Case and Research Letters
Microvenular Hemangioma: Morphological Study of 3 Cases
Hemangioma microvenular: estudio morfológico de 3 casos
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Giacaman, L.J. del Pozo, A. Bauzá, C. Saus" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Giacaman" "email" => array:1 [ 0 => "anizagiacaman@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "L.J." "apellidos" => "del Pozo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Bauzá" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "C." "apellidos" => "Saus" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitari Son Espases, Palma de Mallorca, Islas Baleares, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitari Son Espases, Palma de Mallorca, Islas Baleares, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hemangioma microvenular: estudio morfológico de 3 casos" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1685 "Ancho" => 1500 "Tamanyo" => 392084 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Case 1: MVH on right forearm in a 67-year-old man. B, A homogeneous area of pinkish color only is observed along with fine arborizing telangiectasias. The whitish area corresponds to the biopsy scar. C, Case 2: MVH (right) adjacent to a ruby dot (left) on the forearm of a 70-year-old male. D, Dermoscopic image of MVH showing a reddish homogeneous central area and fine, patchy telangiectasias. E, Case 3: MVH on the right side of a 32-year-old woman. F, Dermoscopy shows a central area of whitish-pink color with branched telangiectasias and a milium pseudocyst inside, surrounded by an erythematous area with a peripheral network of telangiectasias.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Microvenular hemangioma (MVH) is a rare acquired benign vascular tumor that clinically can be confused with a malignant lesion.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1,2</span></a> Around 67 cases have been reported in the literature,<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1–4</span></a> but dermoscopic study has only been reported in 3 of these.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3–5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This study presents 3 new cases of MVH, 2 in men and 1 in a woman. <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> presents the clinical information of interest and <a class="elsevierStyleCrossRef" href="#fig0005">Figure 1</a> shows the findings of the physical examination and dermoscopy. The lesions were excised and histological findings were diagnostic of MVH and similar in all 3 cases (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>A and B).</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">MVH presents clinically as asymptomatic or mildly pruriginous macules, papules, or nodules of erythematous appearance or violaceous color, which are slow growing and often present as multiple lesions.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> The preferred site is the forearm, as occurred in 2 of our cases. Lesions have also been reported on the chest, abdomen, forehead, legs, and soles.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">6–9</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The pathogenesis of MVH is unknown, although the lesion has been associated with immunosuppression.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> The first of our patients had received treatment for cancer and diabetes could be considered as an immunosuppressive factor in the second case. The disease has also been associated with hormonal factors, which may explain the slight predominance in women,<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">7</span></a> and hormonal factors could have played a role in the third case, in which the lesion developed after a miscarriage.</p><p id="par0025" class="elsevierStylePara elsevierViewall">MVH is not usually suspected clinically. In fact, in 50% of published cases, the lesion was excised without any clinical diagnosis. In all remaining cases, the clinical diagnosis issued was incorrect, with malignant vascular tumor being the main suspected condition (Kaposi sarcoma [KS] and well-differentiated angiosarcoma), followed by benign vascular tumor (hemosiderotic hemangioma, tufted angioma, capillary angioma, pyogenic granuloma, angiolipoma, or angiokeratoma). Some cases, including those presented as multiple lesions, were confused with leiomyomas, dermatofibromas, nevocellular nevi, epidermoid cysts, and inflammatory diseases.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1–10</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In dermoscopy, all our cases as well as the other 3 published cases showed a pinkish tone and fine telangiectasias.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3–5</span></a> In 2 of the published cases, red globules were also present,<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4,5</span></a> but these were lacking in the third published case<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">3</span></a> and in all of our cases (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). In 2 patients, a network of peripheral pigment was observed. The pinkish tone and fine arborizing telangiectasias can also be observed in superficial basal cell carcinoma (sBCC), initial KS, and cutaneous leishmaniasis (CL); and so these lesions may be indistinguishable from MVH. However, MVH does not present characteristic findings of sBCC such as nests and grey-blue globules, maple-leaf structures, wagon wheels, or superficial erosions. Initial KS can also show superficial scaling and peripheral pigment network, but the background tone can be more bluish and, although infrequent, the characteristic pattern described as rainbow form can be seen. Cutaneous leishmaniasis lesions, for their part, usually have an orange-colored background (pointing to the granulomatous etiology of the process), white-yellowish lumps that resemble yellow tears, and, in the most advanced lesions, central ulceration surrounded by hyperkeratosis described as white starburst pattern.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Definitive diagnosis of MVH is histological. Poorly defined vascular proliferation is observed in the papillary and reticular dermis, with small fine-walled vessels comprising a single layer of endothelial cells and collapsed lumen with no signs of atypia, sometimes grouped into lobules,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> which resemble those observed in tufted angioma, occasionally accompanied by lymphoplasmacytic infiltrate.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Immunohistochemistry is positive for CD31, CD34, and the angiogenesis marker WT1, and negative for the D2-40 marker of lymphatic differentiation as well as for GLUT-1 (specific to infantile hemangioma), and herpes virus <span class="elsevierStyleSmallCaps">VIII</span> (positive in KS).<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion, we present 3 cases of MVH, 2 located on the forearm of elderly patients possibly related to immunosuppression and 1 on the chest of a young woman with a history of recent miscarriage. Dermoscopic study of these 3 patients revealed a pinkish background and fine telangiectasias. Unlike the published cases, we did not observe red globules or a peripheral pigment network. Although the dermoscopic findings do not enable diagnosis to be reached, they do distinguish between many but not all of the other lesions included in the differential diagnosis. It is therefore necessary to provide more cases of MVH with dermoscopic study.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Giacaman A, del Pozo LJ, Bauzá A, Saus C. Hemangioma microvenular: estudio morfológico de 3 casos. Actas Dermosifiliogr. 2018;109:381–384.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1685 "Ancho" => 1500 "Tamanyo" => 392084 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Case 1: MVH on right forearm in a 67-year-old man. B, A homogeneous area of pinkish color only is observed along with fine arborizing telangiectasias. The whitish area corresponds to the biopsy scar. C, Case 2: MVH (right) adjacent to a ruby dot (left) on the forearm of a 70-year-old male. D, Dermoscopic image of MVH showing a reddish homogeneous central area and fine, patchy telangiectasias. E, Case 3: MVH on the right side of a 32-year-old woman. F, Dermoscopy shows a central area of whitish-pink color with branched telangiectasias and a milium pseudocyst inside, surrounded by an erythematous area with a peripheral network of telangiectasias.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1201 "Ancho" => 900 "Tamanyo" => 525750 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Proliferation of small vessels with inconspicuous lumina in the reticular dermis in the biopsy of the first patient (hematoxylin-eosin X10). B, Image of increased amplification showing the fine wall vessels without signs of atypia in the third patient (hematoxylin-eosin X20).</p>" ] ] 2 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: BCC, basal cell carcinoma; CT, chemotherapy; F, female; M, male; MM, melanoma; NR, not reported; RT, radiotherapy.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Case \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Author/Year \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Age \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Sex \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Comorbidity \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Clinical description \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Lesion duration<br> \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Site \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Size, mm \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Symptoms \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Predisposing factor \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Differential diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Dermoscopy \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Fernández-Morano (2016) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Erythematous papule with whitish halo \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">8 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Abdomen \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">10<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pinkish background<br>Scaling<br>Fine pigment network at the periphery \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Rivas-Tolosa (2016) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dysplastic nevus syndrome<br>In situ MM<br>(3 years previously) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Erythematous-violaceous macule \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 year \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Chest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pinkish background<br>Small red globules \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Scalvenzi (2007) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">31 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Erythematous plaque \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Dorsal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">NR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pinkish background<br>Red globules of differing sizes<br>Fine pigment network at the periphery \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Present series \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lung carcinoma<br>metastatic<br>(RT<span class="elsevierStyleHsp" style=""></span>+<span class="elsevierStyleHsp" style=""></span>CT)<br>(18 years previously)<br><br>Aortic valve disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Erythematous plaque measuring 20<span class="elsevierStyleHsp" style=""></span>mm (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>a)<br> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Several<br>years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Right forearm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Immunosuppression \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">BCC<br>Amelanotic MM<br>Cutaneous lupus<br>Lymphoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pinkish background<br>Fine arborizing telangiectasias \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Present series \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Type <span class="elsevierStyleSmallCaps">II</span> diabetes mellitus, hypertension, and dyslipidemia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Erythematous macule measuring 6<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>8 mm<br>(<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>c) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">1 year \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Right forearm \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">6<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Occasional pruritus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Immunosuppression \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Kaposi sarcoma<br>Acquired elastotic hemangioma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pinkish background<br>Fine telangiectasias \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Present series \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Miscarriage 1 month earlier<br>(8th week of pregnancy)<br> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Erythematous papule measuring 7<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm<br>(<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>e) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">4 months \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Chest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">7<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Occasional pruritus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Hormonal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Leishmaniasis<br>Spider veins \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Pinkish background<br>Fine telangiectasias<br>White globule \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1737273.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Published Cases of Microvenular Hemangioma With Dermoscopic Description.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0055" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hemangioma microvenular: lesión vascular benigna de patrón infiltrante Presentación de 3 casos y revisión de la literatura" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 8 | 14 |
| 2024 October | 137 | 49 | 186 |
| 2024 September | 137 | 29 | 166 |
| 2024 August | 172 | 58 | 230 |
| 2024 July | 144 | 51 | 195 |
| 2024 June | 125 | 31 | 156 |
| 2024 May | 93 | 40 | 133 |
| 2024 April | 102 | 41 | 143 |
| 2024 March | 103 | 39 | 142 |
| 2024 February | 90 | 38 | 128 |
| 2024 January | 67 | 35 | 102 |
| 2023 December | 95 | 14 | 109 |
| 2023 November | 99 | 21 | 120 |
| 2023 October | 122 | 22 | 144 |
| 2023 September | 101 | 29 | 130 |
| 2023 August | 65 | 19 | 84 |
| 2023 July | 89 | 41 | 130 |
| 2023 June | 79 | 19 | 98 |
| 2023 May | 104 | 29 | 133 |
| 2023 April | 78 | 21 | 99 |
| 2023 March | 95 | 25 | 120 |
| 2023 February | 93 | 28 | 121 |
| 2023 January | 64 | 42 | 106 |
| 2022 December | 71 | 53 | 124 |
| 2022 November | 60 | 36 | 96 |
| 2022 October | 32 | 21 | 53 |
| 2022 September | 26 | 37 | 63 |
| 2022 August | 29 | 47 | 76 |
| 2022 July | 30 | 31 | 61 |
| 2022 June | 18 | 29 | 47 |
| 2022 May | 76 | 41 | 117 |
| 2022 April | 73 | 27 | 100 |
| 2022 March | 72 | 49 | 121 |
| 2022 February | 59 | 35 | 94 |
| 2022 January | 89 | 39 | 128 |
| 2021 December | 58 | 36 | 94 |
| 2021 November | 96 | 61 | 157 |
| 2021 October | 63 | 57 | 120 |
| 2021 September | 56 | 43 | 99 |
| 2021 August | 61 | 45 | 106 |
| 2021 July | 97 | 40 | 137 |
| 2021 June | 60 | 29 | 89 |
| 2021 May | 53 | 50 | 103 |
| 2021 April | 107 | 71 | 178 |
| 2021 March | 108 | 31 | 139 |
| 2021 February | 91 | 35 | 126 |
| 2021 January | 69 | 27 | 96 |
| 2020 December | 56 | 24 | 80 |
| 2020 November | 56 | 28 | 84 |
| 2020 October | 38 | 16 | 54 |
| 2020 September | 34 | 20 | 54 |
| 2020 August | 28 | 24 | 52 |
| 2020 July | 30 | 17 | 47 |
| 2020 June | 42 | 35 | 77 |
| 2020 May | 35 | 27 | 62 |
| 2020 April | 34 | 15 | 49 |
| 2020 March | 34 | 24 | 58 |
| 2020 February | 2 | 2 | 4 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 8 | 0 | 8 |
| 2019 November | 4 | 0 | 4 |
| 2019 September | 10 | 0 | 10 |
| 2019 August | 2 | 0 | 2 |
| 2019 July | 6 | 0 | 6 |
| 2019 June | 4 | 0 | 4 |
| 2019 May | 6 | 0 | 6 |
| 2019 April | 2 | 0 | 2 |
| 2019 March | 2 | 0 | 2 |
| 2019 February | 4 | 0 | 4 |
| 2018 December | 4 | 0 | 4 |
| 2018 November | 2 | 0 | 2 |
| 2018 October | 1 | 0 | 1 |
| 2018 September | 2 | 0 | 2 |
Show all
