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Dermatofibrosarcoma protuberans" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1533 "Ancho" => 2016 "Tamanyo" => 222001 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Algorithm for managing DFSP. CT indicates computed tomography; DFSP, dermatofibrosarcoma protuberans; FISH, fluorescence in situ hybridization; MMS, Mohs micrographic surgery; MRI, magnetic resonance imaging; RT-PCR, reverse transcript polymerase chain reaction.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "B. Llombart, C. Serra, C. Requena, M. Alsina, D. 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"apellidos" => "Sanmartín" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018302618" "doi" => "10.1016/j.ad.2018.05.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302618?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018303548?idApp=UINPBA000044" "url" => "/15782190/0000010900000010/v1_201812060634/S1578219018303548/v1_201812060634/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219018303706" "issn" => "15782190" "doi" => "10.1016/j.adengl.2018.04.022" "estado" => "S300" "fechaPublicacion" => "2018-12-01" "aid" => "2005" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2018;109:855-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 17 "formatos" => array:2 [ "HTML" => 15 "PDF" => 2 ] ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>" "titulo" => "The Hidden Agenda" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "855" "paginaFinal" => "857" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La agenda oculta" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "E. Martínez-García, A. Buendía-Eisman" "autores" => array:2 [ 0 => array:2 [ "nombre" => "E." "apellidos" => "Martínez-García" ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Buendía-Eisman" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731018302904" "doi" => "10.1016/j.ad.2018.04.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731018302904?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018303706?idApp=UINPBA000044" "url" => "/15782190/0000010900000010/v1_201812060634/S1578219018303706/v1_201812060634/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Novelties in Dermatology</span>" "titulo" => "Laser-Assisted Drug Delivery" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "858" "paginaFinal" => "867" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "A. Alegre-Sánchez, N. Jiménez-Gómez, P. Boixeda" "autores" => array:3 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Alegre-Sánchez" "email" => array:1 [ 0 => "adrian.alegresanchez@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "N." "apellidos" => "Jiménez-Gómez" ] 2 => array:2 [ "nombre" => "P." "apellidos" => "Boixeda" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Unidad de Láser, Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Vehiculización de fármacos asistida por láser" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1403 "Ancho" => 2334 "Tamanyo" => 345030 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Various types of laser used in laser-assisted drug delivery. A, Fully ablative lasers, mainly CO<span class="elsevierStyleInf">2</span> (10 600<span class="elsevierStyleHsp" style=""></span>nm) and Er:YAG (2940<span class="elsevierStyleHsp" style=""></span>nm). These perform full, not fractional ablation, of the epidermis, thus enabling the drug to reach the dermis. B, Ablative fractional lasers. These are a fractional version of the ablative lasers described in A. They generate microscopic ablation channels through which the drugs reach the dermis. C, Nonablative fractional lasers, such as Er:Glass 1550<span class="elsevierStyleHsp" style=""></span>nm, which generate microscopic columns of coagulated tissue without ablating the epidermis. D, Nonablative dermal remodelling. This subtype includes all those lasers with chromophores other than water, which deposit energy in the area of the chromophore, generally in the dermis, as, for example, with lasers used to treat vascular anomalies, such as the 585/595-nm pulsed dye laser or Nd:YAG (1064<span class="elsevierStyleHsp" style=""></span>nm). gr1.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">One of the most typical parts of the dermatologist's work is that of prescribing topical treatments to induce a local effect against a skin disease. However, absorption of these agents is limited by the skin's main function as a barrier to the external environment. Given its composition and location as the outermost layer, the stratum corneum is the key player in this defense function.<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">It is estimated that around 1%-5% of topical preparations cross an intact epidermis.<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">2</span></a> The epidermis can be crossed via 3 pathways: (<span class="elsevierStyleItalic">1</span>) the intercellular pathway, through which the most lipophilic substances are absorbed via the desmosomes in the spaces between cells; 2) the transcellular pathway, across the aqueous pores of the keratinocytes; and 3) the transappendageal pathway, which is mainly across hair follicles and, to a lesser extent, acrosyringea.<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">3</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">We must also take account of the intrinsic properties of the drug that directly affect absorption. According to the Fick laws of diffusion, the flux of absorption is determined not only by differences in the concentration of drug absorbed between the external environment and the dermis, but also by the solubility and diffusion coefficient of the drug. The heaviest molecules, ie, those with the highest molecular weight, diffuse more slowly than smaller or neutral molecules. Lipophilic and hydrophobic substances make their way across the dermis more quickly.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">4</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Topical drugs can be more easily absorbed by means of physical methods in what is known as transdermal delivery. One of the main methods involves lasers, which have led to exponential growth in the use of the technique known as laser-assisted drug delivery (LADD).<a class="elsevierStyleCrossRef" href="#bib0335"><span class="elsevierStyleSup">1</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Transdermal Drug Delivery</span><p id="par0025" class="elsevierStylePara elsevierViewall">Transdermal drug delivery involves assisted transport of substances across the epidermis using various physical methods. This promising method of drug delivery to the body makes it possible to increase the absorption achieved with respect to topical delivery. In addition, oral delivery often entails problems of real bioavailability owing to the first-pass effect and may be limited by the greater risk of adverse effects. Studies on transdermal drug delivery have investigated scraping, dermabrasion, microneedling, pressure waves, vacuum effect, and lasers. These modalities have been used to delivery various types of drugs and substances, such as triamcinolone, methyl aminolevulinic acid (MAL), 5-fluorouracil, and methotrexate.<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">5–11</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Few studies have compared the efficacy of the various techniques available. One well-designed study compared the efficacy of topical MAL with that of photodynamic therapy (PDT) after application of MAL in addition to various physical methods, such as ablative fractional laser (AFL), nonablative fractional laser (NAFL), curettage, dermabrasion, and microneedling.<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">12</span></a> The authors concluded that there were no differences in the formation of protoporphyrin <span class="elsevierStyleSmallCaps">ix</span> after application of MAL alone or in combination with NAFL. However, the remaining techniques did prove superior with respect to formation of protoporphyrin <span class="elsevierStyleSmallCaps">ix</span>. The most effective of all was AFL. These results have been confirmed, at least partially, by subsequent studies; therefore, AFLs are currently considered the most effective drug delivery technique.<a class="elsevierStyleCrossRefs" href="#bib0395"><span class="elsevierStyleSup">13,14</span></a></p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Laser-Assisted Drug Delivery: General Considerations</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Lasers</span><p id="par0035" class="elsevierStylePara elsevierViewall">Different types of laser have been used for LADD. Each type is more or less effective, although it is also important to know the individual safety profile. In practical terms, we can divide the lasers used in LADD into 4 groups: (<span class="elsevierStyleItalic">1</span>) Fully ablative lasers, such as the carbon dioxide (CO<span class="elsevierStyleInf">2</span>) laser (10 600<span class="elsevierStyleHsp" style=""></span>nm) or the erbium-doped yttrium aluminum garnet (Er:YAG) laser (2940<span class="elsevierStyleHsp" style=""></span>nm), whose main chromophore is water and which lead to heating and total vaporization of the skin; (<span class="elsevierStyleItalic">2</span>) AFLs, which are the same as the previous group, although when used fractionally, they lead to columns of thermal injury, which are microscopic treatment zones (MTZs); (<span class="elsevierStyleItalic">3</span>) NAFL, which are similar to the previous group and include lasers such as the erbium fiber laser (1550<span class="elsevierStyleHsp" style=""></span>nm). These also produce MTZs, although in the columns, only heating of the skin is observed, with no ablation of the dermal-epidermal junction; and (<span class="elsevierStyleItalic">4</span>) Nonablative dermal remodelling lasers. This group includes all lasers with chromophores other than water but which have been used to induce greater drug absorption. They also include lasers for the treatment of vascular anomalies, such as the 585/595-nm pulsed dye laser or the neodymium-doped YAG laser (1064<span class="elsevierStyleHsp" style=""></span>nm).<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">15</span></a> The characteristics of AFL have led it to be the most widely studied in LADD, followed by NAFL (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0040" class="elsevierStylePara elsevierViewall">While the risk of adverse effects such as erythema, vesiculation, crusting, or even scarring are lower with fractional lasers than with conventional ablative lasers, these effects may appear when high fluences and densities are applied.<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">16–18</span></a> If AFLs are used for LADD, the settings must be optimized to achieve the best results possible with the minimum risk.</p><p id="par0045" class="elsevierStylePara elsevierViewall">The density of fractional lasers refers to the amount of tissue covered by the MTZs. The total density depends on both the number of channels and on the size of the laser beam. Initial studies with MAL, which were subsequently corroborated with other agents (diclofenac, tretinoin), showed that the concentrations of the product in skin increased with increases in density up to a maximum of 5%, at which point the concentrations stabilized.<a class="elsevierStyleCrossRefs" href="#bib0425"><span class="elsevierStyleSup">19–22</span></a> Thus, densities higher than 5% in treatment with AFL carry no clear benefits but do carry a greater risk of adverse events.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Another key parameter is the depth of the channel itself, which depends directly on laser fluence. As a general rule, we should apply higher fluences in order to reach the deeper layers of the dermis if we wish to treat conditions such as alopecia or scarring. The most superficial layers of the dermis would be appropriate for treatment of photodamage, melasma, or superficial scarring. In patients with melasma, vitiligo, or superficial nonmelanoma skin cancer, ablation restricted to the epidermis could be sufficient.<a class="elsevierStyleCrossRef" href="#bib0445"><span class="elsevierStyleSup">23</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In the case of AFLs, drug absorption is affected by the coagulation zone (CZ) surrounding the channels, as well as by total ablation depth. The area of the CZ ranges from around 50<span class="elsevierStyleHsp" style=""></span>mm to 150<span class="elsevierStyleHsp" style=""></span>mm, depending on fluence and, in particular, laser wavelength, and is greater for CO<span class="elsevierStyleInf">2</span> lasers (10 600<span class="elsevierStyleHsp" style=""></span>nm) than for Er:YAG lasers (2940<span class="elsevierStyleHsp" style=""></span>nm).<a class="elsevierStyleCrossRefs" href="#bib0450"><span class="elsevierStyleSup">24,25</span></a> The greater affinity of Er:YAG for water leads to “purer” ablation, with almost no heat given off around the MTZs, whereas in the case of CO<span class="elsevierStyleInf">2</span>, a wider CZ is generated owing to the reduced affinity for water. The presence of CZs implies even greater absorption of the drug delivered across the channels, thus also explaining the superiority of AFL over modalities that do not involve the generation of heat around the channels, as is the case in microneedling.<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">12</span></a> However, it is important to remember that the presence of CZs only reflects transmission of heat to the surrounding dermis, which may be associated with undesirable local reactions.<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">26</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Drugs and Application Techniques</span><p id="par0060" class="elsevierStylePara elsevierViewall">Given that lipophilic substances have a greater intrinsic ability to cross an intact epidermis, the more marked effect of LADD is observed with hydrophilic substances.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">4</span></a> Other relevant factors that affect absorption include the vehicle used, the type of preparation, and the presence of additives or excipients. Liquid and gel formulations cross the channels produced by AFL with greater affinity than more oily formulations in the form of creams or ointments.<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">27</span></a> This observation should be taken into account owing to the greater efficacy and the greater risk of adverse effects when these formulations are used.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">4</span></a></p><p id="par0065" class="elsevierStylePara elsevierViewall">There is also some disparity between hydrophobic and hydrophilic substances and their association with penetration via the laser channels. In the case of hydrophilic substances, such as 5-fluorouracil or methotrexate, greater absorption has been detected in direct relation to AFL fluence and, therefore, the depth of the channels. However, this finding has not been confirmed in studies with hydrophobic substances such as imiquimod and lidocaine.<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">8,9,23,28</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Various considerations must be taken into account with respect to the suitability of applying topical drugs directly to the dermis. First, we must ask whether the substances and excipients we intend to use are suitable for subcutaneous application. Local hypersensitivity has been reported with the application of vitamin C serum delivered via microneedling, which led to the formation of histologically confirmed granulomas or even systemic hypersensitivity reactions.<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">29</span></a> Under ideal conditions, we would use only highly sterile products, although not all topical products are available as such. AFL itself carries some risk of bacterial infection owing to direct exposure of the dermis, and this risk increases when we apply drugs such as 5-fluorouracil, corticosteroids, and MAL.<a class="elsevierStyleCrossRefs" href="#bib0400"><span class="elsevierStyleSup">14,17,30,31</span></a> It is important to insist on aseptic conditions for application of LADD procedures.</p><p id="par0075" class="elsevierStylePara elsevierViewall">Another key factor in LADD is the interval between use of the laser and application of the product to the skin. It is important to remember that the microscopic channels close with time owing to debris such as fibrin, inflammatory mediators, and keratinocytes.<a class="elsevierStyleCrossRefs" href="#bib0490"><span class="elsevierStyleSup">32–34</span></a> One study showed that topical application 6<span class="elsevierStyleHsp" style=""></span>hours after use of the laser increases absorption, which is most successful during the first 30<span class="elsevierStyleHsp" style=""></span>minutes. However, no increase in absorption is observed when the product is applied after 24<span class="elsevierStyleHsp" style=""></span>hours.<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">35</span></a><a class="elsevierStyleCrossRef" href="#fig0010">Figure 2</a> shows the appropriate steps for LADD and the considerations to be taken into account for each one.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Patients</span><p id="par0080" class="elsevierStylePara elsevierViewall">As is the case with topical treatments, absorption of drugs using LADD depends on many characteristics that are intrinsic to the patient, the skin disease treated, and the area affected by the disease. Thus, absorption is more potent in cases of inflamed or eroded skin. Similarly, more hydrated skin exhibits greater affinity for the absorption of oily substances. Furthermore, the patient's age is important, given that atrophy, erosion, and ulceration are more likely to affect older people, who are also at greater risk of infection and take longer to recover.<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">36</span></a> Therefore, the ideal approach would be to make a correct evaluation of the patient's skin type, since there may be some atrophy due to solar elastosis in patients with low skin types, even younger patients. In such cases, laser fluence should be reduced, and in CO<span class="elsevierStyleInf">2</span> AFL devices that allow it, pulses with a lower heat deposit should be administered to prevent pathological scarring. As for location, the drug is absorbed mainly across the transappendageal pathway through the follicles in hairy areas; therefore, the parameters for using LADD should be applied with greater caution.</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Laser-Delivered Drugs</span><p id="par0085" class="elsevierStylePara elsevierViewall">For practical purposes, we focus on 2 of the main applications of LADD: delivery of corticosteroids for hypertrophic and keloid scars and laser-assisted PDT.<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">6,37–40</span></a> In addition to these 2 indications, numerous drugs have been delivered in many other dermatologic indications.<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">7–9,17,23,28,41–50</span></a> Data on these studies are shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Aminolevulinic Acid and Methyl 5-Aminolevulinate: Laser-Assisted Photodynamic Therapy</span><p id="par0090" class="elsevierStylePara elsevierViewall">Some studies report enhanced absorption of aminolevulinic acid and methyl 5-aminolevulinate assisted by various types of laser, and there are even studies that use devices such as pulsed dye lasers as light sources. In the present analysis, we are interested in those studies that use lasers to deliver photosensitizers to the dermis and thus ensure greater effectiveness with PDT. Thus, studies of the usefulness of LADD in the context of PDT—both for treatment of actinic keratosis and for superficial basal cell and squamous cell carcinoma—have reported greater rates of effectiveness, but also more adverse effects (eg, crusting, pruritus, pain, and erythema).<a class="elsevierStyleCrossRefs" href="#bib0585"><span class="elsevierStyleSup">51–60</span></a> Haedersdal et al.<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">56</span></a> demonstrated absorption rates for MAL that were 13.8 times greater with continuous-wave Er:YAG and up to 7.3 times greater with the fractional version. Similar results have been reported from animal models based on CO<span class="elsevierStyleInf">2</span> lasers.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Hypertrophic Scars: Triamcinolone Acetonide</span><p id="par0095" class="elsevierStylePara elsevierViewall">Triamcinolone acetonide (TCA) is one of the most widely used intralesional or subcutaneous corticosteroids in various skin diseases owing to its sustained release. The main adverse effects include atrophy, ecchymosis, telangiectasia, infection, and even ulceration at the injection site.<a class="elsevierStyleCrossRef" href="#bib0480"><span class="elsevierStyleSup">30</span></a> Application of this agent using LADD has mainly been investigated in the treatment of pathologic scarring (hypertrophic and keloid scars) and in the sequelae of burns. While this drug has been investigated in several studies, that of Waibel et al.<a class="elsevierStyleCrossRef" href="#bib0360"><span class="elsevierStyleSup">6</span></a> on hypertrophic scars causing functional restriction is noteworthy. The authors administered TCA using LADD (fractional CO<span class="elsevierStyleInf">2</span> laser), with 3-5 treatments every 2-3 months. Improvement was recorded not only in texture and thickness, but also for dyschromia and scar functionality. Several studies have reported similar results.<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">37,38,61,62</span></a> Of particular interest is a study comparing effectiveness and tolerability in the treatment of hypertrophic scars using fractional Er:YAG followed by intralesional corticosteroid injections (TCA 10%) or topical corticosteroids (desoximetasone 0.25% under occlusion), with 4 sessions every 6 weeks. The results show the topical corticosteroid to be slightly more effective than the intralesional drug, although the difference was not statistically significant. The authors also reported much better scores for pain and patient preference.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Our experience shows that the combination of CO<span class="elsevierStyleInf">2</span> laser and TCA 10% applied with smooth massage during the 15<span class="elsevierStyleHsp" style=""></span>minutes following application of the laser yields very good results both for hypertrophic and keloid scars and for the sequelae of burns (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). In addition, the simple application of topical anesthetic before laser treatment ensures better tolerance than combining laser treatment with subsequent TCA injections. In the case of very vascularized erythematous scars, this technique can be combined with a previous vascular approach based on techniques such as pulsed dye laser or intense pulsed light. For this purpose, we generally use pulsed dye laser (595<span class="elsevierStyleHsp" style=""></span>nm) with pulses of 0.5-6<span class="elsevierStyleHsp" style=""></span>ms and fluence of 5-7<span class="elsevierStyleHsp" style=""></span>J/cm<span class="elsevierStyleSup">2</span>, followed immediately by AFL.</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Application of Laser-Assisted Drug Delivery in Fields Other Than Dermatology</span><p id="par0105" class="elsevierStylePara elsevierViewall">LADD has been used to introduce drugs and substances into the body for many and various reasons, in addition to those we have seen in dermatology. Studies in animals and humans have shown the efficacy of fully ablative and fractional lasers for introducing small interfering RNA molecules (siRNA) and antibodies.<a class="elsevierStyleCrossRefs" href="#bib0445"><span class="elsevierStyleSup">23,63</span></a> siRNA can inhibit translation of various genes, and this has proven useful in many diseases. Although the only studies on LADD with siRNA to date have been performed in mice, this pathway could be explored in the future in dermatological diseases using siRNA, as is the case with microRNA 21 in psoriasis, for example.</p><p id="par0110" class="elsevierStylePara elsevierViewall">LADD has even proven effective for generating a favorable immune response with topical vaccines.<a class="elsevierStyleCrossRefs" href="#bib0440"><span class="elsevierStyleSup">22,64,65</span></a> Even more advanced are pilot studies with hematopoietic stem cells applied topically in combination with ablative laser in mice, thus paving the way for possible application of LADD as an alternative in hematopoietic progenitor transplant.<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">66</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conclusions</span><p id="par0115" class="elsevierStylePara elsevierViewall">LADD can yield better results with topical treatments by facilitating absorption and achieving a synergic effect between medical treatment (drugs) and physical treatment (lasers). Safety and the most appropriate technique remain controversial, although there is no doubt that these issues will gradually be resolved in the coming years.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conflicts of Interest</span><p id="par0120" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:12 [ 0 => array:3 [ "identificador" => "xres1123996" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1058680" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1123995" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1058679" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Transdermal Drug Delivery" ] 6 => array:3 [ "identificador" => "sec0015" "titulo" => "Laser-Assisted Drug Delivery: General Considerations" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Lasers" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Drugs and Application Techniques" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Patients" ] ] ] 7 => array:3 [ "identificador" => "sec0035" "titulo" => "Laser-Delivered Drugs" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Aminolevulinic Acid and Methyl 5-Aminolevulinate: Laser-Assisted Photodynamic Therapy" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Hypertrophic Scars: Triamcinolone Acetonide" ] ] ] 8 => array:2 [ "identificador" => "sec0050" "titulo" => "Application of Laser-Assisted Drug Delivery in Fields Other Than Dermatology" ] 9 => array:2 [ "identificador" => "sec0055" "titulo" => "Conclusions" ] 10 => array:2 [ "identificador" => "sec0060" "titulo" => "Conflicts of Interest" ] 11 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2018-05-20" "fechaAceptado" => "2018-07-13" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1058680" "palabras" => array:5 [ 0 => "Laser-assisted drug delivery" 1 => "Ablative fractional laser" 2 => "CO<span class="elsevierStyleInf">2</span> laser" 3 => "Hypertrophic scars" 4 => "Keloid scars" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1058679" "palabras" => array:5 [ 0 => "Vehiculización de fármacos asistida por láser" 1 => "Láser fraccional ablativo" 2 => "Láser CO<span class="elsevierStyleInf">2</span>" 3 => "Cicatrices hipertróficas" 4 => "Queloides" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Absorption of topical products through the epidermis is limited by the skin's barrier function. Numerous techniques and agents such as microneedling, dermabrasion, radiofrequency, and lasers have been used to increase penetration within an approach known as transdermal drug delivery. One of these techniques is laser-assisted drug delivery (LADD), which often uses ablative fractional lasers (CO<span class="elsevierStyleInf">2</span> or erbium:YAG lasers) because of their capacity to produce microscopic ablated channels. The parameters in LADD need to be adjusted to the patient, the skin condition and its location, and the drug. LADD has been used with various topical products, such as corticosteroids, photosensitizers, and immunotherapy agents (imiquimod or 5-fluorouracil) to treat numerous conditions, including scars, nonmelanoma skin cancer, and photodamage. LADD is a promising technique that enhances the absorption of topical molecules while adding the synergic effect of the laser.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">La absorción de productos tópicos a través de la epidermis está limitada por la función de barrera cutánea. Existen distintas técnicas, tales como el <span class="elsevierStyleItalic">microneedling</span>, la dermoabrasión, la radiofrecuencia o los láseres, que se han empleado para aumentar la absorción de estas sustancias en una estrategia conocida como vehiculización transdérmica de fármacos. Entre estas técnicas destaca la vehiculización de fármacos asistida por láseres (VFAL), especialmente láseres fraccionales ablativos (CO<span class="elsevierStyleInf">2</span>/Er:YAG), por su capacidad de generar canales de microablación. En la VFAL se deben ajustar los parámetros en función del tipo de paciente, la dermatosis, la localización y el fármaco empleado. Se ha estudiado la VFAL en el uso de corticoides, fotosensibilizantes o inmunoterapia tópica (imiquimod o 5-fluorouracilo), entre otros, y en múltiples indicaciones: cicatrices, cáncer cutáneo no melanoma, fotodaño, etc. La VFAL es una técnica prometedora que permite aumentar la absorción de moléculas tópicas consiguiendo, además, el efecto sinérgico del láser.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Alegre-Sánchez A, Jiménez-Gómez N, Boixeda P. Vehiculización de fármacos asistida por láser. Actas Dermosifiliogr. 2018;109:858–867.</p>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1403 "Ancho" => 2334 "Tamanyo" => 345030 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Various types of laser used in laser-assisted drug delivery. A, Fully ablative lasers, mainly CO<span class="elsevierStyleInf">2</span> (10 600<span class="elsevierStyleHsp" style=""></span>nm) and Er:YAG (2940<span class="elsevierStyleHsp" style=""></span>nm). These perform full, not fractional ablation, of the epidermis, thus enabling the drug to reach the dermis. B, Ablative fractional lasers. These are a fractional version of the ablative lasers described in A. They generate microscopic ablation channels through which the drugs reach the dermis. C, Nonablative fractional lasers, such as Er:Glass 1550<span class="elsevierStyleHsp" style=""></span>nm, which generate microscopic columns of coagulated tissue without ablating the epidermis. D, Nonablative dermal remodelling. This subtype includes all those lasers with chromophores other than water, which deposit energy in the area of the chromophore, generally in the dermis, as, for example, with lasers used to treat vascular anomalies, such as the 585/595-nm pulsed dye laser or Nd:YAG (1064<span class="elsevierStyleHsp" style=""></span>nm). gr1.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1627 "Ancho" => 2521 "Tamanyo" => 402522 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Laser-assisted drug delivery: steps and aspects to be taken into account. PDT indicates photodynamic therapy. gr2.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 2011 "Ancho" => 2334 "Tamanyo" => 651251 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Example of delivery of triamcinolone acetonide assisted by ablative fractional CO<span class="elsevierStyleInf">2</span> laser in a patient with sequelae of a facial burn. A, Before treatment. B, Pass of CO<span class="elsevierStyleInf">2</span> laser with a fractional scanner over the whole surface of the facial burn; a smoke extractor is used alongside the treatment. C, Application of injectable triamcinolone acetonide 10% solution: the solution is applied topically over the area treated with the laser. D, Extension of the corticosteroid over the whole area of the burn. E, Smooth massage to ensure better penetration of the product. gr3.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: bFGF, basic fibroblast growth factor; LADD, laser-assisted drug delivery; 5-MAL: methyl 5-aminolevulinate; PDT, photodynamic therapy; TCA, triamcinolone acetonide.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Drug \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main Indications Assessed \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Design of Main Studies \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Outcome \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Aminolevulinic acid and 5-MAL: laser-assisted PDT<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">48–57</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1. Actinic keratosis<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">48</span></a><br>2. Fine nodular basal cell carcinoma (<<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>mm)<a class="elsevierStyleCrossRef" href="#bib0610"><span class="elsevierStyleSup">56</span></a><br>3. Superficial squamous cell carcinoma<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">57</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1. One session of fractional Er:YAG (550<span class="elsevierStyleHsp" style=""></span>μm; 22% density)<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>PDT with conventional 5-MAL vs 1 session of PDT with conventional 5-MAL<br>2. One session of fractional Er:YAG (550<span class="elsevierStyleHsp" style=""></span>μm; 22% density)<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>PDT with 5-MAL vs 2 sessions with conventional PDT<br>3. Two sessions of fractional Er:YAG (550<span class="elsevierStyleHsp" style=""></span>μm; 22% density)<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>PDT with 5-MAL vs 2 sessions of conventional PDT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1. Response rate of 91% in laser-assisted PDT vs 65.6% in conventional PDT at 3 months<br>2. Total response of 84% in laser-assisted PDT vs 50% in conventional PDT at 3 months<br>3. Total response of 84.3% in laser-assisted PDT vs 52% in conventional PDT at 3 months \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TCA<a class="elsevierStyleCrossRefs" href="#bib0505"><span class="elsevierStyleSup">35,58,59</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypertrophic and keloid scars \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Fractional Er:YAG (first pass 150-200<span class="elsevierStyleHsp" style=""></span>μm without coagulation; second pass 300-400<span class="elsevierStyleHsp" style=""></span>μm with coagulation; 22% density)<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>intralesional TCA 10% vs fractional Er:YAG<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>topical corticosteroids (desoximetasone 0.25%). Four sessions with intervals of 6 weeks<span class="elsevierStyleSup">35</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Improvement in both cases. No significant differences compared with postlaser intralesional or topical corticosteroids, although tolerance is much better with topical delivery and patient preference is greater \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Methotrexate<a class="elsevierStyleCrossRef" href="#bib0375"><span class="elsevierStyleSup">9</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Studies of absorption in an animal model (murine) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Topical application after continuous-wave Er:YAG 2940<span class="elsevierStyleHsp" style=""></span>nm vs electroporation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Better outcome for absorption with LADD (3-80 times greater than topical treatment alone depending on fluence) vs electroporation (2 times greater than topical treatment alone) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Imiquimod<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">22</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Studies on absorption in an animal model (murine) with various types of laser \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">0.4% aqueous formulation of imiquimod after fractional Er:YAG 2940<span class="elsevierStyleHsp" style=""></span>nm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Similar intradermal concentrations with the 0.4% aqueous formulation in LADD and with topical imiquimod 5% cream \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ingenol mebutate<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">43</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Bowen disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Ingenol mebutate 0.015% for 3 days on the face and 0.05% for 2 days on the rest of the body; preceded or not by fractional CO<span class="elsevierStyleInf">2</span> laser on the first day of treatment (100<span class="elsevierStyleHsp" style=""></span>mJ; 100<span class="elsevierStyleHsp" style=""></span>spot/cm<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">2</span></a>) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Complete response in 88.9% of patients treated using LADD vs 12.5% with ingenol mebutate alone \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5-Fluorouracil<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">7,11</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1. Absorption studies in an animal model (murine) with various types of laser<br>2. Superficial basal cell carcinoma and Bowen disease on the trunk and limbs<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>cm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1. Q-switched ruby laser (694<span class="elsevierStyleHsp" style=""></span>nm) vs continuous-wave Er:YAG (2940<span class="elsevierStyleHsp" style=""></span>nm) vs continuous-wave CO<span class="elsevierStyleInf">2</span><br>2. Thirty patients treated with fractional CO<span class="elsevierStyleInf">2</span> laser (0.12<span class="elsevierStyleHsp" style=""></span>mm spot; 10<span class="elsevierStyleHsp" style=""></span>mJ per pulse; density 5%) followed by 5-fluorouracil 5% under occlusion for 7 days \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1. Better rates of absorption with continuous Er:YAG reaching<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>156<br>2. Histologically confirmed cure of 87% cases of Bowen disease and 71% of cases of basal cell carcinoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Timolol<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">41</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Deep infantile hemangioma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Timolol 0.5% in ophthalmic solution applied 4-5 times per day with weekly sessions of ablative fractional CO<span class="elsevierStyleInf">2</span> laser (0.12<span class="elsevierStyleHsp" style=""></span>mm spot; 25-30<span class="elsevierStyleHsp" style=""></span>mJ per pulse; density 5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Good/excellent response in more than 80% of patients with a mean of 14 weeks of treatment \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Pimecrolimus, tretinoin, and bimatoprost<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">49</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hypopigmented scars \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Topical bimatoprost 0.03%<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>tretinoin 0.05%<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>pimecrolimus 1% twice daily for 3 mo. Combined with nonablative fractional laser (1550<span class="elsevierStyleHsp" style=""></span>nm; 20-70<span class="elsevierStyleHsp" style=""></span>mJ; 20%-32% density), mean of 4.5 sessions at intervals of 4-8 wk \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Partial repigmentation<span class="elsevierStyleHsp" style=""></span>><span class="elsevierStyleHsp" style=""></span>50% in 86% of cases \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Poly-L-lactic acid<a class="elsevierStyleCrossRef" href="#bib0570"><span class="elsevierStyleSup">48</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Atrophic scars \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sculptra (Valeant Aesthetics) reconstituted with saline solution, lidocaine, and epinephrine in combination with fractional CO<span class="elsevierStyleInf">2</span> laser (120<span class="elsevierStyleHsp" style=""></span>μm spot size, 375-500<span class="elsevierStyleHsp" style=""></span>μm depth, density 10%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Improvement of more than 30% in most cases. Lower formation of delayed papules than with intralesional treatment \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Finasteride<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">50</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Male pattern baldness \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Combination of finasteride 0.05% and growth factors with nonablative fractional Er:Glass laser (1550<span class="elsevierStyleHsp" style=""></span>nm, 8 passes, 7<span class="elsevierStyleHsp" style=""></span>mJ, 3-9% density) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Improvement in follow-up photographs in 4 patients \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Vitamins<a class="elsevierStyleCrossRef" href="#bib0560"><span class="elsevierStyleSup">46</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Recovery after rejuvenation treatment with ablative fractional laser \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Formula with vitamin C, vitamin E, and ferulic acid applied with fractional CO<span class="elsevierStyleInf">2</span> laser daily during reepithelization. Randomized controlled study \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Improved recovery with fewer adverse effects. In molecular terms, increase in expression of bFGF compared with placebo group \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Anesthetics<a class="elsevierStyleCrossRefs" href="#bib0470"><span class="elsevierStyleSup">28,42,43</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Studies on absorption of and preexposure to subcutaneous injections \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Topical lidocaine 4% combined with ablative fractional Er:YAG laser \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Increased serum levels of lidocaine and its metabolites in LADD vs topical administration. Lower pain scores in the group treated with lidocaine in LADD before subcutaneous injection \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1915126.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Medications Used in Laser-Assisted Drug Delivery.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:66 [ 0 => array:3 [ "identificador" => "bib0335" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser-assisted drug delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "L.A. Zaleski-Larsen" 1 => "S.G. Fabi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DSS.0000000000000556" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2016" "volumen" => "42" "paginaInicial" => "919" "paginaFinal" => "931" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27191783" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0340" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "[Accessed April 29, 2018]. Available at: <a class="elsevierStyleInterRef" target="_blank" id="intr0005" href="http://www.ncbi.nlm.nih.gov/pubmed/1428465">http://www.ncbi.nlm.nih.gov/pubmed/1428465</a>" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bioequivalence studies of topical preparations: Statistical considerations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "W.W. Hauck" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Int J Dermatol." "fecha" => "1992" "volumen" => "31" "numero" => "Suppl 1" "paginaInicial" => "29" "paginaFinal" => "33" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1428465" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0345" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Challenges to laser-assisted drug delivery: Applying theory to clinical practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "O. Ibrahim" 1 => "E. Wenande" 2 => "S. Hogan" 3 => "K.A. Arndt" 4 => "M. Haedersdal" 5 => "J.S. Dover" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22769" "Revista" => array:5 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2018" "volumen" => "50" "paginaInicial" => "20" "paginaFinal" => "27" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0350" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "[Accessed April 29, 2018]. Available at: <a class="elsevierStyleInterRef" target="_blank" id="intr0010" href="http://www.ncbi.nlm.nih.gov/pubmed/6358066">http://www.ncbi.nlm.nih.gov/pubmed/6358066</a>" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kinetics of cutaneous drug penetration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "T.J. Franz" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol." "fecha" => "1983" "volumen" => "22" "paginaInicial" => "499" "paginaFinal" => "505" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6358066" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0355" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Kinetics of skin resealing after insertion of microneedles in human subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J. Gupta" 1 => "H.S. Gill" 2 => "S.N. Andrews" 3 => "M.R. Prausnitz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jconrel.2011.05.021" "Revista" => array:6 [ "tituloSerie" => "J Control Release." "fecha" => "2011" "volumen" => "154" "paginaInicial" => "148" "paginaFinal" => "155" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21640148" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0360" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of hypertrophic scars using laser and laser assisted corticosteroid delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.S. Waibel" 1 => "A.J. Wulkan" 2 => "P.R. Shumaker" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22120" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2013" "volumen" => "45" "paginaInicial" => "135" "paginaFinal" => "140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23460557" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0365" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional laser-assisted topical delivery leads to enhanced, accelerated and deeper cutaneous 5-fluorouracil uptake" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Wenande" 1 => "U.H. Olesen" 2 => "M.M.B. Nielsen" 3 => "C. Janfelt" 4 => "S.H. Hansen" 5 => "R.R. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/17425247.2017.1260119" "Revista" => array:6 [ "tituloSerie" => "Expert Opin Drug Deliv." "fecha" => "2017" "volumen" => "14" "paginaInicial" => "307" "paginaFinal" => "317" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27835937" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0370" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional laser-assisted drug delivery: Laser channel depth influences biodistribution and skin deposition of methotrexate" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.H. Taudorf" 1 => "C.M. Lerche" 2 => "A.M. Erlendsson" 3 => "P.A. Philipsen" 4 => "S.H. Hansen" 5 => "C. Janfelt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22484" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2016" "volumen" => "48" "paginaInicial" => "519" "paginaFinal" => "529" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26846733" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0375" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical delivery of methotrexate via skin pretreated with physical enhancement techniques: Low-fluence erbium:YAG laser and electroporation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.R. Lee" 1 => "S.C. Shen" 2 => "C.L. Fang" 3 => "R.Z. Zhuo" 4 => "J.Y. Fang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.20655" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2008" "volumen" => "40" "paginaInicial" => "468" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18727021" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0380" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional laser-assisted drug delivery: Active filling of laser channels with pressure and vacuum alteration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.M. Erlendsson" 1 => "A.G. Doukas" 2 => "W.A. Farinelli" 3 => "B. Bhayana" 4 => "R.R. Anderson" 5 => "M. Haedersdal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22374" "Revista" => array:5 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2016" "volumen" => "48" "paginaInicial" => "116" "paginaFinal" => "124" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0385" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ablative fractional laser-assisted topical fluorouracil for the treatment of superficial basal cell carcinoma and squamous cell carcinoma in situ: A follow-up study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.H. Hsu" 1 => "S.D. Gan" 2 => "B.T. Nguyen" 3 => "N. Konnikov" 4 => "C.A. Liang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/DSS.0000000000000814" "Revista" => array:5 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2016" "volumen" => "42" "paginaInicial" => "1050" "paginaFinal" => "1053" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0390" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparison of physical pretreatment regimens to enhance protoporphyrin <span class="elsevierStyleSmallCaps">ix</span> uptake in photodynamic therapy: A randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C. Bay" 1 => "C.M. Lerche" 2 => "B. Ferrick" 3 => "P.A. Philipsen" 4 => "K. Togsverd-Bo" 5 => "M. Haedersdal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2016.5268" "Revista" => array:6 [ "tituloSerie" => "JAMA Dermatol." "fecha" => "2017" "volumen" => "153" "paginaInicial" => "270" "paginaFinal" => "278" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28146245" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0395" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser-induced thermal coagulation enhances skin uptake of topically applied compounds" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.S. Haak" 1 => "J. Hannibal" 2 => "U. Paasch" 3 => "R.R. Anderson" 4 => "M. Haedersdal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22642" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2017" "volumen" => "49" "paginaInicial" => "582" "paginaFinal" => "591" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28181673" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0400" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A pilot split-face study comparing conventional methyl aminolevulinate-photodynamic therapy (PDT) with microneedling-assisted PDT on actinically damaged skin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Torezan" 1 => "Y. Chaves" 2 => "A. Niwa" 3 => "J.A. Sanches" 4 => "C. Festa-Neto" 5 => "R.M. Szeimies" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dsu.12233" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2013" "volumen" => "39" "paginaInicial" => "1197" "paginaFinal" => "1201" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23638986" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0405" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional photothermolysis: A new concept for cutaneous remodeling using microscopic patterns of thermal injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D. Manstein" 1 => "G.S. Herron" 2 => "R.K. Sink" 3 => "H. Tanner" 4 => "R.R. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.20048" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2004" "volumen" => "34" "paginaInicial" => "426" "paginaFinal" => "438" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15216537" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0410" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The spectrum of laser skin resurfacing: Nonablative, fractional, and ablative laser resurfacing" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "M.R. Alexiades-Armenakas" 1 => "J.S. Dover" 2 => "K.A. Arndt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2008.01.003" "Revista" => array:6 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2008" "volumen" => "58" "paginaInicial" => "719" "paginaFinal" => "737" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18423256" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0415" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carbon dioxide laser plus topical 5-fluorouracil: A new combination therapeutic modality for acral vitiligo" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.A. Mohamed" 1 => "G.F. Mohammed" 2 => "A.H.A. Gomaa" 3 => "M.M.K. Eyada" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/14764172.2014.1003241" "Revista" => array:6 [ "tituloSerie" => "J Cosmet Laser Ther." "fecha" => "2015" "volumen" => "17" "paginaInicial" => "216" "paginaFinal" => "223" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25549816" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0420" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carbon dioxide laser combined with botulinum toxin A for patients with periorbital syringomas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.M. Seo" 1 => "J.Y. Choi" 2 => "J. Min" 3 => "W.S. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/14764172.2015.1052517" "Revista" => array:6 [ "tituloSerie" => "J Cosmet Laser Ther." "fecha" => "2016" "volumen" => "18" "paginaInicial" => "149" "paginaFinal" => "153" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26073121" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0425" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ablative fractional laser enhances MAL-induced PpIX accumulation: Impact of laser channel density, incubation time and drug concentration" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.S. Haak" 1 => "K. Christiansen" 2 => "A.M. Erlendsson" 3 => "E.H. Taudorf" 4 => "D. Thaysen-Petersen" 5 => "H.C. Wulf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jphotobiol.2016.03.021" "Revista" => array:6 [ "tituloSerie" => "J Photochem Photobiol B." "fecha" => "2016" "volumen" => "159" "paginaInicial" => "42" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27016718" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0430" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Using laser microporation to improve transdermal delivery of diclofenac: Increasing bioavailability and the range of therapeutic applications" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Y.G. Bachhav" 1 => "A. Heinrich" 2 => "Y.N. Kalia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejpb.2011.03.006" "Revista" => array:6 [ "tituloSerie" => "Eur J Pharm Biopharm." "fecha" => "2011" "volumen" => "78" "paginaInicial" => "408" "paginaFinal" => "414" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21397689" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0435" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk assessment of excess drug and sunscreen absorption via skin with ablative fractional laser resurfacing: Optimization of the applied dose for postoperative care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.Y. Chen" 1 => "C.L. Fang" 2 => "S.A. Al-Suwayeh" 3 => "H.H. Yang" 4 => "Y.C. Li" 5 => "J.Y. Fang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10103-012-1257-2" "Revista" => array:6 [ "tituloSerie" => "Lasers Med Sci." "fecha" => "2013" "volumen" => "28" "paginaInicial" => "1363" "paginaFinal" => "1374" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23291917" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0440" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Skin vaccination via fractional infrared laser ablation - Optimization of laser-parameters and adjuvantation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Scheiblhofer" 1 => "A. Strobl" 2 => "V. Hoepflinger" 3 => "T. Thalhamer" 4 => "M. Steiner" 5 => "J. Thalhamer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.vaccine.2016.11.105" "Revista" => array:6 [ "tituloSerie" => "Vaccine." "fecha" => "2017" "volumen" => "35" "paginaInicial" => "1802" "paginaFinal" => "1809" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28117172" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0445" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser-assisted topical drug delivery by using a low-fluence fractional laser: Imiquimod and macromolecules" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "W.R. Lee" 1 => "S.C. Shen" 2 => "S.A. Al-Suwayeh" 3 => "H.H. Yang" 4 => "C.Y. Yuan" 5 => "J.Y. Fang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jconrel.2011.03.015" "Revista" => array:6 [ "tituloSerie" => "J Control Release." "fecha" => "2011" "volumen" => "153" "paginaInicial" => "240" "paginaFinal" => "248" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21435360" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0450" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "[Accessed April 29, 2018]. Available at: <a class="elsevierStyleInterRef" target="_blank" id="intr0015" href="http://www.ncbi.nlm.nih.gov/pubmed/8624659">http://www.ncbi.nlm.nih.gov/pubmed/8624659</a>" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A histopathological comparison of “char-free” carbon dioxide lasers" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.N. Kauvar" 1 => "H.A. Waldorf" 2 => "R.G. Geronemus" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "1996" "volumen" => "22" "paginaInicial" => "343" "paginaFinal" => "348" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8624659" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0455" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "[Accessed April 29, 2018]. Available at: <a class="elsevierStyleInterRef" target="_blank" id="intr0020" href="http://www.ncbi.nlm.nih.gov/pubmed/2225547">http://www.ncbi.nlm.nih.gov/pubmed/2225547</a>" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulsed 2.94-microns erbium-YAG laser skin ablation--Experimental results and first clinical application" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Kaufmann" 1 => "R. Hibst" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Clin Exp Dermatol." "fecha" => "1990" "volumen" => "15" "paginaInicial" => "389" "paginaFinal" => "393" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2225547" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0460" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser-induced thermal coagulation enhances skin uptake of topically applied compounds" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.S. Haak" 1 => "J. Hannibal" 2 => "U. Paasch" 3 => "R.R. Anderson" 4 => "M. Haedersdal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22642" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2017" "volumen" => "49" "paginaInicial" => "582" "paginaFinal" => "591" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28181673" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0465" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vehicle type affects filling of fractional laser-ablated channels imaged by optical coherence tomography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "U.H. Olesen" 1 => "M. Mogensen" 2 => "M. Haedersdal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10103-017-2168-z" "Revista" => array:6 [ "tituloSerie" => "Lasers Med Sci." "fecha" => "2017" "volumen" => "32" "paginaInicial" => "679" "paginaFinal" => "684" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28213875" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0470" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Can fractional lasers enhance transdermal absorption of topical lidocaine in an in vivo animal model?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Oni" 1 => "S.A. Brown" 2 => "J.M. Kenkel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.21130" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2012" "volumen" => "44" "paginaInicial" => "168" "paginaFinal" => "174" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22302761" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0475" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Facial allergic granulomatous reaction and systemic hypersensitivity associated with microneedle therapy for skin rejuvenation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Soltani-Arabshahi" 1 => "J.W. Wong" 2 => "K.L. Duffy" 3 => "D.L. Powell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2013.6955" "Revista" => array:4 [ "tituloSerie" => "JAMA Dermatol." "fecha" => "2014" "volumen" => "150" "paginaInicial" => "68" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0480" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of a preceding fractional carbon dioxide laser on the outcome of combined local narrowband ultraviolet B and topical steroids in patients with vitiligo in difficult-to-treat areas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Vachiramon" 1 => "C. Chaiyabutr" 2 => "P. Rattanaumpawan" 3 => "S. Kanokrungsee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22389" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2016" "volumen" => "48" "paginaInicial" => "197" "paginaFinal" => "202" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26175036" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0485" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser-assisted drug delivery: Mode of action and use in daily clinical practice" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S.A. Braun" 1 => "H. Schrumpf" 2 => "B.A. Buhren" 3 => "B. Homey" 4 => "P.A. Gerber" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/ddg.12963" "Revista" => array:6 [ "tituloSerie" => "J Dtsch Dermatol Ges." "fecha" => "2016" "volumen" => "14" "paginaInicial" => "480" "paginaFinal" => "488" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27119468" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0490" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunohistochemical investigation of wound healing in response to fractional photothermolysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D. Helbig" 1 => "M.O. Bodendorf" 2 => "S. Grunewald" 3 => "M. Kendler" 4 => "J.C. Simon" 5 => "U. Paasch" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1117/1.3275479" "Revista" => array:4 [ "tituloSerie" => "J Biomed Opt." "fecha" => "2009" "volumen" => "14" "paginaInicial" => "64044" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0495" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spatiotemporal closure of fractional laser-ablated channels imaged by optical coherence tomography and reflectance confocal microscopy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.A. Banzhaf" 1 => "B.S. Wind" 2 => "M. Mogensen" 3 => "A.A. Meesters" 4 => "U. Paasch" 5 => "A. Wolkerstorfer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22386" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2016" "volumen" => "48" "paginaInicial" => "157" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26266688" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0500" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hair follicles contribute significantly to penetration through human skin only at times soon after application as a solvent deposited solid in man" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "X. Liu" 1 => "J.E. Grice" 2 => "J. Lademann" 3 => "N. Otberg" 4 => "S. Trauer" 5 => "A. Patzelt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2125.2011.04022.x" "Revista" => array:6 [ "tituloSerie" => "Br J Clin Pharmacol." "fecha" => "2011" "volumen" => "72" "paginaInicial" => "768" "paginaFinal" => "774" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21599723" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0505" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional laser-assisted drug uptake: Impact of time-related topical application to achieve enhanced delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.A. Banzhaf" 1 => "D. Thaysen-Petersen" 2 => "C. Bay" 3 => "P.A. Philipsen" 4 => "M. Mogensen" 5 => "T. Prow" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22610" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2017" "volumen" => "49" "paginaInicial" => "348" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27885682" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0510" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:3 [ "comentario" => "[Accessed April 29, 2018]. Available at: <a class="elsevierStyleInterRef" target="_blank" id="intr0025" href="http://www.ncbi.nlm.nih.gov/pubmed/22735504">http://www.ncbi.nlm.nih.gov/pubmed/22735504</a>" "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Age-related percutaneous penetration part 2: Effect of age on dermatopharmacokinetics and overview of transdermal products" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Konda" 1 => "S.R. Meier-Davis" 2 => "B. Cayme" 3 => "J. Shudo" 4 => "H.I. Maibach" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Skin Therapy Lett." "fecha" => "2012" "volumen" => "17" "paginaInicial" => "5" "paginaFinal" => "7" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0515" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser-assisted topical corticosteroid delivery for the treatment of keloids" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J.H. Park" 1 => "J.Y. Chun" 2 => "J.H. Lee" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10103-017-2154-5" "Revista" => array:6 [ "tituloSerie" => "Lasers Med Sci." "fecha" => "2017" "volumen" => "32" "paginaInicial" => "601" "paginaFinal" => "608" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28124198" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0520" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of keloids with laser-assisted topical steroid delivery: A retrospective study of 23 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Cavalié" 1 => "L. Sillard" 2 => "H. Montaudié" 3 => "P. Bahadoran" 4 => "J.P. Lacour" 5 => "T. Passeron" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dth.12187" "Revista" => array:6 [ "tituloSerie" => "Dermatol Ther." "fecha" => "2015" "volumen" => "28" "paginaInicial" => "74" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25471297" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0525" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractionated aminolevulinic acid-photodynamic therapy provides additional evidence for the use of PDT for non-melanoma skin cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "E.R. De Haas" 1 => "H.C. de Vijlder" 2 => "H.J. Sterenborg" 3 => "H.A. Neumann" 4 => "D.J. Robinson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1468-3083.2007.02445.x" "Revista" => array:5 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2008" "volumen" => "22" "paginaInicial" => "426" "paginaFinal" => "430" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0530" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of pain associated with photodynamic therapy: A retrospective study of 658 treatments" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C.B. Halldin" 1 => "M. Gillstedt" 2 => "J. Paoli" 3 => "A.M. Wennberg" 4 => "H. Gonzalez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-1101" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol." "fecha" => "2011" "volumen" => "91" "paginaInicial" => "545" "paginaFinal" => "551" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21611684" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0535" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional carbon dioxide laser-assisted drug delivery of topical timolol solution for the treatment of deep infantile hemangioma: A pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Ma" 1 => "P. Wu" 2 => "X. Lin" 3 => "H. Chen" 4 => "X. Hu" 5 => "Y. Jin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/pde.12299" "Revista" => array:6 [ "tituloSerie" => "Pediatr Dermatol." "fecha" => "2014" "volumen" => "31" "paginaInicial" => "286" "paginaFinal" => "291" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24602019" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0540" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional CO<span class="elsevierStyleInf">2</span> laser assisted delivery of topical anesthetics: A randomized controlled pilot study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.A. Meesters" 1 => "M.M. Bakker" 2 => "M.A. de Rie" 3 => "A. Wolkerstorfer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22376" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med." "fecha" => "2016" "volumen" => "48" "paginaInicial" => "208" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26032635" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0545" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical lidocaine enhanced by laser pretreatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "G. Oni" 1 => "Y. Rasko" 2 => "J. Kenkel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/1090820X13496248" "Revista" => array:5 [ "tituloSerie" => "Aesthet Surg J." "fecha" => "2013" "volumen" => "33" "paginaInicial" => "854" "paginaFinal" => "861" ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0550" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.W. Lee" 1 => "H.H. Ahn" 2 => "Y.C. Kye" 3 => "S.H. Seo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1346-8138.14240" "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "2018" "volumen" => "45" "paginaInicial" => "425" "paginaFinal" => "430" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29383745" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0555" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative study of fractional CO<span class="elsevierStyleInf">2</span> laser and fractional CO<span class="elsevierStyleInf">2</span> laser-assisted drug delivery of topical steroid and topical vitamin C in macular amyloidosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R.M. Sobhi" 1 => "I. Sharaoui" 2 => "E.A. El Nabarawy" 3 => "R.S. El Nemr Esmail" 4 => "R.A. Hegazy" 5 => "D.H.F. Aref" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10103-018-2457-1" "Revista" => array:6 [ "tituloSerie" => "Lasers Med Sci." "fecha" => "2018" "volumen" => "33" "paginaInicial" => "909" "paginaFinal" => "916" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29480422" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0560" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser-assisted delivery of vitamin C, vitamin E, and ferulic acid formula serum decreases fractional laser postoperative recovery by increased beta fibroblast growth factor expression" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.S. Waibel" 1 => "Q.S. Mi" 2 => "D. Ozog" 3 => "L. Qu" 4 => "L. Zhou" 5 => "A. Rudnick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lsm.22448" "Revista" => array:6 [ "tituloSerie" => "Lasers Surg Med" "fecha" => "2016" "volumen" => "48" "paginaInicial" => "238" "paginaFinal" => "244" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26612341" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0565" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erbium-yttrium-aluminum-garnet laser irradiation ameliorates skin permeation and follicular delivery of antialopecia drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.R. Lee" 1 => "S.C. Shen" 2 => "I.A. Aljuffali" 3 => "Y.C. Li" 4 => "J.Y. Fang" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jps.24143" "Revista" => array:6 [ "tituloSerie" => "J Pharm Sci." "fecha" => "2014" "volumen" => "103" "paginaInicial" => "3542" "paginaFinal" => "3552" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25187109" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0570" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of atrophic scars with fractionated CO2 laser facilitating delivery of topically applied poly-L-lactic acid" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Rkein" 1 => "D. Ozog" 2 => "J.S. Waibel" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dsu.0000000000000010" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2014" "volumen" => "40" "paginaInicial" => "624" "paginaFinal" => "631" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24852466" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0575" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Repigmentation of hypopigmented scars using an erbium-doped 1,550-nm fractionated laser and topical bimatoprost" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.B. Massaki" 1 => "S.G. Fabi" 2 => "R. Fitzpatrick" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1524-4725.2012.02389.x" "Revista" => array:6 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2012" "volumen" => "38" "paginaInicial" => "995" "paginaFinal" => "1001" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22540767" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0580" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional non-ablative laser-assisted drug delivery leads to improvement in male and female pattern hair loss" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.C.J. Bertin" 1 => "A. Vilarinho" 2 => "A.L.A. Junqueira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/14764172.2017.1418516" "Revista" => array:5 [ "tituloSerie" => "J Cosmet Laser Ther." "fecha" => "2018" "paginaInicial" => "1" "paginaFinal" => "4" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/30118355" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0585" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of ablative fractional laser-assisted photodynamic therapy with short-incubation time for the treatment of facial and scalp actinic keratosis: 12-month follow-up results of a randomized, prospective, comparative trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.H. Choi" 1 => "K.H. Kim" 2 => "K.H. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12953" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2015" "volumen" => "29" "paginaInicial" => "1598" "paginaFinal" => "1605" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25640401" "web" => "Medline" ] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0590" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional erbium: YAG laser-assisted photodynamic therapy for facial actinic keratoses: A randomized, comparative, prospective study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.Y. Ko" 1 => "S.Y. Jeon" 2 => "K.H. Kim" 3 => "K.H. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12334" "Revista" => array:5 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2014" "volumen" => "28" "paginaInicial" => "1529" "paginaFinal" => "1539" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0595" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intensified photodynamic therapy of actinic keratoses with fractional CO2 laser: A randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "K. Togsverd-Bo" 1 => "C.S. Haak" 2 => "D. Thaysen-Petersen" 3 => "H.C. Wulf" 4 => "R.R. Anderson" 5 => "M. Hædersdal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2012.10893.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2012" "volumen" => "166" "paginaInicial" => "1262" "paginaFinal" => "1269" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22348388" "web" => "Medline" ] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0600" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intensified fractional CO<span class="elsevierStyleInf">2</span> laser-assisted photodynamic therapy vs laser alone for organ transplant recipients with multiple actinic keratoses and wart-like lesions: A randomized half-side comparative trial on dorsal hands" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Helsing" 1 => "K. Togsverd-Bo" 2 => "M.B. Veierød" 3 => "G. Mørk" 4 => "M. Haedersdal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.12507" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2013" "volumen" => "169" "paginaInicial" => "1087" "paginaFinal" => "1092" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23855503" "web" => "Medline" ] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0605" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Combination of ablative fractional laser and daylight-mediated photodynamic therapy for actinic keratosis in organ transplant recipients - A randomized controlled trial" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "K. Togsverd-Bo" 1 => "U. Lei" 2 => "A.M. Erlendsson" 3 => "E.H. Taudorf" 4 => "P.A. Philipsen" 5 => "H.C. Wulf" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/bjd.13222" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol." "fecha" => "2015" "volumen" => "172" "paginaInicial" => "467" "paginaFinal" => "474" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24975199" "web" => "Medline" ] ] ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0610" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Translational medicine in the field of ablative fractional laser (AFXL)-assisted drug delivery: A critical review from basics to current clinical status" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Haedersdal" 1 => "A.M. Erlendsson" 2 => "U. Paasch" 3 => "R.R. Anderson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jaad.2015.12.008" "Revista" => array:5 [ "tituloSerie" => "J Am Acad Dermatol." "fecha" => "2016" "volumen" => "74" "paginaInicial" => "981" "paginaFinal" => "1004" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0615" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional carbon dioxide laser improves nodular basal cell carcinoma treatment with photodynamic therapy with methyl 5-aminolevulinate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Lippert" 1 => "R. Smucler" 2 => "M. Vlk" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/dsu.12242" "Revista" => array:5 [ "tituloSerie" => "Dermatol Surg." "fecha" => "2013" "volumen" => "39" "paginaInicial" => "1202" "paginaFinal" => "1208" ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0620" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fractional carbon dioxide laser-assisted photodynamic therapy for patients with actinic keratosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "H.S. Song" 1 => "S.E. Jung" 2 => "Y.H. Jang" 3 => "H.Y. Kang" 4 => "E.S. Lee" 5 => "Y.C. Kim" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/phpp.12184" "Revista" => array:6 [ "tituloSerie" => "Photodermatol Photoimmunol Photomed." "fecha" => "2015" "volumen" => "31" "paginaInicial" => "296" "paginaFinal" => "301" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26012779" "web" => "Medline" ] ] ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0625" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Er:YAG ablative fractional laser-primed photodynamic therapy with methyl aminolevulinate as an alternative treatment option for patients with thin nodular basal cell carcinoma: 12-month follow-up results of a randomized, prospective, comparative trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.H. Choi" 1 => "K.H. Kim" 2 => "K.H. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.13453" "Revista" => array:5 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2016" "volumen" => "30" "paginaInicial" => "783" "paginaFinal" => "788" ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0630" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of methyl aminolevulinate photodynamic therapy with and without ablative fractional laser treatment in patients with microinvasive squamous cell carcinoma: A randomized clinical trial" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S.H. Choi" 1 => "K.H. Kim" 2 => "K.H. Song" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jamadermatol.2016.4463" "Revista" => array:6 [ "tituloSerie" => "JAMA Dermatol." "fecha" => "2017" "volumen" => "153" "paginaInicial" => "289" "paginaFinal" => "295" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28199463" "web" => "Medline" ] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0635" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Laser and light-based treatment of keloids - A review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A.D. Mamalis" 1 => "H. Lev-Tov" 2 => "D.H. Nguyen" 3 => "J.R. Jagdeo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.12253" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol." "fecha" => "2014" "volumen" => "28" "paginaInicial" => "689" "paginaFinal" => "699" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24033440" "web" => "Medline" ] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0640" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Topical delivery of triamcinolone via skin pretreated with ablative radiofrequency: A new method in hypertrophic scar treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.C. Issa" 1 => "L.E. Kassuga" 2 => "N.S. Chevrand" 3 => "M.T. Pires" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2012.05704.x" "Revista" => array:5 [ "tituloSerie" => "Int J Dermatol." "fecha" => "2013" "volumen" => "52" "paginaInicial" => "367" "paginaFinal" => "370" ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0645" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Erbium:YAG fractional laser ablation for percutaneous delivery of intact functional therapeutic antibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "J. Yu" 1 => "D.R. Kalaria" 2 => "Y.N. Kalia" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jconrel.2011.07.024" "Revista" => array:6 [ "tituloSerie" => "J Control Release." "fecha" => "2011" "volumen" => "156" "paginaInicial" => "53" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21803083" "web" => "Medline" ] ] ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0650" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transcutaneous delivery of CpG-adjuvanted allergen via laser-generated micropores" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Hessenberger" 1 => "R. Weiss" 2 => "E.E. Weinberger" 3 => "C. Boehler" 4 => "J. Thalhamer" 5 => "S. Scheiblhofer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Vaccine." "fecha" => "2013" "volumen" => "25" "paginaInicial" => "3427" "paginaFinal" => "3434" ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0655" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Facilitation of transcutaneous drug delivery and vaccine immunization by safe laser technology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "X. Chen" 1 => "D. Shah" 2 => "G. Iositratna" 3 => "D. Manstein" 4 => "R.R. Anderson" 5 => "M.X. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jconrel.2012.01.002" "Revista" => array:6 [ "tituloSerie" => "J Control Release." "fecha" => "2012" "volumen" => "159" "paginaInicial" => "43" "paginaFinal" => "51" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22261281" "web" => "Medline" ] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0660" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Percutaneous bone marrow transplantation using fractional ablative Erbium:YAG laser" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Rodriguez-Menocal" 1 => "M. Salgado" 2 => "S. Davis" 3 => "J. Waibel" 4 => "A. Shabbir" 5 => "A. Cox" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pone.0093004" "Revista" => array:5 [ "tituloSerie" => "PLoS One." "fecha" => "2014" "volumen" => "9" "paginaInicial" => "e93004" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24667438" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010900000010/v1_201812060634/S1578219018303664/v1_201812060634/en/main.assets" "Apartado" => array:4 [ "identificador" => "6170" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Novelties in Dermatology" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000010/v1_201812060634/S1578219018303664/v1_201812060634/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018303664?idApp=UINPBA000044" ]
Year/Month | Html | Total | |
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2024 November | 32 | 18 | 50 |
2024 October | 212 | 57 | 269 |
2024 September | 278 | 80 | 358 |
2024 August | 258 | 84 | 342 |
2024 July | 226 | 57 | 283 |
2024 June | 222 | 61 | 283 |
2024 May | 188 | 71 | 259 |
2024 April | 191 | 62 | 253 |
2024 March | 222 | 62 | 284 |
2024 February | 277 | 71 | 348 |
2024 January | 279 | 51 | 330 |
2023 December | 243 | 50 | 293 |
2023 November | 270 | 72 | 342 |
2023 October | 203 | 71 | 274 |
2023 September | 154 | 58 | 212 |
2023 August | 125 | 37 | 162 |
2023 July | 118 | 36 | 154 |
2023 June | 88 | 31 | 119 |
2023 May | 151 | 42 | 193 |
2023 April | 105 | 29 | 134 |
2023 March | 132 | 42 | 174 |
2023 February | 102 | 34 | 136 |
2023 January | 89 | 25 | 114 |
2022 December | 125 | 51 | 176 |
2022 November | 88 | 44 | 132 |
2022 October | 77 | 37 | 114 |
2022 September | 94 | 51 | 145 |
2022 August | 96 | 49 | 145 |
2022 July | 70 | 51 | 121 |
2022 June | 62 | 41 | 103 |
2022 May | 169 | 68 | 237 |
2022 April | 150 | 61 | 211 |
2022 March | 122 | 65 | 187 |
2022 February | 92 | 51 | 143 |
2022 January | 114 | 113 | 227 |
2021 December | 84 | 54 | 138 |
2021 November | 96 | 79 | 175 |
2021 October | 103 | 71 | 174 |
2021 September | 95 | 69 | 164 |
2021 August | 110 | 64 | 174 |
2021 July | 128 | 59 | 187 |
2021 June | 114 | 40 | 154 |
2021 May | 140 | 66 | 206 |
2021 April | 285 | 187 | 472 |
2021 March | 143 | 60 | 203 |
2021 February | 147 | 59 | 206 |
2021 January | 123 | 73 | 196 |
2020 December | 157 | 39 | 196 |
2020 November | 68 | 30 | 98 |
2020 October | 52 | 19 | 71 |
2020 September | 65 | 26 | 91 |
2020 August | 47 | 38 | 85 |
2020 July | 36 | 31 | 67 |
2020 June | 44 | 47 | 91 |
2020 May | 23 | 22 | 45 |
2020 April | 18 | 12 | 30 |
2020 March | 31 | 23 | 54 |
2020 February | 2 | 4 | 6 |
2020 January | 1 | 1 | 2 |
2019 March | 1 | 0 | 1 |
2019 February | 2 | 2 | 4 |
2019 January | 2 | 4 | 6 |