment for this infection&#44; and encouraged by our good results in onychomycosis&#44;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> proposed this treatment to the patient&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">For five days prior to PDT&#44; a combination of 40&#37; urea and 1&#37; bifonazole &#40;Mycospor Onicoset<span class="elsevierStyleSup">&#174;</span>&#41; ointment was applied every night in occlusion to the nail plates&#46; On the day of treatment&#44; methyl-aminolevulinate &#40;Metvix<span class="elsevierStyleSup">&#174;</span>&#41; was applied to the nail plates and periungual skin&#44; which were then covered with an occlusive dressing &#40;Tegaderm<span class="elsevierStyleSup">&#174;</span>&#41; and protected from light for 3<span class="elsevierStyleHsp" style=""></span>h&#44; as previously described&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> When the dressing was removed&#44; the nails were cleaned with 70&#37; ethanol and irradiated using a 635<span class="elsevierStyleHsp" style=""></span>nm light emitting diode lamp &#40;Aktilite<span class="elsevierStyleSup">&#174;</span>&#44; 37<span class="elsevierStyleHsp" style=""></span>J&#47;cm<span class="elsevierStyleSup">2</span>&#41;&#46; No side effects were observed during or after treatment&#46; The same procedure was repeated 1 week later and every 2 weeks thereafter&#46; Microbiological cultures became negative after the third session&#46; A total of 4 sessions were administered&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Clinical improvement was noticed after 2 months&#46; Four months later&#44; the patient was clinically and microbiologically cured according to the standard criteria &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; After 6 months of follow-up&#44; cultures became positive in 1 of the 2 nails&#44; but the nails remained clinically cured and there was no evidence under microscopy of nail penetration&#46;</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">Infection with <span class="elsevierStyleItalic">S&#46; dimidiatum</span> accounts for under 1&#37; of cases of onychomycosis and seldom responds to amorolfine or terbinafine&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Recently&#44; an intermittent posaconazole regimen has been proposed to treat superficial <span class="elsevierStyleItalic">S&#46; dimidiatum</span> infection&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; all of these drugs are expensive and can have significant adverse effects&#46; Moreover&#44; there is little or no evidence of their effectiveness in this setting&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Fewer than 50 cases of onychomycosis treated with aminolevulinic acid or methyl-aminolevulinate PDT have been reported and most of these were caused by dermatophytes&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;8</span></a> Our group obtained good results with methyl-aminolevulinate&#44; using one protocol based on the one previously reported by Piraccini et al&#46;<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#8211;7</span></a> In localized mycosis&#44; the therapeutic effect of PDT is twofold&#58; the treatment directly kills the fungus and also reinforces the fungicidal effect by stimulating host immune cells&#44; especially neutrophils&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Although in previous cases<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5&#44;6</span></a> we have successfully used a protocol with a 2-week interval between sessions&#44; in this case we made some modifications&#46; We reduced the interval between the first and second sessions to 1 week in an attempt to reduce the recovery capacity of the fungus&#46; The results of <span class="elsevierStyleItalic">in vitro</span> experiments with dermatophytes suggest that reducing the interval between PDT sessions will improve the fungicidal effect&#46;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">Microbiological diagnosis of onychomycosis is difficult&#59; 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ISSN: 00017310
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