Case and Research Letters
Dermoscopic Features of Spiradenocylindroma
Espiroadenocilindroma: hallazgos dermatoscópicos
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A) Imagen de campo: espiroadenoma (*) y cilindroma (+) que conforman una misma lesión (40X).</p> <p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">B) Porción superior formada por células con pequeños núcleos hipercromáticos y otras de núcleos grandes y pálidos. Espiroadenoma (400X). C) Porción inferior: nidos tumorales dispuestos en damero, rodeados por bandas hialinas. Cilindroma (400X).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "A. Senarega, L. Flores, A.C. Innocenti, V. Parra" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A." "apellidos" => "Senarega" ] 1 => array:2 [ "nombre" => "L." "apellidos" => "Flores" ] 2 => array:2 [ "nombre" => "A.C." "apellidos" => "Innocenti" ] 3 => array:2 [ "nombre" => "V." "apellidos" => "Parra" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219019302033" "doi" => "10.1016/j.adengl.2019.06.002" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019302033?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018305490?idApp=UINPBA000044" "url" => "/00017310/0000011000000007/v1_201909021023/S0001731018305490/v1_201909021023/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219019302045" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.03.021" "estado" => "S300" "fechaPublicacion" => "2019-09-01" "aid" => "2140" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Actas Dermosifiliogr. 2019;110:606-10" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Absolute Versus Relative Psoriasis Area and Severity Index in Clinical Practice" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "606" "paginaFinal" => "610" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "PASI absoluto versus PASI relativo en la práctica clínica real" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 4178 "Ancho" => 2569 "Tamanyo" => 479748 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Psoriasis area and severity index (PASI) score: absolute (PASI ≤3 and PASI ≤5) and relative (PASI 90 and PASI 75) scores after 1 (A), 3 (B), and 5 (C) years of biological drug treatment (<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>).</p> <p id="spar8085" class="elsevierStyleSimplePara elsevierViewall">The 3 treatment groups were compared using the χ2 test for nominal variables (<span class="elsevierStyleSup">*</span>p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.05, <span class="elsevierStyleSup">**</span>p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.01).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. del Alcázar Viladomiu, N. 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"apellidos" => "Salleras Redonnet" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731019300110" "doi" => "10.1016/j.ad.2018.03.029" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731019300110?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019302045?idApp=UINPBA000044" "url" => "/15782190/0000011000000007/v1_201909021030/S1578219019302045/v1_201909021030/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219019300484" "issn" => "15782190" "doi" => "10.1016/j.adengl.2019.02.010" "estado" => "S300" "fechaPublicacion" => "2019-09-01" "aid" => "2034" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2019;110:e17" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 4 "formatos" => array:2 [ "EPUB" => 1 "HTML" => 3 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">e-Images in Dermatology</span>" "titulo" => "Infarcted Giant Skin Tag" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "e17" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fibroma blando gigante infartado" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:6 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 859 "Ancho" => 2500 "Tamanyo" => 308260 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E.C. López-Jiménez, R. Ruiz-Rodríguez, I. Sánchez-Carpintero" "autores" => array:3 [ 0 => array:2 [ "nombre" => "E.C." "apellidos" => "López-Jiménez" ] 1 => array:2 [ "nombre" => "R." "apellidos" => "Ruiz-Rodríguez" ] 2 => array:2 [ "nombre" => "I." "apellidos" => "Sánchez-Carpintero" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018303533" "doi" => "10.1016/j.ad.2017.11.022" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018303533?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019300484?idApp=UINPBA000044" "url" => "/15782190/0000011000000007/v1_201909021030/S1578219019300484/v1_201909021030/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Case and Research Letters</span>" "titulo" => "Dermoscopic Features of Spiradenocylindroma" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "604" "paginaFinal" => "606" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Senarega, L. Flores, A.C. Innocenti, V. Parra" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Senarega" "email" => array:1 [ 0 => "adrianasenarega@hotmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L." "apellidos" => "Flores" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A.C." "apellidos" => "Innocenti" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "V." "apellidos" => "Parra" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Luis Lagomaggiore, Mendoza, Argentina" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Espiroadenocilindroma: hallazgos dermatoscópicos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 407 "Ancho" => 1500 "Tamanyo" => 197819 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Spiradenoma (*) and cylindroma (+) within a single lesion (hematoxylin-eosin, original magnification ×40). B, Spiradenoma: upper portion of the lesion consisting of cells with small hyperchromatic nuclei and others with large, pale nuclei (hematoxylin-eosin, original magnification ×400). C, Cylindroma: lower portion of the lesion consisting of tumoral nests arranged in a checkerboard pattern and surrounded by hyaline bands (hematoxylin-eosin, original magnification ×400).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Benign cutaneous adnexal tumors are a heterogeneous group of uncommon lesions that includes spiradenoma and cylindroma. We report a case of coexisting spiradenoma and cylindroma and describe the corresponding dermoscopic findings.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 37-year-old woman with no known medical history of interest was seen for an asymptomatic scalp lesion that was located on the hairline and had appeared 6 months earlier. Physical examination revealed a soft, rounded, skin-colored nodule (1 cm in diameter), upon which was a bluish, hard-elastic papule (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Dermoscopy revealed a salmon-pink area containing linear vessels on the lesion surface and the presence at the lesion periphery of associated structures with homogeneous blue coloration. Yellowish-brown desquamation corresponding to seborrhoeic eczema was also observed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><p id="par0020" class="elsevierStylePara elsevierViewall">An excisional biopsy was performed. Subsequent histopathology revealed 2 distinct histological patterns. The first, more superficial pattern corresponded to a dermal tumor composed of multiple basophilic nodules formed by strands of dark basaloid cells and larger cells with pale nuclei. Ductal structures were also observed inside the lobes, as well as hyaline drops and squamous corpuscles (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">The second pattern, observed in the deepest part of the lesion, consisted of irregular strands of basophilic cells arranged in a checkerboard pattern and surrounded by eosinophilic hyaline bands (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). Based on these findings a diagnosis of spiradenocylindroma was established.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Spiradenoma, first described by Kersting and Helwing in 1956,<span class="elsevierStyleSup">1</span> is more frequent in females aged 15 to 35 years. The clinical presentation consists of a single, soft, bluish nodule of 1 cm to 2 cm in diameter that is painful on palpation and is typically located on the trunk or neck.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1,2</span></a> In 2015 Sahin<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">3</span></a> reported the following dermoscopic features of this lesion: bluish pigmentation, varied vascular structures, and reticulated pigmentation at the lesion periphery. In the same year Ankad and coworkers<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">4</span></a> described the trichoscopic features of spiradenoma, including the presence of red serpentine linear structures surrounded by whitish areas.</p><p id="par0035" class="elsevierStylePara elsevierViewall">The term cylindroma was first used by Billroth in 1856 to describe a benign adnexal tumor that mainly affects women aged 20 to 30 years.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">5,6</span></a> Cylindroma presents as a firm, pink nodule located on the face or scalp, usually grows slowly, and has a mean size of 2<span class="elsevierStyleHsp" style=""></span>mm to 6 mm.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> Reported dermoscopic patterns include arboriform vessels on a whitish, salmon-pink background, blue dots and globules, and ulceration.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">8,9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">Spiradenoma and cylindroma are neoplasms of controversial histogenesis. Historically, spiradenoma has been considered a tumor of eccrine differentiation. However, its association with trichoepitheliomas in Brooke-Spiegler syndrome and with milium cysts in Rasmussen syndrome suggests a probable apocrine origin. Cylindroma was originally considered an apocrine tumor. Recent studies have revealed apocrine and eccrine characteristics in both tumor types. Some authors even claim that these tumors are derived from the follicular epithelium, since they are positive for CD200, an immunohistochemical marker of hair-follicle stem cells.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">5,10</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">While co-occurrence of both neoplasms in the same patient has been previously reported, coexistence within the same clinical lesion is highly unusual. Meybehm and Fischer proposed the term spiradenocylindroma for this particular presentation.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Spiradenocylindroma presents as a benign tumor, which can be solitary or, in the case of Brooke-Spiegler syndrome, multiple. Physical examination of our patient, who had no family history of interest, revealed a solitary lesion and no other pathological findings.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">10,11</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">The dermoscopic features of spiradenocylindroma have not been previously described. In our case, the main dermoscopic findings were areas with salmon-pink coloration, linear vessels, and the presence at the lesion periphery of structures with a homogeneous blue coloration (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">We have reported this case to share our finding of a very rare adnexal tumor and to describe the dermoscopic features of spiradenocylindroma.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:2 [ "identificador" => "xack423720" "titulo" => "Acknowledgments" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-11-27" "fechaAceptado" => "2018-03-09" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Senarega A. Espiroadenocilindroma: hallazgos dermatoscópicos. 2019;110:604–606.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 666 "Ancho" => 1300 "Tamanyo" => 210292 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Skin-colored nodule on which a bluish papule is located. B, Dermoscopy showing a salmon-pink area, linear vessels, and homogeneous blue pigmentation.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 407 "Ancho" => 1500 "Tamanyo" => 197819 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Spiradenoma (*) and cylindroma (+) within a single lesion (hematoxylin-eosin, original magnification ×40). B, Spiradenoma: upper portion of the lesion consisting of cells with small hyperchromatic nuclei and others with large, pale nuclei (hematoxylin-eosin, original magnification ×400). C, Cylindroma: lower portion of the lesion consisting of tumoral nests arranged in a checkerboard pattern and surrounded by hyaline bands (hematoxylin-eosin, original magnification ×400).</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spiradenoma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cylindroma \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spiradenocylindroma \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age at presentation, y \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15–35<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20–30<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">6</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20–73<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Clinical appearance \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Soft bluish nodule, painful on palpation, located on the trunk and neck.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">1,2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Firm, pink nodule located on the face or scalp.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">7</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Solitary or multiple lesions. Frequently associated with Brooke-Spiegler syndrome.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Histology \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Nodules composed of 2 cell types: small hyperchromatic cells and other larger cells with pale nuclei and ductal differentiation. Thin basal membrane.Frequent lymphocytic infiltration.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Small lobules of basaloid cells arranged in a checkerboard pattern and surrounded by a prominent hyaline basement membrane.Positive periodic acid-Schiff staining. Absence of inflammatory infiltrate.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Two distinct histological patterns within the same lesion.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Dermoscopic features \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Light blue pigment with peripheral reticulate pigmentation, associated with reddish linear serpentine structures surrounded by whitish areas.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">3,4</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Blue dots and globules associated with arboriform vessels on a whitish, salmon-pink background.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">8,9</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Salmon-pink areas, linear vessels, and peripheral structures with homogeneous blue pigmentation. \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2114535.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Differential Diagnosis of Spiradenoma, Cylindroma, and Spiradenocylindroma</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0065" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eccrine spiradenoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.W. 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"fecha" => "1999" "volumen" => "46" "paginaInicial" => "419" "paginaFinal" => "425" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack423720" "titulo" => "Acknowledgments" "texto" => "<p id="par0070" class="elsevierStylePara elsevierViewall">We thank the patient, who provided written consent to publication of the images included in this report.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000011000000007/v1_201909021030/S1578219019302033/v1_201909021030/en/main.assets" "Apartado" => array:4 [ "identificador" => "6157" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Case and Research Letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000011000000007/v1_201909021030/S1578219019302033/v1_201909021030/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219019302033?idApp=UINPBA000044" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 7 | 7 | 14 |
| 2024 October | 99 | 41 | 140 |
| 2024 September | 104 | 22 | 126 |
| 2024 August | 108 | 71 | 179 |
| 2024 July | 92 | 22 | 114 |
| 2024 June | 87 | 35 | 122 |
| 2024 May | 93 | 43 | 136 |
| 2024 April | 79 | 22 | 101 |
| 2024 March | 60 | 31 | 91 |
| 2024 February | 62 | 31 | 93 |
| 2024 January | 72 | 37 | 109 |
| 2023 December | 62 | 24 | 86 |
| 2023 November | 97 | 27 | 124 |
| 2023 October | 73 | 28 | 101 |
| 2023 September | 77 | 30 | 107 |
| 2023 August | 70 | 17 | 87 |
| 2023 July | 90 | 33 | 123 |
| 2023 June | 61 | 23 | 84 |
| 2023 May | 89 | 29 | 118 |
| 2023 April | 46 | 16 | 62 |
| 2023 March | 80 | 25 | 105 |
| 2023 February | 60 | 21 | 81 |
| 2023 January | 52 | 20 | 72 |
| 2022 December | 60 | 34 | 94 |
| 2022 November | 42 | 25 | 67 |
| 2022 October | 50 | 23 | 73 |
| 2022 September | 64 | 31 | 95 |
| 2022 August | 66 | 29 | 95 |
| 2022 July | 34 | 36 | 70 |
| 2022 June | 22 | 26 | 48 |
| 2022 May | 61 | 47 | 108 |
| 2022 April | 56 | 28 | 84 |
| 2022 March | 63 | 50 | 113 |
| 2022 February | 61 | 39 | 100 |
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| 2021 December | 89 | 37 | 126 |
| 2021 November | 87 | 49 | 136 |
| 2021 October | 136 | 59 | 195 |
| 2021 September | 73 | 50 | 123 |
| 2021 August | 87 | 36 | 123 |
| 2021 July | 48 | 28 | 76 |
| 2021 June | 40 | 33 | 73 |
| 2021 May | 57 | 57 | 114 |
| 2021 April | 123 | 62 | 185 |
| 2021 March | 91 | 22 | 113 |
| 2021 February | 74 | 17 | 91 |
| 2021 January | 44 | 9 | 53 |
| 2020 December | 52 | 18 | 70 |
| 2020 November | 28 | 16 | 44 |
| 2020 October | 20 | 11 | 31 |
| 2020 September | 46 | 13 | 59 |
| 2020 August | 32 | 22 | 54 |
| 2020 July | 26 | 13 | 39 |
| 2020 June | 25 | 20 | 45 |
| 2020 May | 16 | 12 | 28 |
| 2020 April | 18 | 6 | 24 |
| 2020 March | 17 | 5 | 22 |
| 2020 February | 2 | 2 | 4 |
| 2019 September | 1 | 0 | 1 |
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