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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Mycosis fungoides &#40;MF&#41; is the most common type of primary cutaneous T-cell lymphoma &#40;CTCL&#41;&#44; affecting middle-aged and elderly population&#46; The clinical manifestations are limited to the skin in early stages &#40;eMF&#41;&#46; Skin histopathology&#44; immunohistochemistry and other complementary studies are required&#44; in order to classify MF stages&#46; The prognosis of eMF is favourable&#44; with 98&#37; five-year survival rate for limited patch or plaque disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The most recommended treatments for eMF are topical therapies and phototherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Narrowband UVB phototherapy &#40;NB-UVB&#41; is considered to have a safer profile than PUVA and broadband UVB regarding side effects&#44; tolerability and carcinogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Up to the present&#44; most MF and NB-UVB studies were performed on Caucasian and Asian populations with a schedule of three sessions per week&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The aims of this study are to evaluate the response&#44; relapse and side effects of a twice-weekly NB-UVB regimen in eMF&#46; We compared the results with the classic three times a week schedule published in the literature&#46; We also described for the first time the response to NB-UVB therapy in an Argentinean cohort&#44; a mixture of Caucasian and Mestizo people &#40;Amerindian and European ancestry&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We present a retrospective analysis of adult patients &#40;&#62; 18 years old&#41; with confirmed eMF&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> who underwent NB-UVB in the Department of Dermatology at &#8220;Hospital Italiano de Buenos Aires&#8221; for 8 years&#46; Patient data were obtained from the electronic medical records&#46; No patients presented advanced-stage MF prior to the treatment&#46; NB-UVB treatment scheme is depicted in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Clinical evaluation was performed every 10 sessions or in the presence of side effects&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Clinical response was classified as complete &#40;CR&#44; &#62;95&#37; of skin lesions clearance&#41;&#44; partial &#40;PR&#44; 50&#37; to 95&#37;&#41;&#44; stable disease &#40;&#60;50&#37;&#41; and progressive disease&#46; After achieving CR&#44; NB-UVB frequency was reduced once-weekly for 5 weeks and then&#44; discontinued&#46; Remission and relapse were clinically assessed every 3 months and skin biopsies were performed&#44; provided that the clinical picture was unclear&#46; Late relapse was defined as the recurrence of MF more than 12 months after completion of NB-UVB&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We included a cohort of eighteen eMF patients&#46; The study was completed by fifteen patients&#44; while three were excluded as they developed a progressive disease&#46; The eMF population and NB-UVB details are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; All twelve CR patients received maintenance and five did not relapse during the follow-up period up to 36 months&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a> shows the response to NB-UVB in eMF patients&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">NB-UVB is an effective therapy to improve life quality and to induce a short-term CR in MF&#46; Our cohort of patients was treated with a twice-weekly schedule&#44; reaching a 80&#37; CR in a mean time of 6&#46;1 months&#46; Hofer et al<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> reported 6 patients treated with NB-UVB 3-4 times-weekly for 5 to 10 weeks&#44; with a mean cumulative dose &#40;CuD&#41; of 16&#46;3<span class="elsevierStyleHsp" style=""></span>J&#47;cm2&#46; Although 83&#37; of the patients achieved CR&#44; all of them relapsed within 6 months&#46; G&#246;kdemir et al<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> published a prospective study with 23 early-stage MF patients&#44; treated with a thrice-weekly schedule&#46; A CR was achieved in 91&#46;3&#37; patients&#44; the mean CuD was 90&#46;3<span class="elsevierStyleHsp" style=""></span>J&#47;cm2 with an average of 36 sessions&#46; In the 3-year follow-up period&#44; only one CR patient relapsed&#46; Relapse rate appears to be related to the CuD&#44; rather than to the number of sessions or the schedule applied&#46; However&#44; we also observed a late relapse in 2 patients&#44; which it would suggest that the response variability is still insufficiently understood&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The establishment of a maintenance therapy should be mandatory as relapse is expected in most of the patients&#46; Boztepe <span class="elsevierStyleItalic">et al</span> described a maintenance therapy based on 80-160 NB-UVB sessions &#40;12-30 months&#41; on a decreasing frequency schedule&#46; During this period&#44; no relapse was observed&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> In regard to avoiding unnecessary energy accumulation and longer therapy&#44; we decided a short-term maintenance&#44; with a close follow-up&#46; Relapsed eMF patients restarted NB-UVB or began PUVA &#40;data not shown&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In order to lower side effects&#44; we apply a common schedule to our cohort and no severe reactions were observed&#46; Despite most publications show a shorter mean time treatment to reach CR &#40;3-4 months&#41;&#44; twice-weekly regimen reduces theoretically the risk of acute side effects&#44; as well as the immunosuppressive response in the short term&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">A twice-weekly NB-UVB schedule in eMF is as effective as the three-times-weekly regimen&#46; Our CR and relapse rate can be compared to the classic scheme&#44; which confirms that the total amount of energy delivered could be more important than the frequency of exposure or the initial dose&#46; Although longer treatments could be required to reach CuD&#44; we emphasize the low rate of side effects and an adequate treatment compliance&#46; Based on our clinical study&#44; we can recommend a twice-weekly schedule as an alternative to the classical schedule&#44; if patients report intolerance to NB-UVB&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">Conflicts of Interest The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Female patient with plaque stage MF in both legs&#46; Complete resolution of the skin lesions after 60 sessions of UVB-NB therapy&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sex ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;75 females per male &#40;11 female&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>60&#46;8 years old<br>Range<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>28 to 81 years old&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fitzpatrick classification scale&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin type II<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8 patients<br>Skin type III<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8 patients<br>Skin type IV<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MF clinical stage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patch stage<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5 patients<br>Plaque stage<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TNMB staging system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IA<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 patients<br>IB<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Concomitant treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Potent topical steroids &#40;class I-II&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">One patient received PUVA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NB-UVB phototherapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mean sessions<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39<br>Range sessions<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20 to 65<br>Mean CuD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>28&#46;7 J&#47;cm2<br>Range CuD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21 to 61&#46;1 J&#47;cm2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Study completion and response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#47;18 patients<br>CR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12 &#40;66&#37;&#41;<br>PR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3 &#40;16&#46;5&#37;&#41;<br>CR Mean time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#46;1 months<br>CR Median time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;5 months<br>CR Range time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3 to 13 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Side effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#47;18 patients<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>moderate erythema<br>4&#47;18 patients<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>burning sensation<br>1&#47;18 patients<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>SCC &#40;previous photodamaged skin&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Relapse&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#47;12 CR patients<br>Mean time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;4 months<br>Median time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3 months<br>Range time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 to 60 months<br>Histological confirmation<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NB-UVB Cabinet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Jorlan&#174; Argentina&#59; 44 fluorescent TL&#47;01 Philips lamps 100W&#44; peak emission at 311&#47;312 nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NB-UVB frequency&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Twice a week on nonconsecutive days&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Initial dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1 J&#47;cm2 &#40;regardless of the skin phototype&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Increasing dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1 J&#47;cm2 per session&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Maximal dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5 J&#47;cm2 or maximal well-tolerated dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mild side effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">If marked erythema or discomfort&#58; 1 week pause and restart with 20&#37; to 30&#37; lower dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Persistent side effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Highest well-tolerated dose until the end of the treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                      "titulo" => "Narrowband UVB phototherapy for early-stage mycosis fungoides&#58; Evaluation of clinical and histopathological changes"
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Case and Research Letters
The Effectiveness of a Twice-weekly Narrowband Ultraviolet B Phototherapy Schedule in Early-stage Mycosis Fungoides in a Cohort of 18 Argentinian Patients
Efectividad de la fototerapia ultravioleta B de banda estrecha con un esquema bisemanal en el tratamiento de la micosis fungoide estadio temprano en una cohorte de 18 pacientes argentinos
D.A. De Luca
Corresponding author
daviddeluca@gmail.com

Corresponding author.
, E.A. Zambrano, R.L. Galimberti, P.A. Enz
Servicio de Dermatología, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Mycosis fungoides &#40;MF&#41; is the most common type of primary cutaneous T-cell lymphoma &#40;CTCL&#41;&#44; affecting middle-aged and elderly population&#46; The clinical manifestations are limited to the skin in early stages &#40;eMF&#41;&#46; Skin histopathology&#44; immunohistochemistry and other complementary studies are required&#44; in order to classify MF stages&#46; The prognosis of eMF is favourable&#44; with 98&#37; five-year survival rate for limited patch or plaque disease&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#44;2</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The most recommended treatments for eMF are topical therapies and phototherapy&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> Narrowband UVB phototherapy &#40;NB-UVB&#41; is considered to have a safer profile than PUVA and broadband UVB regarding side effects&#44; tolerability and carcinogenesis&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">4</span></a> Up to the present&#44; most MF and NB-UVB studies were performed on Caucasian and Asian populations with a schedule of three sessions per week&#46;<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">2&#44;5</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The aims of this study are to evaluate the response&#44; relapse and side effects of a twice-weekly NB-UVB regimen in eMF&#46; We compared the results with the classic three times a week schedule published in the literature&#46; We also described for the first time the response to NB-UVB therapy in an Argentinean cohort&#44; a mixture of Caucasian and Mestizo people &#40;Amerindian and European ancestry&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">We present a retrospective analysis of adult patients &#40;&#62; 18 years old&#41; with confirmed eMF&#44;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> who underwent NB-UVB in the Department of Dermatology at &#8220;Hospital Italiano de Buenos Aires&#8221; for 8 years&#46; Patient data were obtained from the electronic medical records&#46; No patients presented advanced-stage MF prior to the treatment&#46; NB-UVB treatment scheme is depicted in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; Clinical evaluation was performed every 10 sessions or in the presence of side effects&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0025" class="elsevierStylePara elsevierViewall">Clinical response was classified as complete &#40;CR&#44; &#62;95&#37; of skin lesions clearance&#41;&#44; partial &#40;PR&#44; 50&#37; to 95&#37;&#41;&#44; stable disease &#40;&#60;50&#37;&#41; and progressive disease&#46; After achieving CR&#44; NB-UVB frequency was reduced once-weekly for 5 weeks and then&#44; discontinued&#46; Remission and relapse were clinically assessed every 3 months and skin biopsies were performed&#44; provided that the clinical picture was unclear&#46; Late relapse was defined as the recurrence of MF more than 12 months after completion of NB-UVB&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">We included a cohort of eighteen eMF patients&#46; The study was completed by fifteen patients&#44; while three were excluded as they developed a progressive disease&#46; The eMF population and NB-UVB details are described in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#46; All twelve CR patients received maintenance and five did not relapse during the follow-up period up to 36 months&#46; <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a> shows the response to NB-UVB in eMF patients&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0035" class="elsevierStylePara elsevierViewall">NB-UVB is an effective therapy to improve life quality and to induce a short-term CR in MF&#46; Our cohort of patients was treated with a twice-weekly schedule&#44; reaching a 80&#37; CR in a mean time of 6&#46;1 months&#46; Hofer et al<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> reported 6 patients treated with NB-UVB 3-4 times-weekly for 5 to 10 weeks&#44; with a mean cumulative dose &#40;CuD&#41; of 16&#46;3<span class="elsevierStyleHsp" style=""></span>J&#47;cm2&#46; Although 83&#37; of the patients achieved CR&#44; all of them relapsed within 6 months&#46; G&#246;kdemir et al<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">8</span></a> published a prospective study with 23 early-stage MF patients&#44; treated with a thrice-weekly schedule&#46; A CR was achieved in 91&#46;3&#37; patients&#44; the mean CuD was 90&#46;3<span class="elsevierStyleHsp" style=""></span>J&#47;cm2 with an average of 36 sessions&#46; In the 3-year follow-up period&#44; only one CR patient relapsed&#46; Relapse rate appears to be related to the CuD&#44; rather than to the number of sessions or the schedule applied&#46; However&#44; we also observed a late relapse in 2 patients&#44; which it would suggest that the response variability is still insufficiently understood&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">The establishment of a maintenance therapy should be mandatory as relapse is expected in most of the patients&#46; Boztepe <span class="elsevierStyleItalic">et al</span> described a maintenance therapy based on 80-160 NB-UVB sessions &#40;12-30 months&#41; on a decreasing frequency schedule&#46; During this period&#44; no relapse was observed&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> In regard to avoiding unnecessary energy accumulation and longer therapy&#44; we decided a short-term maintenance&#44; with a close follow-up&#46; Relapsed eMF patients restarted NB-UVB or began PUVA &#40;data not shown&#41;&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">In order to lower side effects&#44; we apply a common schedule to our cohort and no severe reactions were observed&#46; Despite most publications show a shorter mean time treatment to reach CR &#40;3-4 months&#41;&#44; twice-weekly regimen reduces theoretically the risk of acute side effects&#44; as well as the immunosuppressive response in the short term&#46;<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">8&#8211;10</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">A twice-weekly NB-UVB schedule in eMF is as effective as the three-times-weekly regimen&#46; Our CR and relapse rate can be compared to the classic scheme&#44; which confirms that the total amount of energy delivered could be more important than the frequency of exposure or the initial dose&#46; Although longer treatments could be required to reach CuD&#44; we emphasize the low rate of side effects and an adequate treatment compliance&#46; Based on our clinical study&#44; we can recommend a twice-weekly schedule as an alternative to the classical schedule&#44; if patients report intolerance to NB-UVB&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0055" class="elsevierStylePara elsevierViewall">Conflicts of Interest The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "identificador" => "sec0005"
          "titulo" => "Conflicts of Interest"
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          "titulo" => "R&#233;f&#233;rences"
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    "tienePdf" => true
    "fechaRecibido" => "2017-06-28"
    "fechaAceptado" => "2017-11-21"
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; De Luca DA&#44; Zambrano EA&#44; Galimberti RL&#44; Enz PA&#46; Efectividad de la fototerapia ultravioleta B de banda estrecha con un esquema bisemanal en el tratamiento de la micosis fungoide estadio temprano en una cohorte de 18 pacientes argentinos&#46; Actas Dermosifiliogr&#46; 2018&#59;109&#58;922&#8211;924&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Female patient with plaque stage MF in both legs&#46; Complete resolution of the skin lesions after 60 sessions of UVB-NB therapy&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Population&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sex ratio&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;75 females per male &#40;11 female&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mean<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>60&#46;8 years old<br>Range<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>28 to 81 years old&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fitzpatrick classification scale&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Skin type II<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8 patients<br>Skin type III<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>8 patients<br>Skin type IV<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">MF clinical stage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Patch stage<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5 patients<br>Plaque stage<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">TNMB staging system&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IA<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 patients<br>IB<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Concomitant treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Potent topical steroids &#40;class I-II&#41;<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Previous treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">One patient received PUVA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NB-UVB phototherapy&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Mean sessions<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>39<br>Range sessions<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>20 to 65<br>Mean CuD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>28&#46;7 J&#47;cm2<br>Range CuD<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>21 to 61&#46;1 J&#47;cm2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Study completion and response&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#47;18 patients<br>CR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>12 &#40;66&#37;&#41;<br>PR<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3 &#40;16&#46;5&#37;&#41;<br>CR Mean time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>6&#46;1 months<br>CR Median time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>5&#46;5 months<br>CR Range time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3 to 13 months&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Side effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">9&#47;18 patients<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>moderate erythema<br>4&#47;18 patients<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>burning sensation<br>1&#47;18 patients<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>SCC &#40;previous photodamaged skin&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Relapse&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#47;12 CR patients<br>Mean time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>13&#46;4 months<br>Median time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>3 months<br>Range time<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 to 60 months<br>Histological confirmation<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>2 patients&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Early-stage mycosis fungoides population features&#46;</p>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NB-UVB Cabinet&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Jorlan&#174; Argentina&#59; 44 fluorescent TL&#47;01 Philips lamps 100W&#44; peak emission at 311&#47;312 nm&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NB-UVB frequency&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Twice a week on nonconsecutive days&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Initial dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1 J&#47;cm2 &#40;regardless of the skin phototype&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Increasing dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#46;1 J&#47;cm2 per session&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Maximal dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#46;5 J&#47;cm2 or maximal well-tolerated dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mild side effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">If marked erythema or discomfort&#58; 1 week pause and restart with 20&#37; to 30&#37; lower dose&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Persistent side effects&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Highest well-tolerated dose until the end of the treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Narrowband UVB treatment scheme&#46;</p>"
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                            0 => "R&#46;C&#46; Gathers"
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                            2 => "F&#46; Malick"
                            3 => "D&#46;P&#46; Fivenson"
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                        "tituloSerie" => "J Am Acad Dermatol&#46;"
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ISSN: 15782190
Original language: English
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