array:24 [
  "pii" => "S0001731012001743"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2011.12.015"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "aid" => "608"
  "copyright" => "Elsevier España, S.L. and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2012;103:833-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5579
    "formatos" => array:3 [
      "EPUB" => 39
      "HTML" => 4833
      "PDF" => 707
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S1578219012003393"
      "issn" => "15782190"
      "doi" => "10.1016/j.adengl.2011.12.008"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "aid" => "608"
      "copyright" => "Elsevier España, S.L. and AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2012;103:833-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7103
        "formatos" => array:3 [
          "EPUB" => 42
          "HTML" => 6559
          "PDF" => 502
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "Metastatic Melanoma of the Tongue&#58; A Rare Case"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "833"
            "paginaFinal" => "836"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Melanoma metast&#225;sico de la lengua&#58; un caso raro"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1068
                "Ancho" => 1585
                "Tamanyo" => 158088
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Macular lesion on the dorsum of the tongue associated with small&#44; stiff nodules with an ulcerated-surface located on the left margin and the midline of the anterior third of the tongue&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "D&#46; Compilato, S&#46; Amato, G&#46; Campisi"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Compilato"
              ]
              1 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Amato"
              ]
              2 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "Campisi"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0001731012001743"
          "doi" => "10.1016/j.ad.2011.12.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001743?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012003393?idApp=UINPBA000044"
      "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012003393/v1_201304241357/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731012001871"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2011.12.016"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "612"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:836-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4983
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 4104
        "PDF" => 878
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => "Un nuevo marcador dermatosc&#243;pico de tinea capitis&#58; &#171;pelos en coma&#187;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "836"
          "paginaFinal" => "837"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Comma Hairs&#58; A New Dermoscopic Marker for Tinea Capitis"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 711
              "Ancho" => 950
              "Tamanyo" => 154198
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Placa alop&#233;cica descamativa en la regi&#243;n occipital&#46; Detalle de la tricodermatoscopia con varios &#171;pelos en coma&#187; &#40;c&#237;rculos&#41; &#40;dermatoscopio de mano Dermlite II Pro&#44; c&#225;mara Sony DSC-W55<span class="elsevierStyleSup">&#174;</span>&#44; &#215; 40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Hern&#225;ndez-Bel, J&#46; Malvehy, A&#46; Crocker, J&#46;L&#46; S&#225;nchez-Carazo, I&#46; Febrer, V&#46; Alegre"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Hern&#225;ndez-Bel"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Malvehy"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Crocker"
            ]
            3 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "S&#225;nchez-Carazo"
            ]
            4 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Febrer"
            ]
            5 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Alegre"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219012002843"
        "doi" => "10.1016/j.adengl.2011.12.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002843?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001871?idApp=UINPBA000044"
    "url" => "/00017310/0000010300000009/v1_201304241717/S0001731012001871/v1_201304241717/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731012001639"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2012.01.016"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "606"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:832-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4172
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 3531
        "PDF" => 592
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Widespread Cutaneous Necrosis as the First Clinical Manifestation of Secondary Antiphospholipid Syndrome"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "832"
          "paginaFinal" => "833"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Necrosis cut&#225;nea extensa como la primera manifestaci&#243;n cl&#237;nica de un s&#237;ndrome antifosfol&#237;pidico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 715
              "Ancho" => 950
              "Tamanyo" => 84175
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous lesions on admission&#46; Bullous erythematous violaceous plaques on the right leg&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;R&#46; Perell&#243;-Alzamora, J&#46;C&#46; Santos-Duran, A&#46; Santos-Briz, P&#46; Unamuno"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;R&#46;"
              "apellidos" => "Perell&#243;-Alzamora"
            ]
            1 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "Santos-Duran"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Santos-Briz"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Unamuno"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219012003381"
        "doi" => "10.1016/j.adengl.2012.10.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012003381?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001639?idApp=UINPBA000044"
    "url" => "/00017310/0000010300000009/v1_201304241717/S0001731012001639/v1_201304241717/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Metastatic Melanoma of the Tongue&#58; A Rare Case"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "833"
        "paginaFinal" => "836"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "D&#46; Compilato, S&#46; Amato, G&#46; Campisi"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "D&#46;"
            "apellidos" => "Compilato"
            "email" => array:1 [
              0 => "compilato&#64;odonto&#46;unipa&#46;it"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Amato"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Campisi"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Department of Surgical and Oncological Disciplines&#44; V&#46; Margiotta Oral Medicine Unit&#44; Palermo University Hospital&#44; Palermo&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Dermatology Unit&#44; ARNAS&#44; Ospedale Civico e Fatebenefratelli G&#46; Di Cristina e Maurizio Ascoli&#44; Palermo&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Melanoma metast&#225;sico de la lengua&#58; un caso raro"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 641
            "Ancho" => 950
            "Tamanyo" => 98354
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Macular lesion on the dorsum of the tongue associated with small&#44; stiff nodules with an ulcerated-surface located on the left margin and the midline of the anterior third of the tongue&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cutaneous melanoma is an extremely aggressive malignant tumor arising from melanocytes and accounting some 15&#37; of all cancers&#46; Incidence varies from 3&#8211;5 cases per 100<span class="elsevierStyleHsp" style=""></span>000 inhabitants and year in the Mediterranean region to 12&#8211;20 cases per 100<span class="elsevierStyleHsp" style=""></span>000 inhabitants and year in Nordic countries&#44; and is still increasing worldwide&#46; Cutaneous melanoma is believed to be a cancer that primarily affects white skin&#44; and the risk of developing these tumors is 10 times higher in white-skinned populations than in those with darker skin&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Melanoma is known for its aggressiveness&#44; and metastases to bones&#44; lungs&#44; brain&#44; liver&#44; or lymph nodes are expected&#46; However&#44; there have been very few reports of oral metastases&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> which mainly affect the gingiva&#44; tongue&#44; tonsils&#44; and mandible&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of an 86-year-old white man admitted with a black lesion on the tongue that had persisted for about 2 months&#46; During the consultation&#44; the patient rejected the idea that he had a disease and complained about the appearance&#44; concurrently with the lingual lesions&#44; of dark nodules on his neck and upper limbs associated with intense and persistent itching&#44; which had on occasion spread to the trunk&#46; These skin lesions had been treated with antihistamines and topical corticosteroids prescribed initially by his family physician and subsequently by a dermatologist&#44; without clinical improvement&#46; Intraoral examination revealed the presence of a wide&#44; irregularly shaped&#44; sepia-black macular lesion that was firm to the touch and asymptomatic&#44; extending from the dorsal to the ventral surface of the tongue&#46; This was associated with small stiff nodules with an ulcerated surface on the left margin and the midline of the anterior third of the tongue &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Extraoral examination &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A and B&#41; revealed the presence of blackish oval nodular lesions&#44; palpable and painless&#44; localized to the neck and upper limbs&#46; A diffuse cervical lymphadenopathy was also detected&#46; These clinical findings gave rise to a suspected diagnosis of oral melanoma&#46; While considering it important to establish whether the oral lesions were primary or metastatic&#44; we preferred to start the diagnostic work-up of the suspected melanoma with an examination of the skin lesions&#46; The results of routine blood tests were within normal limits&#44; with the exception of an increased erythrocyte sedimentation rate&#46; Tests for neoplastic markers revealed the carcino-embryogenic antigen&#46; A more detailed clinical and dermoscopic examination of the skin &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41; revealed the following findings&#58; <span class="elsevierStyleItalic">a</span>&#41; a brown-black variegated pigmented nevus on the spinal column between the shoulders&#44; irregular in shape and color measuring 21<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>16<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#44; third arrow&#41; and characterized by a blue&#8211;gray veil and irregularly shaped globules&#59; the presumptive diagnosis was melanoma with in-transit metastases &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#59; <span class="elsevierStyleItalic">b</span>&#41; 3 pigmented blue-brown lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#44; C&#44; second arrow&#41; situated 14<span class="elsevierStyleHsp" style=""></span>mm from the first lesion&#59; and <span class="elsevierStyleItalic">c</span>&#41; an irregularly shaped variegated brown lesion on the right parascapular region&#44; of 14<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#44; first arrow&#41; characterized by a fragmented thickened network and areas of regression&#44; consistent with the diagnosis of melanoma &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B and C&#41;&#46; Histopathology examination of an incisional biopsy of the parascapular lesion showed a dermis colonized by atypical epithelioid cells indicating a melanoma &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; Unexpectedly&#44; after the diagnosis of cutaneous melanoma was confirmed&#44; the patient refused to undergo oral biopsy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A diagnosis of cutaneous melanoma with oral metastases was confirmed on the basis of the clinical&#44; dermoscopic&#44; and histological data&#46; A chest radiograph demonstrated no active parenchymal lesions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A computed tomography scan of the maxillofacial region&#44; neck&#44; brain&#44; thorax and abdomen revealed no further metastases&#44; but generalized lymphadenopathy&#46; Due to the presence of in-transit metastases&#44; sentinel lymph-node biopsy was not performed&#44; as recently reported&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was referred to an oncology unit&#44; but no therapeutic regimen was undertaken given his age&#44; his refusal to consent to treatment&#44; and the number and extent of his lesions&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Melanoma is a tumor caused by the malignant transformation of melanocytes&#44; a cell line derived from the neuroectoderm&#46; Although the skin continues to be the most frequent site of primary disease &#40;95&#37; of cases&#41;&#44; the embryologic origin of melanocytes explains why melanoma is not exclusively a skin cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In fact&#44; melanomas may also arise in extracutaneous sites&#44; including the mucosal surfaces of the respiratory&#44; gastrointestinal&#44; and genitourinary tracts and other sites where neural crest cells migrate&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The appearance of a primary melanoma located in the oral cavity is very rare&#44; accounting for only 1&#8211;2&#37; of all mucosal melanomas and 0&#46;5&#37; of all oral malignancies&#59; secondary or metastatic forms are even more rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;8</span></a> When the maxillofacial region is involved&#44; metastases of cutaneous melanoma are mainly reported in the tongue&#44; tonsils&#44; mandible&#44; gingiva&#44; and parotid glands&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">When a patient presents with a pigmented oral lesion&#44; an extraoral clinical examination should be performed&#59; in fact&#44; according to Greene and coworkers&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;9</span></a> in order to consider an oral melanoma as primary&#44; the following 3 criteria must be met&#58; <span class="elsevierStyleItalic">a</span>&#41; demonstration of melanoma only in the oral cavity&#59; <span class="elsevierStyleItalic">b</span>&#41; presence of junctional activity&#59; and <span class="elsevierStyleItalic">c</span>&#41; inability to demonstrate extra-oral primary melanoma&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In our case&#44; the presence of a cutaneous lesion with a histopathological diagnosis of melanoma allowed us to consider the oral lesions as metastatic&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">When analyzing a suspicious skin lesion&#44; it is important to bear in mind the ABCD rule in which A refers to asymmetry&#44; B to border irregularities&#44; C to color heterogeneity&#44; and D to dynamics &#40;in color&#44; elevation&#44; or size&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Furthermore&#44; it has been noted&#44; that dermoscopy always enhances the diagnostic accuracy and identifies lesions that must be biopsied&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> as was the case in this patient&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; the appearance of a metastatic lingual melanoma is a very rare event&#44; hence close collaboration among different specialists is very important in case of suspicious pigmented lesions to ensure their early detection and a prompt treatment of such aggressive neoplasm&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 641
            "Ancho" => 950
            "Tamanyo" => 98354
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Macular lesion on the dorsum of the tongue associated with small&#44; stiff nodules with an ulcerated-surface located on the left margin and the midline of the anterior third of the tongue&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1003
            "Ancho" => 1400
            "Tamanyo" => 186875
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; and &#40;B&#41; Oval&#44; blackish&#44; palpable&#44; and painless nodular lesions on the neck and upper limbs&#46; &#40;C&#41; Pigmented skin lesions localized on the spinal column and parascapular region &#40;arrows&#44; from the top to the bottom&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 365
            "Ancho" => 2000
            "Tamanyo" => 109976
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Dermoscopic image of the lesion localized on the spinal column and parascapular region&#59; note the in-transit metastases&#46; &#40;B&#41; and &#40;C&#41; Dermoscopic images of the parascapular brown lesion with regression areas&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 710
            "Ancho" => 950
            "Tamanyo" => 246925
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Histological features of a biopsied specimen of the parascapular lesion&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma in the 21st century&#44; part 1&#58; epidemiology&#44; risk factors&#44; screening&#44; prevention&#44; and diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;N&#46; Markovic"
                            1 => "L&#46;A&#46; Erickson"
                            2 => "R&#46;D&#46; Rao"
                            3 => "R&#46;H&#46; Weening"
                            4 => "B&#46;A&#46; Pockaj"
                            5 => "A&#46; Bardia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4065/82.3.364"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "2007"
                        "volumen" => "82"
                        "paginaInicial" => "364"
                        "paginaFinal" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17352373"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma&#58; ESMO Clinical Practice Guidelines for diagnosis&#44; treatment and follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Dummer"
                            1 => "A&#46; Hauschild"
                            2 => "M&#46; Guggenheim"
                            3 => "L&#46; Jost"
                            4 => "G&#46; Pentheroudakis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdq188"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2010"
                        "volumen" => "21"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "v194"
                        "paginaFinal" => "v197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20555080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral malignant melanoma&#58; a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Meleti"
                            1 => "C&#46;R&#46; Leemans"
                            2 => "W&#46;J&#46; Mooi"
                            3 => "P&#46; Vescovi"
                            4 => "I&#46; van der Waal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.oraloncology.2006.04.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Oncol"
                        "fecha" => "2007"
                        "volumen" => "43"
                        "paginaInicial" => "116"
                        "paginaFinal" => "121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16931116"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary melanoma of the oral cavity&#58; ten cases and review of 177 cases from literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;C&#46; Aguas"
                            1 => "M&#46;C&#46; Quarracino"
                            2 => "A&#46;N&#46; Lence"
                            3 => "H&#46;E&#46; Lanfranchi-Tizeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Oral Patol Oral Cir Bucal"
                        "fecha" => "2009"
                        "volumen" => "14"
                        "paginaInicial" => "E265"
                        "paginaFinal" => "E271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19300378"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic melanoma to the mandible&#58; case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Rivera"
                            1 => "M&#46; Diamante"
                            2 => "S&#46;J&#46; Kasten"
                            3 => "B&#46;B&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.joms.2010.06.181"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Maxillofac Surg"
                        "fecha" => "2010"
                        "volumen" => "68"
                        "paginaInicial" => "2903"
                        "paginaFinal" => "2906"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20869148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for in-transit metastasis in patients with cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Clemente-Ruiz de Almiron"
                            1 => "S&#46; Serrano-Ortega"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral malignant melanoma&#58; a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Femiano"
                            1 => "A&#46; Lanza"
                            2 => "C&#46; Buonaiuto"
                            3 => "F&#46; Gombos"
                            4 => "F&#46; Di Spirito"
                            5 => "N&#46; Cirillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0714.2008.00660.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "2008"
                        "volumen" => "37"
                        "paginaInicial" => "383"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18284541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral metastasis of ciliary body melanoma&#46; A case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Angiero"
                            1 => "S&#46; Torti"
                            2 => "R&#46; Crippa"
                            3 => "M&#46; Stefani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Minerva Stomatol"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "401"
                        "paginaFinal" => "407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16971885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral melanoma&#58; case reports and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;M&#46; Manganaro"
                            1 => "H&#46;L&#46; Hammond"
                            2 => "M&#46;J&#46; Dalton"
                            3 => "T&#46;P&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1995"
                        "volumen" => "80"
                        "paginaInicial" => "670"
                        "paginaFinal" => "676"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8680974"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopic study of cutaneous malignant melanoma&#58; descriptive analysis of 45 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; de Troya-Martin"
                            1 => "N&#46; Blazquez-Sanchez"
                            2 => "I&#46; Fernandez-Canedo"
                            3 => "M&#46; Frieyro-Elicegui"
                            4 => "R&#46; Funez-Liebana"
                            5 => "F&#46; Rivas-Ruiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "44"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18206086"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000010300000009/v1_201304241717/S0001731012001743/v1_201304241717/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6160"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000010300000009/v1_201304241717/S0001731012001743/v1_201304241717/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001743?idApp=UINPBA000044"
]
Compartir
Información de la revista

Estadísticas

Siga este enlace para acceder al texto completo del artículo

Case and Research Letter
Metastatic Melanoma of the Tongue: A Rare Case
Melanoma metastásico de la lengua: un caso raro
D. Compilatoa,
Autor para correspondencia
compilato@odonto.unipa.it

Corresponding author.
, S. Amatob, G. Campisia
a Department of Surgical and Oncological Disciplines, V. Margiotta Oral Medicine Unit, Palermo University Hospital, Palermo, Italy
b Dermatology Unit, ARNAS, Ospedale Civico e Fatebenefratelli G. Di Cristina e Maurizio Ascoli, Palermo, Italy
Leído
11443
Veces
se ha leído el artículo
2481
Total PDF
8962
Total HTML
Compartir estadísticas
 array:24 [
  "pii" => "S0001731012001743"
  "issn" => "00017310"
  "doi" => "10.1016/j.ad.2011.12.015"
  "estado" => "S300"
  "fechaPublicacion" => "2012-11-01"
  "aid" => "608"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
  "copyrightAnyo" => "2011"
  "documento" => "simple-article"
  "crossmark" => 0
  "subdocumento" => "cor"
  "cita" => "Actas Dermosifiliogr. 2012;103:833-6"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 5579
    "formatos" => array:3 [
      "EPUB" => 39
      "HTML" => 4833
      "PDF" => 707
    ]
  ]
  "Traduccion" => array:1 [
    "en" => array:19 [
      "pii" => "S1578219012003393"
      "issn" => "15782190"
      "doi" => "10.1016/j.adengl.2011.12.008"
      "estado" => "S300"
      "fechaPublicacion" => "2012-11-01"
      "aid" => "608"
      "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
      "documento" => "simple-article"
      "crossmark" => 0
      "subdocumento" => "cor"
      "cita" => "Actas Dermosifiliogr. 2012;103:833-6"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 7103
        "formatos" => array:3 [
          "EPUB" => 42
          "HTML" => 6559
          "PDF" => 502
        ]
      ]
      "en" => array:11 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
        "titulo" => "Metastatic Melanoma of the Tongue&#58; A Rare Case"
        "tienePdf" => "en"
        "tieneTextoCompleto" => "en"
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "833"
            "paginaFinal" => "836"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "es" => array:1 [
            "titulo" => "Melanoma metast&#225;sico de la lengua&#58; un caso raro"
          ]
        ]
        "contieneTextoCompleto" => array:1 [
          "en" => true
        ]
        "contienePdf" => array:1 [
          "en" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 0
          "multimedia" => array:7 [
            "identificador" => "fig0005"
            "etiqueta" => "Figure 1"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => true
            "mostrarDisplay" => false
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "gr1.jpeg"
                "Alto" => 1068
                "Ancho" => 1585
                "Tamanyo" => 158088
              ]
            ]
            "descripcion" => array:1 [
              "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Macular lesion on the dorsum of the tongue associated with small&#44; stiff nodules with an ulcerated-surface located on the left margin and the midline of the anterior third of the tongue&#46;</p>"
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "D&#46; Compilato, S&#46; Amato, G&#46; Campisi"
            "autores" => array:3 [
              0 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Compilato"
              ]
              1 => array:2 [
                "nombre" => "S&#46;"
                "apellidos" => "Amato"
              ]
              2 => array:2 [
                "nombre" => "G&#46;"
                "apellidos" => "Campisi"
              ]
            ]
          ]
        ]
      ]
      "idiomaDefecto" => "en"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S0001731012001743"
          "doi" => "10.1016/j.ad.2011.12.015"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001743?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012003393?idApp=UINPBA000044"
      "url" => "/15782190/0000010300000009/v1_201304241357/S1578219012003393/v1_201304241357/en/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S0001731012001871"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2011.12.016"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "612"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; y AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:836-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4983
      "formatos" => array:3 [
        "EPUB" => 1
        "HTML" => 4104
        "PDF" => 878
      ]
    ]
    "es" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Carta cient&#237;fico-cl&#237;nica</span>"
      "titulo" => "Un nuevo marcador dermatosc&#243;pico de tinea capitis&#58; &#171;pelos en coma&#187;"
      "tienePdf" => "es"
      "tieneTextoCompleto" => "es"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "836"
          "paginaFinal" => "837"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Comma Hairs&#58; A New Dermoscopic Marker for Tinea Capitis"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "es" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figura 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 711
              "Ancho" => 950
              "Tamanyo" => 154198
            ]
          ]
          "descripcion" => array:1 [
            "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Placa alop&#233;cica descamativa en la regi&#243;n occipital&#46; Detalle de la tricodermatoscopia con varios &#171;pelos en coma&#187; &#40;c&#237;rculos&#41; &#40;dermatoscopio de mano Dermlite II Pro&#44; c&#225;mara Sony DSC-W55<span class="elsevierStyleSup">&#174;</span>&#44; &#215; 40&#41;&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "P&#46; Hern&#225;ndez-Bel, J&#46; Malvehy, A&#46; Crocker, J&#46;L&#46; S&#225;nchez-Carazo, I&#46; Febrer, V&#46; Alegre"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Hern&#225;ndez-Bel"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Malvehy"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Crocker"
            ]
            3 => array:2 [
              "nombre" => "J&#46;L&#46;"
              "apellidos" => "S&#225;nchez-Carazo"
            ]
            4 => array:2 [
              "nombre" => "I&#46;"
              "apellidos" => "Febrer"
            ]
            5 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Alegre"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219012002843"
        "doi" => "10.1016/j.adengl.2011.12.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012002843?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001871?idApp=UINPBA000044"
    "url" => "/00017310/0000010300000009/v1_201304241717/S0001731012001871/v1_201304241717/es/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S0001731012001639"
    "issn" => "00017310"
    "doi" => "10.1016/j.ad.2012.01.016"
    "estado" => "S300"
    "fechaPublicacion" => "2012-11-01"
    "aid" => "606"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46; and AEDV"
    "documento" => "simple-article"
    "crossmark" => 0
    "subdocumento" => "cor"
    "cita" => "Actas Dermosifiliogr. 2012;103:832-3"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 4172
      "formatos" => array:3 [
        "EPUB" => 49
        "HTML" => 3531
        "PDF" => 592
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>"
      "titulo" => "Widespread Cutaneous Necrosis as the First Clinical Manifestation of Secondary Antiphospholipid Syndrome"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "832"
          "paginaFinal" => "833"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Necrosis cut&#225;nea extensa como la primera manifestaci&#243;n cl&#237;nica de un s&#237;ndrome antifosfol&#237;pidico"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 715
              "Ancho" => 950
              "Tamanyo" => 84175
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Cutaneous lesions on admission&#46; Bullous erythematous violaceous plaques on the right leg&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M&#46;R&#46; Perell&#243;-Alzamora, J&#46;C&#46; Santos-Duran, A&#46; Santos-Briz, P&#46; Unamuno"
          "autores" => array:4 [
            0 => array:2 [
              "nombre" => "M&#46;R&#46;"
              "apellidos" => "Perell&#243;-Alzamora"
            ]
            1 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "Santos-Duran"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Santos-Briz"
            ]
            3 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Unamuno"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "en" => array:9 [
        "pii" => "S1578219012003381"
        "doi" => "10.1016/j.adengl.2012.10.003"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "en"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219012003381?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001639?idApp=UINPBA000044"
    "url" => "/00017310/0000010300000009/v1_201304241717/S0001731012001639/v1_201304241717/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letter</span>"
    "titulo" => "Metastatic Melanoma of the Tongue&#58; A Rare Case"
    "tieneTextoCompleto" => true
    "saludo" => "To the Editor&#44;"
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "833"
        "paginaFinal" => "836"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "D&#46; Compilato, S&#46; Amato, G&#46; Campisi"
        "autores" => array:3 [
          0 => array:4 [
            "nombre" => "D&#46;"
            "apellidos" => "Compilato"
            "email" => array:1 [
              0 => "compilato&#64;odonto&#46;unipa&#46;it"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">¿</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "S&#46;"
            "apellidos" => "Amato"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "G&#46;"
            "apellidos" => "Campisi"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Department of Surgical and Oncological Disciplines&#44; V&#46; Margiotta Oral Medicine Unit&#44; Palermo University Hospital&#44; Palermo&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Dermatology Unit&#44; ARNAS&#44; Ospedale Civico e Fatebenefratelli G&#46; Di Cristina e Maurizio Ascoli&#44; Palermo&#44; Italy"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff0010"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Melanoma metast&#225;sico de la lengua&#58; un caso raro"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 641
            "Ancho" => 950
            "Tamanyo" => 98354
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Macular lesion on the dorsum of the tongue associated with small&#44; stiff nodules with an ulcerated-surface located on the left margin and the midline of the anterior third of the tongue&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Cutaneous melanoma is an extremely aggressive malignant tumor arising from melanocytes and accounting some 15&#37; of all cancers&#46; Incidence varies from 3&#8211;5 cases per 100<span class="elsevierStyleHsp" style=""></span>000 inhabitants and year in the Mediterranean region to 12&#8211;20 cases per 100<span class="elsevierStyleHsp" style=""></span>000 inhabitants and year in Nordic countries&#44; and is still increasing worldwide&#46; Cutaneous melanoma is believed to be a cancer that primarily affects white skin&#44; and the risk of developing these tumors is 10 times higher in white-skinned populations than in those with darker skin&#46;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> Melanoma is known for its aggressiveness&#44; and metastases to bones&#44; lungs&#44; brain&#44; liver&#44; or lymph nodes are expected&#46; However&#44; there have been very few reports of oral metastases&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> which mainly affect the gingiva&#44; tongue&#44; tonsils&#44; and mandible&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We describe the case of an 86-year-old white man admitted with a black lesion on the tongue that had persisted for about 2 months&#46; During the consultation&#44; the patient rejected the idea that he had a disease and complained about the appearance&#44; concurrently with the lingual lesions&#44; of dark nodules on his neck and upper limbs associated with intense and persistent itching&#44; which had on occasion spread to the trunk&#46; These skin lesions had been treated with antihistamines and topical corticosteroids prescribed initially by his family physician and subsequently by a dermatologist&#44; without clinical improvement&#46; Intraoral examination revealed the presence of a wide&#44; irregularly shaped&#44; sepia-black macular lesion that was firm to the touch and asymptomatic&#44; extending from the dorsal to the ventral surface of the tongue&#46; This was associated with small stiff nodules with an ulcerated surface on the left margin and the midline of the anterior third of the tongue &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Extraoral examination &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>A and B&#41; revealed the presence of blackish oval nodular lesions&#44; palpable and painless&#44; localized to the neck and upper limbs&#46; A diffuse cervical lymphadenopathy was also detected&#46; These clinical findings gave rise to a suspected diagnosis of oral melanoma&#46; While considering it important to establish whether the oral lesions were primary or metastatic&#44; we preferred to start the diagnostic work-up of the suspected melanoma with an examination of the skin lesions&#46; The results of routine blood tests were within normal limits&#44; with the exception of an increased erythrocyte sedimentation rate&#46; Tests for neoplastic markers revealed the carcino-embryogenic antigen&#46; A more detailed clinical and dermoscopic examination of the skin &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#41; revealed the following findings&#58; <span class="elsevierStyleItalic">a</span>&#41; a brown-black variegated pigmented nevus on the spinal column between the shoulders&#44; irregular in shape and color measuring 21<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>16<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#44; third arrow&#41; and characterized by a blue&#8211;gray veil and irregularly shaped globules&#59; the presumptive diagnosis was melanoma with in-transit metastases &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>A&#41;&#59; <span class="elsevierStyleItalic">b</span>&#41; 3 pigmented blue-brown lesions &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#44; C&#44; second arrow&#41; situated 14<span class="elsevierStyleHsp" style=""></span>mm from the first lesion&#59; and <span class="elsevierStyleItalic">c</span>&#41; an irregularly shaped variegated brown lesion on the right parascapular region&#44; of 14<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>mm &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>C&#44; first arrow&#41; characterized by a fragmented thickened network and areas of regression&#44; consistent with the diagnosis of melanoma &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>B and C&#41;&#46; Histopathology examination of an incisional biopsy of the parascapular lesion showed a dermis colonized by atypical epithelioid cells indicating a melanoma &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; Unexpectedly&#44; after the diagnosis of cutaneous melanoma was confirmed&#44; the patient refused to undergo oral biopsy&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A diagnosis of cutaneous melanoma with oral metastases was confirmed on the basis of the clinical&#44; dermoscopic&#44; and histological data&#46; A chest radiograph demonstrated no active parenchymal lesions&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">A computed tomography scan of the maxillofacial region&#44; neck&#44; brain&#44; thorax and abdomen revealed no further metastases&#44; but generalized lymphadenopathy&#46; Due to the presence of in-transit metastases&#44; sentinel lymph-node biopsy was not performed&#44; as recently reported&#46;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient was referred to an oncology unit&#44; but no therapeutic regimen was undertaken given his age&#44; his refusal to consent to treatment&#44; and the number and extent of his lesions&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Melanoma is a tumor caused by the malignant transformation of melanocytes&#44; a cell line derived from the neuroectoderm&#46; Although the skin continues to be the most frequent site of primary disease &#40;95&#37; of cases&#41;&#44; the embryologic origin of melanocytes explains why melanoma is not exclusively a skin cancer&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> In fact&#44; melanomas may also arise in extracutaneous sites&#44; including the mucosal surfaces of the respiratory&#44; gastrointestinal&#44; and genitourinary tracts and other sites where neural crest cells migrate&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The appearance of a primary melanoma located in the oral cavity is very rare&#44; accounting for only 1&#8211;2&#37; of all mucosal melanomas and 0&#46;5&#37; of all oral malignancies&#59; secondary or metastatic forms are even more rare&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;8</span></a> When the maxillofacial region is involved&#44; metastases of cutaneous melanoma are mainly reported in the tongue&#44; tonsils&#44; mandible&#44; gingiva&#44; and parotid glands&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">When a patient presents with a pigmented oral lesion&#44; an extraoral clinical examination should be performed&#59; in fact&#44; according to Greene and coworkers&#44;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;9</span></a> in order to consider an oral melanoma as primary&#44; the following 3 criteria must be met&#58; <span class="elsevierStyleItalic">a</span>&#41; demonstration of melanoma only in the oral cavity&#59; <span class="elsevierStyleItalic">b</span>&#41; presence of junctional activity&#59; and <span class="elsevierStyleItalic">c</span>&#41; inability to demonstrate extra-oral primary melanoma&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In our case&#44; the presence of a cutaneous lesion with a histopathological diagnosis of melanoma allowed us to consider the oral lesions as metastatic&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">When analyzing a suspicious skin lesion&#44; it is important to bear in mind the ABCD rule in which A refers to asymmetry&#44; B to border irregularities&#44; C to color heterogeneity&#44; and D to dynamics &#40;in color&#44; elevation&#44; or size&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Furthermore&#44; it has been noted&#44; that dermoscopy always enhances the diagnostic accuracy and identifies lesions that must be biopsied&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> as was the case in this patient&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">In conclusion&#44; the appearance of a metastatic lingual melanoma is a very rare event&#44; hence close collaboration among different specialists is very important in case of suspicious pigmented lesions to ensure their early detection and a prompt treatment of such aggressive neoplasm&#46;</p></span>"
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "multimedia" => array:4 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 641
            "Ancho" => 950
            "Tamanyo" => 98354
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Macular lesion on the dorsum of the tongue associated with small&#44; stiff nodules with an ulcerated-surface located on the left margin and the midline of the anterior third of the tongue&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1003
            "Ancho" => 1400
            "Tamanyo" => 186875
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; and &#40;B&#41; Oval&#44; blackish&#44; palpable&#44; and painless nodular lesions on the neck and upper limbs&#46; &#40;C&#41; Pigmented skin lesions localized on the spinal column and parascapular region &#40;arrows&#44; from the top to the bottom&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 365
            "Ancho" => 2000
            "Tamanyo" => 109976
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Dermoscopic image of the lesion localized on the spinal column and parascapular region&#59; note the in-transit metastases&#46; &#40;B&#41; and &#40;C&#41; Dermoscopic images of the parascapular brown lesion with regression areas&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 710
            "Ancho" => 950
            "Tamanyo" => 246925
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Histological features of a biopsied specimen of the parascapular lesion&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Malignant melanoma in the 21st century&#44; part 1&#58; epidemiology&#44; risk factors&#44; screening&#44; prevention&#44; and diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;N&#46; Markovic"
                            1 => "L&#46;A&#46; Erickson"
                            2 => "R&#46;D&#46; Rao"
                            3 => "R&#46;H&#46; Weening"
                            4 => "B&#46;A&#46; Pockaj"
                            5 => "A&#46; Bardia"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4065/82.3.364"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "2007"
                        "volumen" => "82"
                        "paginaInicial" => "364"
                        "paginaFinal" => "380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17352373"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Melanoma&#58; ESMO Clinical Practice Guidelines for diagnosis&#44; treatment and follow-up"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Dummer"
                            1 => "A&#46; Hauschild"
                            2 => "M&#46; Guggenheim"
                            3 => "L&#46; Jost"
                            4 => "G&#46; Pentheroudakis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/annonc/mdq188"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Oncol"
                        "fecha" => "2010"
                        "volumen" => "21"
                        "numero" => "Suppl&#46; 5"
                        "paginaInicial" => "v194"
                        "paginaFinal" => "v197"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20555080"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral malignant melanoma&#58; a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Meleti"
                            1 => "C&#46;R&#46; Leemans"
                            2 => "W&#46;J&#46; Mooi"
                            3 => "P&#46; Vescovi"
                            4 => "I&#46; van der Waal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.oraloncology.2006.04.001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Oncol"
                        "fecha" => "2007"
                        "volumen" => "43"
                        "paginaInicial" => "116"
                        "paginaFinal" => "121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16931116"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary melanoma of the oral cavity&#58; ten cases and review of 177 cases from literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S&#46;C&#46; Aguas"
                            1 => "M&#46;C&#46; Quarracino"
                            2 => "A&#46;N&#46; Lence"
                            3 => "H&#46;E&#46; Lanfranchi-Tizeira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Oral Patol Oral Cir Bucal"
                        "fecha" => "2009"
                        "volumen" => "14"
                        "paginaInicial" => "E265"
                        "paginaFinal" => "E271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19300378"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Metastatic melanoma to the mandible&#58; case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R&#46;D&#46; Rivera"
                            1 => "M&#46; Diamante"
                            2 => "S&#46;J&#46; Kasten"
                            3 => "B&#46;B&#46; Ward"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.joms.2010.06.181"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Maxillofac Surg"
                        "fecha" => "2010"
                        "volumen" => "68"
                        "paginaInicial" => "2903"
                        "paginaFinal" => "2906"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20869148"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Risk factors for in-transit metastasis in patients with cutaneous melanoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A&#46; Clemente-Ruiz de Almiron"
                            1 => "S&#46; Serrano-Ortega"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2011"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral malignant melanoma&#58; a review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "F&#46; Femiano"
                            1 => "A&#46; Lanza"
                            2 => "C&#46; Buonaiuto"
                            3 => "F&#46; Gombos"
                            4 => "F&#46; Di Spirito"
                            5 => "N&#46; Cirillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1600-0714.2008.00660.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Oral Pathol Med"
                        "fecha" => "2008"
                        "volumen" => "37"
                        "paginaInicial" => "383"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18284541"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral metastasis of ciliary body melanoma&#46; A case report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "F&#46; Angiero"
                            1 => "S&#46; Torti"
                            2 => "R&#46; Crippa"
                            3 => "M&#46; Stefani"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Minerva Stomatol"
                        "fecha" => "2006"
                        "volumen" => "55"
                        "paginaInicial" => "401"
                        "paginaFinal" => "407"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16971885"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral melanoma&#58; case reports and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46;M&#46; Manganaro"
                            1 => "H&#46;L&#46; Hammond"
                            2 => "M&#46;J&#46; Dalton"
                            3 => "T&#46;P&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oral Surg Oral Med Oral Pathol Oral Radiol Endod"
                        "fecha" => "1995"
                        "volumen" => "80"
                        "paginaInicial" => "670"
                        "paginaFinal" => "676"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8680974"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dermoscopic study of cutaneous malignant melanoma&#58; descriptive analysis of 45 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; de Troya-Martin"
                            1 => "N&#46; Blazquez-Sanchez"
                            2 => "I&#46; Fernandez-Canedo"
                            3 => "M&#46; Frieyro-Elicegui"
                            4 => "R&#46; Funez-Liebana"
                            5 => "F&#46; Rivas-Ruiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Actas Dermosifiliogr"
                        "fecha" => "2008"
                        "volumen" => "99"
                        "paginaInicial" => "44"
                        "paginaFinal" => "53"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18206086"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/00017310/0000010300000009/v1_201304241717/S0001731012001743/v1_201304241717/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6160"
    "tipo" => "SECCION"
    "es" => array:2 [
      "titulo" => "Cartas cient&#237;fico-cl&#237;nicas"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "es"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/00017310/0000010300000009/v1_201304241717/S0001731012001743/v1_201304241717/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731012001743?idApp=UINPBA000044"
]
Información del artículo
ISSN: 00017310
Idioma original: Inglés
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Noviembre 5 5 10
2024 Octubre 63 51 114
2024 Septiembre 62 23 85
2024 Agosto 106 67 173
2024 Julio 81 31 112
2024 Junio 103 49 152
2024 Mayo 104 38 142
2024 Abril 69 28 97
2024 Marzo 85 28 113
2024 Febrero 46 32 78
2024 Enero 49 29 78
2023 Diciembre 84 31 115
2023 Noviembre 76 31 107
2023 Octubre 81 26 107
2023 Septiembre 79 37 116
2023 Agosto 66 16 82
2023 Julio 100 34 134
2023 Junio 94 19 113
2023 Mayo 109 15 124
2023 Abril 96 19 115
2023 Marzo 119 23 142
2023 Febrero 119 22 141
2023 Enero 92 34 126
2022 Diciembre 110 35 145
2022 Noviembre 111 37 148
2022 Octubre 124 33 157
2022 Septiembre 119 42 161
2022 Agosto 107 43 150
2022 Julio 89 45 134
2022 Junio 89 31 120
2022 Mayo 148 36 184
2022 Abril 99 44 143
2022 Marzo 72 52 124
2022 Febrero 70 32 102
2022 Enero 96 42 138
2021 Diciembre 51 43 94
2021 Noviembre 66 54 120
2021 Octubre 76 65 141
2021 Septiembre 46 45 91
2021 Agosto 37 33 70
2021 Julio 37 32 69
2021 Junio 40 23 63
2021 Mayo 34 33 67
2021 Abril 100 28 128
2021 Marzo 100 31 131
2021 Febrero 58 25 83
2021 Enero 57 21 78
2020 Diciembre 44 23 67
2020 Noviembre 25 10 35
2020 Octubre 39 8 47
2020 Septiembre 28 10 38
2020 Agosto 35 18 53
2020 Julio 29 7 36
2020 Junio 26 28 54
2020 Mayo 23 18 41
2020 Abril 28 22 50
2020 Marzo 26 31 57
2020 Febrero 3 6 9
2020 Enero 6 1 7
2019 Diciembre 8 2 10
2019 Noviembre 4 2 6
2019 Octubre 0 4 4
2019 Septiembre 4 1 5
2019 Agosto 4 9 13
2019 Julio 4 13 17
2019 Junio 6 21 27
2019 Mayo 4 34 38
2019 Abril 2 6 8
2019 Marzo 4 7 11
2019 Febrero 0 4 4
2019 Enero 3 1 4
2018 Diciembre 2 1 3
2018 Noviembre 1 7 8
2018 Octubre 4 0 4
2018 Septiembre 4 0 4
2018 Abril 1 0 1
2018 Marzo 4 1 5
2018 Febrero 25 1 26
2018 Enero 38 4 42
2017 Diciembre 42 5 47
2017 Noviembre 25 5 30
2017 Octubre 34 1 35
2017 Septiembre 31 8 39
2017 Agosto 46 15 61
2017 Julio 61 4 65
2017 Junio 75 16 91
2017 Mayo 41 6 47
2017 Abril 32 11 43
2017 Marzo 29 12 41
2017 Febrero 122 10 132
2017 Enero 55 3 58
2016 Diciembre 62 12 74
2016 Noviembre 99 10 109
2016 Octubre 140 26 166
2016 Septiembre 170 11 181
2016 Agosto 40 3 43
2016 Julio 51 7 58
2016 Junio 19 19 38
2016 Mayo 9 0 9
2016 Abril 7 4 11
2016 Marzo 7 2 9
2016 Febrero 7 3 10
2016 Enero 9 19 28
2015 Diciembre 9 9 18
2015 Noviembre 22 12 34
2015 Octubre 44 12 56
2015 Septiembre 63 10 73
2015 Agosto 48 12 60
2015 Julio 295 2 297
2015 Junio 175 10 185
2015 Mayo 166 14 180
2015 Abril 215 10 225
2015 Marzo 187 4 191
2015 Febrero 132 1 133
2015 Enero 143 0 143
2014 Diciembre 108 0 108
2014 Noviembre 115 0 115
2014 Octubre 115 0 115
2014 Septiembre 62 0 62
2014 Agosto 80 0 80
2014 Julio 70 0 70
2014 Junio 73 0 73
2014 Mayo 87 0 87
2014 Abril 55 0 55
2014 Marzo 110 9 119
2014 Febrero 91 12 103
2014 Enero 127 10 137
2013 Diciembre 124 20 144
2013 Noviembre 120 24 144
2013 Octubre 77 12 89
2013 Septiembre 65 14 79
2013 Agosto 85 17 102
2013 Julio 50 30 80
2013 Junio 49 21 70
2013 Mayo 59 18 77
2013 Abril 57 25 82
2013 Marzo 57 20 77
2013 Febrero 41 11 52
2013 Enero 66 11 77
2012 Diciembre 39 15 54
2012 Noviembre 8 10 18
2012 Octubre 2 1 3
Mostrar todo

Siga este enlace para acceder al texto completo del artículo

Idiomas
Actas Dermo-Sifiliográficas
es en

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?