Commentaries
Histoplasmosis: An Emerging Endemic Mycosis
Histoplasmosis, una micosis endémica emergente
A. Pulido Pérez
Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain
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B, Multinucleated Langhans giant cells (hematoxylin-eosin, original magnification ×40). C, Multiple multinucleated giant cells (periodic acid-Schiff, original magnification ×40). D, Intrahistiocytic yeast-like structures (periodic acid-Schiff, original magnification ×100).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "L.V. Gómez-Santana, A.C. Torre, B.A. Hernández, V.I. Volonteri, B. Laura, R. Luis-Galimberti" "autores" => array:6 [ 0 => array:2 [ "nombre" => "L.V." "apellidos" => "Gómez-Santana" ] 1 => array:2 [ "nombre" => "A.C." "apellidos" => "Torre" ] 2 => array:2 [ "nombre" => "B.A." "apellidos" => "Hernández" ] 3 => array:2 [ "nombre" => "V.I." "apellidos" => "Volonteri" ] 4 => array:2 [ "nombre" => "B." "apellidos" => "Laura" ] 5 => array:2 [ "nombre" => "R." "apellidos" => "Luis-Galimberti" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731017305008" "doi" => "10.1016/j.ad.2017.08.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731017305008?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300489?idApp=UINPBA000044" "url" => "/15782190/0000010900000004/v1_201805040442/S1578219018300489/v1_201805040442/en/main.assets" ] ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Commentaries</span>" "titulo" => "Histoplasmosis: An Emerging Endemic Mycosis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "295" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "A. Pulido Pérez" "autores" => array:1 [ 0 => array:3 [ "nombre" => "A." "apellidos" => "Pulido Pérez" "email" => array:1 [ 0 => "ana.pulido@salud.madrid.org" ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servicio de Dermatología, Hospital General Universitario Gregorio Marañón, Madrid, Spain" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Histoplasmosis, una micosis endémica emergente" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Histoplasmosis is the most commonly described endemic mycosis in Spain. Although <span class="elsevierStyleItalic">Histoplasma capsulatum</span> is found mainly on the American and African continents, it is now distributed worldwide. Spain has seen a notable increase in the number of reported cases in recent decades, possibly because of the rise in travel abroad for either business or leisure. It should also be noted that up to a third of immigrants residing in Spain come from countries in the Americas where endemic mycoses are common.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Histoplasmosis is classically associated with high mortality in patients with immunosuppression caused by human immunodeficiency virus (HIV) infection. In this issue of the journal, Gómez-Santana and colleagues<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> report 3 cases of disseminated histoplasmosis in patients with immune compromise unrelated to HIV. Because they were cases of American histoplasmosis, caused by <span class="elsevierStyleItalic">H capsulatum</span> var. <span class="elsevierStyleItalic">capsulatum</span>, pulmonary signs and polymorphic skin involvement (eg, papules, nodules, cutaneous-mucous ulcers) predominated. Thus, manifestations at any stage of this variant of the disease can mimic tuberculosis.</p><p id="par0015" class="elsevierStylePara elsevierViewall">This emerging mycosis affects travelers and immigrants, and given that more and more patients are prescribed immunosuppressive treatments (including biological therapies for autoimmune diseases<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a>) every year, a high level of suspicion is warranted in patients coming from areas where <span class="elsevierStyleItalic">H capsulatum</span> is endemic. Diagnostic delays that could further worsen the prognosis must be avoided.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-10-15" "fechaAceptado" => "2017-10-17" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Pulido Pérez A. Histoplasmosis, una micosis endémica emergente. Actas Dermosifiliogr. 2018;109:295.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Manifestaciones mucocutáneas de la infección por <span class="elsevierStyleItalic">Histoplasma capsulatum</span> en pacientes inmunosuprimidos no VIH" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L.V. Gómez-Santana" 1 => "A.C. Torre" 2 => "B.A. Hernández" 3 => "V.I. Volonteri" 4 => "B. Laura" 5 => "R. Luis-Galimberti" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifiliogr" "fecha" => "2018" "volumen" => "109" "paginaInicial" => "e27" "paginaFinal" => "e32" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Histoplasmosis complicating tumor necrosis factor-α blocker therapy: A retrospective analysis of 98 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Vergidis" 1 => "R.K. Avery" 2 => "L.J. Wheat" 3 => "J.L. Dotson" 4 => "M.A. Assi" 5 => "S.A. Antoun" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/cid/civ299" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2015" "volumen" => "61" "paginaInicial" => "409" "paginaFinal" => "417" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25870331" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010900000004/v1_201805040442/S1578219018300477/v1_201805040442/en/main.assets" "Apartado" => array:4 [ "identificador" => "66476" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Commentaries" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010900000004/v1_201805040442/S1578219018300477/v1_201805040442/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219018300477?idApp=UINPBA000044" ]
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