Case and Research Letters
Our Experience With Strain Elastography in 2 Cases of Suspected Malignant Subcutaneous Lesions
Experiencia de elastografía strain en 2 casos de lesiones subcutáneas sospechosas de malignidad
a Servicio de Dermatología, Complejo Hospitalario Universitario de Ferrol, Ferrol, A Coruña, España
b Servicio de Dermatología, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España
c Servicio de Anatomía Patológica, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España
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Vilas-Sueiro, F. Alfageme-Roldán, P. Nájera, G. Roustán" "autores" => array:4 [ 0 => array:4 [ "nombre" => "A." "apellidos" => "Vilas-Sueiro" "email" => array:1 [ 0 => "avilassueiro@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "F." "apellidos" => "Alfageme-Roldán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "P." "apellidos" => "Nájera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "G." "apellidos" => "Roustán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Dermatología, Complejo Hospitalario Universitario de Ferrol, Ferrol, A Coruña, España" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Dermatología, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital Universitario Puerta de Hierro-Majadahonda, Majadahonda, Madrid, España" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Experiencia de elastografía <span class="elsevierStyleItalic">strain</span> en 2 casos de lesiones subcutáneas sospechosas de malignidad" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1175 "Ancho" => 3000 "Tamanyo" => 253722 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Color Doppler skin ultrasound scan showing an oval, hypoechoic lesion in the dermis-hyopdermis associated with slight peripheral hypervascularization. B, Strain elastogram showing the mean percentage of stiffness within the lesion.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The appearance of subcutaneous lesions in patients with a history of malignancy nearly always raises diagnostic uncertainty. We present 2 such cases in which ultrasound elastography showed significant differences between one lesion and the other.</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 55-year-old woman presented with a mildly painful subcutaneous lesion in the periumbilical region that had been present for 10 days. Approximately 4 months earlier, she had been diagnosed with peritoneal carcinomatosis. The neoplastic cells analyzed in the different locations were consistent with adenocarcinoma. Considering the patient's history and the possibility that the mass could be a cutaneous metastasis, we decided to perform an ultrasound examination prior to histologic evaluation. The ultrasound image, captured with a variable-frequency linear probe (8-18<span class="elsevierStyleHsp" style=""></span>MHz), showed a hypoechoic, structurally asymmetric lesion with a well-defined border in the dermis and hypodermis. Doppler color imaging showed slight peripheral hypervascularization. Because these findings were consistent with a possible diagnosis of cutaneous metastasis, we decided to perform strain elastography. The results of the elastogram showed a mean intralesional stiffness of 44.9% (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). The corresponding strain ratio was 0.79 and the elasticity score was 2 (of a total of 5). Histopathologic examination ruled out the tentative diagnosis of cutaneous metastasis and showed features consistent with an abscessed retention cyst. The patient was prescribed oral antibiotics, which led to full resolution of the lesion.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">A 45-year-old woman presented with a nodular lesion on the neck measuring approximately 1<span class="elsevierStyleHsp" style=""></span>cm at its widest diameter. Four years earlier, she had undergone surgery to excise a stage T4b superficial spreading melanoma on her right cheek. The staging study showed no evidence of local recurrence or distant spread. Cutaneous ultrasound with an 18-MHz linear probe showed an irregular, hypoechoic structure in the hypodermis. Color Doppler imaging revealed intense intralesional hypervascularization. Although this is a nonspecific finding, it is suggestive of malignancy. According to the strain elastogram, there was a mean stiffness of 84.6% (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The strain ratio was 2.21 and the elasticity score was 3. Unlike in the previous case (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>A), excision of the lesion and subsequent histopathologic examination with hematoxylin-eosin and immunohistochemical staining confirmed the diagnosis of metastatic melanoma (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>B).</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The introduction of ultrasound imaging for dermatologic applications has led to considerable improvements in the diagnosis, treatment, and monitoring of inflammatory and neoplastic diseases in recent years. Ultrasound is a very important tool for the investigation of melanoma as it can assess tumor thickness and vascularization and rule out subcutaneous and lymph node metastases.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">1</span></a> Cutaneous ultrasound can provide key diagnostic information in such cases and also in cases where there is a strong suspicion of melanoma metastasis.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">2</span></a> Irregular hypoechoic nodules with more intense acoustic shadowing in the subcutaneous tissue are highly suggestive of malignancy. These nodules typically have an oval, lobulated, or on occasions, potato-shaped appearance. The above findings, however, are nonspecific and can give rise to false negatives.<a class="elsevierStyleCrossRefs" href="#bib0065"><span class="elsevierStyleSup">3,4</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Elastography can help when ultrasound does not provide the full diagnostic picture. It has been used to assess liver, breast, and thyroid tissue, but its use in dermatology is relatively new.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> When tissue is subject to pressure applied either mechanically or through an ultrasound beam, it deforms before generally returning to its original shape. Resistance to deformation is a reflection of the hardness or stiffness of a tissue.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> Elastography systems can be classified as strain imaging (based on tissue deformation calculations) or shear wave imaging (based on the characterization of shear wave speed). The 2 main measures used in elastography are stiffness of the target lesion in relation to that of the adjacent parenchyma (strain ratio) and percentage of tissue hardness or stiffness within a lesion.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">7–9</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">On analyzing the use of elastography for the diagnosis of primary tumors and lymph node metastases in patients with malignant melanoma, Hinz et al.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> found that elastography combined with ultrasound had greater sensitivity for the detection of lymph node metastases than ultrasound alone. For the elastography study, they correlated findings with patterns of different degrees of elasticity.</p><p id="par0035" class="elsevierStylePara elsevierViewall">In our series, elastography showed evident differences between the 2 lesions (for both strain ratio and percentage of intralesional stiffness), and in addition, the technique was more sensitive than B-mode and Doppler color ultrasound, supporting the findings of Hinz et al.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a> Based on the Tsukaba Elasticity Score system, the first lesion, with an elasticity score of 2, had a greater likelihood of being benign than the second lesion (score of 3)</p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion, we have provided comparative data from an elastography study of 2 cutaneous lesions in patients with a high risk of malignancy. The differences observed suggest that elastography could provide key diagnostic information when clinical examination and skin ultrasound findings are inconclusive. With the current technology, however, histopathologic confirmation is still required. More studies are needed to determine whether elastography could become a key diagnostic tool for dermatologists.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Conflicts of Interest" ] 1 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Vilas-Sueiro A, Alfageme-Roldán F, Nájera P, Roustán G. Experiencia de elastografía <span class="elsevierStyleItalic">strain</span> en 2 casos de lesiones subcutáneas sospechosas de malignidad. Actas Dermosifiliogr. 2018;109:274–276.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1175 "Ancho" => 3000 "Tamanyo" => 253722 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">A, Color Doppler skin ultrasound scan showing an oval, hypoechoic lesion in the dermis-hyopdermis associated with slight peripheral hypervascularization. B, Strain elastogram showing the mean percentage of stiffness within the lesion.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1111 "Ancho" => 3000 "Tamanyo" => 272692 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A, Color Doppler ultrasound scan showing a hypoechoic lesion in the hypodermis with intralesional hypervascularization. B, Strain elastogram showing a considerable percentage of mean stiffness.</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1125 "Ancho" => 1500 "Tamanyo" => 564631 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">A, Histopathologic image showing abundant macrophages, polymorphonuclear leukocytes, and traces of keratin consistent with a retention cyst (hematoxylin-eosin, original magnification ×40). 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 9 | 4 | 13 |
| 2024 October | 91 | 37 | 128 |
| 2024 September | 72 | 18 | 90 |
| 2024 August | 123 | 44 | 167 |
| 2024 July | 79 | 27 | 106 |
| 2024 June | 77 | 28 | 105 |
| 2024 May | 89 | 33 | 122 |
| 2024 April | 86 | 33 | 119 |
| 2024 March | 84 | 28 | 112 |
| 2024 February | 55 | 28 | 83 |
| 2024 January | 48 | 28 | 76 |
| 2023 December | 83 | 34 | 117 |
| 2023 November | 71 | 37 | 108 |
| 2023 October | 58 | 17 | 75 |
| 2023 September | 69 | 32 | 101 |
| 2023 August | 51 | 10 | 61 |
| 2023 July | 67 | 32 | 99 |
| 2023 June | 65 | 19 | 84 |
| 2023 May | 68 | 20 | 88 |
| 2023 April | 36 | 28 | 64 |
| 2023 March | 78 | 34 | 112 |
| 2023 February | 275 | 33 | 308 |
| 2023 January | 41 | 34 | 75 |
| 2022 December | 68 | 42 | 110 |
| 2022 November | 24 | 32 | 56 |
| 2022 October | 36 | 18 | 54 |
| 2022 September | 22 | 44 | 66 |
| 2022 August | 35 | 39 | 74 |
| 2022 July | 20 | 37 | 57 |
| 2022 June | 29 | 20 | 49 |
| 2022 May | 50 | 46 | 96 |
| 2022 April | 69 | 45 | 114 |
| 2022 March | 77 | 78 | 155 |
| 2022 February | 59 | 44 | 103 |
| 2022 January | 62 | 44 | 106 |
| 2021 December | 53 | 55 | 108 |
| 2021 November | 44 | 54 | 98 |
| 2021 October | 51 | 66 | 117 |
| 2021 September | 29 | 40 | 69 |
| 2021 August | 30 | 37 | 67 |
| 2021 July | 32 | 41 | 73 |
| 2021 June | 25 | 39 | 64 |
| 2021 May | 46 | 61 | 107 |
| 2021 April | 98 | 78 | 176 |
| 2021 March | 66 | 36 | 102 |
| 2021 February | 54 | 44 | 98 |
| 2021 January | 41 | 45 | 86 |
| 2020 December | 58 | 48 | 106 |
| 2020 November | 37 | 39 | 76 |
| 2020 October | 27 | 22 | 49 |
| 2020 September | 48 | 21 | 69 |
| 2020 August | 24 | 30 | 54 |
| 2020 July | 30 | 24 | 54 |
| 2020 June | 32 | 36 | 68 |
| 2020 May | 16 | 17 | 33 |
| 2020 April | 26 | 22 | 48 |
| 2020 March | 21 | 17 | 38 |
| 2020 February | 6 | 1 | 7 |
| 2020 January | 4 | 0 | 4 |
| 2019 December | 18 | 2 | 20 |
| 2019 November | 2 | 0 | 2 |
| 2019 September | 4 | 0 | 4 |
| 2019 August | 4 | 0 | 4 |
| 2019 July | 10 | 0 | 10 |
| 2019 June | 4 | 0 | 4 |
| 2019 May | 7 | 0 | 7 |
| 2019 April | 4 | 0 | 4 |
| 2019 February | 4 | 0 | 4 |
| 2018 November | 4 | 0 | 4 |
| 2018 October | 2 | 0 | 2 |
| 2018 September | 4 | 0 | 4 |
| 2018 April | 1 | 0 | 1 |
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