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Vol. 99. Núm. 1.
Páginas 64-68 (enero - febrero 2008)
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Vol. 99. Núm. 1.
Páginas 64-68 (enero - febrero 2008)
Case reports
Acceso a texto completo
Efficacy of Dapsone in Disseminated Granuloma Annulare: A Case Report and Review of the Literature
Eficacia de la Dapsona en el Granuloma Anular Diseminado: Presentación de un Caso y Revisión de la Literatura
Visitas
8411
E. Martín-Sáeza,
Autor para correspondencia
jestherichia@yahoo.es

Correspondence: Servicio de Dermatología. Hospital Ramón y Cajal, Carretera de Colmenar Viejo, km 9,100, 28034 Madrid, Spain.
, M. Fernández-Guarinoa, R. Carrillo-Gijónb, E Muñoz-Zatoa, P Jaén-Olasoloa
a Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, Spain
b Servicio de Anatomía Patológica, Hospital Universitario Ramón y Cajal, Madrid, Spain
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Información del artículo
Abstract

Granuloma annulare is a dermatosis of unknown cause that is generally self-limiting and has several clinical forms of presentation. It may be associated with pruritus or present asymptomatically. The disseminated variant of the disease accounts for 15% of all cases. Most authors consider that the duration of this form is longer and that treatment response is worse than for localized forms. A range of therapeutic options have been tried for this disease with a wide range of outcomes. We present a patient with disseminated granuloma annulare who started treatment with dapsone after several therapeutic failures. With dapsone therapy, her cutaneous symptoms showed a clear improvement without any relevant side effects. We then review reports in the literature of cases of disseminated granuloma annulare treated with dapsone.

Key words:
disseminated granuloma annulare
dapsone
treatment
Resumen

El granuloma anular es una dermatosis de causa desconocida, habitualmente autorresolutiva, con varias formas clínicas de presentación. Puede asociar prurito o manifestarse de forma asintomática. La variante diseminada de la enfermedad supone el 15% de los casos, y para la mayoría de los autores su duración es mayor y la respuesta al tratamiento peor que en las formas localizadas. Se han propuesto múltiples opciones terapéuticas para esta patología, con resultados muy variables. Presentamos el caso de una paciente con granuloma anular generalizado que tras varios fracasos terapéuticos inició tratamiento con dapsona, obteniéndose una clara mejoría de la clínica cutánea hasta su total resolución, sin efectos secundarios significativos. Aportamos una revisión de los casos de granuloma anular diseminado tratados con dapsona hallados en la literatura.

Palabras clave:
granuloma anular diseminado
dapsona
tratamiento
El Texto completo está disponible en PDF
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Copyright © 2008. Academia Española de Dermatología y Venereología and Elsevier España, S.L.
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