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3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Amelanotic subungual melanoma generally manifests as a persistent vascular or ulcerated nodule&#46; The differential diagnosis is broad and includes glomus tumor&#44; squamous cell carcinoma&#44; and&#44; most importantly&#44; telangiectatic granuloma&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;7&#44;8</span></a> Some of the most main US characteristics that can help to distinguish between these conditions are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Clinically&#44; subungual melanomas have a dull erythematous surface&#44; while the majority of vascular tumors have a bright red surface&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> They also tend to bleed less and grow slowly&#44; over the course of months or years&#44; unlike telangiectatic melanoma&#44; which typically grows in a matter of weeks&#46; There may be a history of trauma in up to 25&#37; of cases of subungual melanoma&#46; The case of amelanotic subungual melanoma described in this report was difficult to diagnose by US&#44; as it lacked well-defined borders and erosion of the bone margin of the distal phalanx&#44; 2 common features of this tumor&#46; In addition&#44; the ability of US to detect pigment is currently limited&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A strong correlation has been reported between tumor thickness measured by color Doppler US and Breslow depth &#40;histology&#41; in cutaneous melanoma&#44; and US is therefore a useful additional tool for investigating suspected cases of subungual melanoma&#46; Although color Doppler US is used to study a wide variety of nail lesions&#44; it has only been used in isolated cases of amelanotic subungual melanoma and none of the studies have used plain US&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Early studies reported 5-year survival rates of close to 16&#37; for subungual melanoma&#44; and even lower rates were described for patients who had undergone distal amputation at the metacarpophalangeal or metatarsophalangeal levels&#46; Proximal amputation is thus the current treatment of choice&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Mohs micrographic surgery has also been proposed as a potentially interesting treatment for subungual melanoma&#46; The drawback&#44; however&#44; is that it has been used in small series and more cases are needed to determine its effectiveness&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; amelanotic subungual melanoma is difficult to diagnose both clinically and sonographically&#46; It is therefore essential to rule out other malignant or benign tumors and to perform an early biopsy&#46; Amelanotic subungual melanoma can mimic subungual telangiectatic granulomas on US&#44; particularly in the absence of erosion of the phalanx or nail plate&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Silva-Feistner M&#44; Ortiz E&#44; Alvarez-V&#233;liz S&#44; Wortsman X&#46; Melanoma amelan&#243;tico subungueal simulando granuloma telangiect&#225;sico&#46; Correlaci&#243;n cl&#237;nica&#44; histol&#243;gico y radiol&#243;gica&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;785&#8211;787&#46;</p>"
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          "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Color Doppler ultrasound &#40;18<span class="elsevierStyleHsp" style=""></span>Hz&#41; of the nail unit&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Lesion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Echogenicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Borders&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Nail Plate Erosion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bone Remodeling<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bone Erosion<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hypervascularization&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ungual melanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poorly defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Telangiectatic granuloma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poorly defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rare&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glomus tumor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Well defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rare&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rare&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Squamous cell carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic or heterogeneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poorly defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "identificador" => "tblfn0005"
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Bone remodeling involves change to the relief or convexity of the distal phalanx without interruption of the cortex&#46; Bone erosion involves interruption of the cortex of the distal phalanx&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Ultrasound Features of the Main Entities in the Differential Diagnosis&#46;</p>"
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      "titulo" => "References"
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                          "etal" => false
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Case and Research Letter
Amelanotic Subungual Melanoma Mimicking Telangiectatic Granuloma: Clinical, Histologic, and Radiologic Correlations
Melanoma amelanótico subungueal simulando granuloma telangiectásico. Correlación clínica, histológico y radiológica
M. Silva-Feistnera,
Corresponding author
marcos.silva.feistner@gmail.com

Corresponding author.
, E. Ortiza, S. Alvarez-Véliza, X. Wortsmanb
a Departamento de Dermatología, Pontificia Universidad Católica de Chile, Santiago, Chile
b IDIEP-Instituto de Investigación y Diagnóstico por Imágenes en Piel y Tejidos Blandos, Departamento Dermatología, Universidad de Chile, Santiago, Chile
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        "titulo" => "Melanoma amelan&#243;tico subungueal simulando granuloma telangiect&#225;sico&#46; Correlaci&#243;n cl&#237;nica&#44; histol&#243;gico y radiol&#243;gica"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histology&#46; Ulcerated amelanotic melanoma&#59; Breslow depth&#44; 3<span class="elsevierStyleHsp" style=""></span>mm&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Subungual melanoma is uncommon and accounts for just 2&#37; to 3&#37; of all cutaneous melanomas&#46; Less than 10&#37; of subungual melanomas are amelanotic and 90&#37; of these occur on the thumb or great toe&#46; They typically appear in the seventh decade of life and are associated with a delayed diagnosis and a poor prognosis&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">1&#8211;4</span></a> Amelanotic subungual melanoma generally manifests as a persistent vascular or ulcerated nodule&#46; On ultrasound &#40;US&#41;&#44; subungual melanoma appears as a moderately well-defined hypoechoic area with increased thickness and decreased echogenicity of the nail bed&#44; which frequently erodes into the bone margin of the distal phalanx&#44; viewed as a hyperechoic structure pushing up and eroding into the bilaminar hyperechoic structure of the nail plate&#46; Color Doppler US shows marked hypervascularization&#46; Telangiectatic granuloma is the main entity to be considered in the differential diagnosis&#46; This benign acquired vascular tumor is relatively common&#44; and frequently affects the nail&#44; the nail bed&#44; and the periungual tissues&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">6</span></a> On US&#44; subungual telangiectatic granuloma appears as a focal hypoechoic area with thickening and decreased echogenicity of the nail bed&#44; which pushes up the nail plate but does not erode into the bone margin of the distal phalanx&#59; hypervascularization is also observed&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a> Subungual melanoma requires a high index of clinical suspicion given its similarity to other conditions&#46; We report on such a case evaluated at our department&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">A 67-year-old man presented with a fast-growing asymptomatic lesion of 1 month&#39;s duration on the nail of his left great toe&#46; He reported bleeding following minor trauma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Physical examination revealed a friable subungual erythematous nodule with a vascular appearance associated with disruption of the nail plate&#46; Color Doppler US showed increased thickness and a diffuse decrease in echogenicity of the nail bed&#46; Diffuse hypervascularization of the nail bed was also observed&#46; These findings were consistent with subungual inflammation associated with granulomatous changes predominantly affecting the central zone&#44; suggesting a preliminary diagnosis of telangiectatic granuloma &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The lesion was surgically excised with wide margins&#44; and the histologic evaluation showed nodular&#44; ulcerated malignant melanoma of the nail bed&#44; with a Clark level III&#44; a Breslow depth of 3<span class="elsevierStyleHsp" style=""></span>mm&#44; and a mitotic rate of 10 mitoses&#47;mm<span class="elsevierStyleSup">2</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">Amelanotic subungual melanoma generally manifests as a persistent vascular or ulcerated nodule&#46; The differential diagnosis is broad and includes glomus tumor&#44; squamous cell carcinoma&#44; and&#44; most importantly&#44; telangiectatic granuloma&#46;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">4&#44;7&#44;8</span></a> Some of the most main US characteristics that can help to distinguish between these conditions are summarized in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Clinically&#44; subungual melanomas have a dull erythematous surface&#44; while the majority of vascular tumors have a bright red surface&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">9</span></a> They also tend to bleed less and grow slowly&#44; over the course of months or years&#44; unlike telangiectatic melanoma&#44; which typically grows in a matter of weeks&#46; There may be a history of trauma in up to 25&#37; of cases of subungual melanoma&#46; The case of amelanotic subungual melanoma described in this report was difficult to diagnose by US&#44; as it lacked well-defined borders and erosion of the bone margin of the distal phalanx&#44; 2 common features of this tumor&#46; In addition&#44; the ability of US to detect pigment is currently limited&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A strong correlation has been reported between tumor thickness measured by color Doppler US and Breslow depth &#40;histology&#41; in cutaneous melanoma&#44; and US is therefore a useful additional tool for investigating suspected cases of subungual melanoma&#46; Although color Doppler US is used to study a wide variety of nail lesions&#44; it has only been used in isolated cases of amelanotic subungual melanoma and none of the studies have used plain US&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">5</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Early studies reported 5-year survival rates of close to 16&#37; for subungual melanoma&#44; and even lower rates were described for patients who had undergone distal amputation at the metacarpophalangeal or metatarsophalangeal levels&#46; Proximal amputation is thus the current treatment of choice&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Mohs micrographic surgery has also been proposed as a potentially interesting treatment for subungual melanoma&#46; The drawback&#44; however&#44; is that it has been used in small series and more cases are needed to determine its effectiveness&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">10</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; amelanotic subungual melanoma is difficult to diagnose both clinically and sonographically&#46; It is therefore essential to rule out other malignant or benign tumors and to perform an early biopsy&#46; Amelanotic subungual melanoma can mimic subungual telangiectatic granulomas on US&#44; particularly in the absence of erosion of the phalanx or nail plate&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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          "titulo" => "References"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0015">Please cite this article as&#58; Silva-Feistner M&#44; Ortiz E&#44; Alvarez-V&#233;liz S&#44; Wortsman X&#46; Melanoma amelan&#243;tico subungueal simulando granuloma telangiect&#225;sico&#46; Correlaci&#243;n cl&#237;nica&#44; histol&#243;gico y radiol&#243;gica&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;785&#8211;787&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Erythematous subungual nodule&#46;</p>"
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          "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Histology&#46; Ulcerated amelanotic melanoma&#59; Breslow depth&#44; 3<span class="elsevierStyleHsp" style=""></span>mm&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Lesion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Echogenicity&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Borders&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Nail Plate Erosion&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bone Remodeling<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Bone Erosion<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hypervascularization&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ungual melanoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poorly defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Telangiectatic granuloma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poorly defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rare&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Glomus tumor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Well defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rare&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Rare&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Squamous cell carcinoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Hypoechoic or heterogeneous&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Poorly defined&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0010"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43;<span class="elsevierStyleHsp" style=""></span>&#43;<a class="elsevierStyleCrossRef" href="#tblfn0005"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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              "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Bone remodeling involves change to the relief or convexity of the distal phalanx without interruption of the cortex&#46; Bone erosion involves interruption of the cortex of the distal phalanx&#46;</p>"
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          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Ultrasound Features of the Main Entities in the Differential Diagnosis&#46;</p>"
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      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0015"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0055"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Amelanotic subungual melanoma&#58; A case report"
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                        0 => array:2 [
                          "etal" => false
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                            0 => "C&#46;P&#46; Gosselink"
                            1 => "J&#46;L&#46; Sindone"
                            2 => "B&#46;J&#46; Meadows"
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                          ]
                        ]
                      ]
                    ]
                  ]
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                    0 => array:2 [
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                          "etal" => false
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ISSN: 15782190
Original language: English
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