Información del artículo
Abstract
Cutaneous lymphomas represent a heterogenous group of malignant lymphoid diseases with particular tropism for the skin. Prognosis and treatment depend on the type of lymphoma, thus precise diagnosis and classification are of paramount importance. Classification of cutaneous lymphomas relies on a synthesis of all available information, including clinical history and presentation, histopathology, immunophenotype, and molecular data. Thanks to the efforts of the lymphoma groups of both the World Health Organization (WHO) and the European Organization for Research and Treatment of Cancer (EORTC), a joint WHO-EORTC classification for primary cutaneous lymphomas has been proposed in 2005. The WHO-EORTC classification has been adsorbed with minor changes in the 2008 WHO classification of tumours of haematopoietic and lymphoid tissues, thus including for the first time primary cutaneous lymphomas as distinct subtypes of extranodal lymphomas in a general classification of lymphomas.
Key words:
cutaneous lymphomas
mycosis fungoides
cutaneous B-cell lymphoma
cutaneous T-cell lymphoma
Resumen
Los linfomas cutáneos representan un grupo heterogéneo de neoplasias linfoides con un tropismo particular por la piel. El pronóstico y el tratamiento dependen del tipo de linfoma, por tanto son de suma importancia un diagnóstico y clasificación precisos. La clasificación de los linfomas cutáneos se basa en un compendio de toda la información disponible, incluyendo la historia clínica y la presentación, la histopatología, el inmunofenotipo y los datos moleculares. Gracias a los esfuerzos de los grupos de linfoma, tanto de la Organización Mundial de la Salud (siglas en inglés WHO) como de la Organización Europea para la Investigación y el Tratamiento del Cáncer (siglas en inglés EORTC), se ha propuesto una clasificación conjunta WHO-EORTC para los linfomas cutáneos primarios en 2005. La clasificación de la WHO de 2008 de los tumores de los tejidos hematopoyéticos y linfoides ha incorporado la clasificación de la WHO-EORTC con cambios mínimos incluyendo, por primera vez, a los linfomas cutáneos primarios como subtipos distintos de linfomas extraganglionares en una clasificación general de linfomas.
Palabras clave:
linfomas cutáneos
micosis fungoide
linfoma cutáneo de células B
linfoma cutáneo de células T
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