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"apellidos" => "Bonifaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Fich" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Vial-Letelier" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "D." "apellidos" => "Berroeta-Mauriziano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Dermatología, Clínica Alemana de Valdivia, Valdivia, Chile" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Dermatología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Micología, Hospital General de México, Ciudad de México, Mexico" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Afectación cutánea en las micosis profundas: una revisión de la literatura. Parte II. Micosis sistémicas" ] ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0030" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 888 "Ancho" => 1333 "Tamanyo" => 143314 ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The systemic mycoses are infections caused by fungi that enter the body through an internal organ or a deep focus, such as the lungs, the digestive tract, or the paranasal sinuses. Infections can spread through the blood, causing disseminated disease with frequent skin involvement. There are 2 types of systemic mycoses: opportunistic mycoses (systemic candidiasis, aspergillosis, and systemic mucormycosis) and endemic respiratory infections (histoplasmosis, blastomycosis, coccidioidomycosis, paracoccidioidomycosis, and cryptococcosis). In practice, however, it is difficult to distinguish between the 2 types as they tend to affect predisposed patients. Accordingly, they are generally studied together.</p><p id="par0010" class="elsevierStylePara elsevierViewall">In the second part of this review, we discuss the main deep mycoses that produce cutaneous manifestations during the course of disease.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Mucormycosis</span><p id="par0015" class="elsevierStylePara elsevierViewall">Mucormycosis affects the visceral organs in immunosuppressed patients.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> It is caused by mucoraceous Zygomycetes and can lead to rhinocerebral, cutaneous, or pulmonary manifestations, or disseminated disease. The most common presentation is rhinocerebral mucormycosis, which involves the nasal sinuses and causes palatal ulcers and extensive necrotic lesions involving the brain and skin. Most cases are associated with decompensated diabetes mellitus or neutropenic states (leukemia).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Clinical Forms</span><p id="par0020" class="elsevierStylePara elsevierViewall">Mucormycosis typically follows an acute, rapidly progressive course associated with high mortality. Rhinocerebral manifestations are the most common clinical presentation, followed by pulmonary, intestinal, and cutaneous manifestations and dissemination.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Primary cutaneous manifestations are extremely rare and occur mainly at venipuncture sites; they are therefore seen most often on the extremities. Lesions present as papules or nodules that progress to ulcers with a necrotic center and a foul-smelling or purulent exudate. Locally, primary infection can affect the deep tissues (muscle and bone) and is highly destructive.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Secondary cutaneous manifestations are much more common in rhinocerebral mucormycosis, with 25% of patients developing palatal ulcers and extremely painful eyelid sinuses (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Diagnosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Direct mycological examination of necrotic material, sputum, bronchopulmonary lavage fluid, paranasal sinus aspirate, and skin scrapings shows long branching thin-walled cenocytic (nonseptate) hyphae (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Microorganisms grow quickly on Sabouraud dextrose agar (SDA) and can be identified on the basis of reproduction structures or by molecular biology techniques; the most widely used technique is polymerase chain reaction (PCR) analysis of internal transcribed spacer (ITS) regions of ribosomal DNA (rDNA).<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,4</span></a></p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Treatment</span><p id="par0030" class="elsevierStylePara elsevierViewall">Treatment is multifactorial and includes control of predisposing factors (ketoacidosis, neutropenia, etc.), systemic antifungals, and aggressive surgical debridement.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Potassium iodide, ketoconazole, and fluconazole are used for subcutaneous lesions and can be combined with trimethoprim-sulfametoxazole.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The antifungal of choice is amphotericin B and it can be used in association with caspofungin or posaconazole.</p></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Paracoccidioidomycosis</span><p id="par0035" class="elsevierStylePara elsevierViewall">Paracoccidioidomycosis is a chronic, subacute, or, in rare cases, acute mycosis caused by <span class="elsevierStyleItalic">Paracoccidioides brasiliensis</span> and <span class="elsevierStyleItalic">Paracoccidioides lutzii</span>. It affects the skin and visceral organs.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> This potentially fatal systemic granulomatous disease is considered endemic in Mexico, Argentina, Guyana, Brazil, Venezuela, and Colombia.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a><span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">brasiliensis</span> is a dimorphic fungus that grows as mycelia in vegetation and soil in humid regions. It is not known whether human-to-human transmission occurs. The fungus enters the body through the respiratory system. Infections acquired through inhalation can remain latent for 1 or 2 decades and reactivation is dependent on immune status.<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">6–8</span></a></p><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Clinical Forms</span><p id="par0040" class="elsevierStylePara elsevierViewall">Primary infection tends to be asymptomatic and can resolve or leave a residual lesion (scar). Symptomatic disease is a result of the parasite-host relationship in which the virulence of each strain has an important role. Chronic paracoccidioidomycosis, which typically affects adults, is the most common form of disease (>90% of patients develop lung lesions and metastases in diverse organs). There is also an acute juvenile form characterized by pulmonary and reticuloendothelial involvement, with enlarged lymph nodes, hepatosplenomegaly, and bone involvement.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Patients may also develop lesions in the oropharyngeal mucosa, mimicking chronic tonsillitis, periodontal and laryngeal lesions, and perioral ulcero-vegetative lesions. There may also be nodular cutaneous lesions that can become necrotic or result in subcutaneous cold abscesses (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>).<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> There have been reports of extragenital lesions mimicking syphilis sores.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0045" class="elsevierStylePara elsevierViewall">The differential diagnosis should include mucocutaneous leishmaniasis, Wegener granulomatosis, syphilis, lymphoma, sporotrichosis, and scrofuloderma, among other entities.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Diagnosis</span><p id="par0050" class="elsevierStylePara elsevierViewall">A diagnosis can be made by direct visualization of multiple budding of yeast cells forming a structure similar to a ship's wheel (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) in sputum samples, skin scrapings, or pus. The microorganisms grow over a period of 15 to 20 days on SDA with or without antibiotics, producing white filamentous colonies with visible mycelia. PCR analysis of tissue or serum targeting ITS<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> or other regions<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> can also be used for diagnosis. Skin biopsy shows a suppurative cutaneous granulomatous inflammation and pseudoepitheliomatous hyperplasia.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a></p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Treatment</span><p id="par0055" class="elsevierStylePara elsevierViewall">Treatment includes long-term administration of amphotericin<span class="elsevierStyleHsp" style=""></span>B, systemic triazoles, and sulfonamides.</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Coccidioidomycosis</span><p id="par0060" class="elsevierStylePara elsevierViewall">Coccidioidomycosis is caused by 2 dimorphic fungi: <span class="elsevierStyleItalic">Coccidioides immitis</span> and <span class="elsevierStyleItalic">Coccidioides</span> posadasii. The reservoir of the fungi is dry soil with an alkaline pH. Coccidioidomycosis affects both humans and animals and the infection is acquired by inhalation of <span class="elsevierStyleItalic">C</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">immitis</span> arthroconidia from soil in endemic regions (United States, Mexico, Argentina, Paraguay, Colombia, Venezuela, and Brazil). The incubation period is 1 to 4 weeks.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,11,12</span></a></p><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Clinical Forms</span><p id="par0065" class="elsevierStylePara elsevierViewall">Pulmonary involvement is the predominant clinical form of coccidioidomycosis, but the infection can also affect the skin, larynx, bones, joints, and meninges. Skin lesions are diverse and can present as papules, pustules, plaques, abscesses, sinus tracts (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>), ulcers, diffuse macular rash, erythema multiforme, or erythema nodosum.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a></p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">The differential diagnosis should include tuberculosis, paracoccidioidomycosis, sporotrichosis, histoplasmosis, and even neoplasms.</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Diagnosis</span><p id="par0075" class="elsevierStylePara elsevierViewall">Culture and direct mycological examination show double-membrane spherules containing spores (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). The fungi can be cultivated on SDA with or without antibiotics, although the procedure is dangerous due to the high risk of infection. Colonies will show hyaline arthroconidia separated from each other by a disjunctor cell following lysis. Histology is useful as it can detect spherules with endospores (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) Serology with specific immunoglobulin (Ig) M antibodies in acute infections is diagnostic only after 4 weeks. Coccidioidin skin tests and complement levels are also important diagnostic aids.<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11,12</span></a> Finally, coccidioidomycosis can be diagnosed by PCR analysis of the 28S region of rDNA.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Treatment</span><p id="par0080" class="elsevierStylePara elsevierViewall">Treatment consists of deoxycholate or liposomal amphotericin, itraconazole, or fluconazole for 6 to 12 months.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a></p></span></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Histoplasmosis</span><p id="par0085" class="elsevierStylePara elsevierViewall">American histoplasmosis or Darling disease is a systemic mycosis that is caused by the dimorphic fungus <span class="elsevierStyleItalic">Histoplasma capsulatum</span> var. <span class="elsevierStyleItalic">capsulatum</span><a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> and primarily affects the reticuloendothelial system.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">The lung is the most common site of primary infection. The fungus may subsequently spread to various organs, including the skin.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Histoplasmosis is the most common pulmonary fungal infection and it occurs worldwide, with cases reported in over 60 countries. The pathogen is particularly prevalent in regions with tropical climates, such as Central and South America, Eastern United States, and South Mexico. It is found in soil, decomposing organic matter, and in the droppings of bats (typically in caves)<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> and some birds such as chickens, turkeys, pigeons, and geese.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a></p><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Clinical Forms</span><p id="par0095" class="elsevierStylePara elsevierViewall">Ninety-five percent of people infected with histoplasmosis do not show clinical manifestations. In the acute form of disease, symptoms range from flu-like symptoms to more complex manifestations with radiological images showing disseminated calcifications and findings similar to those seen in tuberculosis.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">16</span></a> Acute forms can progress to chronic forms, which preferentially affect men aged over 50 years. Acute disease is characterized by cough and expectoration but it is difficult to isolate <span class="elsevierStyleItalic">H capsulatum</span> in sputum. Mucosal involvement is highly characteristic in chronic disseminated forms, and ulcerative granulomatous lesions are common on the oral mucosa, tongue, nasal septum, and larynx. Finally, meningoencephalitis and focal osteolysis in the metaphysis of long bones may be observed in acute disseminated histoplasmosis, which typically affects patients with AIDS. Around 11% of patients with AIDS develop skin manifestations,<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> which tend to be disseminated and include papular lesions on the face and the trunk (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>) and, sometimes, ulcerative lesions on the mucosa.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Diagnosis</span><p id="par0100" class="elsevierStylePara elsevierViewall">The fungus can be isolated in blood, bone marrow, cerebrospinal fluid, bone marrow aspirate, or biopsy specimens of infected tissues. Specimens can be inoculated on SDA with or without antibiotics. Identification is also possible using molecular biology techniques such as PCR analysis of fungal DNA (ITS or 18S rDNA).<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">17,18</span></a></p><p id="par0105" class="elsevierStylePara elsevierViewall">Direct examination of Giemsa-stained specimens shows characteristic intracellular yeast forms surrounded by a halo simulating a capsule (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p></span><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Treatment</span><p id="par0110" class="elsevierStylePara elsevierViewall">Treatment consists of itraconazole for 6 to 24<span class="elsevierStyleHsp" style=""></span>months or amphotericin<span class="elsevierStyleHsp" style=""></span>B.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a></p></span></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Cryptococcosis</span><p id="par0115" class="elsevierStylePara elsevierViewall">Cryptococcosis is a systemic mycosis caused by an encapsulated yeast of the genus <span class="elsevierStyleItalic">Cryptococcus</span>. The 2 most common species are <span class="elsevierStyleItalic">Cryptococcus neoformans</span> and <span class="elsevierStyleItalic">Cryptococcus gatii</span>. The lungs are the main route of entry for the pathogen. Clinical manifestations range from asymptomatic lung colonization to systemic dissemination. The main clinical manifestation is meningoencephalitis.<a class="elsevierStyleCrossRefs" href="#bib0095"><span class="elsevierStyleSup">19,20</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">C neoformans</span> is typically found in soil and in pigeon and bat droppings. In urban areas, it is disseminated through domestic dust from trees.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Clinical Forms</span><p id="par0125" class="elsevierStylePara elsevierViewall">Inhaled yeasts and spores reach the alveolar spaces. Subsequent development of disease will depend on the phagocytic efficacy of the macrophages and the host's immune response. Clinical forms involve the lungs, the central nervous system (CNS), or the mucocutaneous structures, and may also be disseminated.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> Lung involvement tends to be asymptomatic, nonspecific, or similar to acute tuberculosis. CNS cryptococcosis is the most common clinical form and presents as chronic meningitis, meningoencephalitis, or cerebral cryptococcal granuloma. The mucocutaneous form is the result of the spread of infection from other foci in patients with disseminated disease. It presents as subcutaneous papules and nodules (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>) on the face and neck, primarily in patients with human immunodeficiency virus infection in the advanced AIDS stage.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15,20</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">Diagnosis can be challenging given the wide range of possible lesions. The most common alternative diagnoses contemplated in the literature are molluscum contagiosum and herpes infections.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p><p id="par0135" class="elsevierStylePara elsevierViewall">These multiple polymorphic lesions, which are common in patients with diseases such as AIDS, lymphoma, sarcoidosis, and diabetes and in transplant recipients—and may also be due to multiple microorganisms—require an exhaustive study.</p></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Diagnosis</span><p id="par0140" class="elsevierStylePara elsevierViewall">Cryptococcus yeasts are large encapsulated cells that are best observed under the microscope with India ink (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>) or Mayer mucicarmine stains. The microorganisms grow on SDA within 24 to 48<span class="elsevierStyleHsp" style=""></span>hours or after a week. Serology is fast and specific. Immunological identification is also possible and one particularly effective test (with a sensitivity and specificity of >80%) is the latex agglutination test, which searches for the cryptococcal capsular antigen in serum.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> Detection is also possible using different PCR assays<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> or MALDI-ToF mass spectrometry.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> The advantage of the latter is that positive results are identified almost immediately (10<span class="elsevierStyleHsp" style=""></span>minutes) and correlate 100% with DNA sequencing results.<a class="elsevierStyleCrossRefs" href="#bib0120"><span class="elsevierStyleSup">24–26</span></a></p></span><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Treatment</span><p id="par0145" class="elsevierStylePara elsevierViewall">Treatment is with deoxycholate or liposomal amphotericin B, with or without fluorocytosine or fluconazole.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a></p></span></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Conclusions</span><p id="par0150" class="elsevierStylePara elsevierViewall">We have reviewed the cutaneous manifestations of the systemic mycoses (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). Recognition of these manifestations is important, as these infections are associated with high mortality. Dermatologists can play an important role in ensuring an accurate diagnosis by recognizing the clinical signs or ordering an appropriate test, such as a skin biopsy.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Conflicts of Interest</span><p id="par0155" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:14 [ 0 => array:3 [ "identificador" => "xres762916" "titulo" => "Graphical abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:3 [ "identificador" => "xres762917" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec764391" "titulo" => "Keywords" ] 3 => array:3 [ "identificador" => "xres762918" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0015" ] ] ] 4 => array:2 [ "identificador" => "xpalclavsec764392" "titulo" => "Palabras clave" ] 5 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 6 => array:3 [ "identificador" => "sec0010" "titulo" => "Mucormycosis" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Treatment" ] ] ] 7 => array:3 [ "identificador" => "sec0030" "titulo" => "Paracoccidioidomycosis" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0045" "titulo" => "Treatment" ] ] ] 8 => array:3 [ "identificador" => "sec0050" "titulo" => "Coccidioidomycosis" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0055" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0060" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0065" "titulo" => "Treatment" ] ] ] 9 => array:3 [ "identificador" => "sec0070" "titulo" => "Histoplasmosis" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0075" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0080" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0085" "titulo" => "Treatment" ] ] ] 10 => array:3 [ "identificador" => "sec0090" "titulo" => "Cryptococcosis" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0095" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0100" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0105" "titulo" => "Treatment" ] ] ] 11 => array:2 [ "identificador" => "sec0110" "titulo" => "Conclusions" ] 12 => array:2 [ "identificador" => "sec0115" "titulo" => "Conflicts of Interest" ] 13 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-01-07" "fechaAceptado" => "2016-05-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec764391" "palabras" => array:5 [ 0 => "Paracoccidioidomycosis" 1 => "Coccidioidomycosis" 2 => "Histoplasmosis" 3 => "Mucormycosis" 4 => "Cryptococcosis" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec764392" "palabras" => array:5 [ 0 => "Paracoccidioidomicosis" 1 => "Coccidioidomicosis" 2 => "Histoplasmosis" 3 => "Mucormicosis" 4 => "Criptococosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">In the second part of this review on the deep mycoses, we describe the main systemic mycoses—paracoccidioidomycosis, coccidioidomycosis, histoplasmosis, mucormycosis, and cryptococcosis—and their cutaneous manifestations. Skin lesions are only occasionally seen in deep systemic mycoses either directly, when the skin is the route of entry for the fungus, or indirectly, when the infection has spread from a deeper focus. These cutaneous signs are often the only clue to the presence of a potentially fatal infection. As with the subcutaneous mycoses, early diagnosis and treatment is important, but in this case, even more so.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">En la segunda parte de este artículo se revisan las principales micosis sistémicas y sus manifestaciones cutáneas: paracoccidioidomicosis, coccidioidomicosis, histoplasmosis, mucormicosis y criptococosis. Las micosis sistémicas presentan lesiones en la piel solo en algunas ocasiones, ya sea por afectación directa de ella como puerta de entrada o tras la diseminación de la infección a partir de un foco profundo. Muchas veces estos signos cutáneos serán la única pista para el diagnóstico certero de patologías potencialmente fatales. Por lo mismo, y con mucho mayor énfasis que las micosis tratadas en la primera parte, es importante saber reconocer y tratar las micosis sistémicas.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Carrasco-Zuber JE, Navarrete-Dechent C, Bonifaz A, Fich F, Vial-Letelier V, Berroeta-Mauriziano D. Afectación cutánea en las micosis profundas: una revisión de la literatura. Parte II. Micosis sistémicas. 2016;107:816–822.</p>" ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 928 "Ancho" => 1600 "Tamanyo" => 263178 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Rhinocerebral-cutaneous mucormycosis in a patient with decompensated diabetes. Cenocytic hyphae in biopsy sample (Grocott, original magnification ×40) and direct examination of <span class="elsevierStyleItalic">Rhizopus arrhizus</span> (lactophenol cotton blue, original magnification ×10). gr1.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 907 "Ancho" => 1500 "Tamanyo" => 256821 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Paracoccidioidomycosis. Multiple budding of <span class="elsevierStyleItalic">Paracoccidioides brasiliensis</span> cells in biopsy sample (Grocott, original magnification ×40).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 990 "Ancho" => 1500 "Tamanyo" => 225798 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Disseminated coccidioidomycosis sinus. Spherules in biopsy sample (Periodic acid-Schiff, original magnification ×10) and <span class="elsevierStyleItalic">Coccidioides immitis</span> arthroconidia (lactophenol cotton blue, original magnification ×40).</p>" ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 988 "Ancho" => 1500 "Tamanyo" => 196486 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Papular lesions in a patient with disseminated cutaneous histoplasmosis and AIDS. Intracellular yeast forms in biopsy sample (hematoxylin-eosin, original magnification ×100) and direct examination of needle-shaped <span class="elsevierStyleItalic">Histoplasma capsulatum</span> conidia (lactophenol cotton blue, original magnification ×40).</p>" ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 997 "Ancho" => 1500 "Tamanyo" => 276087 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Cutaneous ulcer associated with a neural infection in a patient with cryptococcosis and AIDS. Encapsulated <span class="elsevierStyleItalic">Cryptococcus neoformans</span> yeasts (India ink, original magnification ×40) and yeast forms in biopsy sample (periodic acid-Schiff, original magnification ×40).</p>" ] ] 5 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Abbreviations: IgM, immunoglobulin M; PCR, polymerase chain reaction.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mycosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Causative Agent \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Paracoccidioidomycosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Paracoccidioides brasiliensis</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Direct mycological examination and culture; histology; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Long-term systemic antifungals \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Coccidioidomycosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Coccidioides immitis</span>/<span class="elsevierStyleItalic">Coccidioides posadasii</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Direct mycological examination and culture; histology; specific IgM antibodies; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Long-term systemic antifungals \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Histoplasmosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Histoplasma capsulatum</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Histology; detection of fungus in blood, bone marrow, and cerebrospinal fluid; culture; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Systemic antifungals for 6-24 mo \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cryptococcosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top"><span class="elsevierStyleItalic">Cryptococcus neoformans</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Direct microscopic examination with India ink stains; culture; serology; PCR; mass spectrometry (rapid and specific) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Amphotericin B with fluorocytosine; fluconazole (both for long periods depending on response to treatment) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1260344.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Summary of the Characteristics of the Systemic Mycoses.</p>" ] ] 6 => array:5 [ "identificador" => "fig0030" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 888 "Ancho" => 1333 "Tamanyo" => 143314 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous zygomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. 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Year/Month | Html | Total | |
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2024 November | 29 | 11 | 40 |
2024 October | 215 | 62 | 277 |
2024 September | 210 | 36 | 246 |
2024 August | 274 | 72 | 346 |
2024 July | 243 | 37 | 280 |
2024 June | 243 | 58 | 301 |
2024 May | 212 | 60 | 272 |
2024 April | 172 | 47 | 219 |
2024 March | 215 | 50 | 265 |
2024 February | 193 | 58 | 251 |
2024 January | 136 | 43 | 179 |
2023 December | 193 | 90 | 283 |
2023 November | 176 | 49 | 225 |
2023 October | 219 | 54 | 273 |
2023 September | 174 | 38 | 212 |
2023 August | 167 | 23 | 190 |
2023 July | 179 | 46 | 225 |
2023 June | 168 | 45 | 213 |
2023 May | 196 | 33 | 229 |
2023 April | 146 | 41 | 187 |
2023 March | 181 | 45 | 226 |
2023 February | 194 | 38 | 232 |
2023 January | 199 | 44 | 243 |
2022 December | 126 | 68 | 194 |
2022 November | 71 | 51 | 122 |
2022 October | 94 | 33 | 127 |
2022 September | 101 | 55 | 156 |
2022 August | 55 | 45 | 100 |
2022 July | 59 | 51 | 110 |
2022 June | 70 | 30 | 100 |
2022 May | 217 | 44 | 261 |
2022 April | 280 | 52 | 332 |
2022 March | 280 | 54 | 334 |
2022 February | 318 | 56 | 374 |
2022 January | 329 | 61 | 390 |
2021 December | 190 | 59 | 249 |
2021 November | 221 | 77 | 298 |
2021 October | 179 | 74 | 253 |
2021 September | 144 | 46 | 190 |
2021 August | 164 | 49 | 213 |
2021 July | 121 | 33 | 154 |
2021 June | 171 | 45 | 216 |
2021 May | 197 | 68 | 265 |
2021 April | 342 | 79 | 421 |
2021 March | 182 | 48 | 230 |
2021 February | 176 | 41 | 217 |
2021 January | 110 | 36 | 146 |
2020 December | 112 | 28 | 140 |
2020 November | 102 | 32 | 134 |
2020 October | 75 | 32 | 107 |
2020 September | 82 | 33 | 115 |
2020 August | 73 | 22 | 95 |
2020 July | 86 | 33 | 119 |
2020 June | 77 | 48 | 125 |
2020 May | 62 | 22 | 84 |
2020 April | 52 | 23 | 75 |
2020 March | 55 | 20 | 75 |
2020 February | 4 | 0 | 4 |
2020 January | 4 | 0 | 4 |
2019 December | 7 | 0 | 7 |
2019 November | 4 | 0 | 4 |
2019 September | 4 | 0 | 4 |
2019 August | 4 | 0 | 4 |
2019 July | 4 | 0 | 4 |
2019 June | 4 | 0 | 4 |
2019 May | 6 | 1 | 7 |
2019 April | 2 | 3 | 5 |
2019 March | 4 | 0 | 4 |
2019 February | 7 | 0 | 7 |
2019 January | 8 | 0 | 8 |
2018 December | 9 | 0 | 9 |
2018 November | 10 | 0 | 10 |
2018 October | 14 | 0 | 14 |
2018 September | 5 | 0 | 5 |
2018 March | 0 | 1 | 1 |
2018 February | 55 | 12 | 67 |
2018 January | 91 | 29 | 120 |
2017 December | 75 | 14 | 89 |
2017 November | 61 | 12 | 73 |
2017 October | 65 | 14 | 79 |
2017 September | 49 | 9 | 58 |
2017 August | 51 | 16 | 67 |
2017 July | 45 | 9 | 54 |
2017 June | 61 | 31 | 92 |
2017 May | 49 | 21 | 70 |
2017 April | 42 | 40 | 82 |
2017 March | 50 | 31 | 81 |
2017 February | 32 | 21 | 53 |
2017 January | 36 | 27 | 63 |
2016 December | 76 | 55 | 131 |
2016 November | 21 | 34 | 55 |