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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The incidence of herpes zoster &#40;HZ&#41; is 42 cases per 100 000 people per year&#46; Infection in children is very rare&#46; The varicella vaccine offers 90&#37; protection against chickenpox and nearly 100&#37; protection against severe cases&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Immunization against varicella was initially expected to cause a decrease in the incidence of HZ&#46; However&#44; the vaccine virus can cause a latent infection that later manifests as HZ&#46; Recent studies have also demonstrated that the risk of HZ in children who have had natural varicella infection is significantly higher than in vaccinated children with no history of chickenpox&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;3</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 6-year-old boy came to our hospital for assessment of pruritic lesions and pain predominantly in the lower left limb&#46; The patient had received a single dose of the varicella-zoster virus &#40;VZV&#41; vaccine at the age of 15 months&#46; Physical examination revealed vesicles grouped on an erythematous base&#46; The lesions followed a metameric distribution on the medial aspect of the left thigh &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Other scattered lesions were observed on the contralateral lower limb and the lumbar region &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Complete blood count and biochemistry profile were normal except for mild lymphopenia &#40;1&#46;91<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;&#956;L &#91;normal values&#58; 2&#46;70-12&#46;60&#93;&#41;&#46; VZV serology was positive for immunoglobulin G anti-VZV antibody and polymerase chain reaction of a smear from one of the vesicles was positive&#46; After treatment with oral aciclovir at a dose of 250<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span> every 8<span class="elsevierStyleHsp" style=""></span>hours and follow-up after 4 days&#44; clear improvement was observed in the lesions and the pain&#44; with the alteration having disappeared in the course of treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Since 1998&#44; there have been several reports of HZ in children after vaccination&#46; Molecular biology techniques have been used to differentiate between wild-type VZV and the vaccine strain of the virus &#40;Oka&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The estimated incidence of HZ in vaccinated children varies widely between studies&#44; between 262&#46;1 cases per 100 000 person-years by natural infection and 93&#46;3 cases per 100 000 person-years after vaccination&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;4</span></a> This incidence may be underestimated due to underdiagnosis associated with unfamiliarity with HZ or with the low incidence of the entity in children and the atypical nature of postvaccination cases&#46; Cases of HZ caused by the vaccine strain of the virus exhibit clinical differences with respect to cases caused by wild-type VZV&#59; this could lead to a lower consultation rate in the first group&#46; Among other differences&#44; postvaccination HZ lesions tend to be smaller and less painful&#44; with fewer vesicles&#44; and the lesions predominantly appear on the lumbosacral dermatomes&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> In our case&#44; however&#44; the form of presentation was considerably different and atypical&#44; as the patient was a child with disseminated lesions and intense pain in the affected metamere&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Given the greater susceptibility of children with leukemia to developing HZ&#44; studies have been carried out in this population to assess the incidence of this complication&#46; However&#44; it is important to note that routine VZV vaccination is not recommended in immunocompromised patients because the vaccine contains a live attenuated virus&#46; In children with leukemia&#44; the incidence of HZ was 3 times higher in those who had had natural varicella infection than in those who had received the vaccine&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Age at vaccination could be an important factor influencing the appearance of postvaccination HZ because immunogenicity is lower at younger ages&#46; Reactivation of the Oka virus is more frequent in vaccinated children with low anti-VZV titers&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> These data are consistent with evidence that suggests that varicella infection in the first year of life increases considerably the risk of HZ during childhood&#46; This might be due to the fact that immunity levels are lower in children who contract varicella at a younger age&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> The time to manifestation of HZ after contact with the virus is also related to the age at which contact occurs&#46; The mean duration in children between exposure to varicella and development of HZ has been estimated at 4&#46;12 years&#44; and significantly shorter in children diagnosed with varicella before age 2 years&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">One factor that appears to increase the risk of HZ after vaccination against varicella is the appearance of exanthema after administration of the vaccine&#46; The relative risk of HZ in vaccinated children has been found to be 5&#46;75 times greater in children who develop a vaccine-associated skin rash&#46; According to one hypothesis&#44; the skin lesions could allow the virus to enter the cutaneous nerves and establish a latent infection&#46; The lower incidence of HZ after vaccination could be due to the fact that the attenuated varicella vaccine is less able to access the sensory nerves&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; we present a case of disseminated HZ in a boy with a history of incomplete vaccination against VZV&#46; Although this complication is described in the literature&#44; no increase in incidence after vaccination has been observed&#46; Incomplete vaccination probably led to a waning of immunity that favored the development of HZ&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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Case and Research Letters
Disseminated Herpes Zoster After Varicella Vaccination in a Healthy Boy
Herpes zóster diseminado posvacunal en un niño sano
J.M. Rueda
Corresponding author
joserc88@gmail.com

Corresponding author.
, M. Feito-Rodríguez, D. Nieto, R. de Lucas-Laguna
Servicio de Dermatología, Hospital Universitario La Paz, Madrid, Spain
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    "titulo" => "Disseminated Herpes Zoster After Varicella Vaccination in a Healthy Boy"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The incidence of herpes zoster &#40;HZ&#41; is 42 cases per 100 000 people per year&#46; Infection in children is very rare&#46; The varicella vaccine offers 90&#37; protection against chickenpox and nearly 100&#37; protection against severe cases&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">1</span></a> Immunization against varicella was initially expected to cause a decrease in the incidence of HZ&#46; However&#44; the vaccine virus can cause a latent infection that later manifests as HZ&#46; Recent studies have also demonstrated that the risk of HZ in children who have had natural varicella infection is significantly higher than in vaccinated children with no history of chickenpox&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;3</span></a></p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Case Description</span><p id="par0010" class="elsevierStylePara elsevierViewall">A 6-year-old boy came to our hospital for assessment of pruritic lesions and pain predominantly in the lower left limb&#46; The patient had received a single dose of the varicella-zoster virus &#40;VZV&#41; vaccine at the age of 15 months&#46; Physical examination revealed vesicles grouped on an erythematous base&#46; The lesions followed a metameric distribution on the medial aspect of the left thigh &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Other scattered lesions were observed on the contralateral lower limb and the lumbar region &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; Complete blood count and biochemistry profile were normal except for mild lymphopenia &#40;1&#46;91<span class="elsevierStyleHsp" style=""></span>&#215;<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">3</span>&#47;&#956;L &#91;normal values&#58; 2&#46;70-12&#46;60&#93;&#41;&#46; VZV serology was positive for immunoglobulin G anti-VZV antibody and polymerase chain reaction of a smear from one of the vesicles was positive&#46; After treatment with oral aciclovir at a dose of 250<span class="elsevierStyleHsp" style=""></span>mg&#47;m<span class="elsevierStyleSup">2</span> every 8<span class="elsevierStyleHsp" style=""></span>hours and follow-up after 4 days&#44; clear improvement was observed in the lesions and the pain&#44; with the alteration having disappeared in the course of treatment&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Discussion</span><p id="par0015" class="elsevierStylePara elsevierViewall">Since 1998&#44; there have been several reports of HZ in children after vaccination&#46; Molecular biology techniques have been used to differentiate between wild-type VZV and the vaccine strain of the virus &#40;Oka&#41;&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The estimated incidence of HZ in vaccinated children varies widely between studies&#44; between 262&#46;1 cases per 100 000 person-years by natural infection and 93&#46;3 cases per 100 000 person-years after vaccination&#46;<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">2&#44;4</span></a> This incidence may be underestimated due to underdiagnosis associated with unfamiliarity with HZ or with the low incidence of the entity in children and the atypical nature of postvaccination cases&#46; Cases of HZ caused by the vaccine strain of the virus exhibit clinical differences with respect to cases caused by wild-type VZV&#59; this could lead to a lower consultation rate in the first group&#46; Among other differences&#44; postvaccination HZ lesions tend to be smaller and less painful&#44; with fewer vesicles&#44; and the lesions predominantly appear on the lumbosacral dermatomes&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">5</span></a> In our case&#44; however&#44; the form of presentation was considerably different and atypical&#44; as the patient was a child with disseminated lesions and intense pain in the affected metamere&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Given the greater susceptibility of children with leukemia to developing HZ&#44; studies have been carried out in this population to assess the incidence of this complication&#46; However&#44; it is important to note that routine VZV vaccination is not recommended in immunocompromised patients because the vaccine contains a live attenuated virus&#46; In children with leukemia&#44; the incidence of HZ was 3 times higher in those who had had natural varicella infection than in those who had received the vaccine&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Age at vaccination could be an important factor influencing the appearance of postvaccination HZ because immunogenicity is lower at younger ages&#46; Reactivation of the Oka virus is more frequent in vaccinated children with low anti-VZV titers&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">7</span></a> These data are consistent with evidence that suggests that varicella infection in the first year of life increases considerably the risk of HZ during childhood&#46; This might be due to the fact that immunity levels are lower in children who contract varicella at a younger age&#46;<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">8</span></a> The time to manifestation of HZ after contact with the virus is also related to the age at which contact occurs&#46; The mean duration in children between exposure to varicella and development of HZ has been estimated at 4&#46;12 years&#44; and significantly shorter in children diagnosed with varicella before age 2 years&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">One factor that appears to increase the risk of HZ after vaccination against varicella is the appearance of exanthema after administration of the vaccine&#46; The relative risk of HZ in vaccinated children has been found to be 5&#46;75 times greater in children who develop a vaccine-associated skin rash&#46; According to one hypothesis&#44; the skin lesions could allow the virus to enter the cutaneous nerves and establish a latent infection&#46; The lower incidence of HZ after vaccination could be due to the fact that the attenuated varicella vaccine is less able to access the sensory nerves&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">9</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">In conclusion&#44; we present a case of disseminated HZ in a boy with a history of incomplete vaccination against VZV&#46; Although this complication is described in the literature&#44; no increase in incidence after vaccination has been observed&#46; Incomplete vaccination probably led to a waning of immunity that favored the development of HZ&#46;</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Conflicts of Interest</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Rueda JM&#44; Feito-Rodr&#237;guez M&#44; Nieto D&#44; de Lucas-Laguna R&#46; Herpes z&#243;ster diseminado posvacunal en un ni&#241;o sano&#46; Actas Dermosifiliogr&#46; 2017&#59;108&#58;587&#8211;588&#46;</p>"
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Article information
ISSN: 15782190
Original language: English
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Idiomas
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