Editorial Comments
Biologic Therapy as a First-Line Treatment in Patients with Psoriasis: An Unstudied Population
Tratamiento biológico como primera línea en pacientes con psoriasis: una población no estudiada
O. Baniandrés Rodríguez
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España
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Baniandrés Rodríguez" "autores" => array:1 [ 0 => array:3 [ "nombre" => "O." "apellidos" => "Baniandrés Rodríguez" "email" => array:1 [ 0 => "ofelia_baniandres@yahoo.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, España" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Tratamiento biológico como primera línea en pacientes con psoriasis: una población no estudiada" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The BIOBADADERM registry prospectively collects demographic data, clinical management data, and data on adverse events from 14 Spanish hospitals under conditions of daily clinical practice. Therefore, it is extremely useful for determining the therapeutic management of moderate to severe psoriasis in Spain.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In this article from the BIOBADADERM study group,<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> the authors describe the clinical characteristics of patients who receive biologic drugs as first-line therapy in daily clinical practice. These are the first published data of this type, since, according to the summary of product characteristics, biologic drugs are usually prescribed after classic systemic treatments. Patients who receive biologics as first-line therapy more often have arterial hypertension, diabetes mellitus, chronic liver disease, hepatitis C, and HIV infection. Therefore, it seems that the main reason classic systemic options are ruled out as first-line therapy is to avoid associated interactions and adverse effects.</p><p id="par0015" class="elsevierStylePara elsevierViewall">In contrast, there are no differences in clinical characteristics, medical management, or adverse effects between patients who receive biologics as first- or second-line therapy.</p><p id="par0020" class="elsevierStylePara elsevierViewall">This study opens the debate on the advantages and disadvantages of biologic treatment as first-line systemic treatment before conventional therapy.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Baniandrés Rodríguez O. Tratamiento biológico como primera línea en pacientes con psoriasis: una población no estudiada. Actas Dermosifiliogr. 2018;109:579.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:1 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Descripción de los pacientes que reciben biológicos como primer tratamiento sistémico en el registro de BIOBADADERM durante el periodo 2008-2016" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Carretero Hernández" 1 => "C. Ferrándiz" 2 => "R. Rivera Díaz" 3 => "E. Daudén Tello" 4 => "P. de la Cueva-Dobao" 5 => "F.J. Gómez-García" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2018" "volumen" => "109" "paginaInicial" => "617" "paginaFinal" => "623" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010900000007/v1_201809020417/S1578219018302361/v1_201809020417/en/main.assets" "Apartado" => array:4 [ "identificador" => "66476" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Commentaries" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000007/v1_201809020417/S1578219018302361/v1_201809020417/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018302361?idApp=UINPBA000044" ]
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