Journal Information
Vol. 100. Issue S2.
Mirando hacia el futuro en Dermatología Extraordinario del Centenario. Parte II
Pages 75-83 (December 2009)
Vol. 100. Issue S2.
Mirando hacia el futuro en Dermatología Extraordinario del Centenario. Parte II
Pages 75-83 (December 2009)
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Keloid Scarring: New Treatments Ahead
Queloides: nuevos tratamientos en el futuro
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5967
Ulrich Mrowietza,
Corresponding author
umrowietz@dermatology.uni-kiel.de

Correspondence: Department of Dermatology. University Medical Center Schleswig-Holstein, Campus Kiel. Schittenhelmstr. 7. 24105 Kiel. Germany.
, Oliver Seifertb
a Department of Dermatology. University Medical Center Schleswig-Holstein. Campus Kiel. Kiel. Germany
b Department of Dermatology. County Hospital Ryhov. Jönköping. Sweden
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Article information
Abstract

Keloid disease presents a healthcare challenge: patients suffer from pruritus, pain, inflammation, and cosmetic disfigurement. There is no single effective therapeutic regimen for keloids. Numerous treatment options have been described including occlusive dressings, compression therapy, intralesional steroid injections, laser and radiation therapy, cryosurgery, 5-fluorouracil, interferon, and imiquimod cream, but managing keloid disease still is a considerable problem for clinicians. Better understanding of the molecular mechanisms behind keloid disease led to the development of new promising therapies like the application of recombinant TGF-β3, interleukin 10, and imatinib mesylate.

This review provides an overview of the existing therapeutic options for keloid disease and summarizes upcoming future therapies with a special focus on blocking the transforming growth factor-beta pathway.

Key words:
keloid
treatment
physiopathology
molecular mechanisms
TGF-β3
interleukin 10
imatinib mesylate
Resumen

Los queloides representan un reto de atención sanitaria: los pacientes padecen prurito, dolor, inflamación y desfiguración cosmética. No existe ningún tratamiento efectivo para los queloides. Se han descrito numerosas opciones terapéuticas que incluyen vendajes oclusivos, terapia de compresión, corticoides intralesionales, láser, radioterapia, criocirugía, 5-fluorouracilo, interferón e imiquimod, pero el tratamiento continúa siendo un problema considerable para los clínicos.

Se han desarrollado nuevas y prometedoras terapias, como la aplicación de TGF-β3 recombinante, interleuquina 10 y mesilato de imatinib gracias a un mayor conocimiento de los mecanismos moleculares responsables de los queloides.

Esta revisión ofrece una visión de conjunto de las opciones terapéuticas disponibles para los queloides y resume las futuras terapias, haciendo especial énfasis en los bloqueadores de la vía del factor de crecimiento transformador beta.

Palabras clave:
queloides
tratamiento
fisiopatología
mecanismos moleculares
TGF-β3
interleuquina 10
mesilato de imatinib
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