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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Introduction</span><p id="par0240" class="elsevierStylePara elsevierViewall">Advances in our understanding of the pathogenesis of atopic dermatitis &#40;AD&#41; have led to the development of new therapeutic strategies targeting&#44; for the first time in the history of this disease&#44; key elements in the pathogenic pathway&#46; Current treatments vary in their nature and mechanisms of action&#46; Most of the available safety and efficacy data for new treatments are from clinical trials&#44; whose findings led to the authorization of drugs such as dupilumab&#44; baricitinib&#44; upadacitinib&#44; tralokinumab&#44; and abrocitinib&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">While clinical trials are necessary&#44; they are insufficient for determining the true effectiveness and safety of new treatments&#46; There are several reasons for this&#46; First&#44; clinical trials usually study select groups of patients&#44; excluding those with certain comorbidities and a higher risk of toxicity&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> Second&#44; they have limited sample sizes and hence only detect the most common adverse events &#40;AEs&#41;&#46; Less common events &#40;those with a frequency of less than 1&#58;1000&#41; are generally only detected in real-life clinical practice&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Registries are a useful source of data for pharmacovigilance purposes and evaluating long-term data on a broad set of patients&#44; many of whom have comorbidities and are on other treatments&#46; The Healthy Skin Foundation of the Spanish Academy of Dermatology and Venereology &#40;AEDV&#41; has created several registries&#44; including BIOBADADERM &#40;the Spanish Registry of Systemic Treatments in Psoriasis&#41;&#44; which was launched by the AEDV Psoriasis Group in 2007<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> and has become an international reference point for information on psoriasis in real-world clinical settings&#46;<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The Spanish Atopic Dermatitis Registry&#44; BIOBADATOP&#44; was started in 2020&#44; with the inclusion of the first patients&#46; BIOBADATOP is an initiative of the AEDV established in collaboration with 2 of the academy&#39;s working groups&#58; the Spanish Contact Dermatitis and Skin Allergy Research Group &#40;GEIDAC&#41; and the Spanish Pediatric Dermatology Group &#40;GEDP&#41;&#46; The registry was designed in tune with the European TREatment of severe Atopic eczema &#40;TREAT&#41; survey&#44; an international enterprise aimed at standardizing the collection of observational data for patients receiving systemic treatment for AD&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">6</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">The BIOBADATOP registry is designed to collect high-quality&#44; standardized data on the safety&#44; effectiveness&#44; and impact on quality of life of systemic AD treatments used in Spanish hospitals&#46; This information can then be integrated with other national or international registries&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">The main aims of the BIOBADATOP project are to&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#46;</span><p id="par0035" class="elsevierStylePara elsevierViewall">describe the short-term and long-term safety of systemic treatments for AD &#40;including phototherapy&#41; for pharmacovigilance purposes</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#46;</span><p id="par0040" class="elsevierStylePara elsevierViewall">describe the short-term and long-term effectiveness of systemic treatments for AD &#40;including phototherapy&#41; to inform decision-making and guideline development</p></li></ul></p><p id="par0045" class="elsevierStylePara elsevierViewall">The secondary aims are to&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">1&#46;</span><p id="par0050" class="elsevierStylePara elsevierViewall">describe the short- and long-term safety of topical treatments for AD</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">2&#46;</span><p id="par0055" class="elsevierStylePara elsevierViewall">describe the effectiveness of different models of AD care&#44; including patient education</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">3&#46;</span><p id="par0060" class="elsevierStylePara elsevierViewall">describe comorbidities associated with AD</p></li></ul></p><p id="par0065" class="elsevierStylePara elsevierViewall">In this article&#44; we describe the methodology used to create the BIOBADATOP registry and report on its initial findings&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Material and Methods</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Study Design</span><p id="par0070" class="elsevierStylePara elsevierViewall">BIOBADATOP is a multicenter&#44; observational&#44; prospective&#44; cohort study designed to collect information on patients of all ages with AD who are started on a systemic treatment&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Participating Hospitals</span><p id="par0075" class="elsevierStylePara elsevierViewall">To contribute to the BIOBADATOP registry&#44; hospitals must have at least 1 dermatologist with interest and responsibilities in the treatment of moderate to severe AD&#46; Hospitals can gradually join the project&#44; which aims to maintain a sufficiently representative geographic scope&#46; The hospitals in the project at the time of this analysis are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Patient Enrolment</span><p id="par0080" class="elsevierStylePara elsevierViewall">The BIOBADATOP registry contains data on adult and pediatric patients with AD who are started on systemic immunomodulatory therapy in routine clinical practice&#46; To be included&#44; patients must meet the U&#46;K&#46; Working Party&#39;s Diagnostic Criteria for Atopic Dermatitis&#46;<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">7&#44;8</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Exposure and Follow-up</span><p id="par0085" class="elsevierStylePara elsevierViewall">Data collected at the enrolment visit include demographic and diagnostic information&#44; baseline disease severity assessed using the Eczema Area and Severity Index &#40;EASI&#41;&#44; the Dermatology Life Quality Index &#40;DLQI&#41;&#44; and the Patient-Oriented Eczema Measure &#40;POEM&#41;&#44; and information on diagnostic tests&#44; comorbidities&#44; and previous AD treatments&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Follow-up visits are carried out as per usual clinical practice&#46; Data from visits closest to 3 and 6<span class="elsevierStyleHsp" style=""></span>months after the start of each systemic treatment are recorded&#46; Annual visits are recorded thereafter&#46; A note is made of any changes to disease severity or treatment &#40;main systemic treatment and concomitant treatments&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">At each visit&#44; all AEs the patient may have experienced since their last visit are recorded and coded using MedDRA &#40;Medical Dictionary for Drug Regulatory Activities&#41; terms &#40;<a href="https://www.meddra.org/">https&#58;&#47;&#47;www&#46;meddra&#46;org</a>&#41;&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Enrolled patients are expected to remain in the registry for an indefinite period of time&#46; The duration envisaged for the BIOBADATOP project is at least 10 years&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Outcome Measures</span><p id="par0105" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> summarizes the data collected to describe the study population and explore factors that might influence the occurrence of AEs&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Statistical Analysis</span><p id="par0110" class="elsevierStylePara elsevierViewall">We performed a descriptive analysis of patients enrolled in the registry since its launch in March 2020 up to November 2022&#46; Statistical analyses were performed in Stata &#40;version 17&#46;0 Statacorp&#41;&#46; Demographic and clinical data are described using conventional statistics &#40;mean &#91;SD&#93; and absolute and relative frequencies&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Sample Size Estimation</span><p id="par0115" class="elsevierStylePara elsevierViewall">Based on the experience with the BIOBADADERM registry&#44; BIOBADATOP is expected to collect data on approximately 5700 persons-year &#40;approximately 2500 patients in 10<span class="elsevierStyleHsp" style=""></span>years&#41;&#46; It is estimated that this sample will be sufficient to detect&#44; with a statistical power of 80&#37; and a bilateral significance level of 0&#46;05&#44; relative risks of between 1&#46;5 and 2 for an AE incidence of 4 to 10 cases per 1000 person-years in the comparison group&#46; The group will collaborate with other members of TREAT network to detect rare and late AEs&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Data Management and Quality Control</span><p id="par0120" class="elsevierStylePara elsevierViewall">Data are entered&#44; following a standardized method&#44; into an online software system &#40;REDCap &#91;Research Electronic Data Capture&#93;&#41;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> hosted by the Healthy Skin Foundation&#46; Each patient is assigned a unique identifier&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Ethical Considerations</span><p id="par0125" class="elsevierStylePara elsevierViewall">The study was approved by the research ethics committee of Arag&#243;n &#40;PA18&#47;051&#41;&#44; the Spanish Agency for Medicines and Medical Devices &#40;AEMPS&#41;&#44; and all participating hospitals&#46; It was conducted in compliance with the principles of the Declaration of Helsinki and current legislation&#46; The BIOBADATOP project has also received the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance &#40;ENCePP&#41; quality seal attesting to scientific independence and transparency&#46; The ENCePP is coordinated by the European Medicines Agency&#46;</p></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Results</span><p id="par0130" class="elsevierStylePara elsevierViewall">The first 2 patients were enrolled in BIOBADATOP in March 2020&#46; This report describes entries recorded up to November 2022&#46; At the time of analysis&#44; 13 hospitals were contributing to the registry&#46;</p><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Main Baseline Characteristics</span><p id="par0135" class="elsevierStylePara elsevierViewall">As of November 2022&#44; BIOBADATOP contained data on 258 patients &#40;139 &#91;54&#46;3&#37;&#93; males&#41;&#46; Mean &#40;SD&#41; age on enrolment was 32&#46;6 &#40;16&#46;2&#41; years&#46; Mean follow-up was 9 months&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">The main comorbidities are shown in <a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a>&#46; The most common conditions were asthma &#40;50&#46;4&#37;&#41; and allergic rhinoconjunctivitis &#40;56&#46;5&#37;&#41;&#46; Just 17&#37; of patients had an atopic eye disease&#46; Other notable comorbidities were anxiety &#40;21&#46;8&#37;&#41;&#44; chronic respiratory disease &#40;17&#46;7&#37;&#41;&#44; and depression &#40;10&#46;5&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0145" class="elsevierStylePara elsevierViewall">The most common clinical presentations were dermatitis involving extensor surfaces &#40;93&#46;3&#37;&#41;&#44; the face and eyelids &#40;84&#46;6&#37;&#41;&#44; and the hands &#40;67&#46;1&#37;&#41;&#46; There was also genital involvement &#40;31&#46;6&#37;&#41;&#44; erythroderma &#40;covering<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>70&#37; of the body surface area&#41; &#40;17&#46;2&#37;&#41;&#44; palmoplantar eczema &#40;12&#46;1&#37;&#41;&#44; nummular eczema &#40;12&#46;6&#37;&#41;&#44; and prurigo nodularis &#40;&#8805;5 palpable nodules&#41; &#40;11&#46;6&#37;&#41;&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Systemic treatments received prior to inclusion in the BIOBADATOP registry are shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#46; Twenty percent of patients had not been previously treated with a systemic agent&#46; The most widely used previous systemic treatments were cyclosporine &#40;&#62; 50&#37; of patients&#41; and oral corticosteroids &#40;49&#37;&#41;&#44; followed at quite a distance by methotrexate&#44; at just over 20&#37;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0155" class="elsevierStylePara elsevierViewall">Phototherapy&#44; mostly with narrowband UVB light&#44; had been used in 44&#46;3&#37; of cases&#46; The vast majority of patients &#40;97&#46;4&#37;&#41; had been treated with topical corticosteroids&#59; 44&#46;3&#37; had received topical calcineurin inhibitors&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Baseline and Follow-up Findings</span><p id="par0160" class="elsevierStylePara elsevierViewall">Mean &#40;SD&#41; AD severity according to the EASI was 23&#46;4 &#40;11&#46;9&#59; range&#44; 0&#8211;63&#41; at baseline&#46; The mean &#40;SD&#41; quality of life scores on enrolment were 19&#46;7 &#40;6&#46;3&#41; for POEM&#44; 14&#46;6 &#40;7&#46;6&#41; for DLQI in patients<span class="elsevierStyleHsp" style=""></span>&#62;<span class="elsevierStyleHsp" style=""></span>15<span class="elsevierStyleHsp" style=""></span>years&#44; and 9&#46;7 &#40;5&#46;6&#41; in patients aged 15<span class="elsevierStyleHsp" style=""></span>years&#46; The baseline scores for the main outcomes of interest are summarized in <a class="elsevierStyleCrossRef" href="#tbl0020">Table 4</a>&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0165" class="elsevierStylePara elsevierViewall">A total of 347 systemic therapies were started between March 2020 and November 2022 &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">Table 5</a>&#41;&#46; Practically all the treatments &#40;90&#37;&#41; were primary treatments&#46; The discontinuation rate for newly initiated treatments was 29&#46;4&#37;&#44; and the main reason was a lack of effectiveness &#40;10&#46;7&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0170" class="elsevierStylePara elsevierViewall">Of the 258 patients enrolled in the database&#44; 232 &#40;89&#46;9&#37;&#41; were still under active treatment with a systemic drug at the time of analysis&#44; 15 &#40;5&#46;8&#37;&#41; had been taken off systemic treatment&#44; and 11 &#40;4&#46;3&#37;&#41; had been lost to follow-up&#46;</p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Description of AEs</span><p id="par0175" class="elsevierStylePara elsevierViewall">In total&#44; 132 AEs were registered during follow-up&#59; 7 of these &#40;5&#46;3&#37;&#41; were considered serious&#46; Of the 132 documented AEs&#44; 65&#37; &#40;86&#41; were linked to the new systemic treatment&#46; The most common drugs implicated were dupilumab &#40;39 AEs&#41; and cyclosporine &#40;38&#41;&#46; The most common AEs were conjunctivitis &#40;11 cases&#41;&#44; headache &#40;6&#41;&#44; hypertrichosis &#40;5&#41;&#44; and nausea &#40;4&#41;&#46; We were unable to calculate incidence rates according to MedDRA terms because of the low frequency of cases at the time of analysis&#46; The AEs recorded are shown by drug in <a class="elsevierStyleCrossRef" href="#tbl0030">Table 6</a>&#46; There was just 1 serious event&#8212;acute mastoiditis requiring hospital admission&#8212;in a patient treated with cyclosporine&#46; The patient recovered completely and the drug was permanently discontinued&#46;</p><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Discussion</span><p id="par0180" class="elsevierStylePara elsevierViewall">The AEDV BIOBADATOP registry was created to collect clinical-epidemiological&#44; pharmacovigilance&#44; and effectiveness data on patients with moderate to severe AD under treatment with conventional or novel systemic therapies at a turning point in the history of the treatment of this disease&#46; In this first report&#44; we describe the current situation captured by the registry and the main characteristics of the patients enrolled&#46;</p><p id="par0185" class="elsevierStylePara elsevierViewall">Most patients prescribed a systemic treatment for AD in our setting have severe disease&#44; in terms of not just clinical manifestations but also itching severity and impact on quality of life&#46; While these are key aspects that influence decisions by both physicians and patients&#44; they are not part of the reimbursement criteria for new drugs&#46; Despite the clinical heterogeneity of AD&#44; almost all the patients in the BIOBADATOP registry had dermatitis affecting the extensor surfaces&#46; In addition&#44; many patients had lesions in locations that have a greater impact on everyday life and can be challenging to treat&#44; such as the face&#44; eyelids&#44; genitals&#44; and hands&#46; A large percentage of patients had atopic comorbidities such as asthma&#46; Other comorbidities&#44; notably mood disorders&#44; were also common&#46;</p><p id="par0190" class="elsevierStylePara elsevierViewall">Dupilumab was approved by the European Medicines Agency in September 2017&#46; Authorization was subsequently granted for baricitinib&#44; followed by tralokinumab and upadacitinib&#46; Dupilumab is the most widely used systemic AD treatment used by the hospitals participating in the BIOBADATOP project&#46; This is&#44; at least in part&#44; because it was approved earlier&#44; meaning that clinicians are more familiar with its use&#44; and there is a greater understanding of longer-term effects in real-world settings&#46; Choice of drug&#44; however&#44; can also be influenced by other factors&#44; such as access to authorization or first-line treatment policies in different health care regions&#46;</p><p id="par0195" class="elsevierStylePara elsevierViewall">Although the BIOBADATOP registry covers both pediatric and adult patients&#44; the patients included were on average aged between 30 and 40&#46; This is probably because most of the researchers that contribute to the registry are heads of units that mainly treat adults with moderate to severe AD&#46; Pediatric units are less well represented&#46; In addition&#44; new systemic therapies for AD were approved later&#44; and at different time points&#44; for children&#46;</p><p id="par0200" class="elsevierStylePara elsevierViewall">This first report on the BIOBADATOP registry is limited by the short follow-up times&#44; which precluded comparisons and an accurate measure of incidence rates&#46; We were only able to describe frequencies&#44; which do not reflect time of exposure to given drugs&#46; Most of the AEs reported were associated with the most widely used drugs&#58; dupilumab and cyclosporine&#46; Despite this limitation&#44; no serious AEs had been reported for any of the novel systemic treatments at the time of this analysis&#46; There was 1 serious infection &#40;mastoiditis&#41;&#44; linked to cyclosporine&#46; Other nonserious but relatively common AEs were headache&#44; hypertrichosis&#44; and gum bleeding&#46;</p><p id="par0205" class="elsevierStylePara elsevierViewall">Of all the novel systemic treatments used by Spanish hospitals in the BIOBADATOP registry&#44; dupilumab was the medication with the most available data&#46; The most common AEs were conjunctivitis and other AEs affecting the surface of the eye&#44; such as blepharitis and xerophthalmia&#46; There was just 1 case of facial erythema&#46; These findings are consistent with recent real-world data on drug safety&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">10&#44;11</span></a> Our findings did not reveal any new safety alerts&#46;</p><p id="par0210" class="elsevierStylePara elsevierViewall">The incidence of certain key AEs&#44; such as cancer and other potentially serious AEs&#44; is too low to be accurately captured in national registries&#44; but this limitation can be overcome by combining data from different countries&#46; BIOBADATOP is directly linked to the TREAT project and uses a standardized European protocol&#44; similar to that followed by the United Kingdom&#44; the Netherlands&#44; Germany&#44; and other European countries&#46; Combining data from different registries should provide the necessary statistical power to calculate incidence rates for less common AEs&#46; Germany &#40;TREATgermany&#41;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> and Denmark &#40;SCRATCH&#41;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> have both reported findings from their national registries&#44; and the TREAT Registry Taskforce published a recent status update on the 8 databases in the network&#44; including BIOBADATOP&#46; The update covered 4702 patients enrolled up to May 2022&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a></p><p id="par0215" class="elsevierStylePara elsevierViewall">The treatment of AD is undergoing a major transformation&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a> Until very recently&#44; patients with disease refractory to topical treatment and&#47;or phototherapy were largely treated with cyclosporine or off-label immunosuppressants&#44; such as methotrexate and azathioprine&#46; This is reflected in the data on previous treatments showing the use of at 1 conventional immunosuppressive treatment and a high use of corticosteroids&#46; Although clinical trial data suggest that novel systemic therapies for AD have an adequate safety profile&#44; their effects in the broader population must be studied&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">The BIOBADATOP registry will generate useful data for pharmacovigilance purposes and for evaluating treatment effectiveness in real-world clinical settings&#44; contributing to a greater understanding of moderate to severe AD and better management of this disease&#46;</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Funding</span><p id="par0225" class="elsevierStylePara elsevierViewall">The BIOBADATOP project is led by the Healthy Skin Foundation of the Spanish Academy of Dermatology and Venereology &#40;AEDV&#41; and receives funding from the pharmaceutical companies Sanofi&#44; AbbVie&#44; Pfizer&#44; and LEO Pharma&#46; None of these companies had any involvement in study design or conduct&#59; data collection&#44; management&#44; analysis&#44; or interpretation&#59; manuscript preparation&#44; revision&#44; or approval&#59; or the decision to submit this manuscript for publication&#46;</p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Conflicts of Interest</span><p id="par0230" class="elsevierStylePara elsevierViewall">M&#46; Munera-Campos has received fees for consultancy services&#44; presentations&#44; and other related activities from AbbVie&#44; LEO Pharma&#44; Janssen&#44; Sanofi&#44; and Galderma and has served as a principal or co-investigator on clinical trials sponsored by Lilly&#44; LEO Pharma&#44; Novartis&#44; Janssen&#44; Sanofi&#44; Pfizer&#44; AbbVie&#44; Almirall&#44; UCB&#44; and Galderma&#46; P&#46; Chicharro has provided consultancy services for and participated in presentations and clinical trials organized by Janssen Pharmaceuticals&#44; Almirall&#44; Sanofi Genzyme&#44; Lilly&#44; AbbVie&#44; Novartis&#44; LEO Pharma&#44; and Pfizer-Wyeth&#46; A&#46; Gonz&#225;lez Quesada has provided consultancy services and participated in presentations and clinical trials for AbbVie&#44; Pfizer&#44; Novartis&#44; Sanofi&#44; Boeringher&#44; Bristol-Meyer&#44; LEO Pharma&#44; and Jansen&#46; &#193;&#46; Fl&#243;rez Men&#233;ndez has participated in clinical trials&#44; given presentations&#44; and provided consultancy services for AbbVie&#44; Almirall&#44; Amgen&#44; Janssen&#44; LEO Pharma&#44; Lilly&#44; Novartis&#44; Pfizer&#44; Sanofi&#44; and UCB Pharma&#46; P&#46; de la Cueva Dobao has served as a consultant and&#47;or researcher and&#47;or speaker for AbbVie&#44; Almirall&#44; BMS&#44; Boehringer&#44; Celgene&#44; Janssen&#44; LEO Pharma&#44; Lilly&#44; MSD&#44; Novartis&#44; Pfizer&#44; Roche&#44; Sanofi&#44; and UCB&#46; A&#46; M&#46; Gimenez-Arnau has served as a medical advisor for Uriach Pharma&#47;Neucor&#44; Genentech&#44; Novartis&#44; FAES&#44; GSK&#44; Sanofi-Regeneron&#44; Amgen&#44; Thermo Fisher Scientific&#44; Almirall&#44; Celldex&#44; and LEO Pharma&#46; Y&#46; Gilaberte-Calzada has served as a consultant for Isdin and Roche Posay&#44; and Galderma&#44; given presentations for Almirall&#44; Sanofi&#44; Avene&#44; Rilastil&#44; Lylly&#44; Uriage&#44; Novartis&#44; and Cantabria Labs&#44; and participated in research projects for Almirall&#44; Sanofi&#44; Pfizer&#44; AbbVie&#44; and LEO Pharma&#46; M&#46; Rodr&#237;guez Serna has served as a consultant for Sanofi&#44; Pfizer&#44; LEO Pharma&#44; Novartis&#44; and Abbie&#46; M&#46; Elosua-Gonz&#225;lez has served as a researcher and&#47;or speaker for AbbVie&#44; Lilly&#44; Galderma&#44; LEO Pharma&#44; Pfizer&#44; UCB Pharma&#44; and Sanofi Genzyme&#46; E&#46; del Alc&#225;zar has served as a speaker and&#47;or principal or co-investigator on clinical trials for Amgen&#44; Almirall&#44; Janssen&#44; Lilly&#44; LEO Pharma&#44; Novartis&#44; UCB&#44; and AbbVie&#46; A&#46; Batalla has participated in training activities and attended courses and conferences for AbbVie&#44; Celgene&#44; Faes Farma&#44; Isdin&#44; Janssen&#44; LEO Pharma&#44; Lethipharma&#44; Lilly&#44; Mylan&#44; Novartis&#44; Pierre Fabre&#44; and Sanofi&#59; served as a co-investigator on clinical trials sponsored by AbbVie&#44; Celgene&#44; LEO Pharma&#44; Lilly&#44; Novartis&#44; Pfizer&#44; and Sanofi&#59; and provided consultancy services for AbbVie and Sanofi&#46; H&#46; Jin Suh Oh has received training fees and provided consultancy services and&#47;or participated in clinical trials for AbbVie&#44; Celgene&#44; and Faes Farma&#46; C&#46; Maule&#243;n Fern&#225;ndez has participated in clinical trials on atopic dermatitis for LEO Pharma and Sanofi&#46; L&#46; Curto Barredo has received speaker&#39;s and consultancy fees from Novartis&#44; Sanofi&#44; AbbVie&#44; Lilly&#44; LEO pharma&#44; and Menarini and has worked as a principal and&#47;or co-investigator in research projects&#47;clinical trials for Sanofi&#44; Amgen&#44; Almirall&#44; Lilly&#44; LEO Pharma&#44; Novartis&#44; AbbVie&#44; and Pfizer&#46; G&#46; Roustan Gull&#243;n has received consultancy and training fees from Sanofi&#44; AbbVie&#44; Lilly&#44; Pfizer&#44; and LEO Pharma&#46; A&#46; Rosell D&#237;az has received speaker&#39;s fees from Sanofi and LEO Pharma and worked as a co-investigator in studies for Sanofi and Pfizer&#46; I&#46; Garc&#237;a-Doval has received financial support for attending conferences from AbbVie&#44; MSD&#44; Pfizer&#44; and Sanofi&#46; Jos&#233; Manuel Carrascosa has served as a principal&#47;co-investigator and&#47;or received speaker&#39;s fees&#44; and&#47;or served on expert or steering committees for AbbVie&#44; Novartis&#44; Janssen&#44; Lilly&#44; Sandoz&#44; Amgen&#44; Almirall&#44; BMS&#44; Boehringer Ingelheim&#44; Biogen&#44; UCB&#46; The other authors declare no conflicts of interest&#46;</p></span></span>"
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            1 => "Dermatitis at&#243;pica"
            2 => "Acontecimientos adversos"
            3 => "Biol&#243;gicos"
            4 => "Inhibidores de JAK"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Background</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In recent years&#44; remarkable improvements in our understanding of atopic dermatitis &#40;AD&#41; have revolutionized treatment perspectives&#44; but access to reliable data from clinical practice is essential&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Materials and method</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The Spanish Atopic Dermatitis Registry&#44; BIOBADATOP&#44; is a prospective&#44; multicenter database that collects information on patients of all ages with AD requiring systemic therapy with conventional or novel drugs&#46; We analyzed the registry to describe patient characteristics&#44; diagnoses&#44; treatments&#44; and adverse events &#40;AEs&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">We studied data entries for 258 patients who had received 347 systemic treatments for AD&#46; Treatment was discontinued in 29&#46;4&#37; of cases&#44; mostly due to a lack of effectiveness &#40;in 10&#46;7&#37; of cases&#41;&#46; A total of 132 AEs were described during follow-up&#46; Eighty-six AEs &#40;65&#37;&#41; were linked to a systemic treatment&#44; most commonly dupilumab &#40;39 AEs&#41; and cyclosporine &#40;38 AEs&#41;&#46; The most common AEs were conjunctivitis &#40;11 patients&#41;&#44; headache &#40;6&#41;&#44; hypertrichosis &#40;5&#41;&#44; and nausea &#40;4&#41;&#46; There was 1 severe AE &#40;acute mastoiditis&#41; associated with cyclosporine&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Conclusions</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Initial findings on AEs from the Spanish BIOBADATOP registry are limited by short follow-up times precluding comparisons or calculation of crude and adjusted incidence rates&#46; At the time of our analysis&#44; no severe AEs had been reported for novel systemic therapies&#46; BIOBADATOP will help answer questions on the effectiveness and safety of conventional and novel systemic therapies in AD&#46;</p></span>"
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        "resumen" => "<span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Antecedentes</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">En los &#250;ltimos a&#241;os se ha producido una revoluci&#243;n en el conocimiento de la dermatitis at&#243;pica &#40;DA&#41; que ha revertido en un salto cualitativo en las expectativas terap&#233;uticas&#46; En este contexto&#44; resulta fundamental disponer de datos de pr&#225;ctica cl&#237;nica de calidad&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Material y m&#233;todo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">BIOBADATOP es el Registro Espa&#241;ol de Dermatitis At&#243;pica&#44; un estudio observacional&#44; prospectivo y multic&#233;ntrico&#44; con una cohorte de pacientes de cualquier edad con DA que requieren el empleo de tratamiento sist&#233;mico &#40;convencional o innovador&#41;&#46; Se registraron los datos demogr&#225;ficos&#44; de diagn&#243;stico&#44; los tratamientos y los acontecimientos adversos &#40;AA&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Resultados</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 258 pacientes&#44; con 347 tratamientos sist&#233;micos iniciados para la DA&#46; Se suspendieron el 29&#44;4&#37; de los tratamientos&#44; principalmente por falta de eficacia &#40;10&#44;7&#37;&#41;&#46; Durante el per&#237;odo de seguimiento se registraron 132 AA&#46; Del total&#44; el 65&#37; &#40;86&#41; se relacionaron con el tratamiento sist&#233;mico iniciado&#44; siendo los m&#225;s frecuentes dupilumab &#40;39 AA&#41; y ciclosporina &#40;38 AA&#41;&#46; Los AA m&#225;s frecuentes fueron&#58; conjuntivitis &#40;11 pacientes&#41;&#44; cefalea &#40;6&#41;&#44; hipertricosis &#40;5&#41; y n&#225;useas &#40;4&#41;&#46; Se registr&#243; un AA grave &#40;mastoiditis aguda&#41; relacionado con ciclosporina&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Conclusiones</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">En este primer informe&#44; la descripci&#243;n de AA est&#225; limitada por los cortos per&#237;odos de seguimiento&#44; que no permiten el c&#225;lculo de tasas de incidencias crudas ni ajustadas&#44; y no se han realizado comparaciones&#46; Hasta la fecha del an&#225;lisis no se han registrado AA graves en relaci&#243;n con las nuevas terapias&#46; BIOBADATOP permitir&#225; generar conocimiento en t&#233;rminos de efectividad y de seguridad de los tratamientos sist&#233;micos cl&#225;sicos y de las nuevas terapias en DA&#46;</p></span>"
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                  \t\t\t\t">&#40;2&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&#40;16&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">5&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hospital Universitari Germans Trias i Pujol&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">18&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">7&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hospital General Universitario de Alicante&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">2&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">5&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Family and personal history of atopic comorbidities&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Personal diagnosis of atopic dermatitis and treatment history&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Comorbidities from the Charlson Comorbidity Index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Forms of atopic dermatitis&#58; nummular eczema&#44; palmoplantar eczema&#44; prurigo nodularis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&#8226; Description of affected areas&#58; face and eyelids&#44; genitals&#44; hands&#44; erythroderma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Total immunoglobulin E levels&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Disease severity on enrolment&#58; EASI&#44; pruritus VAS&#44; DLQI&#44; POEM&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Patient training or education programs &#40;atopy schools&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Previous screening tests &#40;serology for HBV&#44; HCV&#44; HIV&#44; and VZV&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">&#8226; Previous treatments &#40;including topical and systemic treatments and phototherapy&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Follow-up visits</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Changes in atopic dermatitis type&#44; location&#44; and&#47;or severity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Evaluation of main systemic treatment and&#47;or concomitant treatments&#44; phototherapy&#44; and topical treatments&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; If the main treatment has been changed&#58; reasons for change and patient results on initiation of new treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Reasons for treatment discontinuation if applicable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Evaluation of adverse events since last visit&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Additional visits to a hospital or health care center related to atopic dermatitis or treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Loss of productivity &#40;days of activity impairment due to atopic dermatitis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8226; Atopic dermatitis severity at time of visit&#58; EASI&#44; pruritus VAS&#44; DLQI&#44; POEM&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">No&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Personal history of cancer</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Asthma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">124&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">50&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Allergic rhinoconjunctivitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">135&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">56&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Atopic eye disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">40&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">17&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Personal history of atopy</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>First-degree relative with atopic dermatitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">76&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">37&#46;8&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>First-degree relative with asthma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">26&#46;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>First-degree relative with allergic rhinoconjunctivitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">44&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">23&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>First-degree relative with atopic eye disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Nonatopic comorbidities</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Anxiety</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Depression</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">10&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Myocardial infarction</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Cerebrovascular disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Dementia</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Chronic respiratory disease</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">42&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">17&#46;7&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Connective tissue disease</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Gastroduodenal ulcer</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Mild chronic liver disease</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  """
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          "leyenda" => "<p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">Abbreviations&#58; DLQI&#44; Dermatology Life Quality Index&#59; EASI&#44; Eczema Area and Severity Index&#59; POEM&#44; Patient-Oriented Eczema Measure&#59; VAS&#44; visual assessment scale&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Observations&#44; no&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Pruritus VAS &#40;0&#8211;10&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">POEM &#40;0&#8211;28&#41;&nbsp;\t\t\t\t\t\t\n
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                  """
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Upadacitinib&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adjuvant treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">M<span class="elsevierStyleItalic">ain treatment &#40;current status&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Active&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">245&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">70&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Discontinued&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">102&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Reason for discontinuation</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lack of effectiveness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Adverse event&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Physician&#39;s decision&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Patient&#39;s preference&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Disease remission&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                0 => """
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="5" align="center" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Treatment</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cyclosporine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Methotrexate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dupilumab&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Adverse event</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acne&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Alopecia areata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Iron deficiency anemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Burning sensation on skin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asthenia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Blepharitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dermatitis flare-up&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Creatine kinase elevation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Headache&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Conjunctivitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Allergic conjunctivitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>High creatinine&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abdominal pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Injection site pain&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Atopic eczema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Excessive tearing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Erythema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Facial erythema&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Erythromelalgia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Folliculitis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diminished renal function&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gastroenteritis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Blood pressure-high&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Oral herpes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Conjunctival hyperemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gingival hyperplasia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Arterial hypertension&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hypertransaminasemia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hypertrichosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gingival hypertrophy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">Blastocystis hominis</span> infection&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Red eye&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tearing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Increased tearing&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dizziness&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mastoiditis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nauseous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Nausea&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Acute otitis media&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Paresthesia in fingers&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Xerophthalmia&nbsp;\t\t\t\t\t\t\n
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                  """
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      "titulo" => "References"
      "seccion" => array:1 [
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          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:15 [
            0 => array:3 [
              "identificador" => "bib0080"
              "etiqueta" => "1"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Atopic dermatitis&#58; pathomechanisms and lessons learned from novel systemic therapeutic options"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T&#46; Bieber"
                            1 => "A&#46;S&#46; Paller"
                            2 => "K&#46; Kabashima"
                            3 => "M&#46; Feely"
                            4 => "M&#46;J&#46; Rueda"
                            5 => "J&#46;A&#46; Ross Terres"
                          ]
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                      "doi" => "10.1111/jdv.18225"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2022"
                        "volumen" => "36"
                        "paginaInicial" => "1432"
                        "paginaFinal" => "1449"
                        "link" => array:1 [
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Journal Information
Vol. 114. Issue 6.
Pages T479-T487 (June 2023)
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Vol. 114. Issue 6.
Pages T479-T487 (June 2023)
Original Article
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BIOBADATOP Spanish Atopic Dermatitis Registry: Description and Early Findings
BIOBADATOP: Registro Español de Dermatitis Atópica. Descripción y primeros resultados
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M. Munera-Camposa,
Corresponding author
muneracampos@gmail.com

Corresponding author.
, P. Chicharrob, A. Gonzalez Quesadac, Á. Flórez Menéndezd, P. de la Cueva Dobaoe, A.M. Gimenez Arnauf, Y. Gilaberte Calzadag, M. Rodríguez Sernah, T. Montero-Vilchezi, J.F. Silvestrej, M. Elosua-Gonzálezk, E. del Alcázara, C. Santamaríab, J. Sánchez-Pérezb, G. Carretero Hernándezc, A. Batallad, H. Jin Suh Ohd, C. Mauleón Fernándeze, L. Curto Barredof, M. Bertolín-Colillaf..., A. Navarro Bielsag, A. Ballano Ruizg, R. Botella Estradah, S. Arias Santiagoi, I. Betllochj, G. Roustan Gullónk, A. Rosell Díazk, M.A. Descalzol, I. García-Dovall,m, J.M. CarrascosaaVer más
a Servicio de Dermatología, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Germans Trias i Pujol Research Institute (IGTP), Badalona, Barcelona, Spain
b Servicio de Dermatología, Hospital Universitario de La Princesa, Madrid, Spain
c Servicio de Dermatología, Hospital Universitario de Gran Canaria Doctor Negrín, Las Palmas de Gran Canaria, Spain
d Servicio de Dermatología, Complejo Hospitalario Universitario de Pontevedra, Pontevedra, Spain
e Servicio de Dermatología, Hospital Universitario Infanta Leonor, Madrid, Spain
f Servicio de Dermatología, Hospital del Mar-Parc de Salut Mar, Barcelona, Spain
g Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, Spain
h Servicio de Dermatología, Hospital Universitario y Politécnico la Fe, Valencia, Spain
i Servicio de Dermatología, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain
j Servicio de Dermatología, Hospital General Universitario Dr Balmis, ISABIAL, Alicante, Spain
k Servicio de Dermatología, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain
l Unidad de Investigación, Fundación Piel Sana AEDV, Madrid, Spain
m Servicio de Dermatología, Complexo Hospitalario Universitario de Vigo, Vigo, Pontevedra, Spain
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Actas Dermosifiliogr. 2023;114:479-8710.1016/j.ad.2023.03.001
M. Munera-Campos, P. Chicharro, A. Gonzalez Quesada, Á. Flórez Menéndez, P. de la Cueva Dobao, A.M. Gimenez Arnau, Y. Gilaberte Calzada, M. Rodríguez Serna, T. Montero-Vilchez, J.F. Silvestre, M. Elosua-González, E. del Alcázar, C. Santamaría, J. Sánchez-Pérez, G. Carretero Hernández, A. Batalla, H. Jin Suh Oh, C. Mauleón Fernández, L. Curto Barredo, M. Bertolín-Colilla, A. Navarro Bielsa, A. Ballano Ruiz, R. Botella Estrada, S. Arias Santiago, I. Betlloch, G. Roustan Gullón, A. Rosell Díaz, M.A. Descalzo, I. García-Doval, J.M. Carrascosa
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Table 1. Demographic Description.
Table 2. Baseline and Follow-up Patient Data.
Table 3. Atopic and Nonatopic Comorbidities in Enrolled Patients.
Table 4. Baseline Scores for Main Outcome Measures.
Table 5. New Systemic Treatments Initiated (Baseline or BIOBADATOP Visit).
Table 6. Relevant Adverse Events Associated With Initiation of New Systemic Treatment.
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Abstract
Background

In recent years, remarkable improvements in our understanding of atopic dermatitis (AD) have revolutionized treatment perspectives, but access to reliable data from clinical practice is essential.

Materials and method

The Spanish Atopic Dermatitis Registry, BIOBADATOP, is a prospective, multicenter database that collects information on patients of all ages with AD requiring systemic therapy with conventional or novel drugs. We analyzed the registry to describe patient characteristics, diagnoses, treatments, and adverse events (AEs).

Results

We studied data entries for 258 patients who had received 347 systemic treatments for AD. Treatment was discontinued in 29.4% of cases, mostly due to a lack of effectiveness (in 10.7% of cases). A total of 132 AEs were described during follow-up. Eighty-six AEs (65%) were linked to a systemic treatment, most commonly dupilumab (39 AEs) and cyclosporine (38 AEs). The most common AEs were conjunctivitis (11 patients), headache (6), hypertrichosis (5), and nausea (4). There was 1 severe AE (acute mastoiditis) associated with cyclosporine.

Conclusions

Initial findings on AEs from the Spanish BIOBADATOP registry are limited by short follow-up times precluding comparisons or calculation of crude and adjusted incidence rates. At the time of our analysis, no severe AEs had been reported for novel systemic therapies. BIOBADATOP will help answer questions on the effectiveness and safety of conventional and novel systemic therapies in AD.

Keywords:
Treatments
Atopic dermatitis
Adverse events
Biologics
JAK inhibitors
Registries
Resumen
Antecedentes

En los últimos años se ha producido una revolución en el conocimiento de la dermatitis atópica (DA) que ha revertido en un salto cualitativo en las expectativas terapéuticas. En este contexto, resulta fundamental disponer de datos de práctica clínica de calidad.

Material y método

BIOBADATOP es el Registro Español de Dermatitis Atópica, un estudio observacional, prospectivo y multicéntrico, con una cohorte de pacientes de cualquier edad con DA que requieren el empleo de tratamiento sistémico (convencional o innovador). Se registraron los datos demográficos, de diagnóstico, los tratamientos y los acontecimientos adversos (AA).

Resultados

Se incluyeron 258 pacientes, con 347 tratamientos sistémicos iniciados para la DA. Se suspendieron el 29,4% de los tratamientos, principalmente por falta de eficacia (10,7%). Durante el período de seguimiento se registraron 132 AA. Del total, el 65% (86) se relacionaron con el tratamiento sistémico iniciado, siendo los más frecuentes dupilumab (39 AA) y ciclosporina (38 AA). Los AA más frecuentes fueron: conjuntivitis (11 pacientes), cefalea (6), hipertricosis (5) y náuseas (4). Se registró un AA grave (mastoiditis aguda) relacionado con ciclosporina.

Conclusiones

En este primer informe, la descripción de AA está limitada por los cortos períodos de seguimiento, que no permiten el cálculo de tasas de incidencias crudas ni ajustadas, y no se han realizado comparaciones. Hasta la fecha del análisis no se han registrado AA graves en relación con las nuevas terapias. BIOBADATOP permitirá generar conocimiento en términos de efectividad y de seguridad de los tratamientos sistémicos clásicos y de las nuevas terapias en DA.

Palabras clave:
Tratamientos
Dermatitis atópica
Acontecimientos adversos
Biológicos
Inhibidores de JAK
Registro prospectivo
Full Text
Introduction

Advances in our understanding of the pathogenesis of atopic dermatitis (AD) have led to the development of new therapeutic strategies targeting, for the first time in the history of this disease, key elements in the pathogenic pathway. Current treatments vary in their nature and mechanisms of action. Most of the available safety and efficacy data for new treatments are from clinical trials, whose findings led to the authorization of drugs such as dupilumab, baricitinib, upadacitinib, tralokinumab, and abrocitinib.1

While clinical trials are necessary, they are insufficient for determining the true effectiveness and safety of new treatments. There are several reasons for this. First, clinical trials usually study select groups of patients, excluding those with certain comorbidities and a higher risk of toxicity.2 Second, they have limited sample sizes and hence only detect the most common adverse events (AEs). Less common events (those with a frequency of less than 1:1000) are generally only detected in real-life clinical practice.

Registries are a useful source of data for pharmacovigilance purposes and evaluating long-term data on a broad set of patients, many of whom have comorbidities and are on other treatments. The Healthy Skin Foundation of the Spanish Academy of Dermatology and Venereology (AEDV) has created several registries, including BIOBADADERM (the Spanish Registry of Systemic Treatments in Psoriasis), which was launched by the AEDV Psoriasis Group in 20073 and has become an international reference point for information on psoriasis in real-world clinical settings.4,5

The Spanish Atopic Dermatitis Registry, BIOBADATOP, was started in 2020, with the inclusion of the first patients. BIOBADATOP is an initiative of the AEDV established in collaboration with 2 of the academy's working groups: the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) and the Spanish Pediatric Dermatology Group (GEDP). The registry was designed in tune with the European TREatment of severe Atopic eczema (TREAT) survey, an international enterprise aimed at standardizing the collection of observational data for patients receiving systemic treatment for AD.6

The BIOBADATOP registry is designed to collect high-quality, standardized data on the safety, effectiveness, and impact on quality of life of systemic AD treatments used in Spanish hospitals. This information can then be integrated with other national or international registries.

The main aims of the BIOBADATOP project are to:

  • 1.

    describe the short-term and long-term safety of systemic treatments for AD (including phototherapy) for pharmacovigilance purposes

  • 2.

    describe the short-term and long-term effectiveness of systemic treatments for AD (including phototherapy) to inform decision-making and guideline development

The secondary aims are to:

  • 1.

    describe the short- and long-term safety of topical treatments for AD

  • 2.

    describe the effectiveness of different models of AD care, including patient education

  • 3.

    describe comorbidities associated with AD

In this article, we describe the methodology used to create the BIOBADATOP registry and report on its initial findings.

Material and MethodsStudy Design

BIOBADATOP is a multicenter, observational, prospective, cohort study designed to collect information on patients of all ages with AD who are started on a systemic treatment.

Participating Hospitals

To contribute to the BIOBADATOP registry, hospitals must have at least 1 dermatologist with interest and responsibilities in the treatment of moderate to severe AD. Hospitals can gradually join the project, which aims to maintain a sufficiently representative geographic scope. The hospitals in the project at the time of this analysis are shown in Table 1.

Table 1.

Demographic Description.

Sex, No. %
Male  139  54.3 
Female  117  45.7 
Mean follow-up (SD), y  0.7  (2.2) 
Mean (SD) age, y  32.6  (16.2) 
Hospital, no., %
Hospital Universitario de Gran Canaria Doctor Negrín  42  16.3 
Hospital Universitario de La Princesa  32  12.4 
Hospital del Mar-IMIM  15  5.8 
Hospital Universitari Germans Trias i Pujol  47  18.2 
Hospital Universitario Miguel Servet Zaragoza  20  7.8 
Hospital General Universitario de Alicante  2.7 
Hospital Universitario La Fe  15  5.8 
Complejo Hospitalario Universitario de Pontevedra  37  14.3 
Hospital Universitario Infanta Leonor  36  14.0 
Hospital Universitario Virgen de las Nieves  2.7 
Patient Enrolment

The BIOBADATOP registry contains data on adult and pediatric patients with AD who are started on systemic immunomodulatory therapy in routine clinical practice. To be included, patients must meet the U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis.7,8

Exposure and Follow-up

Data collected at the enrolment visit include demographic and diagnostic information, baseline disease severity assessed using the Eczema Area and Severity Index (EASI), the Dermatology Life Quality Index (DLQI), and the Patient-Oriented Eczema Measure (POEM), and information on diagnostic tests, comorbidities, and previous AD treatments.

Follow-up visits are carried out as per usual clinical practice. Data from visits closest to 3 and 6months after the start of each systemic treatment are recorded. Annual visits are recorded thereafter. A note is made of any changes to disease severity or treatment (main systemic treatment and concomitant treatments).

At each visit, all AEs the patient may have experienced since their last visit are recorded and coded using MedDRA (Medical Dictionary for Drug Regulatory Activities) terms (https://www.meddra.org).

Enrolled patients are expected to remain in the registry for an indefinite period of time. The duration envisaged for the BIOBADATOP project is at least 10 years.

Outcome Measures

Table 2 summarizes the data collected to describe the study population and explore factors that might influence the occurrence of AEs.

Table 2.

Baseline and Follow-up Patient Data.

Baseline visit 
• Demographic data, including ethnic background 
• Weight and height 
• Family and personal history of atopic comorbidities 
• Personal diagnosis of atopic dermatitis and treatment history 
• Comorbidities from the Charlson Comorbidity Index 
• Forms of atopic dermatitis: nummular eczema, palmoplantar eczema, prurigo nodularis 
• Description of affected areas: face and eyelids, genitals, hands, erythroderma 
• Total immunoglobulin E levels 
• Disease severity on enrolment: EASI, pruritus VAS, DLQI, POEM 
• Patient training or education programs (atopy schools) 
• Previous screening tests (serology for HBV, HCV, HIV, and VZV) 
• Previous treatments (including topical and systemic treatments and phototherapy) 
 
Follow-up visits 
• Changes in atopic dermatitis type, location, and/or severity 
• Evaluation of main systemic treatment and/or concomitant treatments, phototherapy, and topical treatments 
• If the main treatment has been changed: reasons for change and patient results on initiation of new treatment 
• Reasons for treatment discontinuation if applicable 
• Evaluation of adverse events since last visit 
• Additional visits to a hospital or health care center related to atopic dermatitis or treatment 
• Loss of productivity (days of activity impairment due to atopic dermatitis) 
• Atopic dermatitis severity at time of visit: EASI, pruritus VAS, DLQI, POEM 

Abbreviations: DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; HCV, hepatitis C virus; HBV, hepatitis B virus; POEM, Patient-Oriented Eczema Measure; VAS, visual assessment scale; VZV, varicella zoster virus.

Statistical Analysis

We performed a descriptive analysis of patients enrolled in the registry since its launch in March 2020 up to November 2022. Statistical analyses were performed in Stata (version 17.0 Statacorp). Demographic and clinical data are described using conventional statistics (mean [SD] and absolute and relative frequencies).

Sample Size Estimation

Based on the experience with the BIOBADADERM registry, BIOBADATOP is expected to collect data on approximately 5700 persons-year (approximately 2500 patients in 10years). It is estimated that this sample will be sufficient to detect, with a statistical power of 80% and a bilateral significance level of 0.05, relative risks of between 1.5 and 2 for an AE incidence of 4 to 10 cases per 1000 person-years in the comparison group. The group will collaborate with other members of TREAT network to detect rare and late AEs.

Data Management and Quality Control

Data are entered, following a standardized method, into an online software system (REDCap [Research Electronic Data Capture])9 hosted by the Healthy Skin Foundation. Each patient is assigned a unique identifier.

Ethical Considerations

The study was approved by the research ethics committee of Aragón (PA18/051), the Spanish Agency for Medicines and Medical Devices (AEMPS), and all participating hospitals. It was conducted in compliance with the principles of the Declaration of Helsinki and current legislation. The BIOBADATOP project has also received the European Network of Centres for Pharmacoepidemiology and Pharmacovigilance (ENCePP) quality seal attesting to scientific independence and transparency. The ENCePP is coordinated by the European Medicines Agency.

Results

The first 2 patients were enrolled in BIOBADATOP in March 2020. This report describes entries recorded up to November 2022. At the time of analysis, 13 hospitals were contributing to the registry.

Main Baseline Characteristics

As of November 2022, BIOBADATOP contained data on 258 patients (139 [54.3%] males). Mean (SD) age on enrolment was 32.6 (16.2) years. Mean follow-up was 9 months.

The main comorbidities are shown in Table 3. The most common conditions were asthma (50.4%) and allergic rhinoconjunctivitis (56.5%). Just 17% of patients had an atopic eye disease. Other notable comorbidities were anxiety (21.8%), chronic respiratory disease (17.7%), and depression (10.5%).

Table 3.

Atopic and Nonatopic Comorbidities in Enrolled Patients.

  No. 
Atopic comorbidities
Personal history of cancer
Asthma  124  50.4 
Allergic rhinoconjunctivitis  135  56.5 
Atopic eye disease  40  17.0 
Personal history of atopy     
First-degree relative with atopic dermatitis  76  37.8 
First-degree relative with asthma  52  26.9 
First-degree relative with allergic rhinoconjunctivitis  44  23.7 
First-degree relative with atopic eye disease  11  5.9 
Nonatopic comorbidities
Anxiety  50  21.8 
Depression  24  10.5 
Myocardial infarction  0.4 
Heart failure 
Peripheral artery disease  1.7 
Cerebrovascular disease 
Dementia 
Chronic respiratory disease  42  17.7 
Connective tissue disease 
Gastroduodenal ulcer 
Mild chronic liver disease 
Moderate/severe chronic liver disease  1.3 
Diabetes 
Diabetes with target-organ damage 
Hemiparesis 
Moderate/severe chronic kidney failure  0.4 
Solid tumor or neoplasm  0.8 
Solid tumor or neoplasm with metastasis  0.8 
Leukemia 
Lymphoma  1.3 
Defined AIDS 

The most common clinical presentations were dermatitis involving extensor surfaces (93.3%), the face and eyelids (84.6%), and the hands (67.1%). There was also genital involvement (31.6%), erythroderma (covering>70% of the body surface area) (17.2%), palmoplantar eczema (12.1%), nummular eczema (12.6%), and prurigo nodularis (≥5 palpable nodules) (11.6%).

Systemic treatments received prior to inclusion in the BIOBADATOP registry are shown in Fig. 1. Twenty percent of patients had not been previously treated with a systemic agent. The most widely used previous systemic treatments were cyclosporine (> 50% of patients) and oral corticosteroids (49%), followed at quite a distance by methotrexate, at just over 20%.

Figure 1.

Systemic treatments initiated prior to enrolment in the BIOBADOTOP registry.

(0.14MB).

Phototherapy, mostly with narrowband UVB light, had been used in 44.3% of cases. The vast majority of patients (97.4%) had been treated with topical corticosteroids; 44.3% had received topical calcineurin inhibitors.

Baseline and Follow-up Findings

Mean (SD) AD severity according to the EASI was 23.4 (11.9; range, 0–63) at baseline. The mean (SD) quality of life scores on enrolment were 19.7 (6.3) for POEM, 14.6 (7.6) for DLQI in patients>15years, and 9.7 (5.6) in patients aged 15years. The baseline scores for the main outcomes of interest are summarized in Table 4.

Table 4.

Baseline Scores for Main Outcome Measures.

  Observations, no.  Mean  SD  Minimum  Maximum 
Pruritus VAS (0–10)  219  7.5  2.1  10 
EASI (0–72)  245  23.4  11.9  63 
POEM (0–28)  173  19.7  6.3  28 
DLQI score (0–30)  164  14.6  7.6  30 
Children's DLQI (0–30)  20  9.7  5.6  23 

Abbreviations: DLQI, Dermatology Life Quality Index; EASI, Eczema Area and Severity Index; POEM, Patient-Oriented Eczema Measure; VAS, visual assessment scale.

A total of 347 systemic therapies were started between March 2020 and November 2022 (Table 5). Practically all the treatments (90%) were primary treatments. The discontinuation rate for newly initiated treatments was 29.4%, and the main reason was a lack of effectiveness (10.7%).

Table 5.

New Systemic Treatments Initiated (Baseline or BIOBADATOP Visit).

  No. 
Systemic treatment
Cyclosporine  120  34.6 
Azathioprine  0.3 
Methotrexate  10  2.9 
Mycophenolate mofetil  0.3 
Dupilumab  161  46.4 
Corticosteroids  23  6.6 
Omalizumab  0.3 
Baricitinib  0.3 
Upadacitinib  23  6.6 
Tralokimumab  1.7 
Type of Treatment
Main treatment  305  90.0 
Adjuvant treatment  34  10.0 
Main treatment (current status)
Active  245  70.6 
Discontinued  102  29.4 
Reason for discontinuation
Lack of effectiveness  37  10.7 
Adverse event  21  6.1 
Physician's decision  14  4.0 
Patient's preference  2.3 
Disease remission  12  3.5 
Other  10  2.9 

Of the 258 patients enrolled in the database, 232 (89.9%) were still under active treatment with a systemic drug at the time of analysis, 15 (5.8%) had been taken off systemic treatment, and 11 (4.3%) had been lost to follow-up.

Description of AEs

In total, 132 AEs were registered during follow-up; 7 of these (5.3%) were considered serious. Of the 132 documented AEs, 65% (86) were linked to the new systemic treatment. The most common drugs implicated were dupilumab (39 AEs) and cyclosporine (38). The most common AEs were conjunctivitis (11 cases), headache (6), hypertrichosis (5), and nausea (4). We were unable to calculate incidence rates according to MedDRA terms because of the low frequency of cases at the time of analysis. The AEs recorded are shown by drug in Table 6. There was just 1 serious event—acute mastoiditis requiring hospital admission—in a patient treated with cyclosporine. The patient recovered completely and the drug was permanently discontinued.

Table 6.

Relevant Adverse Events Associated With Initiation of New Systemic Treatment.

  Treatment
  Cyclosporine  Methotrexate  Dupilumab  Other  Total 
Adverse event
Acne 
Alopecia areata 
Iron deficiency anemia 
Burning sensation on skin 
Asthenia 
Blepharitis 
Dermatitis flare-up 
Creatine kinase elevation 
Headache 
Conjunctivitis  11  11 
Allergic conjunctivitis 
High creatinine 
Abdominal pain 
Injection site pain 
Atopic eczema 
Excessive tearing 
Erythema 
Facial erythema 
Erythromelalgia 
Folliculitis 
Diminished renal function 
Gastroenteritis 
Blood pressure-high 
Oral herpes 
Conjunctival hyperemia 
Gingival hyperplasia 
Hypertension 
Arterial hypertension 
Hypertransaminasemia 
Hypertrichosis 
Gingival hypertrophy 
Blastocystis hominis infection 
Red eye 
Tearing 
Increased tearing 
Dizziness 
Mastoiditis 
Nauseous 
Nausea 
Acute otitis media 
Paresthesia in fingers 
Plaque psoriasis 
Hepatitis B reactivation 
Gum bleeding 
Dry eye sensation 
Hot flushes 
Tension 
Urticaria 
Uveitis 
Xerophthalmia 
Xerostomia 
Total          86 
Discussion

The AEDV BIOBADATOP registry was created to collect clinical-epidemiological, pharmacovigilance, and effectiveness data on patients with moderate to severe AD under treatment with conventional or novel systemic therapies at a turning point in the history of the treatment of this disease. In this first report, we describe the current situation captured by the registry and the main characteristics of the patients enrolled.

Most patients prescribed a systemic treatment for AD in our setting have severe disease, in terms of not just clinical manifestations but also itching severity and impact on quality of life. While these are key aspects that influence decisions by both physicians and patients, they are not part of the reimbursement criteria for new drugs. Despite the clinical heterogeneity of AD, almost all the patients in the BIOBADATOP registry had dermatitis affecting the extensor surfaces. In addition, many patients had lesions in locations that have a greater impact on everyday life and can be challenging to treat, such as the face, eyelids, genitals, and hands. A large percentage of patients had atopic comorbidities such as asthma. Other comorbidities, notably mood disorders, were also common.

Dupilumab was approved by the European Medicines Agency in September 2017. Authorization was subsequently granted for baricitinib, followed by tralokinumab and upadacitinib. Dupilumab is the most widely used systemic AD treatment used by the hospitals participating in the BIOBADATOP project. This is, at least in part, because it was approved earlier, meaning that clinicians are more familiar with its use, and there is a greater understanding of longer-term effects in real-world settings. Choice of drug, however, can also be influenced by other factors, such as access to authorization or first-line treatment policies in different health care regions.

Although the BIOBADATOP registry covers both pediatric and adult patients, the patients included were on average aged between 30 and 40. This is probably because most of the researchers that contribute to the registry are heads of units that mainly treat adults with moderate to severe AD. Pediatric units are less well represented. In addition, new systemic therapies for AD were approved later, and at different time points, for children.

This first report on the BIOBADATOP registry is limited by the short follow-up times, which precluded comparisons and an accurate measure of incidence rates. We were only able to describe frequencies, which do not reflect time of exposure to given drugs. Most of the AEs reported were associated with the most widely used drugs: dupilumab and cyclosporine. Despite this limitation, no serious AEs had been reported for any of the novel systemic treatments at the time of this analysis. There was 1 serious infection (mastoiditis), linked to cyclosporine. Other nonserious but relatively common AEs were headache, hypertrichosis, and gum bleeding.

Of all the novel systemic treatments used by Spanish hospitals in the BIOBADATOP registry, dupilumab was the medication with the most available data. The most common AEs were conjunctivitis and other AEs affecting the surface of the eye, such as blepharitis and xerophthalmia. There was just 1 case of facial erythema. These findings are consistent with recent real-world data on drug safety.10,11 Our findings did not reveal any new safety alerts.

The incidence of certain key AEs, such as cancer and other potentially serious AEs, is too low to be accurately captured in national registries, but this limitation can be overcome by combining data from different countries. BIOBADATOP is directly linked to the TREAT project and uses a standardized European protocol, similar to that followed by the United Kingdom, the Netherlands, Germany, and other European countries. Combining data from different registries should provide the necessary statistical power to calculate incidence rates for less common AEs. Germany (TREATgermany)12 and Denmark (SCRATCH)13 have both reported findings from their national registries, and the TREAT Registry Taskforce published a recent status update on the 8 databases in the network, including BIOBADATOP. The update covered 4702 patients enrolled up to May 2022.14

The treatment of AD is undergoing a major transformation.15 Until very recently, patients with disease refractory to topical treatment and/or phototherapy were largely treated with cyclosporine or off-label immunosuppressants, such as methotrexate and azathioprine. This is reflected in the data on previous treatments showing the use of at 1 conventional immunosuppressive treatment and a high use of corticosteroids. Although clinical trial data suggest that novel systemic therapies for AD have an adequate safety profile, their effects in the broader population must be studied.

The BIOBADATOP registry will generate useful data for pharmacovigilance purposes and for evaluating treatment effectiveness in real-world clinical settings, contributing to a greater understanding of moderate to severe AD and better management of this disease.

Funding

The BIOBADATOP project is led by the Healthy Skin Foundation of the Spanish Academy of Dermatology and Venereology (AEDV) and receives funding from the pharmaceutical companies Sanofi, AbbVie, Pfizer, and LEO Pharma. None of these companies had any involvement in study design or conduct; data collection, management, analysis, or interpretation; manuscript preparation, revision, or approval; or the decision to submit this manuscript for publication.

Conflicts of Interest

M. Munera-Campos has received fees for consultancy services, presentations, and other related activities from AbbVie, LEO Pharma, Janssen, Sanofi, and Galderma and has served as a principal or co-investigator on clinical trials sponsored by Lilly, LEO Pharma, Novartis, Janssen, Sanofi, Pfizer, AbbVie, Almirall, UCB, and Galderma. P. Chicharro has provided consultancy services for and participated in presentations and clinical trials organized by Janssen Pharmaceuticals, Almirall, Sanofi Genzyme, Lilly, AbbVie, Novartis, LEO Pharma, and Pfizer-Wyeth. A. González Quesada has provided consultancy services and participated in presentations and clinical trials for AbbVie, Pfizer, Novartis, Sanofi, Boeringher, Bristol-Meyer, LEO Pharma, and Jansen. Á. Flórez Menéndez has participated in clinical trials, given presentations, and provided consultancy services for AbbVie, Almirall, Amgen, Janssen, LEO Pharma, Lilly, Novartis, Pfizer, Sanofi, and UCB Pharma. P. de la Cueva Dobao has served as a consultant and/or researcher and/or speaker for AbbVie, Almirall, BMS, Boehringer, Celgene, Janssen, LEO Pharma, Lilly, MSD, Novartis, Pfizer, Roche, Sanofi, and UCB. A. M. Gimenez-Arnau has served as a medical advisor for Uriach Pharma/Neucor, Genentech, Novartis, FAES, GSK, Sanofi-Regeneron, Amgen, Thermo Fisher Scientific, Almirall, Celldex, and LEO Pharma. Y. Gilaberte-Calzada has served as a consultant for Isdin and Roche Posay, and Galderma, given presentations for Almirall, Sanofi, Avene, Rilastil, Lylly, Uriage, Novartis, and Cantabria Labs, and participated in research projects for Almirall, Sanofi, Pfizer, AbbVie, and LEO Pharma. M. Rodríguez Serna has served as a consultant for Sanofi, Pfizer, LEO Pharma, Novartis, and Abbie. M. Elosua-González has served as a researcher and/or speaker for AbbVie, Lilly, Galderma, LEO Pharma, Pfizer, UCB Pharma, and Sanofi Genzyme. E. del Alcázar has served as a speaker and/or principal or co-investigator on clinical trials for Amgen, Almirall, Janssen, Lilly, LEO Pharma, Novartis, UCB, and AbbVie. A. Batalla has participated in training activities and attended courses and conferences for AbbVie, Celgene, Faes Farma, Isdin, Janssen, LEO Pharma, Lethipharma, Lilly, Mylan, Novartis, Pierre Fabre, and Sanofi; served as a co-investigator on clinical trials sponsored by AbbVie, Celgene, LEO Pharma, Lilly, Novartis, Pfizer, and Sanofi; and provided consultancy services for AbbVie and Sanofi. H. Jin Suh Oh has received training fees and provided consultancy services and/or participated in clinical trials for AbbVie, Celgene, and Faes Farma. C. Mauleón Fernández has participated in clinical trials on atopic dermatitis for LEO Pharma and Sanofi. L. Curto Barredo has received speaker's and consultancy fees from Novartis, Sanofi, AbbVie, Lilly, LEO pharma, and Menarini and has worked as a principal and/or co-investigator in research projects/clinical trials for Sanofi, Amgen, Almirall, Lilly, LEO Pharma, Novartis, AbbVie, and Pfizer. G. Roustan Gullón has received consultancy and training fees from Sanofi, AbbVie, Lilly, Pfizer, and LEO Pharma. A. Rosell Díaz has received speaker's fees from Sanofi and LEO Pharma and worked as a co-investigator in studies for Sanofi and Pfizer. I. García-Doval has received financial support for attending conferences from AbbVie, MSD, Pfizer, and Sanofi. José Manuel Carrascosa has served as a principal/co-investigator and/or received speaker's fees, and/or served on expert or steering committees for AbbVie, Novartis, Janssen, Lilly, Sandoz, Amgen, Almirall, BMS, Boehringer Ingelheim, Biogen, UCB. The other authors declare no conflicts of interest.

Acknowledgments

We would like to thank all the BIOBADATOP researchers for their dedication and diligence in recording detailed information on adverse events and other relevant data in routine practice and other clinical settings, where both time and financial resources linked to other dermatology department activities are typically allocated to these tasks.

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