Article information
Summary
Neurotrophins (NTs) belong to a family of structurally and functionally related proteins that, depending on the tissue context and the receptors involved, promote neuronal cell survival and differentiation or cell death. NTs also exert important functions in other organs besides the nervous system, including the skin. The presence in the skin of diverse cell types which are able to secrete and/or to respond to stimulation by NTs creates a unique network of molecular signaling in the cutaneous microenvironment. This review summarizes currently available data on the expression and function of NTs and their receptors in several cell types in the skin (namely, keratinocytes, melanocytes and fibroblasts). The role of the skin NT network in the development and maintenance of some relevant skin diseases is presented and the potential implications for therapeutic intervention are discussed.
Key words:
neurotrophins
Trk
p75NTR
skin
psoriasis
melanoma
Resumen
Las neurotrofinas (NT) pertenecen a una familia de proteínas relacionadas estructural y funcionalmente que, dependiendo del tejido y del receptor implicados, promueven la supervicencia y diferenciación neuronal o la apoptosis. Las NT también ejercen importantes funciones en otros órganos, aparte del sistema nervioso, incluyendo la piel. La presencia de diversos tipos celulares en la piel que son capaces de segregar o responder al estímulo de las NT, crea una red única de señalización molecular en el microambiente cutáneo. Esta revisión resume los datos disponibles actualmente sobre la expresión y función de las NT y sus receptores en diversos tipos celulares de la piel (a saber: queratinocitos, melanocitos, fibroblastos). Se discute el papel de la red de NT cutáneas en el desarrollo y mantenimiento de algunas enfermedades cutáneas relevantes, así como las implicaciones potenciales para una intervención terapéutica.
Palabras clave:
neurotrofinas
Trk
p75NTR
piel
psoriasis
melanoma
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