Cutaneous Involvement in the Deep Mycoses: A Literature Review. Part I—Subcutaneous Mycoses

array:24 ["pii" => "S1578219016302402" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.05.026" "estado" => "S300" "fechaPublicacion" => "2016-12-01" "aid" => "1456" "copyright" => "Elsevier España, S.L.U. and AEDV" "copyrightAnyo" => "2016" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2016;107:806-15" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1890 "formatos" => array:3 [ "EPUB" => 46 "HTML" => 1398 "PDF" => 446 ] ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S000173101630182X" "issn" => "00017310" "doi" => "10.1016/j.ad.2016.05.017" "estado" => "S300" "fechaPublicacion" => "2016-12-01" "aid" => "1456" "copyright" => "AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2016;107:806-15" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 777 "formatos" => array:3 [ "EPUB" => 4 "HTML" => 585 "PDF" => 188 ] ] "es" => array:14 [ "idiomaDefecto" => true "cabecera" => "Revisión" "titulo" => "Afectación cutánea en las micosis profundas: una revisión de la literatura. Parte 1: micosis subcutáneas" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:3 [ 0 => "es" 1 => "es" 2 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "806" "paginaFinal" => "815" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Cutaneous Involvement in the Deep Mycoses: A Literature Review. Part I—Subcutaneous Mycoses" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0030" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 772 "Ancho" => 1333 "Tamanyo" => 98146 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.E. Carrasco-Zuber, C. Navarrete-Dechent, A. Bonifaz, F. Fich, V. Vial-Letelier, D. Berroeta-Mauriziano" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.E." "apellidos" => "Carrasco-Zuber" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Navarrete-Dechent" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Bonifaz" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Fich" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Vial-Letelier" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Berroeta-Mauriziano" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<elsevierMultimedia ident="fig0030"></elsevierMultimedia>" ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1578219016302402" "doi" => "10.1016/j.adengl.2016.05.026" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302402?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101630182X?idApp=UINPBA000044" "url" => "/00017310/0000010700000010/v1_201611260105/S000173101630182X/v1_201611260105/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1578219016302414" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.05.027" "estado" => "S300" "fechaPublicacion" => "2016-12-01" "aid" => "1457" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "ssu" "cita" => "Actas Dermosifiliogr. 2016;107:816-22" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1382 "formatos" => array:3 [ "EPUB" => 45 "HTML" => 957 "PDF" => 380 ] ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "Review" "titulo" => "Cutaneous involvement in the Deep Mycoses: A Review. Part II—Systemic Mycoses" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:3 [ 0 => "en" 1 => "en" 2 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "816" "paginaFinal" => "822" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Afectación cutánea en las micosis profundas: una revisión de la literatura. Parte II. Micosis sistémicas" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0030" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 888 "Ancho" => 1333 "Tamanyo" => 143314 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J.E. Carrasco-Zuber, C. Navarrete-Dechent, A. Bonifaz, F. Fich, V. Vial-Letelier, D. Berroeta-Mauriziano" "autores" => array:6 [ 0 => array:2 [ "nombre" => "J.E." "apellidos" => "Carrasco-Zuber" ] 1 => array:2 [ "nombre" => "C." "apellidos" => "Navarrete-Dechent" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "Bonifaz" ] 3 => array:2 [ "nombre" => "F." "apellidos" => "Fich" ] 4 => array:2 [ "nombre" => "V." "apellidos" => "Vial-Letelier" ] 5 => array:2 [ "nombre" => "D." "apellidos" => "Berroeta-Mauriziano" ] ] ] ] "resumen" => array:1 [ 0 => array:3 [ "titulo" => "Graphical abstract" "clase" => "graphical" "resumen" => "<elsevierMultimedia ident="fig0030"></elsevierMultimedia>" ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016301831" "doi" => "10.1016/j.ad.2016.06.001" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301831?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302414?idApp=UINPBA000044" "url" => "/15782190/0000010700000010/v1_201611260103/S1578219016302414/v1_201611260103/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1578219016302232" "issn" => "15782190" "doi" => "10.1016/j.adengl.2016.09.001" "estado" => "S300" "fechaPublicacion" => "2016-12-01" "aid" => "1470" "copyright" => "Elsevier España, S.L.U. and AEDV" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Actas Dermosifiliogr. 2016;107:801-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1248 "formatos" => array:3 [ "EPUB" => 53 "HTML" => 859 "PDF" => 336 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "Opinion Article" "titulo" => "The Importance of Innate Immunity in Acne" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "801" "paginaFinal" => "805" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Importancia de la inmunidad innata en el acné" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2057 "Ancho" => 2828 "Tamanyo" => 215788 ] ] "descripcion" => array:1 [ "en" => "Inflammatory pathways involved in the pathogenesis of acne vulgaris. Propionibacterium acnes can interact directly with T lymphocytes and favor the release of inflammatory cytokines such as IL-17. In addition, synthesis of other inflammatory cytokines is favored through the TLR-2 and TLR-4 receptors of the perifollicular inflammatory cells. The NRLP3 inflammasome also plays an important role in the production of IL-1β. The release of all these proinflammatory cytokines into the extracellular medium leads to the inflammatory-cell-mediated rupture of the follicular wall. Pacnes also induces an increase in several matrix metalloproteinases through the transcription factor activator protein 1. These enzymes play an active role in tissue destruction and scarring. Finally, the bacteria are capable of causing the inveterate activation of antimicrobial peptides that perpetuate the inflammatory microenvironment. AMP indicates antimicrobial peptide; AP, activator protein; IL, interleukin; MMPs, matrix metalloproteinases; N, neutrophil; NLR, NOD-like receptor; P acnes, Propionibacterium acnes; TL, T lymphocyte; TLR, toll-like receptor; TNF, tumor necrosis factor." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "O.M. Moreno-Arrones, P. Boixeda" "autores" => array:2 [ 0 => array:2 [ "nombre" => "O.M." "apellidos" => "Moreno-Arrones" ] 1 => array:2 [ "nombre" => "P." "apellidos" => "Boixeda" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0001731016302617" "doi" => "10.1016/j.ad.2016.07.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016302617?idApp=UINPBA000044" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302232?idApp=UINPBA000044" "url" => "/15782190/0000010700000010/v1_201611260103/S1578219016302232/v1_201611260103/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "Review" "titulo" => "Cutaneous Involvement in the Deep Mycoses: A Literature Review. Part I—Subcutaneous Mycoses" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "806" "paginaFinal" => "815" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "J.E. Carrasco-Zuber, C. Navarrete-Dechent, A. Bonifaz, F. Fich, V. Vial-Letelier, D. Berroeta-Mauriziano" "autores" => array:6 [ 0 => array:4 [ "nombre" => "J.E." "apellidos" => "Carrasco-Zuber" "email" => array:1 [ 0 => "juaneduardocarrasco@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "C." "apellidos" => "Navarrete-Dechent" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "A." "apellidos" => "Bonifaz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "c" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "F." "apellidos" => "Fich" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "V." "apellidos" => "Vial-Letelier" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "D." "apellidos" => "Berroeta-Mauriziano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Dermatología, consultorio adosado de especialidades, Hospital Regional de Valdivia, Valdivia, Chile" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Dermatología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Micología, Hospital General de México, Ciudad de México, Mexico" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Afectación cutánea en las micosis profundas: una revisión de la literatura. Parte 1: micosis subcutáneas" ] ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0030" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 772 "Ancho" => 1333 "Tamanyo" => 98146 ] ] ] ] "textoCompleto" => "IntroductionThe deep mycoses are uncommon infections caused by fungi; they are divided into subcutaneous and systemic mycoses.<a class="elsevierStyleCrossRef" href="#bib0345">1</a> While skin manifestations always occur in subcutaneous mycoses, or mycoses of implantation, as they are also known, they are only occasionally seen in systemic mycoses. In such cases, the skin is affected either directly, by the penetration of the fungus into the dermis, or indirectly, by an infection that has spread from a deeper focus. According to Rezusta et al.,<a class="elsevierStyleCrossRef" href="#bib0350">2</a> the majority of subcutaneous and systemic mycoses in Spain are imported, with just a few exceptions (e.g., mucormycosis). Epidemiological data on the prevalence and incidence of mycoses in Spain are lacking.Subcutaneous MycosesThe subcutaneous mycoses comprise several clinical entities caused by invasion of the skin and subcutaneous tissue by saprophytic fungi that live in soil and vegetation. However, even though cuts and wounds are very common in people living in rural areas, overall, there are very few cases of subcutaneous mycoses.<a class="elsevierStyleCrossRef" href="#bib0345">1</a>The typical route of entry for the fungus is traumatic inoculation through contaminated material such as splinters, thorns, or other sharp objects, explaining why subcutaneous mycoses are also referred to as mycoses of implantation.<a class="elsevierStyleCrossRef" href="#bib0355">3</a>Although the fungi responsible for subcutaneous mycoses are taxonomically heterogeneous, they are unified by the fact that they share the same route of entry. Any of these infections can affect people who have traveled to endemic areas, even years after their return.The most common subcutaneous mycoses are sporotrichosis, chromoblastomycosis, and mycetoma.<a class="elsevierStyleCrossRef" href="#bib0345">1</a> Other less common entities are lacaziosis, phaeohyphomycosis, hyalohyphomycosis, and conidiobolomycosis.SporotrichosisSporotrichosis is a subacute or chronic infection caused by dimorphic fungi, the most common of which is Sporothrix schenckii.<a class="elsevierStyleCrossRefs" href="#bib0360">4,5</a> These fungi are universal, although they are more common in tropical and subtropical areas. The estimated incidence of sporotrichosis in South America is between 48 and 60 cases per 100000 population a year.<a class="elsevierStyleCrossRefs" href="#bib0370">6,7</a> Only a few autochthonous cases have been reported in Spain and other parts of Europe,<a class="elsevierStyleCrossRef" href="#bib0380">8</a> and the majority of cases in these areas are imported.<a class="elsevierStyleCrossRef" href="#bib0385">9</a>The causative agents belong to a species complex known as S schenckii,<a class="elsevierStyleCrossRefs" href="#bib0390">10,11</a> which comprises Sporothrix brasiliensis, Sporothrix mexicana, Sporothrix luriei, Sporothrix pallida (previously Sporothrix albicans), and Sporothrix schenckii sensu lato (sl.), which is the most common of the five.<a class="elsevierStyleCrossRef" href="#bib0400">12</a>After an incubation period of 15 to 30 days, traumatic inoculation by Sporothrix spp. results in a chronic infection characterized by nodular lesions in the cutaneous and subcutaneous tissue associated with lymphangitis in the affected area.Sporothrix spp. live in vegetation, plants, or plant debris in the soil, and therefore infections are more common in agricultural workers and people working in open areas. Sporotrichosis is considered an occupational disease in forest wardens, horticulturists, gardeners, and farm workers in general.<a class="elsevierStyleCrossRefs" href="#bib0360">4,13</a> Alcoholism and diabetes have also been described as risk factors. Immunosuppression, regardless of the cause, is also a predisposing factor for disseminated or systemic disease.<a class="elsevierStyleCrossRef" href="#bib0345">1</a> The disease can also be acquired through manipulation of the fungus in a laboratory setting. Finally, there was an interesting epidemic in southern Brazil in which sporotrichosis was transmitted to humans through cat scratches, suggesting that it might be a zoonotic infection.<a class="elsevierStyleCrossRef" href="#bib0410">14</a> Most of the species isolated in these cases were S brasiliensis.Clinical Forms<a class="elsevierStyleCrossRef" href="#bib0365">5</a><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005">1)Lymphocutaneous sporotrichosis. Also known as lymphangitic sporotrichosis, this clinical form accounts for over 75% of all cases of sporotrichosis.<a class="elsevierStyleCrossRef" href="#bib0415">15</a> The lesions occur in exposed areas, such as the hands, face, and feet. The disease starts as a painless purple or blackish nodule that erodes into a small ulcer (sporotrichotic chancre) with swollen edges, a painful granulomatous center, and minimal discharge. This is followed by lymphangitis with secondary nodules along the line of lymphatic drainage that can progress to ulcers; this characteristic pattern is known as sporotrichoid spread (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).<a class="elsevierStyleCrossRef" href="#bib0370">6</a> The patient's general health is not affected.<a class="elsevierStyleCrossRef" href="#bib0415">15</a> The course of disease varies according to the host's immune response, the virulence of the strain, the size of the inoculum, and the depth of the lesion.<elsevierMultimedia ident="fig0005"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0010">2)Fixed sporotrichosis. This variant is characterized by the presence of a solitary lesion. The infection is limited and generally presents as a slow-growing, less progressive verrucous plaque. Fixed sporotrichosis does not normally affect the lymph vessels and is more common in endemic areas.<a class="elsevierStyleCrossRef" href="#bib0420">16</a></li><li class="elsevierStyleListItem" id="lsti0015">3)Other clinical forms:</li></ul>Osteoarticular sporotrichosis. This is a disseminated form of sporotrichosis that affects the bones and joints; it is the most common form of systemic involvement.<a class="elsevierStyleCrossRef" href="#bib0425">17</a>Primary pulmonary sporotrichosis. This variant preferentially affects immunosuppressed patients and is acquired by inhalation. It mimics cavitary tuberculosis.<a class="elsevierStyleCrossRef" href="#bib0420">16</a>Metastatic pulmonary sporotrichosis. The metastatic form of pulmonary sporotrichosis is uncommon and has only been described in isolated cases. It occurs in immunocompromised patients, particularly those with human immunodeficiency virus (HIV) infection in the AIDS stage.<a class="elsevierStyleCrossRef" href="#bib0430">18</a>Widespread invasion. Disseminated disease is rare in sporotrichosis, although meningeal and ocular involvement have been described in immunosuppressed patients with uncontrolled diabetes or chronic alcoholism.In Mexico, like other countries in Latin America (home to the largest case series and the most experience with sporotrichosis), lymphocutaneous sporotrichosis accounts for 60% to 80% of all cases of sporotrichosis, fixed cutaneous sporotrichosis for 10% to 30%, and other clinical forms for 1% to 2%.<a class="elsevierStyleCrossRef" href="#bib0420">16</a>Sporotrichosis must be distinguished from tuberculosis, leishmania, tularemia, cutaneous nocardiosis, nontuberculous mycobacterial infections, mycetoma, chromoblastomycosis, and lepromatous leprosy. Sporotrichoid (lymphangitic) spread can be seen in many of these conditions, which must be contemplated in the differential diagnosis.<a class="elsevierStyleCrossRef" href="#bib0435">19</a>Diagnosis<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020">1.Pus (aspirated from nodules). Direct microscopic examination is of no value in sporotrichosis, as lesions contain very few yeast forms. Sabouraud dextrose agar (SDA) and SDA with antibiotics (chloramphenicol and cycloheximide) can be used for culture, which produces yeast colonies that are initially white and then darken (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Growth is characteristically quick (3-5 days)<a class="elsevierStyleCrossRef" href="#bib0440">20</a> but 2 weeks are needed to identify the fungus and confirm diagnosis.<a class="elsevierStyleCrossRef" href="#bib0420">16</a> Molecular identification by polymerase chain reaction (PCR) analysis is also possible.<a class="elsevierStyleCrossRefs" href="#bib0390">10,21</a></li><li class="elsevierStyleListItem" id="lsti0025">2.Histology. Histologic examination reveals a nonspecific mixed granulomatous reaction with neutrophilic microabscesses. The fungus presents as a small cigar-shaped yeast form sometimes surrounded by characteristic radiating eosinophilic material known as an asteroid body. While asteroid bodies can aid diagnosis, they are not pathognomic,<a class="elsevierStyleCrossRefs" href="#bib0420">16,20</a> as they are also found intracellularly in sarcoidosis, silicosis, and lacaziosis (lobomycosis). Extracellular asteroid bodies, however, are more characteristic of sporotrichosis. Several specimens may be needed to visualize the microorganisms, although they are easier to find in the case of disseminated or visceral disease.</li></ul>TreatmentSporotrichosis may resolve spontaneously in some cases, such as during pregnancy, although paradoxically dissemination has also been reported in pregnant women.<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0030">1.Saturated solution of potassium iodide. Treatment with potassium iodide, as a saturated solution, is started at 5 drops per meal. This initial dose is then gradually increased to 20 or 30 drops per meal according to tolerance levels. The treatment should be maintained for 3 to 4 weeks after resolution of the clinical manifestations. The mechanism of action is unknown, although potassium iodide is thought to act as an immunostimulant. Adverse effects include a metallic taste in the mouth, rhinitis, expectoration, urticaria, petechiae, bullous or acneiform rash, vasculitis, and induction of hypothyroidism or hyperthyroidism. Potassium iodide is contraindicated during pregnancy.<a class="elsevierStyleCrossRefs" href="#bib0440">20,22</a></li><li class="elsevierStyleListItem" id="lsti0035">2.Itraconazole 200mg/d for 3 to 6 months.<a class="elsevierStyleCrossRef" href="#bib0450">22</a> This is the first-line treatment recommended in most treatment guidelines. It tends to be a little more expensive than potassium iodide, but it has fewer adverse effects.</li><li class="elsevierStyleListItem" id="lsti0040">3.Other options. Terbinafine 250-1000mg/d for 3 to 6 months<a class="elsevierStyleCrossRefs" href="#bib0455">23,24</a>; fluconazole 400mg/d for 3 to 6 months<a class="elsevierStyleCrossRef" href="#bib0450">22</a>; amphotericin B (deoxycholate) 0.5-1mg/kg/d for systemic disease or liposomal or lipid formulations of amphotericin B at a dose of 3-5mg/kg/d<a class="elsevierStyleCrossRef" href="#bib0450">22</a>; local heat or thermotherapy for 2 or 3 months,<a class="elsevierStyleCrossRef" href="#bib0450">22</a> or a combination of the above treatments (potassium iodide with itraconazole, itraconazole with terbinafine, and terbinafine with potassium iodide).<a class="elsevierStyleCrossRef" href="#bib0465">25</a> The addition of photodynamic therapy with methyl aminolevulinate or even better intralesional methylene blue 1% (combined or not with itraconazole) has produced good results in vitro and in 1 patient.<a class="elsevierStyleCrossRef" href="#bib0470">26</a></li></ul>Surgery can have an important role in osteoarticular sporotrichosis.<a class="elsevierStyleCrossRef" href="#bib0450">22</a> Debridement and arthrodesis were traditionally considered the treatments of choice but prosthetic joint replacement followed by long-term antifungal treatment has also been described as a viable option1.1Chromoblastomycosis (Chromomycosis)Chromoblastomycosis, also known as chromomycosis, is a chronic polymorphic fungal infection of the skin and subcutaneous tissue. It is caused by several species of melanized or dematiaceous fungi, which produce a dark pigment. The parasitic forms of these fungi are called fumagoid or muriform cells (sclerotic bodies).<a class="elsevierStyleCrossRefs" href="#bib0475">27–30</a>The most common species that cause chromoblastomycosis are Fonsecaea pedrosoi, Fonsecaea monophora, Cladophialophora carrionii, Phialophora verrucosa, and Rhinocladiella aquaspersa.<a class="elsevierStyleCrossRefs" href="#bib0365">5,27,28</a> Most patients have a history of a traumatic injury involving wood or vegetation, and over 80% are rural workers in Africa, Asia, and South America who tend to walk barefoot. The fungi responsible for chromoblastomycosis have been found worldwide, though they are more common in tropical and subtropical countries.<a class="elsevierStyleCrossRef" href="#bib0475">27</a>Clinical FormsThe fungus generally penetrates the skin through a skin injury, typically located on the lower limbs.<a class="elsevierStyleCrossRef" href="#bib0495">31</a> About 1 or 2 months later, the infected individual develops a papule that progresses to a slow-growing warty nodule (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The infection is limited to the subcutaneous tissue and does not spread to either muscle or bone, except in immunocompromised patients. Individual lesions can develop a thick cauliflower-like appearance and bacterial superinfection is common. Secondary lymphedema, possibly progressing to elephantiasis, and squamous cell carcinoma may occur.<a class="elsevierStyleCrossRef" href="#bib0475">27</a><elsevierMultimedia ident="fig0010"></elsevierMultimedia>Diagnosis<ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0045">1.Direct examination. Direct examination of crusts and fragments of skin can reveal parasitic forms that occur in isolation or form characteristic septa (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). The microscopic structures observed are common to all species.<a class="elsevierStyleCrossRefs" href="#bib0475">27,28</a></li><li class="elsevierStyleListItem" id="lsti0050">2.Culture. The fungi that cause chromoblastomycosis grow slowly when cultivated on SDA with or without antibiotics (chloramphenicol and cycloheximide); they produce dark olivaceous or black colonies with a flat velvety surface and a raised center. Distinction between species is difficult and is based on reproductive structures and molecular identification.<a class="elsevierStyleCrossRef" href="#bib0490">30</a> Molecular biology techniques (PCR), in particular targeting internal transcribed spacer (ITS) regions of ribosomal DNA (rDNA), are also useful.<a class="elsevierStyleCrossRefs" href="#bib0500">32,33</a></li><li class="elsevierStyleListItem" id="lsti0055">3.Histology. Histologic examination shows characteristic pseudoepitheliomatous hyperplasia in the epidermis and a mixed granulomatous inflammatory infiltrate with giant cells containing characteristic round fungal structures (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) in the dermis.<a class="elsevierStyleCrossRef" href="#bib0475">27</a></li></ul>TreatmentChromoblastomycosis is extremely difficult to treat and is often refractory to diverse options, including nonpharmacological treatments such as curettage, electrocoagulation, and cryosurgery.<a class="elsevierStyleCrossRef" href="#bib0365">5</a> Antifungals must be maintained for at least 6 months, and while they may produce a favorable clinical outcome, recurrences during or after therapy are common. Treatment should be terminated when all the lesions disappear.<a class="elsevierStyleCrossRef" href="#bib0475">27</a>Other treatments include surgical resection of small lesions; local cryosurgery (in association with an antifungal to prevent lymphatic spread); itraconazole 200-400mg/d alone or combined with 5-fluorocitosine 30mg/kg 4 times a day for 6 months; terbinafine 250-500mg/d for 12 months, and in the case of systemic involvement intravenous amphotericin B at a dose of 1mg/kg or liposomal or lipid formulations of amphotericin B at a dose of 3-5mg/kg/d.<a class="elsevierStyleCrossRef" href="#bib0475">27</a>MycetomaMycetoma is a chronic local infection caused by several species of fungi and bacteria. The infection is called actinomycetoma when it is caused by aerobic filamentous bacteria and eumycetoma when it is caused by fungi.<a class="elsevierStyleCrossRef" href="#bib0510">34</a> It is characterized by the formation of aggregates of the causative microorganisms in abscesses. These aggregates are known as grains or granules. Granules can drain through sinuses opening onto the skin or affect adjacent bones. The disease advances via direct spread, with very few cases of dissemination to distant sites. The causative agents are generally found in the soil and they enter the body through broken skin. Most cases involve rural workers.Etiology<ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0060">1.Fungi. The fungi that cause eumycetoma produce white or dark granules. They are particularly common in Africa, India, and Mexico. Dark granules are formed by Madurella mycetomatis, Trematosphaeria grisea, and Leptosphaeria senegalensis,<a class="elsevierStyleCrossRef" href="#bib0515">35</a> while white granules are formed by Fusarium spp., Acremonium spp., and Aspergillus nidulans.</li><li class="elsevierStyleListItem" id="lsti0065">2.Filamentous bacteria or aerobic actinomycetes. The granules formed by these species are red (Actinomadura pelletieri), white-yellow (Actinomadura madurae, Nocardia brasiliensis, and Nocardia spp.), or yellow-brown (Streptomyces somaliensis). Actinomycetes are found all over the world, not just in tropical countries.<a class="elsevierStyleCrossRef" href="#bib0520">36</a></li></ul>Clinical FormsThe clinical characteristics of mycetoma caused by fungi and actinomycetes are very similar. Lesions are more common on the feet, shins, and hands. The earliest clinical manifestation is a hard painless nodule that spreads slowly to produce papules and sinuses that discharge fluid containing granules onto the skin surface.<a class="elsevierStyleCrossRefs" href="#bib0515">35,36</a> The original site of infection is distorted by local tissue swelling, formation of chronic sinuses, and late bone involvement (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). Lesions are rarely painful, except in late stages.<elsevierMultimedia ident="fig0015"></elsevierMultimedia>DiagnosisMycetoma granules (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>) are a key diagnostic finding and are generally found on examining discharge from sinuses or on crushing a crust taken from a lesion. Microscopic examination will show whether these granules are formed by small actinomycetes or wider mycotic filaments. Definitive identification requires culture, which is normally carried out on SDA with or without antibiotics (chloramphenicol and cycloheximide); chloramphenicol alone is preferred in the case of hyaline fungi. The agents can also be identified by molecular biology testing, particularly PCR analysis using different markers<a class="elsevierStyleCrossRef" href="#bib0525">37</a> depending on the causative agents (e.g., ITS regions of rDNA, β-tubulin,<a class="elsevierStyleCrossRef" href="#bib0530">38</a> and D1/D2). Partial ribosomal RNA gene sequence analysis, by contrast, can be used to identify Nocardia and Actinomadura species.<a class="elsevierStyleCrossRef" href="#bib0520">36</a> Histologic findings are similar in all forms of mycetoma, and include an inflammatory center rich in polymorphonuclear cells (true abscesses), epithelioid cells, giant cells, and fibrosis. The granules are located in the center of the inflammation.<a class="elsevierStyleCrossRefs" href="#bib0515">35,39</a> Imaging studies, while complementary, can aid diagnosis by showing soft tissue swelling, osteolytic lesions, and cortical thickening.The differential diagnosis should include bacterial osteomyelitis, tuberculous osteomyelitis, hidradenitis suppurativa, Kaposi sarcoma, and cutaneous tuberculosis, among others.<a class="elsevierStyleCrossRefs" href="#bib0515">35,39</a>TreatmentActinomycetoma. The treatment regimen with the strongest evidence base for nocardial mycetoma is trimethoprim-sulfamethoxazole plus diaminodiphenyl sulfone (dapsone) for 6 months to 2 years. Amoxicillin-clavulanic acid, administered over 6 months, can be used for refractory cases.<a class="elsevierStyleCrossRefs" href="#bib0540">40–42</a> The treatment of choice for extensive infection and/or visceral involvement is amikacin combined with trimetoprim-sulfametoxazol<a class="elsevierStyleCrossRef" href="#bib0535">39</a> or meropenem.<a class="elsevierStyleCrossRefs" href="#bib0555">43,44</a> There have been isolated reports of successful outcomes with other agents in patients who do not respond to these treatments.<a class="elsevierStyleCrossRefs" href="#bib0520">36,39,45</a>Eumycetoma. Unlike in actinomycetoma, where pharmacological treatment is associated with good outcomes, the standard treatment in eumycetoma is a combination of medical treatment and surgery. Acceptable results have been reported for the use of last-generation triazoles, such as itraconazole and fluconazole used alone or in combination with terbinafine. These drugs are administered over a long period and only after exhausting all surgical options.<a class="elsevierStyleCrossRefs" href="#bib0515">35,45</a>PhaeohyphomycosisPhaeohyphomycosis is a heterogeneous group of mycoses caused by dark-walled (dematiaceous) fungi.<a class="elsevierStyleCrossRefs" href="#bib0570">46,47</a> These fungi are found in all climates, although they are more common in tropical climates. There has been a recent rise in cases among immunosuppressed patients with HIV infection or AIDS, transplant recipients, and diabetic patients, among others.<a class="elsevierStyleCrossRefs" href="#bib0570">46,48</a>The most common causative agents are Exophiala spp., Bipolaris spp., Curvularia spp., Pleurophomopsis spp., Phaeoacremonium spp, and Alternaria spp. The fungi are found mainly in organic debris.Clinical Forms<ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0070">1.Subcutaneous phaeohyphomycosis. Following local trauma or inoculation with foreign material, patients develop a slow-growing solitary lesion (generally a cyst or a nodule, or possibly a plaque or abscess) normally located on the extremities (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>).<a class="elsevierStyleCrossRefs" href="#bib0580">48,49</a> The differential diagnosis should include lipomas, epidermal or synoviale cysts, fibromas, foreign body cysts, and bacterial abscesses.<elsevierMultimedia ident="fig0020"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0075">2.Systemic or disseminated phaeohyphomycosis. While very rare, systemic phaeohyphomycosis is very serious in immunosuppressed patients.<a class="elsevierStyleCrossRef" href="#bib0590">50</a></li></ul>DiagnosisWet-mount microscopy shows diagnostic dark septate hyphae forming branches or chains (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). Growth is slow (3-4 weeks) on SDA and colonies acquire an olivaceous or dark brown color. PCR analysis of markers such as β-tubulin and ITS regions can be used for molecular identification.<a class="elsevierStyleCrossRefs" href="#bib0595">51,52</a> Biopsy reveals a cyst wall formed by palisading macrophages with mycotic hyphae.<a class="elsevierStyleCrossRef" href="#bib0585">49</a>TreatmentTreatment of infections caused by Exophiala spp. is controversial, and one option that has been proposed is surgical resection.<a class="elsevierStyleCrossRef" href="#bib0580">48</a> There are also no standard protocols for the treatment of Alternaria infections.<a class="elsevierStyleCrossRef" href="#bib0605">53</a> The best option for phaeohyphomycosis appears to be a combination of antifungal therapy (itraconazole, ketoconazole, or terbinafine) and surgery. Exophiala spp. strains tend to be resistant to fluconazole. Disseminated infections are treated with amphotericin B.<a class="elsevierStyleCrossRefs" href="#bib0580">48,49</a>HyalohyphomycosisHyalohyphomycosis is caused by hyaline fungi (Hyphomycetes) that form septate hyphae in tissue.<a class="elsevierStyleCrossRef" href="#bib0575">47</a> This classification, however, is rather arbitrary as there are many types of terrestrial and aquatic Hyphomycetes. Just a few organisms, however, can cause infections, most of which are opportunistic, in humans.<a class="elsevierStyleCrossRefs" href="#bib0610">54,55</a> Most of the genera involved in hyalohyphomycosis are morphologically identical when observed in tissue sections and they trigger the same pathologic response. Fungi that frequently cause infections or have another particularly distinctive characteristic are assigned to a different category (e.g., aspergillosis).The most common agents involved in hyalohyphomycosis are Aspergillus (fumigatus, niger, flavus), Scopulariopsis spp., Fusarium spp., Acremonium recifei, Paecilomyces spp., Purpureocillum spp., and Neoscytalidium spp.<a class="elsevierStyleCrossRef" href="#bib0615">55</a> They are all widely distributed in nature, and can be found in any type of soil, wood, or decomposing plant material.<a class="elsevierStyleCrossRef" href="#bib0620">56</a> They affect individuals of either sex and at any age, and immunosuppression is not a necessary condition for infection.Clinical FormsHyalohyphomycosis can be classified as superficial, subcutaneous, or systemic.<ul class="elsevierStyleList" id="lis0035"><li class="elsevierStyleListItem" id="lsti0080">1.Superficial hyalohyphomycosis. Superficial infections include dermatomycosis and onychomycosis. They are common in rural workers, fishermen, patients with severe burns, and premature neonates.<a class="elsevierStyleCrossRefs" href="#bib0625">57,58</a></li><li class="elsevierStyleListItem" id="lsti0085">2.Subcutaneous hyalohyphomycosis. Traumatic inoculation causes abscesses, cysts, and tumor-like lesions similar to those seen in mycetoma (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>).<a class="elsevierStyleCrossRef" href="#bib0620">56</a><elsevierMultimedia ident="fig0025"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0090">3.Systemic hyalohyphomycosis. Systemic infections, while uncommon, are very serious. They affect immunosuppressed patients and can be fatal. Hematogenous and lymphatic spread leads to involvement of the lungs and central nervous system.<a class="elsevierStyleCrossRefs" href="#bib0615">55,57</a></li></ul>DiagnosisIdentification of septate hyaline hyphae by microscopic examination of skin scales, nail fragments, secretions, or fragments provides a presumptive diagnosis, which is then confirmed by culture (<a class="elsevierStyleCrossRef" href="#fig0025">Fig. 5</a>). Most fungi grow on SDA without antibiotics or inhibitors.<a class="elsevierStyleCrossRefs" href="#bib0575">47,59</a> As in the cases described above, molecular identification is also possible.<a class="elsevierStyleCrossRef" href="#bib0640">60</a>The differential diagnosis should include other dermatomycoses, epidermal cysts, actinomycetoma, eumycetoma, histoplasmosis, and cryptococcosis.TreatmentIn immunocompetent individuals, the treatments of choice are triazoles, terbinafine, or surgery.<a class="elsevierStyleCrossRef" href="#bib0645">61</a> When the immune system is compromised, the first-line treatment is amphotericin B combined with a triazole (itraconazole 200mg/d for 6 months or fluconazole 150mg twice a week for 6 months).Lacaziosis (Lobomycosis)Lacaziosis, which was formerly known as lobomycosis, is a chronic granulomatous fungal infection of the skin and subcutaneous tissues first described under the name of keloidal blastomycosis in 1930 by Jorge Lobo in Recife, Brazil.<a class="elsevierStyleCrossRef" href="#bib0650">62</a> It is a rare infection found in Central and South America; it is caused by Lacazia loboi,<a class="elsevierStyleCrossRefs" href="#bib0650">62,63</a> a yeast that cannot be grown in culture. The source of infection is thought to be in soil and vegetation. The fungus probably enters through the skin following a penetrating injury, such as a thorn prick or insect bite.Lacaziosis is characterized by keloidal lesions with well-defined lobulated edges in exposed areas of the body (frequently the face, arms, or legs). The lesions spread to contiguous sites, although transmission to distant sites is also possible via autoinoculation.DiagnosisDiagnosis is facilitated by the identification of abundant fungal structures during direct examination and chains of diffuse round cells connected by small tubular structures in biopsy samples.<a class="elsevierStyleCrossRef" href="#bib0650">62</a> Causative agents can also be identified in tissue by PCR analysis, in particular assays targeting the 18S rDNA fragment.<a class="elsevierStyleCrossRef" href="#bib0660">64</a>The differential diagnosis should include keloids, lepromatous leprosy, and anergic leishmania.TreatmentAntifungals are not effective in lacaziosis and the definitive treatment is surgical resection.<a class="elsevierStyleCrossRefs" href="#bib0650">62,63</a>ZygomycosisZygomycosis is a heterogeneous group of fungal infections caused by opportunistic Zygomycetes of the orders Mucorales (Rhizopus, Lichtheimia, Mucor, and Rhizomucor) and Entomophthorales (Basidiobolus and Conidiobolus).<a class="elsevierStyleCrossRef" href="#bib0665">65</a> In this section, we will only discuss Entomophthorales fungi, as the Mucorales are addressed in the second part of this review, which looks at systemic mycoses.Entomophthoromycosis is characterized by the appearance of a hard, progressive mass that affects the subcutaneous tissues. There are 2 variants. The first is caused by Basidiobolus ranarum and is more common in children.<a class="elsevierStyleCrossRef" href="#bib0670">66</a> Lesions generally appear in the shoulder and pelvic girdles, and present as a slowly spreading woody cellulitis. The second variant is caused by Conidiobolus coronatus and affects adults. The primary infection starts in the lower turbinates of the nose and then spreads to the center of the face, causing painful indurated swelling and severe deformation of the nose, lips, and cheeks.<a class="elsevierStyleCrossRefs" href="#bib0665">65–68</a>ConclusionWe have reviewed the main characteristics of the subcutaneous mycoses and the main diagnostic and treatment methods available (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>).<elsevierMultimedia ident="tbl0005"></elsevierMultimedia>Conflicts of InterestThe authors declare that they have no conflicts of interest." "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres762914" "titulo" => "Graphical abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:3 [ "identificador" => "xres762913" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 2 => array:2 [ "identificador" => "xpalclavsec764389" "titulo" => "Keywords" ] 3 => array:3 [ "identificador" => "xres762915" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0015" ] ] ] 4 => array:2 [ "identificador" => "xpalclavsec764390" "titulo" => "Palabras clave" ] 5 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 6 => array:3 [ "identificador" => "sec0010" "titulo" => "Subcutaneous Mycoses" "secciones" => array:9 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "Sporotrichosis" ] 1 => array:3 [ "identificador" => "sec0020" "titulo" => "Clinical Forms" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Diagnosis" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Treatment" ] ] ] 2 => array:3 [ "identificador" => "sec0035" "titulo" => "Chromoblastomycosis (Chromomycosis)" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0040" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0045" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0050" "titulo" => "Treatment" ] ] ] 3 => array:3 [ "identificador" => "sec0055" "titulo" => "Mycetoma" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0060" "titulo" => "Etiology" ] 1 => array:2 [ "identificador" => "sec0065" "titulo" => "Clinical Forms" ] 2 => array:2 [ "identificador" => "sec0070" "titulo" => "Diagnosis" ] 3 => array:2 [ "identificador" => "sec0075" "titulo" => "Treatment" ] ] ] 4 => array:3 [ "identificador" => "sec0080" "titulo" => "Phaeohyphomycosis" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0085" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0090" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0095" "titulo" => "Treatment" ] ] ] 5 => array:3 [ "identificador" => "sec0100" "titulo" => "Hyalohyphomycosis" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0105" "titulo" => "Clinical Forms" ] 1 => array:2 [ "identificador" => "sec0110" "titulo" => "Diagnosis" ] 2 => array:2 [ "identificador" => "sec0115" "titulo" => "Treatment" ] ] ] 6 => array:3 [ "identificador" => "sec0120" "titulo" => "Lacaziosis (Lobomycosis)" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "sec0125" "titulo" => "Diagnosis" ] ] ] 7 => array:2 [ "identificador" => "sec0130" "titulo" => "Treatment" ] 8 => array:2 [ "identificador" => "sec0135" "titulo" => "Zygomycosis" ] ] ] 7 => array:2 [ "identificador" => "sec0140" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "sec0145" "titulo" => "Conflicts of Interest" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-01-07" "fechaAceptado" => "2016-05-29" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec764389" "palabras" => array:6 [ 0 => "Deep mycosis" 1 => "Subcutaneous mycosis" 2 => "Systemic mycosis" 3 => "Sporotrichosis" 4 => "Chromoblastomycosis" 5 => "Mycetoma" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec764390" "palabras" => array:6 [ 0 => "Micosis profundas" 1 => "Micosis subcutáneas" 2 => "Micosis sistémicas" 3 => "Esporotricosis" 4 => "Cromoblastomicosis" 5 => "Micetomas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "The deep mycoses are uncommon in our setting. These fungal infections occur mainly in immunosuppressed patients or in tropical climates, and include subcutaneous infections and systemic infections. The skin is always involved in the former. In the first part of this review, we describe the main subcutaneous mycoses: sporotrichosis, chromoblastomycosis, mycetoma, phaeohyphomycosis, hyalohyphomycosis, and lacaziosis. Early recognition and treatment is important, as these infections are frequently associated with high morbidity." ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "Las micosis profundas son infecciones poco frecuentes en nuestro medio. Se presentan principalmente en pacientes inmunodeprimidos o en regiones de climas tropicales, que abarcan las micosis subcutáneas y las micosis sistémicas. Las micosis subcutáneas o por implantación siempre producen signos de afectación cutánea. En la primera parte de esta revisión se realizará una revisión de las principales micosis subcutáneas: esporotricosis, cromoblastomicosis, micetomas, feohifomicosis, hialohifomicosis y lacaziosis. Reconocer y tratar estas micosis subcutáneas de forma precoz es importante, ya que a menudo están asociadas a una alta morbilidad." ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Carrasco-Zuber JE, Navarrete-Dechent C, Bonifaz A, Fich F, Vial-Letelier V, Berroeta-Mauriziano D. Afectación cutánea en las micosis profundas: una revisión de la literatura. Parte 1: micosis subcutáneas. Actas Dermosifiliogr. 2016;107:806–815." ] ] "multimedia" => array:7 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 998 "Ancho" => 1500 "Tamanyo" => 217447 ] ] "descripcion" => array:1 [ "en" => "A, Lymphangitic sporotrichosis. B, Sporothrix schenckii culture. C, Microscopic examination of culture on Sabouraud dextrose agar medium (erythrosin 2%, original magnification ×40)." ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1056 "Ancho" => 1500 "Tamanyo" => 281937 ] ] "descripcion" => array:1 [ "en" => "A, Nodular-verrucous chromoblastomycosis. B, Biopsy showing fumagoid cells. C, Direct examination of Fonsecaea pedrosoi culture (biopsy; hematoxylin-eosin and erythrosin 2%, original magnification in both cases ×40)." ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1015 "Ancho" => 1500 "Tamanyo" => 278707 ] ] "descripcion" => array:1 [ "en" => "A, Actinomycetoma of the foot. B, Nocardia sp. granules seen in direct examination (KOH, original magnification ×10). C, Biopsy (hematoxylin-eosin ×40)." ] ] 3 => array:7 [ "identificador" => "fig0020" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1020 "Ancho" => 1500 "Tamanyo" => 229452 ] ] "descripcion" => array:1 [ "en" => "A, Nodular phaeohyphomycosis. B, Filaments and yeasts in biopsy sample (Grocott, original magnification ×10). C, Microscopic examination of Veronaea botryosa (lactophenol cotton blue, original magnification ×40)." ] ] 4 => array:7 [ "identificador" => "fig0025" "etiqueta" => "Figure 5" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr5.jpeg" "Alto" => 870 "Ancho" => 1500 "Tamanyo" => 182234 ] ] "descripcion" => array:1 [ "en" => "Hyalohyphomycosis ulcer due to Acremonium sp. B, Culture (Sabouraud dextrose agar medium). C, Direct examination of exudate (Giemsa, original magnification ×40)." ] ] 5 => array:8 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at1" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "Abbreviation: PCR, polymerase chain reaction." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mycosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main Causative Agent \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis \t\t\t\t\t\t\n \t\t\t\t</th><th class="td" title="table-head " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment \t\t\t\t\t\t\n \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sporotrichosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Sporothrix schenckii \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Cultivation of pus aspirated from nodules; histology; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Saturated solution of potassium iodide for 3 wk; itraconazole 200mg/d for 3–6 mo; combinations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Chromoblastomycosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Fonsecaea pedrosoi \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Microscopic examination; culture; histology \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Very difficult. Itraconazole 200mg/d for 6 mo; terbinafine for 12 mo; amphotericin B; combinations \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mycetoma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Filamentous actinomycetes and filamentous fungi \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Identification of mycetoma granules; culture; histology; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Antibiotics for actinomycetoma; antifungals+surgery for eumycetoma \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Phaeohyphomycosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Exophiala jeanselmei Alternaria spp. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Microscopic examination and culture; histology; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Controversial. Surgery+combination of antifungals \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hyalohyphomycosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Opportunistic Aspergillus (fumigatus, niger, flavus), Fusarium spp., Paecilomyces, etc. \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Microscopic examination and culture; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Immunocompetent patients: triazoles; terbinafine; ciclopirox olamine; surgery Immunosuppressed patients: amphotericin B combined with a triazole for 6 mo \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lacaziosis (lobomycosis) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Lacazia loboi \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Microscopic examination; histology; PCR \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Surgery \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Entomophthoromycosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Conidiobolus coronatus Basidiobolus ranarum \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Direct examination and culture \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="table-entry " align="left" valign="top">Surgery and systemic antifungals \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab1260343.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Summary of the Characteristics of the Subcutaneous Mycoses." ] ] 6 => array:5 [ "identificador" => "fig0030" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 772 "Ancho" => 1333 "Tamanyo" => 98146 ] ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:68 [ 0 => array:3 [ "identificador" => "bib0345" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subcutaenous mycoses" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O. Welsh" 1 => "R. Arenas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.09.005" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "367" "paginaFinal" => "368" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682182" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0350" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Micosis importadas" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Rezusta" 1 => "J. Gil" 2 => "M.C. Rubio" 3 => "M.J. Revillo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Bol Control Calidad SEIMC" "fecha" => "2001" "paginaInicial" => "1" "paginaFinal" => "15" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0355" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous manifestations of deep mycosis: An experience in a tropical pathology laboratory" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M.O. Samaila" 1 => "K. Abdullahi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0019-5154.82481" "Revista" => array:6 [ "tituloSerie" => "Indian J Dermatol" "fecha" => "2011" "volumen" => "56" "paginaInicial" => "282" "paginaFinal" => "286" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21772588" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0360" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic mycoses in immunodepressed patients (AIDS)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Ramos-e-Silva" 1 => "C.M. Lima" 2 => "R.C. Schechtman" 3 => "B.M. Trope" 4 => "S. Carneiro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2012.01.008" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "616" "paginaFinal" => "627" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23068149" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0365" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subcutaneous mycoses: Chromoblastomycosis, sporotrichosis and mycetoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A. Bonifaz" 1 => "D. Vázquez-González" 2 => "A.M. Perusquía-Ortiz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1610-0387.2010.07453.x" "Revista" => array:6 [ "tituloSerie" => "J Dtsch Dermatol Ges" "fecha" => "2010" "volumen" => "8" "paginaInicial" => "619" "paginaFinal" => "627" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20529168" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0370" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Population-based surveillance and a case-control study of risk factors for endemic lymphocutaneous sporotrichosis in Peru" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G.M. Lyon" 1 => "S. Zurita" 2 => "J. Casquero" 3 => "W. Holgado" 4 => "J. Guevara" 5 => "M.E. Brandt" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/345437" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2003" "volumen" => "36" "paginaInicial" => "34" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12491199" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0375" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sporotrichosis in Peru: Description of an area of hyperendemicity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.G. Pappas" 1 => "I. Tellez" 2 => "A.E. Deep" 3 => "D. Nolasco" 4 => "W. Holgado" 5 => "B. Bustamante" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/313607" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2000" "volumen" => "30" "paginaInicial" => "65" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10619735" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0380" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "First autochthone case of sporotrichosis by Sporothrix globosa in Portugal" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.M. De Oliveira" 1 => "C. Veríssimo" 2 => "R. Sabino" 3 => "J. Aranha" 4 => "R.M. Zancopé-Oliveira" 5 => "P. Sampaio" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.diagmicrobio.2013.08.023" "Revista" => array:6 [ "tituloSerie" => "Diagn Microbiol Infect Dis" "fecha" => "2014" "volumen" => "78" "paginaInicial" => "388" "paginaFinal" => "390" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24439448" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0385" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sporotrichosis caused by Sporothrix Mexicana, Portugal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "N.M. Dias" 1 => "M.M. Oliveira" 2 => "C. Santos" 3 => "R.M. Zancope-Oliveira" 4 => "N. Lima" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3201/eid1710.110737" "Revista" => array:6 [ "tituloSerie" => "Emerg Infect Dis" "fecha" => "2011" "volumen" => "17" "paginaInicial" => "1975" "paginaFinal" => "1976" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22000393" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0390" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular identification of the Sporothrix schenckii complex" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M.M. Oliveira" 1 => "R. Almeida-Paes" 2 => "M.C. Gutierrez-Galhardo" 3 => "R.M. Zancope-Oliveira" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.riam.2013.09.008" "Revista" => array:6 [ "tituloSerie" => "Rev Iberoam Micol" "fecha" => "2014" "volumen" => "31" "paginaInicial" => "2" "paginaFinal" => "6" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24270070" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0395" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phylogeography and evolutionary patterns in Sporothrix spanning more than 14 000 human and animal case reports" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Zhang" 1 => "F. Hagen" 2 => "B. Stielow" 3 => "A.M. Rodrigues" 4 => "K. Samerpitak" 5 => "X. Zhou" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3767/003158515X687416" "Revista" => array:6 [ "tituloSerie" => "Persoonia" "fecha" => "2015" "volumen" => "35" "paginaInicial" => "1" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26823625" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0400" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sporothrix brasiliensis, S. globosa, and S. mexicana, three new Sporothrix species of clinical interest" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Marimon" 1 => "J. Cano" 2 => "J. Gené" 3 => "D.A. Sutton" 4 => "M. Kawasaki" 5 => "J. Guarro" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/JCM.00808-07" "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2007" "volumen" => "45" "paginaInicial" => "3198" "paginaFinal" => "3206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17687013" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0405" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aislamiento ambiental de Sporothrix globosa en relación a un caso de esporotricosis linfo-cutánea" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Cruz" 1 => "P. Vieille" 2 => "D. Oschilewski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4067/S0716-10182012000400006" "Revista" => array:6 [ "tituloSerie" => "Rev Chilena Infectol" "fecha" => "2012" "volumen" => "29" "paginaInicial" => "401" "paginaFinal" => "405" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23096539" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0410" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Emergence of pathogenicity in the Sporothrix schenckii complex" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Rodrigues" 1 => "S. de Hoog" 2 => "Z.P. de Camargo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3109/13693786.2012.719648" "Revista" => array:6 [ "tituloSerie" => "Med Mycol" "fecha" => "2013" "volumen" => "51" "paginaInicial" => "405" "paginaFinal" => "412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22989196" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0415" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sporotrichosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "C.A. Kauffman" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/520190" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "1999" "volumen" => "29" "paginaInicial" => "231" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10476718" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0420" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sporotrichosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Vásquez-del-Mercado" 1 => "R. Arenas" 2 => "C. Padilla-Desgarenes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.09.017" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "437" "paginaFinal" => "443" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682194" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0425" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Infectious arthritis as the single manifestation of sporotrichosis: Serology from serum and synovial fluid samples as an aid to diagnosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.O. Costa" 1 => "K.C. de Mesquita" 2 => "P.S. Damasco" 3 => "A.R. Bernardes-Engemann" 4 => "C.M. Dias" 5 => "I.C. Silva" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Iberoam Micol" "fecha" => "2008" "volumen" => "25" "paginaInicial" => "54" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18338931" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0430" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary cavitation and skin lesions mimicking tuberculosis in a HIV negative patient caused by Sporothrix brasiliensis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Orofino-Costa" 1 => "N. Unterstell" 2 => "A. Carlos Gripp" 3 => "P.M. de Macedo" 4 => "A. Brota" 5 => "E. Dias" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.mmcr.2013.02.004" "Revista" => array:6 [ "tituloSerie" => "Med Mycol Case Rep" "fecha" => "2013" "volumen" => "2" "paginaInicial" => "65" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24432220" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0435" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esporotricosis granulomatosa: presentación de dos casos inusuales" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Ramírez-Soto" 1 => "J. Lizárraga-Trujillo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4067/S0716-10182013000500013" "Revista" => array:6 [ "tituloSerie" => "Rev Chilena Infectol" "fecha" => "2013" "volumen" => "30" "paginaInicial" => "548" "paginaFinal" => "553" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24248171" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0440" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Esporotricosis cutánea fija: reporte de un caso" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Castro" 1 => "H. Pacheco" 2 => "D. Juárez" 3 => "Z. Lozano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Pediatr Lat" "fecha" => "2013" "volumen" => "30" "paginaInicial" => "548" "paginaFinal" => "553" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0445" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genotyping species of the Sporothrix schenckii complex by PCR-RFLP of calmodulin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Rodrigues" 1 => "G.S. de Hoog" 2 => "Z.P. de Camargo" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.diagmicrobio.2014.01.004" "Revista" => array:6 [ "tituloSerie" => "Diagn Microbiol Infect Dis" "fecha" => "2014" "volumen" => "78" "paginaInicial" => "383" "paginaFinal" => "387" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24525143" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0450" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "America IDSo" "etal" => false "autores" => array:4 [ 0 => "C.A. Kauffman" 1 => "B. Bustamante" 2 => "S.W. Chapman" 3 => "P.G. Pappas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/522765" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2007" "volumen" => "45" "paginaInicial" => "1255" "paginaFinal" => "1265" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17968818" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0455" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative study of 250mg/day terbinafine and 100mg/day itraconazole for the treatment of cutaneous sporotrichosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "G. Francesconi" 1 => "A.C. Francesconi do Valle" 2 => "S.L. Passos" 3 => "M.B. de Lima Barros" 4 => "R. de Almeida Paes" 5 => "A.L. Curi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11046-010-9380-8" "Revista" => array:6 [ "tituloSerie" => "Mycopathologia" "fecha" => "2011" "volumen" => "171" "paginaInicial" => "349" "paginaFinal" => "354" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21103938" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0460" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative evaluation of the efficacy and safety of two doses of terbinafine (500 and 1000mg day(-1)) in the treatment of cutaneous or lymphocutaneous sporotrichosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.W. Chapman" 1 => "P. Pappas" 2 => "C. Kauffmann" 3 => "E.B. Smith" 4 => "R. Dietze" 5 => "N. Tiraboschi-Foss" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mycoses" "fecha" => "2004" "volumen" => "47" "paginaInicial" => "62" "paginaFinal" => "68" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998402" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0465" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sporotrichosis successfully treated with terbinafine and potassium iodide: Case report and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "B. Coskun" 1 => "Y. Saral" 2 => "N. Akpolat" 3 => "A. Ataseven" 4 => "D. Ciçek" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Mycopathologia" "fecha" => "2004" "volumen" => "158" "paginaInicial" => "53" "paginaFinal" => "56" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15487321" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0470" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous sporotrichosis treated with photodynamic therapy: An in vitro and in vivo study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Gilaberte" 1 => "C. Aspiroz" 2 => "M.C. Alejandre" 3 => "E. Andres-Ciriano" 4 => "B. Fortuño" 5 => "L. Charlez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/pho.2013.3590" "Revista" => array:6 [ "tituloSerie" => "Photomed Laser Surg" "fecha" => "2014" "volumen" => "32" "paginaInicial" => "54" "paginaFinal" => "57" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24328608" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0475" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromoblastomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "E. Torres-Guerrero" 1 => "R. Isa-Isa" 2 => "M. Isa" 3 => "R. Arenas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.09.011" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "403" "paginaFinal" => "408" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682188" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0480" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromoblastomycosis due to Cladosporium carrionii" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "N. Namratha" 1 => "S. Nadgir" 2 => "M. Kale" 3 => "R. Rathod" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4103/0974-2727.66704" "Revista" => array:6 [ "tituloSerie" => "J Lab Physicians" "fecha" => "2010" "volumen" => "2" "paginaInicial" => "47" "paginaFinal" => "48" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21814409" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0485" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromoblastomycosis as an endemic disease in temperate Europe: First confirmed case and review of the literature" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Pindycka-Piaszczyńska" 1 => "P. Krzyściak" 2 => "M. Piaszczyński" 3 => "S. Cieślik" 4 => "K. Januszewski" 5 => "G. Izdebska-Straszak" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s10096-013-1969-7" "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Microbiol Infect Dis" "fecha" => "2014" "volumen" => "33" "paginaInicial" => "391" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24048727" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0490" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromoblastomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.M. Krzyściak" 1 => "M. Pindycka-Piaszczyńska" 2 => "M. Piaszczyński" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.5114/pdia.2014.40949" "Revista" => array:6 [ "tituloSerie" => "Postepy Dermatol Alergol" "fecha" => "2014" "volumen" => "31" "paginaInicial" => "310" "paginaFinal" => "321" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25395928" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0495" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chromomycosis: Report of a disabling case" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Solórzano" 1 => "R. García" 2 => "G. Hernández-Córdova" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Peru Med Exp Salud Publica" "fecha" => "2011" "volumen" => "28" "paginaInicial" => "552" "paginaFinal" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22086640" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0500" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "rDNA-RFLP and ITS1 sequencing of species of the genus Fonsecaea, agents of chromoblastomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "D.S. Attili" 1 => "G.S. de Hoog" 2 => "A.A. Pizzirani-Kleiner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Med Mycol" "fecha" => "1998" "volumen" => "36" "paginaInicial" => "219" "paginaFinal" => "225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9776838" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0505" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rapid identification of Fonsecaea by duplex polymerase chain reaction in isolates from patients with chromoblastomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "T.S. De Andrade" 1 => "A.E. Cury" 2 => "L.G. de Castro" 3 => "M.H. Hirata" 4 => "R.D. Hirata" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.diagmicrobio.2006.08.024" "Revista" => array:6 [ "tituloSerie" => "Diagn Microbiol Infect Dis" "fecha" => "2007" "volumen" => "57" "paginaInicial" => "267" "paginaFinal" => "272" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17338941" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0510" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mycetoma: A review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "V. Lichon" 1 => "A. Khachemoune" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Clin Dermatol" "fecha" => "2006" "volumen" => "7" "paginaInicial" => "315" "paginaFinal" => "321" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17007542" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0515" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eumycetoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "R. Estrada" 1 => "G. Chávez-López" 2 => "G. Estrada-Chávez" 3 => "R. López-Martínez" 4 => "O. Welsh" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.09.009" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "389" "paginaFinal" => "396" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682186" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0520" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Actinomycotic mycetoma due to Actinomadura madurae]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "R. Jerez" 1 => "F. Schafer" 2 => "F. Fich" 3 => "P. García" 4 => "P. León" 5 => "S. González" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4067/S0716-10182012000400018" "Revista" => array:6 [ "tituloSerie" => "Rev Chilena Infectol" "fecha" => "2012" "volumen" => "29" "paginaInicial" => "459" "paginaFinal" => "463" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23096551" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0525" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Eumycetoma and actinomycetoma--an update on causative agents, epidemiology, pathogenesis, diagnostics and therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P. Nenoff" 1 => "W.W. van de Sande" 2 => "A.H. Fahal" 3 => "D. Reinel" 4 => "H. Schöfer" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jdv.13008" "Revista" => array:6 [ "tituloSerie" => "J Eur Acad Dermatol Venereol" "fecha" => "2015" "volumen" => "29" "paginaInicial" => "1873" "paginaFinal" => "1883" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25726758" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0530" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mycetoma caused by Phaeoacremonium parasiticum--a case confirmed with B-tubulin sequence analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A. Aguilar-Donis" 1 => "E. Torres-Guerrero" 2 => "R. Arenas-Guzmán" 3 => "F. Hernández-Hernández" 4 => "L. López-García" 5 => "S. Criales-Vera" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1439-0507.2010.01929.x" "Revista" => array:6 [ "tituloSerie" => "Mycoses" "fecha" => "2011" "volumen" => "54" "paginaInicial" => "e615" "paginaFinal" => "e618" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20701685" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0535" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Actinomycetoma and advances in its treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Welsh" 1 => "L. Vera-Cabrera" 2 => "E. Welsh" 3 => "M.C. Salinas" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.06.027" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "372" "paginaFinal" => "381" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682184" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0540" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous nocardiosis: An underdiagnosed pathogenic infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "S. Pai" 1 => "K. Pai" 2 => "S. Sharma" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "BMJ Case Rep" "fecha" => "2015" "paginaInicial" => "2015" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0545" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Systemic infection with Nocardia asteroides cured with amoxicillin/clavulanic acid, erythromycin and ultrasound-guided transcutaneous aspiration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "P.R. Stella" 1 => "E.J. Vermeulen" 2 => "C. Roggeveen" 3 => "E.H. Overbosch" 4 => "W.T. van Dorp" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Neth J Med" "fecha" => "1994" "volumen" => "44" "paginaInicial" => "178" "paginaFinal" => "181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8028693" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0550" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Treatment of actinomycetoma due to Nocardia spp. with amoxicillin-clavulanate" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Bonifaz" 1 => "P. Flores" 2 => "A. Saúl" 3 => "E. Carrasco-Gerard" 4 => "R.M. Ponce" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2133.2006.07557.x" "Revista" => array:6 [ "tituloSerie" => "Br J Dermatol" "fecha" => "2007" "volumen" => "156" "paginaInicial" => "308" "paginaFinal" => "311" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17223871" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0555" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Successful treatment of Nocardia actinomycetoma with meropenem and amikacin combination therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Ameen" 1 => "F. Vargas" 2 => "R. Arenas" 3 => "E.V. del Mercado" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-4632.2010.04748.x" "Revista" => array:6 [ "tituloSerie" => "Int J Dermatol" "fecha" => "2011" "volumen" => "50" "paginaInicial" => "443" "paginaFinal" => "445" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21413956" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib0560" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Actinomycetoma and Nocardia sp. Report of five cases treated with imipenem or imipenem plus amikacin]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A. Fuentes" 1 => "R. Arenas" 2 => "M. Reyes" 3 => "R.F. Fernández" 4 => "R. Zacarías" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Gac Med Mex" "fecha" => "2006" "volumen" => "142" "paginaInicial" => "247" "paginaFinal" => "252" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16875355" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0565" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mycetoma medical therapy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "O. Welsh" 1 => "H.M. Al-Abdely" 2 => "M.C. Salinas-Carmona" 3 => "A.H. Fahal" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1371/journal.pntd.0003218" "Revista" => array:5 [ "tituloSerie" => "PLoS Negl Trop Dis" "fecha" => "2014" "volumen" => "8" "paginaInicial" => "e3218" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25330342" "web" => "Medline" ] ] ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0570" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Phaeohyphomycosis caused by Cladophialophora bantiana" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "L. Martínez-Lamas" 1 => "M. Álvarez" 2 => "J. Llovo" 3 => "J. Gené" 4 => "J. Cano" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.riam.2013.05.004" "Revista" => array:6 [ "tituloSerie" => "Rev Iberoam Micol" "fecha" => "2014" "volumen" => "31" "paginaInicial" => "203" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23727472" "web" => "Medline" ] ] ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0575" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Opportunistic filamentous mycoses: Aspergillosis, mucormycosis, phaeohyphomycosis and hyalohyphomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Perusquía-Ortiz" 1 => "D. Vázquez-González" 2 => "A. Bonifaz" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1610-0387.2012.07994.x" "Revista" => array:6 [ "tituloSerie" => "J Dtsch Dermatol Ges" "fecha" => "2012" "volumen" => "10" "paginaInicial" => "611" "paginaFinal" => "621" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22925358" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0580" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Feohifomicosis causada por Colletotrichum gloeosporioides y Alternaria infectoria en un paciente trasplantado renal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Ogawa" 1 => "V. Reis" 2 => "P. Godoy" 3 => "F. Gatti de Menezes" 4 => "M. Enokihara" …1 ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.4067/S0716-10182014000400014" "Revista" => array:6 [ "tituloSerie" => "Rev Chilena Infectol" "fecha" => "2014" "volumen" => "31" "paginaInicial" => "468" "paginaFinal" => "472" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0585" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous and subcutaneous phaeohyphomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Skinmed" "fecha" => "2010" "volumen" => "8" "paginaInicial" => "366" "paginaFinal" => "369" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0590" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Disseminated phaeohyphomycosis: Review of an emerging mycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/338636" "Revista" => array:6 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2002" "volumen" => "34" "paginaInicial" => "467" "paginaFinal" => "476" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0595" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case of cutaneous phaeohyphomycosis caused by Phaeoacremonium sp. in a renal transplant recipient" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1346-8138.12719" "Revista" => array:6 [ "tituloSerie" => "J Dermatol" "fecha" => "2015" "volumen" => "42" "paginaInicial" => "263" "paginaFinal" => "266" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib0600" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subcutaneous phaeohyphomycosis caused by Exophiala equina, with susceptibility to eight antifungal drugs" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1099/jmm.0.057406-0" "Revista" => array:6 [ "tituloSerie" => "J Med Microbiol" "fecha" => "2013" "volumen" => "62" "paginaInicial" => "797" "paginaFinal" => "800" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib0605" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subcutaneous phaeohyphomycosis due to Alternaria dennisii in an 85-year-old immunocompromised patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2340/00015555-2343" "Revista" => array:6 [ "tituloSerie" => "Acta Derm Venereol" "fecha" => "2016" "volumen" => "96" "paginaInicial" => "701" "paginaFinal" => "702" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib0610" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Subcutaneous mycoses: An aetiological study of 15 cases in a tertiary care hospital at Dibrugarh, Assam, Northeast India" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11046-015-9861-x" "Revista" => array:6 [ "tituloSerie" => "Mycopathologia" "fecha" => "2015" "volumen" => "179" "paginaInicial" => "425" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib0615" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyalohyphomycosis. Cutaneous manifestations of infections in the immunocompromised host" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:5 [ "fecha" => "2012" "paginaInicial" => "65" "paginaFinal" => "88" "editorial" => "Springer" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib0620" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Micosis subcutánea postraumática por Fusarium solani" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Iberoam Micol" "fecha" => "2003" "volumen" => "20" "paginaInicial" => "29" "paginaFinal" => "30" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib0625" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Localized cutaneous hyalohyphomycosis caused by a Fusarium species infection in a renal transplant patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ …5] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Clin Microbiol" "fecha" => "2003" "volumen" => "41" "paginaInicial" => "905" "paginaFinal" => "907" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib0630" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fusariosis diseminada en paciente con leucemia mieloblástica aguda" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Actas Dermosifioliogr" "fecha" => "2002" "volumen" => "93" "paginaInicial" => "118" "paginaFinal" => "121" ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib0635" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "[Splenic hyalohyphomycosis. Case report]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.riam.2010.10.002" "Revista" => array:6 [ "tituloSerie" => "Rev Iberoam Micol" "fecha" => "2010" "volumen" => "27" "paginaInicial" => "203" "paginaFinal" => "206" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 59 => array:3 [ "identificador" => "bib0640" "etiqueta" => "60" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Use of mycological, nested PCR, and real-time PCR methods on BAL fluids for detection of Aspergillus fumigatus and A. flavus in solid organ transplant recipients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11046-013-9657-9" "Revista" => array:6 [ "tituloSerie" => "Mycopathologia" "fecha" => "2013" "volumen" => "176" "paginaInicial" => "377" "paginaFinal" => "385" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 60 => array:3 [ "identificador" => "bib0645" "etiqueta" => "61" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/1469-0691.12660" "Revista" => array:7 [ "tituloSerie" => "Clin Microbiol Infect" "fecha" => "2014" "volumen" => "20" "numero" => "Suppl 3" "paginaInicial" => "27" "paginaFinal" => "46" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 61 => array:3 [ "identificador" => "bib0650" "etiqueta" => "62" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lobomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ …2] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.09.014" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "420" "paginaFinal" => "424" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 62 => array:3 [ "identificador" => "bib0655" "etiqueta" => "63" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lobomicosis: reporte de un caso" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ …3] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Dermatol Peru" "fecha" => "2012" "volumen" => "22" "paginaInicial" => "111" "paginaFinal" => "114" ] ] ] ] ] ] 63 => array:3 [ "identificador" => "bib0660" "etiqueta" => "64" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enzymatic isolation of Lacazia loboi cells from skin lesions of lobomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ …6] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/13693780802127177" "Revista" => array:6 [ "tituloSerie" => "Med Mycol" "fecha" => "2009" "volumen" => "47" "paginaInicial" => "119" "paginaFinal" => "123" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 64 => array:3 [ "identificador" => "bib0665" "etiqueta" => "65" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cutaneous zygomycosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.09.013" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "413" "paginaFinal" => "419" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 65 => array:3 [ "identificador" => "bib0670" "etiqueta" => "66" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The sinus that breeds fungus: Subcutaneous zygomycosis caused by basidiobolus ranarum at the injection site" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1155/2013/534192" "Revista" => array:5 [ "tituloSerie" => "Case Rep Infect Dis" "fecha" => "2013" "volumen" => "2013" "paginaInicial" => "534192" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 66 => array:3 [ "identificador" => "bib0675" "etiqueta" => "67" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rhinofacial conidiobolus coronatus infection presenting with nasal enlargement" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s15010-008-8056-5" "Revista" => array:6 [ "tituloSerie" => "Infection" "fecha" => "2008" "volumen" => "36" "paginaInicial" => "594" "paginaFinal" => "596" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] 67 => array:3 [ "identificador" => "bib0680" "etiqueta" => "68" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Rhinofacial conidiobolomycosis (entomophthoramycosis)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ …4] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.clindermatol.2011.09.012" "Revista" => array:6 [ "tituloSerie" => "Clin Dermatol" "fecha" => "2012" "volumen" => "30" "paginaInicial" => "409" "paginaFinal" => "412" "link" => array:1 [ 0 => array:2 [ …2] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15782190/0000010700000010/v1_201611260103/S1578219016302402/v1_201611260103/en/main.assets" "Apartado" => array:4 [ "identificador" => "6150" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Review" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000010/v1_201611260103/S1578219016302402/v1_201611260103/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302402?idApp=UINPBA000044"]

Statistics

Review

Cutaneous Involvement in the Deep Mycoses: A Literature Review. Part I—Subcutaneous Mycoses

Afectación cutánea en las micosis profundas: una revisión de la literatura. Parte 1: micosis subcutáneas

J.E. Carrasco-Zubera,

Corresponding author

juaneduardocarrasco@gmail.com

Corresponding author.

, C. Navarrete-Dechentb, A. Bonifazc, F. Fichb, V. Vial-Letelierb, D. Berroeta-Maurizianob

a Unidad de Dermatología, consultorio adosado de especialidades, Hospital Regional de Valdivia, Valdivia, Chile

b Departamento de Dermatología, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile

c Departamento de Micología, Hospital General de México, Ciudad de México, Mexico

Read

23046

Times
was read the article

4660

Total PDF

18386

Total HTML

Share statistics

 array:24 [
  "pii" => "S1578219016302402"
  "issn" => "15782190"
  "doi" => "10.1016/j.adengl.2016.05.026"
  "estado" => "S300"
  "fechaPublicacion" => "2016-12-01"
  "aid" => "1456"
  "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 1
  "subdocumento" => "ssu"
  "cita" => "Actas Dermosifiliogr. 2016;107:806-15"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1890
    "formatos" => array:3 [
      "EPUB" => 46
      "HTML" => 1398
      "PDF" => 446
    ]
  ]
  "Traduccion" => array:1 [
    "es" => array:19 [
      "pii" => "S000173101630182X"
      "issn" => "00017310"
      "doi" => "10.1016/j.ad.2016.05.017"
      "estado" => "S300"
      "fechaPublicacion" => "2016-12-01"
      "aid" => "1456"
      "copyright" => "AEDV"
      "documento" => "article"
      "crossmark" => 1
      "subdocumento" => "ssu"
      "cita" => "Actas Dermosifiliogr. 2016;107:806-15"
      "abierto" => array:3 [
        "ES" => true
        "ES2" => true
        "LATM" => true
      ]
      "gratuito" => true
      "lecturas" => array:2 [
        "total" => 777
        "formatos" => array:3 [
          "EPUB" => 4
          "HTML" => 585
          "PDF" => 188
        ]
      ]
      "es" => array:14 [
        "idiomaDefecto" => true
        "cabecera" => "<span class="elsevierStyleTextfn">Revisi&#243;n</span>"
        "titulo" => "Afectaci&#243;n cut&#225;nea en las micosis profundas&#58; una revisi&#243;n de la literatura&#46; Parte 1&#58; micosis subcut&#225;neas"
        "tienePdf" => "es"
        "tieneTextoCompleto" => "es"
        "tieneResumen" => array:3 [
          0 => "es"
          1 => "es"
          2 => "en"
        ]
        "paginas" => array:1 [
          0 => array:2 [
            "paginaInicial" => "806"
            "paginaFinal" => "815"
          ]
        ]
        "titulosAlternativos" => array:1 [
          "en" => array:1 [
            "titulo" => "Cutaneous Involvement in the Deep Mycoses&#58; A Literature Review&#46; Part I&#8212;Subcutaneous Mycoses"
          ]
        ]
        "contieneResumen" => array:2 [
          "es" => true
          "en" => true
        ]
        "contieneTextoCompleto" => array:1 [
          "es" => true
        ]
        "contienePdf" => array:1 [
          "es" => true
        ]
        "resumenGrafico" => array:2 [
          "original" => 1
          "multimedia" => array:5 [
            "identificador" => "fig0030"
            "tipo" => "MULTIMEDIAFIGURA"
            "mostrarFloat" => false
            "mostrarDisplay" => true
            "figura" => array:1 [
              0 => array:4 [
                "imagen" => "fx1.jpeg"
                "Alto" => 772
                "Ancho" => 1333
                "Tamanyo" => 98146
              ]
            ]
          ]
        ]
        "autores" => array:1 [
          0 => array:2 [
            "autoresLista" => "J&#46;E&#46; Carrasco-Zuber, C&#46; Navarrete-Dechent, A&#46; Bonifaz, F&#46; Fich, V&#46; Vial-Letelier, D&#46; Berroeta-Mauriziano"
            "autores" => array:6 [
              0 => array:2 [
                "nombre" => "J&#46;E&#46;"
                "apellidos" => "Carrasco-Zuber"
              ]
              1 => array:2 [
                "nombre" => "C&#46;"
                "apellidos" => "Navarrete-Dechent"
              ]
              2 => array:2 [
                "nombre" => "A&#46;"
                "apellidos" => "Bonifaz"
              ]
              3 => array:2 [
                "nombre" => "F&#46;"
                "apellidos" => "Fich"
              ]
              4 => array:2 [
                "nombre" => "V&#46;"
                "apellidos" => "Vial-Letelier"
              ]
              5 => array:2 [
                "nombre" => "D&#46;"
                "apellidos" => "Berroeta-Mauriziano"
              ]
            ]
          ]
        ]
        "resumen" => array:1 [
          0 => array:3 [
            "titulo" => "Graphical abstract"
            "clase" => "graphical"
            "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0030"></elsevierMultimedia></p></span>"
          ]
        ]
      ]
      "idiomaDefecto" => "es"
      "Traduccion" => array:1 [
        "en" => array:9 [
          "pii" => "S1578219016302402"
          "doi" => "10.1016/j.adengl.2016.05.026"
          "estado" => "S300"
          "subdocumento" => ""
          "abierto" => array:3 [
            "ES" => true
            "ES2" => true
            "LATM" => true
          ]
          "gratuito" => true
          "lecturas" => array:1 [
            "total" => 0
          ]
          "idiomaDefecto" => "en"
          "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302402?idApp=UINPBA000044"
        ]
      ]
      "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S000173101630182X?idApp=UINPBA000044"
      "url" => "/00017310/0000010700000010/v1_201611260105/S000173101630182X/v1_201611260105/es/main.assets"
    ]
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1578219016302414"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.05.027"
    "estado" => "S300"
    "fechaPublicacion" => "2016-12-01"
    "aid" => "1457"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "ssu"
    "cita" => "Actas Dermosifiliogr. 2016;107:816-22"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1382
      "formatos" => array:3 [
        "EPUB" => 45
        "HTML" => 957
        "PDF" => 380
      ]
    ]
    "en" => array:14 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
      "titulo" => "Cutaneous involvement in the Deep Mycoses&#58; A Review&#46; Part II&#8212;Systemic Mycoses"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => array:3 [
        0 => "en"
        1 => "en"
        2 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "816"
          "paginaFinal" => "822"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Afectaci&#243;n cut&#225;nea en las micosis profundas&#58; una revisi&#243;n de la literatura&#46; Parte II&#46; Micosis sist&#233;micas"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 1
        "multimedia" => array:5 [
          "identificador" => "fig0030"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => false
          "mostrarDisplay" => true
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "fx1.jpeg"
              "Alto" => 888
              "Ancho" => 1333
              "Tamanyo" => 143314
            ]
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;E&#46; Carrasco-Zuber, C&#46; Navarrete-Dechent, A&#46; Bonifaz, F&#46; Fich, V&#46; Vial-Letelier, D&#46; Berroeta-Mauriziano"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "J&#46;E&#46;"
              "apellidos" => "Carrasco-Zuber"
            ]
            1 => array:2 [
              "nombre" => "C&#46;"
              "apellidos" => "Navarrete-Dechent"
            ]
            2 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Bonifaz"
            ]
            3 => array:2 [
              "nombre" => "F&#46;"
              "apellidos" => "Fich"
            ]
            4 => array:2 [
              "nombre" => "V&#46;"
              "apellidos" => "Vial-Letelier"
            ]
            5 => array:2 [
              "nombre" => "D&#46;"
              "apellidos" => "Berroeta-Mauriziano"
            ]
          ]
        ]
      ]
      "resumen" => array:1 [
        0 => array:3 [
          "titulo" => "Graphical abstract"
          "clase" => "graphical"
          "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><elsevierMultimedia ident="fig0030"></elsevierMultimedia></p></span>"
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731016301831"
        "doi" => "10.1016/j.ad.2016.06.001"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016301831?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302414?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000010/v1_201611260103/S1578219016302414/v1_201611260103/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1578219016302232"
    "issn" => "15782190"
    "doi" => "10.1016/j.adengl.2016.09.001"
    "estado" => "S300"
    "fechaPublicacion" => "2016-12-01"
    "aid" => "1470"
    "copyright" => "Elsevier Espa&#241;a&#44; S&#46;L&#46;U&#46; and AEDV"
    "documento" => "article"
    "crossmark" => 1
    "subdocumento" => "sco"
    "cita" => "Actas Dermosifiliogr. 2016;107:801-5"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1248
      "formatos" => array:3 [
        "EPUB" => 53
        "HTML" => 859
        "PDF" => 336
      ]
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Opinion Article</span>"
      "titulo" => "The Importance of Innate Immunity in Acne"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "801"
          "paginaFinal" => "805"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "es" => array:1 [
          "titulo" => "Importancia de la inmunidad innata en el acn&#233;"
        ]
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig0005"
          "etiqueta" => "Figure 1"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "gr1.jpeg"
              "Alto" => 2057
              "Ancho" => 2828
              "Tamanyo" => 215788
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Inflammatory pathways involved in the pathogenesis of acne vulgaris&#46; <span class="elsevierStyleItalic">Propionibacterium acnes</span> can interact directly with T lymphocytes and favor the release of inflammatory cytokines such as IL-17&#46; In addition&#44; synthesis of other inflammatory cytokines is favored through the TLR-2 and TLR-4 receptors of the perifollicular inflammatory cells&#46; The NRLP3 inflammasome also plays an important role in the production of IL-1&#946;&#46; The release of all these proinflammatory cytokines into the extracellular medium leads to the inflammatory-cell-mediated rupture of the follicular wall&#46; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">acnes</span> also induces an increase in several matrix metalloproteinases through the transcription factor activator protein 1&#46; These enzymes play an active role in tissue destruction and scarring&#46; Finally&#44; the bacteria are capable of causing the inveterate activation of antimicrobial peptides that perpetuate the inflammatory microenvironment&#46; AMP indicates antimicrobial peptide&#59; AP&#44; activator protein&#59; IL&#44; interleukin&#59; MMPs&#44; matrix metalloproteinases&#59; N&#44; neutrophil&#59; NLR&#44; NOD-like receptor&#59; <span class="elsevierStyleItalic">P acnes</span>&#44; <span class="elsevierStyleItalic">Propionibacterium acnes</span>&#59; TL&#44; T lymphocyte&#59; TLR&#44; toll-like receptor&#59; TNF&#44; tumor necrosis factor&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "O&#46;M&#46; Moreno-Arrones, P&#46; Boixeda"
          "autores" => array:2 [
            0 => array:2 [
              "nombre" => "O&#46;M&#46;"
              "apellidos" => "Moreno-Arrones"
            ]
            1 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Boixeda"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "Traduccion" => array:1 [
      "es" => array:9 [
        "pii" => "S0001731016302617"
        "doi" => "10.1016/j.ad.2016.07.005"
        "estado" => "S300"
        "subdocumento" => ""
        "abierto" => array:3 [
          "ES" => true
          "ES2" => true
          "LATM" => true
        ]
        "gratuito" => true
        "lecturas" => array:1 [
          "total" => 0
        ]
        "idiomaDefecto" => "es"
        "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0001731016302617?idApp=UINPBA000044"
      ]
    ]
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302232?idApp=UINPBA000044"
    "url" => "/15782190/0000010700000010/v1_201611260103/S1578219016302232/v1_201611260103/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Review</span>"
    "titulo" => "Cutaneous Involvement in the Deep Mycoses&#58; A Literature Review&#46; Part I&#8212;Subcutaneous Mycoses"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "806"
        "paginaFinal" => "815"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "J&#46;E&#46; Carrasco-Zuber, C&#46; Navarrete-Dechent, A&#46; Bonifaz, F&#46; Fich, V&#46; Vial-Letelier, D&#46; Berroeta-Mauriziano"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "J&#46;E&#46;"
            "apellidos" => "Carrasco-Zuber"
            "email" => array:1 [
              0 => "juaneduardocarrasco&#64;gmail&#46;com"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff0005"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor0005"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "C&#46;"
            "apellidos" => "Navarrete-Dechent"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "A&#46;"
            "apellidos" => "Bonifaz"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff0015"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "F&#46;"
            "apellidos" => "Fich"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "V&#46;"
            "apellidos" => "Vial-Letelier"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "D&#46;"
            "apellidos" => "Berroeta-Mauriziano"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff0010"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:3 [
          0 => array:3 [
            "entidad" => "Unidad de Dermatolog&#237;a&#44; consultorio adosado de especialidades&#44; Hospital Regional de Valdivia&#44; Valdivia&#44; Chile"
            "etiqueta" => "a"
            "identificador" => "aff0005"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Dermatolog&#237;a&#44; Escuela de Medicina&#44; Pontificia Universidad Cat&#243;lica de Chile&#44; Santiago&#44; Chile"
            "etiqueta" => "b"
            "identificador" => "aff0010"
          ]
          2 => array:3 [
            "entidad" => "Departamento de Micolog&#237;a&#44; Hospital General de M&#233;xico&#44; Ciudad de M&#233;xico&#44; Mexico"
            "etiqueta" => "c"
            "identificador" => "aff0015"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor0005"
            "etiqueta" => "&#8270;"
            "correspondencia" => "Corresponding author&#46;"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "es" => array:1 [
        "titulo" => "Afectaci&#243;n cut&#225;nea en las micosis profundas&#58; una revisi&#243;n de la literatura&#46; Parte 1&#58; micosis subcut&#225;neas"
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 1
      "multimedia" => array:5 [
        "identificador" => "fig0030"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 772
            "Ancho" => 1333
            "Tamanyo" => 98146
          ]
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The deep mycoses are uncommon infections caused by fungi&#59; they are divided into subcutaneous and systemic mycoses&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">1</span></a> While skin manifestations always occur in subcutaneous mycoses&#44; or <span class="elsevierStyleItalic">mycoses of implantation</span>&#44; as they are also known&#44; they are only occasionally seen in systemic mycoses&#46; In such cases&#44; the skin is affected either directly&#44; by the penetration of the fungus into the dermis&#44; or indirectly&#44; by an infection that has spread from a deeper focus&#46; According to Rezusta et al&#46;&#44;<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">2</span></a> the majority of subcutaneous and systemic mycoses in Spain are imported&#44; with just a few exceptions &#40;e&#46;g&#46;&#44; mucormycosis&#41;&#46; Epidemiological data on the prevalence and incidence of mycoses in Spain are lacking&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Subcutaneous Mycoses</span><p id="par0010" class="elsevierStylePara elsevierViewall">The subcutaneous mycoses comprise several clinical entities caused by invasion of the skin and subcutaneous tissue by saprophytic fungi that live in soil and vegetation&#46; However&#44; even though cuts and wounds are very common in people living in rural areas&#44; overall&#44; there are very few cases of subcutaneous mycoses&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">1</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">The typical route of entry for the fungus is traumatic inoculation through contaminated material such as splinters&#44; thorns&#44; or other sharp objects&#44; explaining why subcutaneous mycoses are also referred to as <span class="elsevierStyleItalic">mycoses of implantation</span>&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">Although the fungi responsible for subcutaneous mycoses are taxonomically heterogeneous&#44; they are unified by the fact that they share the same route of entry&#46; Any of these infections can affect people who have traveled to endemic areas&#44; even years after their return&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The most common subcutaneous mycoses are sporotrichosis&#44; chromoblastomycosis&#44; and mycetoma&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">1</span></a> Other less common entities are lacaziosis&#44; phaeohyphomycosis&#44; hyalohyphomycosis&#44; and conidiobolomycosis&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Sporotrichosis</span><p id="par0030" class="elsevierStylePara elsevierViewall">Sporotrichosis is a subacute or chronic infection caused by dimorphic fungi&#44; the most common of which is <span class="elsevierStyleItalic">Sporothrix schenckii&#46;</span><a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">4&#44;5</span></a> These fungi are universal&#44; although they are more common in tropical and subtropical areas&#46; The estimated incidence of sporotrichosis in South America is between 48 and 60 cases per 100<span class="elsevierStyleHsp" style=""></span>000 population a year&#46;<a class="elsevierStyleCrossRefs" href="#bib0370"><span class="elsevierStyleSup">6&#44;7</span></a> Only a few autochthonous cases have been reported in Spain and other parts of Europe&#44;<a class="elsevierStyleCrossRef" href="#bib0380"><span class="elsevierStyleSup">8</span></a> and the majority of cases in these areas are imported&#46;<a class="elsevierStyleCrossRef" href="#bib0385"><span class="elsevierStyleSup">9</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">The causative agents belong to a species complex known as <span class="elsevierStyleItalic">S schenckii</span>&#44;<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">10&#44;11</span></a> which comprises <span class="elsevierStyleItalic">Sporothrix brasiliensis</span>&#44; <span class="elsevierStyleItalic">Sporothrix mexicana</span>&#44; <span class="elsevierStyleItalic">Sporothrix luriei</span>&#44; <span class="elsevierStyleItalic">Sporothrix pallida</span> &#40;previously <span class="elsevierStyleItalic">Sporothrix albicans</span>&#41;&#44; and <span class="elsevierStyleItalic">Sporothrix schenckii</span> sensu lato &#40;sl&#46;&#41;&#44; which is the most common of the five&#46;<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">12</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">After an incubation period of 15 to 30 days&#44; traumatic inoculation by <span class="elsevierStyleItalic">Sporothrix</span> spp&#46; results in a chronic infection characterized by nodular lesions in the cutaneous and subcutaneous tissue associated with lymphangitis in the affected area&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Sporothrix</span> spp<span class="elsevierStyleItalic">&#46;</span> live in vegetation&#44; plants&#44; or plant debris in the soil&#44; and therefore infections are more common in agricultural workers and people working in open areas&#46; Sporotrichosis is considered an occupational disease in forest wardens&#44; horticulturists&#44; gardeners&#44; and farm workers in general&#46;<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">4&#44;13</span></a> Alcoholism and diabetes have also been described as risk factors&#46; Immunosuppression&#44; regardless of the cause&#44; is also a predisposing factor for disseminated or systemic disease&#46;<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">1</span></a> The disease can also be acquired through manipulation of the fungus in a laboratory setting&#46; Finally&#44; there was an interesting epidemic in southern Brazil in which sporotrichosis was transmitted to humans through cat scratches&#44; suggesting that it might be a zoonotic infection&#46;<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">14</span></a> Most of the species isolated in these cases were <span class="elsevierStyleItalic">S brasiliensis</span>&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Clinical Forms<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">5</span></a></span><p id="par0050" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#41;</span><p id="par0055" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Lymphocutaneous sporotrichosis&#46;</span> Also known as <span class="elsevierStyleItalic">lymphangitic sporotrichosis</span>&#44; this clinical form accounts for over 75&#37; of all cases of sporotrichosis&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">15</span></a> The lesions occur in exposed areas&#44; such as the hands&#44; face&#44; and feet&#46; The disease starts as a painless purple or blackish nodule that erodes into a small ulcer &#40;sporotrichotic chancre&#41; with swollen edges&#44; a painful granulomatous center&#44; and minimal discharge&#46; This is followed by lymphangitis with secondary nodules along the line of lymphatic drainage that can progress to ulcers&#59; this characteristic pattern is known as <span class="elsevierStyleItalic">sporotrichoid spread</span> &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">6</span></a> The patient&#39;s general health is not affected&#46;<a class="elsevierStyleCrossRef" href="#bib0415"><span class="elsevierStyleSup">15</span></a> The course of disease varies according to the host&#39;s immune response&#44; the virulence of the strain&#44; the size of the inoculum&#44; and the depth of the lesion&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#41;</span><p id="par0060" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Fixed sporotrichosis&#46;</span> This variant is characterized by the presence of a solitary lesion&#46; The infection is limited and generally presents as a slow-growing&#44; less progressive verrucous plaque&#46; Fixed sporotrichosis does not normally affect the lymph vessels and is more common in endemic areas&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">16</span></a></p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#41;</span><p id="par0065" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Other clinical forms</span>&#58;</p></li></ul></p><p id="par0070" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Osteoarticular sporotrichosis&#46;</span> This is a disseminated form of sporotrichosis that affects the bones and joints&#59; it is the most common form of systemic involvement&#46;<a class="elsevierStyleCrossRef" href="#bib0425"><span class="elsevierStyleSup">17</span></a></p><p id="par0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Primary pulmonary sporotrichosis&#46;</span> This variant preferentially affects immunosuppressed patients and is acquired by inhalation&#46; It mimics cavitary tuberculosis&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">16</span></a></p><p id="par0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Metastatic pulmonary sporotrichosis&#46;</span> The metastatic form of pulmonary sporotrichosis is uncommon and has only been described in isolated cases&#46; It occurs in immunocompromised patients&#44; particularly those with human immunodeficiency virus &#40;HIV&#41; infection in the AIDS stage&#46;<a class="elsevierStyleCrossRef" href="#bib0430"><span class="elsevierStyleSup">18</span></a></p><p id="par0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Widespread invasion&#46;</span> Disseminated disease is rare in sporotrichosis&#44; although meningeal and ocular involvement have been described in immunosuppressed patients with uncontrolled diabetes or chronic alcoholism&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">In Mexico&#44; like other countries in Latin America &#40;home to the largest case series and the most experience with sporotrichosis&#41;&#44; lymphocutaneous sporotrichosis accounts for 60&#37; to 80&#37; of all cases of sporotrichosis&#44; fixed cutaneous sporotrichosis for 10&#37; to 30&#37;&#44; and other clinical forms for 1&#37; to 2&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">16</span></a></p><p id="par0095" class="elsevierStylePara elsevierViewall">Sporotrichosis must be distinguished from tuberculosis&#44; leishmania&#44; tularemia&#44; cutaneous nocardiosis&#44; nontuberculous mycobacterial infections&#44; mycetoma&#44; chromoblastomycosis&#44; and lepromatous leprosy&#46; Sporotrichoid &#40;lymphangitic&#41; spread can be seen in many of these conditions&#44; which must be contemplated in the differential diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">19</span></a></p><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Diagnosis</span><p id="par0100" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">1&#46;</span><p id="par0105" class="elsevierStylePara elsevierViewall">Pus &#40;aspirated from nodules&#41;&#46; Direct microscopic examination is of no value in sporotrichosis&#44; as lesions contain very few yeast forms&#46; Sabouraud dextrose agar &#40;SDA&#41; and SDA with antibiotics &#40;chloramphenicol and cycloheximide&#41; can be used for culture&#44; which produces yeast colonies that are initially white and then darken &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Growth is characteristically quick &#40;3-5 days&#41;<a class="elsevierStyleCrossRef" href="#bib0440"><span class="elsevierStyleSup">20</span></a> but 2 weeks are needed to identify the fungus and confirm diagnosis&#46;<a class="elsevierStyleCrossRef" href="#bib0420"><span class="elsevierStyleSup">16</span></a> Molecular identification by polymerase chain reaction &#40;PCR&#41; analysis is also possible&#46;<a class="elsevierStyleCrossRefs" href="#bib0390"><span class="elsevierStyleSup">10&#44;21</span></a></p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">2&#46;</span><p id="par0110" class="elsevierStylePara elsevierViewall">Histology&#46; Histologic examination reveals a nonspecific mixed granulomatous reaction with neutrophilic microabscesses&#46; The fungus presents as a small cigar-shaped yeast form sometimes surrounded by characteristic radiating eosinophilic material known as an <span class="elsevierStyleItalic">asteroid body</span>&#46; While asteroid bodies can aid diagnosis&#44; they are not pathognomic&#44;<a class="elsevierStyleCrossRefs" href="#bib0420"><span class="elsevierStyleSup">16&#44;20</span></a> as they are also found intracellularly in sarcoidosis&#44; silicosis&#44; and lacaziosis &#40;lobomycosis&#41;&#46; Extracellular asteroid bodies&#44; however&#44; are more characteristic of sporotrichosis&#46; Several specimens may be needed to visualize the microorganisms&#44; although they are easier to find in the case of disseminated or visceral disease&#46;</p></li></ul></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Treatment</span><p id="par0115" class="elsevierStylePara elsevierViewall">Sporotrichosis may resolve spontaneously in some cases&#44; such as during pregnancy&#44; although paradoxically dissemination has also been reported in pregnant women&#46;<ul class="elsevierStyleList" id="lis0015"><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">1&#46;</span><p id="par0120" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Saturated solution of potassium iodide&#46;</span> Treatment with potassium iodide&#44; as a saturated solution&#44; is started at 5 drops per meal&#46; This initial dose is then gradually increased to 20 or 30 drops per meal according to tolerance levels&#46; The treatment should be maintained for 3 to 4 weeks after resolution of the clinical manifestations&#46; The mechanism of action is unknown&#44; although potassium iodide is thought to act as an immunostimulant&#46; Adverse effects include a metallic taste in the mouth&#44; rhinitis&#44; expectoration&#44; urticaria&#44; petechiae&#44; bullous or acneiform rash&#44; vasculitis&#44; and induction of hypothyroidism or hyperthyroidism&#46; Potassium iodide is contraindicated during pregnancy&#46;<a class="elsevierStyleCrossRefs" href="#bib0440"><span class="elsevierStyleSup">20&#44;22</span></a></p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">2&#46;</span><p id="par0125" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Itraconazole</span> 200<span class="elsevierStyleHsp" style=""></span>mg&#47;d for 3 to 6 months&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">22</span></a> This is the first-line treatment recommended in most treatment guidelines&#46; It tends to be a little more expensive than potassium iodide&#44; but it has fewer adverse effects&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">3&#46;</span><p id="par0130" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Other options</span>&#46; Terbinafine 250-1000<span class="elsevierStyleHsp" style=""></span>mg&#47;d for 3 to 6 months<a class="elsevierStyleCrossRefs" href="#bib0455"><span class="elsevierStyleSup">23&#44;24</span></a>&#59; fluconazole 400<span class="elsevierStyleHsp" style=""></span>mg&#47;d for 3 to 6 months<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">22</span></a>&#59; amphotericin B &#40;deoxycholate&#41; 0&#46;5-1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d for systemic disease or liposomal or lipid formulations of amphotericin B at a dose of 3-5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">22</span></a>&#59; local heat or thermotherapy for 2 or 3 months&#44;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">22</span></a> or a combination of the above treatments &#40;potassium iodide with itraconazole&#44; itraconazole with terbinafine&#44; and terbinafine with potassium iodide&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">25</span></a> The addition of photodynamic therapy with methyl aminolevulinate or even better intralesional methylene blue 1&#37; &#40;combined or not with itraconazole&#41; has produced good results in vitro and in 1 patient&#46;<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">26</span></a></p></li></ul></p><p id="par0135" class="elsevierStylePara elsevierViewall">Surgery can have an important role in osteoarticular sporotrichosis&#46;<a class="elsevierStyleCrossRef" href="#bib0450"><span class="elsevierStyleSup">22</span></a> Debridement and arthrodesis were traditionally considered the treatments of choice but prosthetic joint replacement followed by long-term antifungal treatment has also been described as a viable option</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleLabel">1&#46;1</span><span class="elsevierStyleSectionTitle" id="sect0060">Chromoblastomycosis &#40;Chromomycosis&#41;</span><p id="par0140" class="elsevierStylePara elsevierViewall">Chromoblastomycosis&#44; also known as <span class="elsevierStyleItalic">chromomycosis</span>&#44; is a chronic polymorphic fungal infection of the skin and subcutaneous tissue&#46; It is caused by several species of melanized or dematiaceous fungi&#44; which produce a dark pigment&#46; The parasitic forms of these fungi are called <span class="elsevierStyleItalic">fumagoid</span> or <span class="elsevierStyleItalic">muriform</span> cells &#40;sclerotic bodies&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">27&#8211;30</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">The most common species that cause chromoblastomycosis are <span class="elsevierStyleItalic">Fonsecaea pedrosoi</span>&#44; <span class="elsevierStyleItalic">Fonsecaea monophora&#44; Cladophialophora carrionii&#44; Phialophora verrucosa</span>&#44; and <span class="elsevierStyleItalic">Rhinocladiella aquaspersa</span>&#46;<a class="elsevierStyleCrossRefs" href="#bib0365"><span class="elsevierStyleSup">5&#44;27&#44;28</span></a> Most patients have a history of a traumatic injury involving wood or vegetation&#44; and over 80&#37; are rural workers in Africa&#44; Asia&#44; and South America who tend to walk barefoot&#46; The fungi responsible for chromoblastomycosis have been found worldwide&#44; though they are more common in tropical and subtropical countries&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">27</span></a></p><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Clinical Forms</span><p id="par0150" class="elsevierStylePara elsevierViewall">The fungus generally penetrates the skin through a skin injury&#44; typically located on the lower limbs&#46;<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">31</span></a> About 1 or 2 months later&#44; the infected individual develops a papule that progresses to a slow-growing warty nodule &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The infection is limited to the subcutaneous tissue and does not spread to either muscle or bone&#44; except in immunocompromised patients&#46; Individual lesions can develop a thick cauliflower-like appearance and bacterial superinfection is common&#46; Secondary lymphedema&#44; possibly progressing to elephantiasis&#44; and squamous cell carcinoma may occur&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">27</span></a></p><elsevierMultimedia ident="fig0010"></elsevierMultimedia></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Diagnosis</span><p id="par0155" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0020"><li class="elsevierStyleListItem" id="lsti0045"><span class="elsevierStyleLabel">1&#46;</span><p id="par0160" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Direct examination&#46;</span> Direct examination of crusts and fragments of skin can reveal parasitic forms that occur in isolation or form characteristic septa &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41;&#46; The microscopic structures observed are common to all species&#46;<a class="elsevierStyleCrossRefs" href="#bib0475"><span class="elsevierStyleSup">27&#44;28</span></a></p></li><li class="elsevierStyleListItem" id="lsti0050"><span class="elsevierStyleLabel">2&#46;</span><p id="par0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Culture&#46;</span> The fungi that cause chromoblastomycosis grow slowly when cultivated on SDA with or without antibiotics &#40;chloramphenicol and cycloheximide&#41;&#59; they produce dark olivaceous or black colonies with a flat velvety surface and a raised center&#46; Distinction between species is difficult and is based on reproductive structures and molecular identification&#46;<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">30</span></a> Molecular biology techniques &#40;PCR&#41;&#44; in particular targeting internal transcribed spacer &#40;ITS&#41; regions of ribosomal DNA &#40;rDNA&#41;&#44; are also useful&#46;<a class="elsevierStyleCrossRefs" href="#bib0500"><span class="elsevierStyleSup">32&#44;33</span></a></p></li><li class="elsevierStyleListItem" id="lsti0055"><span class="elsevierStyleLabel">3&#46;</span><p id="par0170" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Histology&#46;</span> Histologic examination shows characteristic pseudoepitheliomatous hyperplasia in the epidermis and a mixed granulomatous inflammatory infiltrate with giant cells containing characteristic round fungal structures &#40;<a class="elsevierStyleCrossRef" href="#fig0010">Fig&#46; 2</a>&#41; in the dermis&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">27</span></a></p></li></ul></p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Treatment</span><p id="par0175" class="elsevierStylePara elsevierViewall">Chromoblastomycosis is extremely difficult to treat and is often refractory to diverse options&#44; including nonpharmacological treatments such as curettage&#44; electrocoagulation&#44; and cryosurgery&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">5</span></a> Antifungals must be maintained for at least 6 months&#44; and while they may produce a favorable clinical outcome&#44; recurrences during or after therapy are common&#46; Treatment should be terminated when all the lesions disappear&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">27</span></a></p><p id="par0180" class="elsevierStylePara elsevierViewall">Other treatments include surgical resection of small lesions&#59; local cryosurgery &#40;in association with an antifungal to prevent lymphatic spread&#41;&#59; itraconazole 200-400<span class="elsevierStyleHsp" style=""></span>mg&#47;d alone or combined with 5-fluorocitosine 30<span class="elsevierStyleHsp" style=""></span>mg&#47;kg 4 times a day for 6 months&#59; terbinafine 250-500<span class="elsevierStyleHsp" style=""></span>mg&#47;d for 12 months&#44; and in the case of systemic involvement intravenous amphotericin B at a dose of 1<span class="elsevierStyleHsp" style=""></span>mg&#47;kg or liposomal or lipid formulations of amphotericin B at a dose of 3-5<span class="elsevierStyleHsp" style=""></span>mg&#47;kg&#47;d&#46;<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">27</span></a></p></span></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Mycetoma</span><p id="par0185" class="elsevierStylePara elsevierViewall">Mycetoma is a chronic local infection caused by several species of fungi and bacteria&#46; The infection is called <span class="elsevierStyleItalic">actinomycetoma</span> when it is caused by aerobic filamentous bacteria and <span class="elsevierStyleItalic">eumycetoma</span> when it is caused by fungi&#46;<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">34</span></a> It is characterized by the formation of aggregates of the causative microorganisms in abscesses&#46; These aggregates are known as <span class="elsevierStyleItalic">grains</span> or <span class="elsevierStyleItalic">granules</span>&#46; Granules can drain through sinuses opening onto the skin or affect adjacent bones&#46; The disease advances via direct spread&#44; with very few cases of dissemination to distant sites&#46; The causative agents are generally found in the soil and they enter the body through broken skin&#46; Most cases involve rural workers&#46;</p><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Etiology</span><p id="par0190" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0025"><li class="elsevierStyleListItem" id="lsti0060"><span class="elsevierStyleLabel">1&#46;</span><p id="par0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Fungi&#46;</span> The fungi that cause eumycetoma produce white or dark granules&#46; They are particularly common in Africa&#44; India&#44; and Mexico&#46; Dark granules are formed by <span class="elsevierStyleItalic">Madurella mycetomatis&#44; Trematosphaeria grisea</span>&#44; and <span class="elsevierStyleItalic">Leptosphaeria</span> senegalensis&#44;<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">35</span></a> while white granules are formed by <span class="elsevierStyleItalic">Fusarium</span> spp<span class="elsevierStyleItalic">&#46;</span>&#44; <span class="elsevierStyleItalic">Acremonium</span> spp<span class="elsevierStyleItalic">&#46;</span>&#44; and <span class="elsevierStyleItalic">Aspergillus nidulans&#46;</span></p></li><li class="elsevierStyleListItem" id="lsti0065"><span class="elsevierStyleLabel">2&#46;</span><p id="par0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Filamentous bacteria or aerobic actinomycetes</span>&#46; The granules formed by these species are red &#40;<span class="elsevierStyleItalic">Actinomadura pelletieri</span>&#41;&#44; white-yellow &#40;<span class="elsevierStyleItalic">Actinomadura madurae</span>&#44; <span class="elsevierStyleItalic">Nocardia brasiliensis</span>&#44; and <span class="elsevierStyleItalic">Nocardia</span> spp&#46;&#41;&#44; or yellow-brown &#40;<span class="elsevierStyleItalic">Streptomyces somaliensis</span>&#41;&#46; Actinomycetes are found all over the world&#44; not just in tropical countries&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">36</span></a></p></li></ul></p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Clinical Forms</span><p id="par0205" class="elsevierStylePara elsevierViewall">The clinical characteristics of mycetoma caused by fungi and actinomycetes are very similar&#46; Lesions are more common on the feet&#44; shins&#44; and hands&#46; The earliest clinical manifestation is a hard painless nodule that spreads slowly to produce papules and sinuses that discharge fluid containing granules onto the skin surface&#46;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">35&#44;36</span></a> The original site of infection is distorted by local tissue swelling&#44; formation of chronic sinuses&#44; and late bone involvement &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41;&#46; Lesions are rarely painful&#44; except in late stages&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Diagnosis</span><p id="par0210" class="elsevierStylePara elsevierViewall">Mycetoma granules &#40;<a class="elsevierStyleCrossRef" href="#fig0015">Fig&#46; 3</a>&#41; are a key diagnostic finding and are generally found on examining discharge from sinuses or on crushing a crust taken from a lesion&#46; Microscopic examination will show whether these granules are formed by small actinomycetes or wider mycotic filaments&#46; Definitive identification requires culture&#44; which is normally carried out on SDA with or without antibiotics &#40;chloramphenicol and cycloheximide&#41;&#59; chloramphenicol alone is preferred in the case of hyaline fungi&#46; The agents can also be identified by molecular biology testing&#44; particularly PCR analysis using different markers<a class="elsevierStyleCrossRef" href="#bib0525"><span class="elsevierStyleSup">37</span></a> depending on the causative agents &#40;e&#46;g&#46;&#44; ITS regions of rDNA&#44; &#946;-tubulin&#44;<a class="elsevierStyleCrossRef" href="#bib0530"><span class="elsevierStyleSup">38</span></a> and D1&#47;D2&#41;&#46; Partial ribosomal RNA gene sequence analysis&#44; by contrast&#44; can be used to identify <span class="elsevierStyleItalic">Nocardia</span> and <span class="elsevierStyleItalic">Actinomadura</span> species&#46;<a class="elsevierStyleCrossRef" href="#bib0520"><span class="elsevierStyleSup">36</span></a> Histologic findings are similar in all forms of mycetoma&#44; and include an inflammatory center rich in polymorphonuclear cells &#40;true abscesses&#41;&#44; epithelioid cells&#44; giant cells&#44; and fibrosis&#46; The granules are located in the center of the inflammation&#46;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">35&#44;39</span></a> Imaging studies&#44; while complementary&#44; can aid diagnosis by showing soft tissue swelling&#44; osteolytic lesions&#44; and cortical thickening&#46;</p><p id="par0215" class="elsevierStylePara elsevierViewall">The differential diagnosis should include bacterial osteomyelitis&#44; tuberculous osteomyelitis&#44; hidradenitis suppurativa&#44; Kaposi sarcoma&#44; and cutaneous tuberculosis&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">35&#44;39</span></a></p></span><span id="sec0075" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Treatment</span><p id="par0220" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Actinomycetoma</span>&#46; The treatment regimen with the strongest evidence base for nocardial mycetoma is trimethoprim-sulfamethoxazole plus diaminodiphenyl sulfone &#40;dapsone&#41; for 6 months to 2 years&#46; Amoxicillin-clavulanic acid&#44; administered over 6 months&#44; can be used for refractory cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0540"><span class="elsevierStyleSup">40&#8211;42</span></a> The treatment of choice for extensive infection and&#47;or visceral involvement is amikacin combined with trimetoprim-sulfametoxazol<a class="elsevierStyleCrossRef" href="#bib0535"><span class="elsevierStyleSup">39</span></a> or meropenem&#46;<a class="elsevierStyleCrossRefs" href="#bib0555"><span class="elsevierStyleSup">43&#44;44</span></a> There have been isolated reports of successful outcomes with other agents in patients who do not respond to these treatments&#46;<a class="elsevierStyleCrossRefs" href="#bib0520"><span class="elsevierStyleSup">36&#44;39&#44;45</span></a></p><p id="par0225" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Eumycetoma</span>&#46; Unlike in actinomycetoma&#44; where pharmacological treatment is associated with good outcomes&#44; the standard treatment in eumycetoma is a combination of medical treatment and surgery&#46; Acceptable results have been reported for the use of last-generation triazoles&#44; such as itraconazole and fluconazole used alone or in combination with terbinafine&#46; These drugs are administered over a long period and only after exhausting all surgical options&#46;<a class="elsevierStyleCrossRefs" href="#bib0515"><span class="elsevierStyleSup">35&#44;45</span></a></p></span></span><span id="sec0080" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Phaeohyphomycosis</span><p id="par0230" class="elsevierStylePara elsevierViewall">Phaeohyphomycosis is a heterogeneous group of mycoses caused by dark-walled &#40;dematiaceous&#41; fungi&#46;<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">46&#44;47</span></a> These fungi are found in all climates&#44; although they are more common in tropical climates&#46; There has been a recent rise in cases among immunosuppressed patients with HIV infection or AIDS&#44; transplant recipients&#44; and diabetic patients&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0570"><span class="elsevierStyleSup">46&#44;48</span></a></p><p id="par0235" class="elsevierStylePara elsevierViewall">The most common causative agents are <span class="elsevierStyleItalic">Exophiala</span> spp<span class="elsevierStyleItalic">&#46;&#44; Bipolaris</span> spp&#46;<span class="elsevierStyleItalic">&#44; Curvularia</span> spp&#46;&#44; <span class="elsevierStyleItalic">Pleurophomopsis</span> spp<span class="elsevierStyleItalic">&#46;</span>&#44; <span class="elsevierStyleItalic">Phaeoacremonium</span> spp&#44; and <span class="elsevierStyleItalic">Alternaria</span> spp&#46; The fungi are found mainly in organic debris&#46;</p><span id="sec0085" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Clinical Forms</span><p id="par0240" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="lis0030"><li class="elsevierStyleListItem" id="lsti0070"><span class="elsevierStyleLabel">1&#46;</span><p id="par0245" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Subcutaneous phaeohyphomycosis</span>&#46; Following local trauma or inoculation with foreign material&#44; patients develop a slow-growing solitary lesion &#40;generally a cyst or a nodule&#44; or possibly a plaque or abscess&#41; normally located on the extremities &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46;<a class="elsevierStyleCrossRefs" href="#bib0580"><span class="elsevierStyleSup">48&#44;49</span></a> The differential diagnosis should include lipomas&#44; epidermal or synoviale cysts&#44; fibromas&#44; foreign body cysts&#44; and bacterial abscesses&#46;</p><elsevierMultimedia ident="fig0020"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0075"><span class="elsevierStyleLabel">2&#46;</span><p id="par0250" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Systemic or disseminated phaeohyphomycosis</span>&#46; While very rare&#44; systemic phaeohyphomycosis is very serious in immunosuppressed patients&#46;<a class="elsevierStyleCrossRef" href="#bib0590"><span class="elsevierStyleSup">50</span></a></p></li></ul></p></span><span id="sec0090" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Diagnosis</span><p id="par0255" class="elsevierStylePara elsevierViewall">Wet-mount microscopy shows diagnostic dark septate hyphae forming branches or chains &#40;<a class="elsevierStyleCrossRef" href="#fig0020">Fig&#46; 4</a>&#41;&#46; Growth is slow &#40;3-4 weeks&#41; on SDA and colonies acquire an olivaceous or dark brown color&#46; PCR analysis of markers such as &#946;-tubulin and ITS regions can be used for molecular identification&#46;<a class="elsevierStyleCrossRefs" href="#bib0595"><span class="elsevierStyleSup">51&#44;52</span></a> Biopsy reveals a cyst wall formed by palisading macrophages with mycotic hyphae&#46;<a class="elsevierStyleCrossRef" href="#bib0585"><span class="elsevierStyleSup">49</span></a></p></span><span id="sec0095" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Treatment</span><p id="par0260" class="elsevierStylePara elsevierViewall">Treatment of infections caused by <span class="elsevierStyleItalic">Exophiala</span> spp&#46; is controversial&#44; and one option that has been proposed is surgical resection&#46;<a class="elsevierStyleCrossRef" href="#bib0580"><span class="elsevierStyleSup">48</span></a> There are also no standard protocols for the treatment of <span class="elsevierStyleItalic">Alternaria</span> infections&#46;<a class="elsevierStyleCrossRef" href="#bib0605"><span class="elsevierStyleSup">53</span></a> The best option for phaeohyphomycosis appears to be a combination of antifungal therapy &#40;itraconazole&#44; ketoconazole&#44; or terbinafine&#41; and surgery&#46; <span class="elsevierStyleItalic">Exophiala</span> spp&#46; strains tend to be resistant to fluconazole&#46; Disseminated infections are treated with amphotericin B&#46;<a class="elsevierStyleCrossRefs" href="#bib0580"><span class="elsevierStyleSup">48&#44;49</span></a></p></span></span><span id="sec0100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Hyalohyphomycosis</span><p id="par0265" class="elsevierStylePara elsevierViewall">Hyalohyphomycosis is caused by hyaline fungi &#40;Hyphomycetes&#41; that form septate hyphae in tissue&#46;<a class="elsevierStyleCrossRef" href="#bib0575"><span class="elsevierStyleSup">47</span></a> This classification&#44; however&#44; is rather arbitrary as there are many types of terrestrial and aquatic Hyphomycetes&#46; Just a few organisms&#44; however&#44; can cause infections&#44; most of which are opportunistic&#44; in humans&#46;<a class="elsevierStyleCrossRefs" href="#bib0610"><span class="elsevierStyleSup">54&#44;55</span></a> Most of the genera involved in hyalohyphomycosis are morphologically identical when observed in tissue sections and they trigger the same pathologic response&#46; Fungi that frequently cause infections or have another particularly distinctive characteristic are assigned to a different category &#40;e&#46;g&#46;&#44; aspergillosis&#41;&#46;</p><p id="par0270" class="elsevierStylePara elsevierViewall">The most common agents involved in hyalohyphomycosis are <span class="elsevierStyleItalic">Aspergillus &#40;fumigatus&#44; niger&#44; flavus&#41;</span>&#44; <span class="elsevierStyleItalic">Scopulariopsis</span> spp&#46;&#44; <span class="elsevierStyleItalic">Fusarium</span> spp&#46;&#44; <span class="elsevierStyleItalic">Acremonium recifei</span>&#44; <span class="elsevierStyleItalic">Paecilomyces</span> spp&#46;&#44; <span class="elsevierStyleItalic">Purpureocillum</span> spp&#46;&#44; and <span class="elsevierStyleItalic">Neoscytalidium</span> spp&#46;<a class="elsevierStyleCrossRef" href="#bib0615"><span class="elsevierStyleSup">55</span></a> They are all widely distributed in nature&#44; and can be found in any type of soil&#44; wood&#44; or decomposing plant material&#46;<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">56</span></a> They affect individuals of either sex and at any age&#44; and immunosuppression is not a necessary condition for infection&#46;</p><span id="sec0105" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Clinical Forms</span><p id="par0275" class="elsevierStylePara elsevierViewall">Hyalohyphomycosis can be classified as superficial&#44; subcutaneous&#44; or systemic&#46;<ul class="elsevierStyleList" id="lis0035"><li class="elsevierStyleListItem" id="lsti0080"><span class="elsevierStyleLabel">1&#46;</span><p id="par0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Superficial hyalohyphomycosis&#46;</span> Superficial infections include dermatomycosis and onychomycosis&#46; They are common in rural workers&#44; fishermen&#44; patients with severe burns&#44; and premature neonates&#46;<a class="elsevierStyleCrossRefs" href="#bib0625"><span class="elsevierStyleSup">57&#44;58</span></a></p></li><li class="elsevierStyleListItem" id="lsti0085"><span class="elsevierStyleLabel">2&#46;</span><p id="par0285" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Subcutaneous hyalohyphomycosis&#46;</span> Traumatic inoculation causes abscesses&#44; cysts&#44; and tumor-like lesions similar to those seen in mycetoma &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0620"><span class="elsevierStyleSup">56</span></a></p><elsevierMultimedia ident="fig0025"></elsevierMultimedia></li><li class="elsevierStyleListItem" id="lsti0090"><span class="elsevierStyleLabel">3&#46;</span><p id="par0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Systemic hyalohyphomycosis</span>&#46; Systemic infections&#44; while uncommon&#44; are very serious&#46; They affect immunosuppressed patients and can be fatal&#46; Hematogenous and lymphatic spread leads to involvement of the lungs and central nervous system&#46;<a class="elsevierStyleCrossRefs" href="#bib0615"><span class="elsevierStyleSup">55&#44;57</span></a></p></li></ul></p></span><span id="sec0110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0135">Diagnosis</span><p id="par0295" class="elsevierStylePara elsevierViewall">Identification of septate hyaline hyphae by microscopic examination of skin scales&#44; nail fragments&#44; secretions&#44; or fragments provides a presumptive diagnosis&#44; which is then confirmed by culture &#40;<a class="elsevierStyleCrossRef" href="#fig0025">Fig&#46; 5</a>&#41;&#46; Most fungi grow on SDA without antibiotics or inhibitors&#46;<a class="elsevierStyleCrossRefs" href="#bib0575"><span class="elsevierStyleSup">47&#44;59</span></a> As in the cases described above&#44; molecular identification is also possible&#46;<a class="elsevierStyleCrossRef" href="#bib0640"><span class="elsevierStyleSup">60</span></a></p><p id="par0300" class="elsevierStylePara elsevierViewall">The differential diagnosis should include other dermatomycoses&#44; epidermal cysts&#44; actinomycetoma&#44; eumycetoma&#44; histoplasmosis&#44; and cryptococcosis&#46;</p></span><span id="sec0115" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0140">Treatment</span><p id="par0305" class="elsevierStylePara elsevierViewall">In immunocompetent individuals&#44; the treatments of choice are triazoles&#44; terbinafine&#44; or surgery&#46;<a class="elsevierStyleCrossRef" href="#bib0645"><span class="elsevierStyleSup">61</span></a> When the immune system is compromised&#44; the first-line treatment is amphotericin B combined with a triazole &#40;itraconazole 200<span class="elsevierStyleHsp" style=""></span>mg&#47;d for 6 months or fluconazole 150<span class="elsevierStyleHsp" style=""></span>mg twice a week for 6 months&#41;&#46;</p></span></span><span id="sec0120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0145">Lacaziosis &#40;Lobomycosis&#41;</span><p id="par0310" class="elsevierStylePara elsevierViewall">Lacaziosis&#44; which was formerly known as <span class="elsevierStyleItalic">lobomycosis</span>&#44; is a chronic granulomatous fungal infection of the skin and subcutaneous tissues first described under the name of <span class="elsevierStyleItalic">keloidal blastomycosis</span> in 1930 by Jorge Lobo in Recife&#44; Brazil&#46;<a class="elsevierStyleCrossRef" href="#bib0650"><span class="elsevierStyleSup">62</span></a> It is a rare infection found in Central and South America&#59; it is caused by <span class="elsevierStyleItalic">Lacazia loboi</span>&#44;<a class="elsevierStyleCrossRefs" href="#bib0650"><span class="elsevierStyleSup">62&#44;63</span></a> a yeast that cannot be grown in culture&#46; The source of infection is thought to be in soil and vegetation&#46; The fungus probably enters through the skin following a penetrating injury&#44; such as a thorn prick or insect bite&#46;</p><p id="par0315" class="elsevierStylePara elsevierViewall">Lacaziosis is characterized by keloidal lesions with well-defined lobulated edges in exposed areas of the body &#40;frequently the face&#44; arms&#44; or legs&#41;&#46; The lesions spread to contiguous sites&#44; although transmission to distant sites is also possible via autoinoculation&#46;</p><span id="sec0125" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0150">Diagnosis</span><p id="par0320" class="elsevierStylePara elsevierViewall">Diagnosis is facilitated by the identification of abundant fungal structures during direct examination and chains of diffuse round cells connected by small tubular structures in biopsy samples&#46;<a class="elsevierStyleCrossRef" href="#bib0650"><span class="elsevierStyleSup">62</span></a> Causative agents can also be identified in tissue by PCR analysis&#44; in particular assays targeting the 18S rDNA fragment&#46;<a class="elsevierStyleCrossRef" href="#bib0660"><span class="elsevierStyleSup">64</span></a></p><p id="par0325" class="elsevierStylePara elsevierViewall">The differential diagnosis should include keloids&#44; lepromatous leprosy&#44; and anergic leishmania&#46;</p></span></span><span id="sec0130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0155">Treatment</span><p id="par0330" class="elsevierStylePara elsevierViewall">Antifungals are not effective in lacaziosis and the definitive treatment is surgical resection&#46;<a class="elsevierStyleCrossRefs" href="#bib0650"><span class="elsevierStyleSup">62&#44;63</span></a></p></span><span id="sec0135" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0160">Zygomycosis</span><p id="par0335" class="elsevierStylePara elsevierViewall">Zygomycosis is a heterogeneous group of fungal infections caused by opportunistic Zygomycetes of the orders Mucorales &#40;<span class="elsevierStyleItalic">Rhizopus&#44; Lichtheimia&#44; Mucor</span>&#44; and <span class="elsevierStyleItalic">Rhizomucor</span>&#41; and Entomophthorales &#40;<span class="elsevierStyleItalic">Basidiobolus</span> and <span class="elsevierStyleItalic">Conidiobolus</span>&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0665"><span class="elsevierStyleSup">65</span></a> In this section&#44; we will only discuss Entomophthorales fungi&#44; as the Mucorales are addressed in the second part of this review&#44; which looks at systemic mycoses&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">Entomophthoromycosis is characterized by the appearance of a hard&#44; progressive mass that affects the subcutaneous tissues&#46; There are 2 variants&#46; The first is caused by <span class="elsevierStyleItalic">Basidiobolus ranarum</span> and is more common in children&#46;<a class="elsevierStyleCrossRef" href="#bib0670"><span class="elsevierStyleSup">66</span></a> Lesions generally appear in the shoulder and pelvic girdles&#44; and present as a slowly spreading woody cellulitis&#46; The second variant is caused by <span class="elsevierStyleItalic">Conidiobolus coronatus</span> and affects adults&#46; The primary infection starts in the lower turbinates of the nose and then spreads to the center of the face&#44; causing painful indurated swelling and severe deformation of the nose&#44; lips&#44; and cheeks&#46;<a class="elsevierStyleCrossRefs" href="#bib0665"><span class="elsevierStyleSup">65&#8211;68</span></a></p></span></span><span id="sec0140" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0165">Conclusion</span><p id="par0345" class="elsevierStylePara elsevierViewall">We have reviewed the main characteristics of the subcutaneous mycoses and the main diagnostic and treatment methods available &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0145" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0170">Conflicts of Interest</span><p id="par0350" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflicts of interest&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:10 [
        0 => array:3 [
          "identificador" => "xres762914"
          "titulo" => "Graphical abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0005"
            ]
          ]
        ]
        1 => array:3 [
          "identificador" => "xres762913"
          "titulo" => "Abstract"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0010"
            ]
          ]
        ]
        2 => array:2 [
          "identificador" => "xpalclavsec764389"
          "titulo" => "Keywords"
        ]
        3 => array:3 [
          "identificador" => "xres762915"
          "titulo" => "Resumen"
          "secciones" => array:1 [
            0 => array:1 [
              "identificador" => "abst0015"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "xpalclavsec764390"
          "titulo" => "Palabras clave"
        ]
        5 => array:2 [
          "identificador" => "sec0005"
          "titulo" => "Introduction"
        ]
        6 => array:3 [
          "identificador" => "sec0010"
          "titulo" => "Subcutaneous Mycoses"
          "secciones" => array:9 [
            0 => array:2 [
              "identificador" => "sec0015"
              "titulo" => "Sporotrichosis"
            ]
            1 => array:3 [
              "identificador" => "sec0020"
              "titulo" => "Clinical Forms"
              "secciones" => array:2 [
                0 => array:2 [
                  "identificador" => "sec0025"
                  "titulo" => "Diagnosis"
                ]
                1 => array:2 [
                  "identificador" => "sec0030"
                  "titulo" => "Treatment"
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "sec0035"
              "titulo" => "Chromoblastomycosis &#40;Chromomycosis&#41;"
              "secciones" => array:3 [
                0 => array:2 [
                  "identificador" => "sec0040"
                  "titulo" => "Clinical Forms"
                ]
                1 => array:2 [
                  "identificador" => "sec0045"
                  "titulo" => "Diagnosis"
                ]
                2 => array:2 [
                  "identificador" => "sec0050"
                  "titulo" => "Treatment"
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "sec0055"
              "titulo" => "Mycetoma"
              "secciones" => array:4 [
                0 => array:2 [
                  "identificador" => "sec0060"
                  "titulo" => "Etiology"
                ]
                1 => array:2 [
                  "identificador" => "sec0065"
                  "titulo" => "Clinical Forms"
                ]
                2 => array:2 [
                  "identificador" => "sec0070"
                  "titulo" => "Diagnosis"
                ]
                3 => array:2 [
                  "identificador" => "sec0075"
                  "titulo" => "Treatment"
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "sec0080"
              "titulo" => "Phaeohyphomycosis"
              "secciones" => array:3 [
                0 => array:2 [
                  "identificador" => "sec0085"
                  "titulo" => "Clinical Forms"
                ]
                1 => array:2 [
                  "identificador" => "sec0090"
                  "titulo" => "Diagnosis"
                ]
                2 => array:2 [
                  "identificador" => "sec0095"
                  "titulo" => "Treatment"
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "sec0100"
              "titulo" => "Hyalohyphomycosis"
              "secciones" => array:3 [
                0 => array:2 [
                  "identificador" => "sec0105"
                  "titulo" => "Clinical Forms"
                ]
                1 => array:2 [
                  "identificador" => "sec0110"
                  "titulo" => "Diagnosis"
                ]
                2 => array:2 [
                  "identificador" => "sec0115"
                  "titulo" => "Treatment"
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "sec0120"
              "titulo" => "Lacaziosis &#40;Lobomycosis&#41;"
              "secciones" => array:1 [
                0 => array:2 [
                  "identificador" => "sec0125"
                  "titulo" => "Diagnosis"
                ]
              ]
            ]
            7 => array:2 [
              "identificador" => "sec0130"
              "titulo" => "Treatment"
            ]
            8 => array:2 [
              "identificador" => "sec0135"
              "titulo" => "Zygomycosis"
            ]
          ]
        ]
        7 => array:2 [
          "identificador" => "sec0140"
          "titulo" => "Conclusion"
        ]
        8 => array:2 [
          "identificador" => "sec0145"
          "titulo" => "Conflicts of Interest"
        ]
        9 => array:1 [
          "titulo" => "References"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-01-07"
    "fechaAceptado" => "2016-05-29"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec764389"
          "palabras" => array:6 [
            0 => "Deep mycosis"
            1 => "Subcutaneous mycosis"
            2 => "Systemic mycosis"
            3 => "Sporotrichosis"
            4 => "Chromoblastomycosis"
            5 => "Mycetoma"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec764390"
          "palabras" => array:6 [
            0 => "Micosis profundas"
            1 => "Micosis subcut&#225;neas"
            2 => "Micosis sist&#233;micas"
            3 => "Esporotricosis"
            4 => "Cromoblastomicosis"
            5 => "Micetomas"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:2 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The deep mycoses are uncommon in our setting&#46; These fungal infections occur mainly in immunosuppressed patients or in tropical climates&#44; and include subcutaneous infections and systemic infections&#46; The skin is always involved in the former&#46; In the first part of this review&#44; we describe the main subcutaneous mycoses&#58; sporotrichosis&#44; chromoblastomycosis&#44; mycetoma&#44; phaeohyphomycosis&#44; hyalohyphomycosis&#44; and lacaziosis&#46; Early recognition and treatment is important&#44; as these infections are frequently associated with high morbidity&#46;</p></span>"
      ]
      "es" => array:2 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0015" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las micosis profundas son infecciones poco frecuentes en nuestro medio&#46; Se presentan principalmente en pacientes inmunodeprimidos o en regiones de climas tropicales&#44; que abarcan las micosis subcut&#225;neas y las micosis sist&#233;micas&#46; Las micosis subcut&#225;neas o por implantaci&#243;n siempre producen signos de afectaci&#243;n cut&#225;nea&#46; En la primera parte de esta revisi&#243;n se realizar&#225; una revisi&#243;n de las principales micosis subcut&#225;neas&#58; esporotricosis&#44; cromoblastomicosis&#44; micetomas&#44; feohifomicosis&#44; hialohifomicosis y lacaziosis&#46; Reconocer y tratar estas micosis subcut&#225;neas de forma precoz es importante&#44; ya que a menudo est&#225;n asociadas a una alta morbilidad&#46;</p></span>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:2 [
        "etiqueta" => "&#9734;"
        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Carrasco-Zuber JE&#44; Navarrete-Dechent C&#44; Bonifaz A&#44; Fich F&#44; Vial-Letelier V&#44; Berroeta-Mauriziano D&#46; Afectaci&#243;n cut&#225;nea en las micosis profundas&#58; una revisi&#243;n de la literatura&#46; Parte 1&#58; micosis subcut&#225;neas&#46; Actas Dermosifiliogr&#46; 2016&#59;107&#58;806&#8211;815&#46;</p>"
      ]
    ]
    "multimedia" => array:7 [
      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 998
            "Ancho" => 1500
            "Tamanyo" => 217447
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">A&#44; Lymphangitic sporotrichosis&#46; B&#44; <span class="elsevierStyleItalic">Sporothrix schenckii</span> culture&#46; C&#44; Microscopic examination of culture on Sabouraud dextrose agar medium &#40;erythrosin 2&#37;&#44; original magnification &#215;40&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig0010"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 1056
            "Ancho" => 1500
            "Tamanyo" => 281937
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">A&#44; Nodular-verrucous chromoblastomycosis&#46; B&#44; Biopsy showing fumagoid cells&#46; C&#44; Direct examination of <span class="elsevierStyleItalic">Fonsecaea pedrosoi</span> culture &#40;biopsy&#59; hematoxylin-eosin and erythrosin 2&#37;&#44; original magnification in both cases &#215;40&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig0015"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 1015
            "Ancho" => 1500
            "Tamanyo" => 278707
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A&#44; Actinomycetoma of the foot&#46; B&#44; <span class="elsevierStyleItalic">Nocardia</span> sp&#46; granules seen in direct examination &#40;KOH&#44; original magnification &#215;10&#41;&#46; C&#44; Biopsy &#40;hematoxylin-eosin &#215;40&#41;&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "fig0020"
        "etiqueta" => "Figure 4"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr4.jpeg"
            "Alto" => 1020
            "Ancho" => 1500
            "Tamanyo" => 229452
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A&#44; Nodular phaeohyphomycosis&#46; B&#44; Filaments and yeasts in biopsy sample &#40;Grocott&#44; original magnification &#215;10&#41;&#46; C&#44; Microscopic examination of <span class="elsevierStyleItalic">Veronaea botryosa</span> &#40;lactophenol cotton blue&#44; original magnification &#215;40&#41;&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "fig0025"
        "etiqueta" => "Figure 5"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr5.jpeg"
            "Alto" => 870
            "Ancho" => 1500
            "Tamanyo" => 182234
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Hyalohyphomycosis ulcer due to <span class="elsevierStyleItalic">Acremonium</span> sp&#46; B&#44; Culture &#40;Sabouraud dextrose agar medium&#41;&#46; C&#44; Direct examination of exudate &#40;Giemsa&#44; original magnification &#215;40&#41;&#46;</p>"
        ]
      ]
      5 => array:8 [
        "identificador" => "tbl0005"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Table "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Abbreviation&#58; PCR&#44; polymerase chain reaction&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Mycosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Main Causative Agent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Diagnosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Treatment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Sporotrichosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Sporothrix schenckii</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cultivation of pus aspirated from nodules&#59; histology&#59; PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Saturated solution of potassium iodide for 3 wk&#59; itraconazole 200<span class="elsevierStyleHsp" style=""></span>mg&#47;d for 3&#8211;6 mo&#59; combinations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Chromoblastomycosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Fonsecaea pedrosoi</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Microscopic examination&#59; culture&#59; histology&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Very difficult&#46; Itraconazole 200<span class="elsevierStyleHsp" style=""></span>mg&#47;d for 6 mo&#59; terbinafine for 12 mo&#59; amphotericin B&#59; combinations&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mycetoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Filamentous actinomycetes and filamentous fungi&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Identification of mycetoma granules&#59; culture&#59; histology&#59; PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Antibiotics for actinomycetoma&#59; antifungals<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>surgery for eumycetoma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Phaeohyphomycosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Exophiala jeanselmei</span><br><span class="elsevierStyleItalic">Alternaria</span> spp&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Microscopic examination and culture&#59; histology&#59; PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Controversial&#46; Surgery<span class="elsevierStyleHsp" style=""></span>&#43;<span class="elsevierStyleHsp" style=""></span>combination of antifungals&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hyalohyphomycosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Opportunistic <span class="elsevierStyleItalic">Aspergillus</span> &#40;<span class="elsevierStyleItalic">fumigatus&#44; niger&#44; flavus</span>&#41;&#44; <span class="elsevierStyleItalic">Fusarium</span> spp&#46;&#44; <span class="elsevierStyleItalic">Paecilomyces</span>&#44; etc&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Microscopic examination and culture&#59; PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Immunocompetent patients&#58; triazoles&#59; terbinafine&#59; ciclopirox olamine&#59; surgery<br>Immunosuppressed patients&#58; amphotericin B combined with a triazole for 6 mo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Lacaziosis &#40;lobomycosis&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Lacazia loboi</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Microscopic examination&#59; histology&#59; PCR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Surgery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Entomophthoromycosis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top"><span class="elsevierStyleItalic">Conidiobolus coronatus</span><br><span class="elsevierStyleItalic">Basidiobolus ranarum</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Direct examination and culture&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Surgery and systemic antifungals&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
              "imagenFichero" => array:1 [
                0 => "xTab1260343.png"
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Summary of the Characteristics of the Subcutaneous Mycoses&#46;</p>"
        ]
      ]
      6 => array:5 [
        "identificador" => "fig0030"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => false
        "mostrarDisplay" => true
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "fx1.jpeg"
            "Alto" => 772
            "Ancho" => 1333
            "Tamanyo" => 98146
          ]
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:68 [
            0 => array:3 [
              "identificador" => "bib0345"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaenous mycoses"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "O&#46; Welsh"
                            1 => "R&#46; Arenas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.005"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "367"
                        "paginaFinal" => "368"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682182"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0350"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Micosis importadas"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A&#46; Rezusta"
                            1 => "J&#46; Gil"
                            2 => "M&#46;C&#46; Rubio"
                            3 => "M&#46;J&#46; Revillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Bol Control Calidad SEIMC"
                        "fecha" => "2001"
                        "paginaInicial" => "1"
                        "paginaFinal" => "15"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0355"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous manifestations of deep mycosis&#58; An experience in a tropical pathology laboratory"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;O&#46; Samaila"
                            1 => "K&#46; Abdullahi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0019-5154.82481"
                      "Revista" => array:6 [
                        "tituloSerie" => "Indian J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "56"
                        "paginaInicial" => "282"
                        "paginaFinal" => "286"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21772588"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0360"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic mycoses in immunodepressed patients &#40;AIDS&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Ramos-e-Silva"
                            1 => "C&#46;M&#46; Lima"
                            2 => "R&#46;C&#46; Schechtman"
                            3 => "B&#46;M&#46; Trope"
                            4 => "S&#46; Carneiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2012.01.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "616"
                        "paginaFinal" => "627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23068149"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0365"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous mycoses&#58; Chromoblastomycosis&#44; sporotrichosis and mycetoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; Bonifaz"
                            1 => "D&#46; V&#225;zquez-Gonz&#225;lez"
                            2 => "A&#46;M&#46; Perusqu&#237;a-Ortiz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1610-0387.2010.07453.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2010"
                        "volumen" => "8"
                        "paginaInicial" => "619"
                        "paginaFinal" => "627"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20529168"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0370"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Population-based surveillance and a case-control study of risk factors for endemic lymphocutaneous sporotrichosis in Peru"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46;M&#46; Lyon"
                            1 => "S&#46; Zurita"
                            2 => "J&#46; Casquero"
                            3 => "W&#46; Holgado"
                            4 => "J&#46; Guevara"
                            5 => "M&#46;E&#46; Brandt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/345437"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2003"
                        "volumen" => "36"
                        "paginaInicial" => "34"
                        "paginaFinal" => "39"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12491199"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0375"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis in Peru&#58; Description of an area of hyperendemicity"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "P&#46;G&#46; Pappas"
                            1 => "I&#46; Tellez"
                            2 => "A&#46;E&#46; Deep"
                            3 => "D&#46; Nolasco"
                            4 => "W&#46; Holgado"
                            5 => "B&#46; Bustamante"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/313607"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2000"
                        "volumen" => "30"
                        "paginaInicial" => "65"
                        "paginaFinal" => "70"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10619735"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0380"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "First autochthone case of sporotrichosis by Sporothrix globosa in Portugal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;M&#46; De Oliveira"
                            1 => "C&#46; Ver&#237;ssimo"
                            2 => "R&#46; Sabino"
                            3 => "J&#46; Aranha"
                            4 => "R&#46;M&#46; Zancop&#233;-Oliveira"
                            5 => "P&#46; Sampaio"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.diagmicrobio.2013.08.023"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Microbiol Infect Dis"
                        "fecha" => "2014"
                        "volumen" => "78"
                        "paginaInicial" => "388"
                        "paginaFinal" => "390"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24439448"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0385"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis caused by Sporothrix Mexicana&#44; Portugal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "N&#46;M&#46; Dias"
                            1 => "M&#46;M&#46; Oliveira"
                            2 => "C&#46; Santos"
                            3 => "R&#46;M&#46; Zancope-Oliveira"
                            4 => "N&#46; Lima"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3201/eid1710.110737"
                      "Revista" => array:6 [
                        "tituloSerie" => "Emerg Infect Dis"
                        "fecha" => "2011"
                        "volumen" => "17"
                        "paginaInicial" => "1975"
                        "paginaFinal" => "1976"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22000393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0390"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Molecular identification of the Sporothrix schenckii complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;M&#46; Oliveira"
                            1 => "R&#46; Almeida-Paes"
                            2 => "M&#46;C&#46; Gutierrez-Galhardo"
                            3 => "R&#46;M&#46; Zancope-Oliveira"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.riam.2013.09.008"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Iberoam Micol"
                        "fecha" => "2014"
                        "volumen" => "31"
                        "paginaInicial" => "2"
                        "paginaFinal" => "6"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24270070"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib0395"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phylogeography and evolutionary patterns in Sporothrix spanning more than 14 000 human and animal case reports"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Zhang"
                            1 => "F&#46; Hagen"
                            2 => "B&#46; Stielow"
                            3 => "A&#46;M&#46; Rodrigues"
                            4 => "K&#46; Samerpitak"
                            5 => "X&#46; Zhou"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3767/003158515X687416"
                      "Revista" => array:6 [
                        "tituloSerie" => "Persoonia"
                        "fecha" => "2015"
                        "volumen" => "35"
                        "paginaInicial" => "1"
                        "paginaFinal" => "20"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26823625"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib0400"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporothrix brasiliensis&#44; S&#46; globosa&#44; and S&#46; mexicana&#44; three new Sporothrix species of clinical interest"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Marimon"
                            1 => "J&#46; Cano"
                            2 => "J&#46; Gen&#233;"
                            3 => "D&#46;A&#46; Sutton"
                            4 => "M&#46; Kawasaki"
                            5 => "J&#46; Guarro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1128/JCM.00808-07"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Microbiol"
                        "fecha" => "2007"
                        "volumen" => "45"
                        "paginaInicial" => "3198"
                        "paginaFinal" => "3206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17687013"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib0405"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aislamiento ambiental de Sporothrix globosa en relaci&#243;n a un caso de esporotricosis linfo-cut&#225;nea"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "R&#46; Cruz"
                            1 => "P&#46; Vieille"
                            2 => "D&#46; Oschilewski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4067/S0716-10182012000400006"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Chilena Infectol"
                        "fecha" => "2012"
                        "volumen" => "29"
                        "paginaInicial" => "401"
                        "paginaFinal" => "405"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23096539"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib0410"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Emergence of pathogenicity in the Sporothrix schenckii complex"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;M&#46; Rodrigues"
                            1 => "S&#46; de Hoog"
                            2 => "Z&#46;P&#46; de Camargo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.3109/13693786.2012.719648"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Mycol"
                        "fecha" => "2013"
                        "volumen" => "51"
                        "paginaInicial" => "405"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22989196"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib0415"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46;A&#46; Kauffman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/520190"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "1999"
                        "volumen" => "29"
                        "paginaInicial" => "231"
                        "paginaFinal" => "236"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10476718"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib0420"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "E&#46; V&#225;squez-del-Mercado"
                            1 => "R&#46; Arenas"
                            2 => "C&#46; Padilla-Desgarenes"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.017"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "437"
                        "paginaFinal" => "443"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682194"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0425"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Infectious arthritis as the single manifestation of sporotrichosis&#58; Serology from serum and synovial fluid samples as an aid to diagnosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46;O&#46; Costa"
                            1 => "K&#46;C&#46; de Mesquita"
                            2 => "P&#46;S&#46; Damasco"
                            3 => "A&#46;R&#46; Bernardes-Engemann"
                            4 => "C&#46;M&#46; Dias"
                            5 => "I&#46;C&#46; Silva"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Iberoam Micol"
                        "fecha" => "2008"
                        "volumen" => "25"
                        "paginaInicial" => "54"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18338931"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib0430"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary cavitation and skin lesions mimicking tuberculosis in a HIV negative patient caused by Sporothrix brasiliensis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R&#46; Orofino-Costa"
                            1 => "N&#46; Unterstell"
                            2 => "A&#46; Carlos Gripp"
                            3 => "P&#46;M&#46; de Macedo"
                            4 => "A&#46; Brota"
                            5 => "E&#46; Dias"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.mmcr.2013.02.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Mycol Case Rep"
                        "fecha" => "2013"
                        "volumen" => "2"
                        "paginaInicial" => "65"
                        "paginaFinal" => "71"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24432220"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0435"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esporotricosis granulomatosa&#58; presentaci&#243;n de dos casos inusuales"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46; Ram&#237;rez-Soto"
                            1 => "J&#46; Liz&#225;rraga-Trujillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4067/S0716-10182013000500013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Chilena Infectol"
                        "fecha" => "2013"
                        "volumen" => "30"
                        "paginaInicial" => "548"
                        "paginaFinal" => "553"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24248171"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0440"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Esporotricosis cut&#225;nea fija&#58; reporte de un caso"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Castro"
                            1 => "H&#46; Pacheco"
                            2 => "D&#46; Ju&#225;rez"
                            3 => "Z&#46; Lozano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Pediatr Lat"
                        "fecha" => "2013"
                        "volumen" => "30"
                        "paginaInicial" => "548"
                        "paginaFinal" => "553"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0445"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Genotyping species of the Sporothrix schenckii complex by PCR-RFLP of calmodulin"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;M&#46; Rodrigues"
                            1 => "G&#46;S&#46; de Hoog"
                            2 => "Z&#46;P&#46; de Camargo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.diagmicrobio.2014.01.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Microbiol Infect Dis"
                        "fecha" => "2014"
                        "volumen" => "78"
                        "paginaInicial" => "383"
                        "paginaFinal" => "387"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24525143"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0450"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical practice guidelines for the management of sporotrichosis&#58; 2007 update by the Infectious Diseases Society of America"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "America IDSo"
                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;A&#46; Kauffman"
                            1 => "B&#46; Bustamante"
                            2 => "S&#46;W&#46; Chapman"
                            3 => "P&#46;G&#46; Pappas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/522765"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "45"
                        "paginaInicial" => "1255"
                        "paginaFinal" => "1265"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17968818"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib0455"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative study of 250<span class="elsevierStyleHsp" style=""></span>mg&#47;day terbinafine and 100<span class="elsevierStyleHsp" style=""></span>mg&#47;day itraconazole for the treatment of cutaneous sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "G&#46; Francesconi"
                            1 => "A&#46;C&#46; Francesconi do Valle"
                            2 => "S&#46;L&#46; Passos"
                            3 => "M&#46;B&#46; de Lima Barros"
                            4 => "R&#46; de Almeida Paes"
                            5 => "A&#46;L&#46; Curi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11046-010-9380-8"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mycopathologia"
                        "fecha" => "2011"
                        "volumen" => "171"
                        "paginaInicial" => "349"
                        "paginaFinal" => "354"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21103938"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib0460"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparative evaluation of the efficacy and safety of two doses of terbinafine &#40;500 and 1000<span class="elsevierStyleHsp" style=""></span>mg day&#40;-1&#41;&#41; in the treatment of cutaneous or lymphocutaneous sporotrichosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S&#46;W&#46; Chapman"
                            1 => "P&#46; Pappas"
                            2 => "C&#46; Kauffmann"
                            3 => "E&#46;B&#46; Smith"
                            4 => "R&#46; Dietze"
                            5 => "N&#46; Tiraboschi-Foss"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mycoses"
                        "fecha" => "2004"
                        "volumen" => "47"
                        "paginaInicial" => "62"
                        "paginaFinal" => "68"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14998402"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0465"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Sporotrichosis successfully treated with terbinafine and potassium iodide&#58; Case report and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "B&#46; Coskun"
                            1 => "Y&#46; Saral"
                            2 => "N&#46; Akpolat"
                            3 => "A&#46; Ataseven"
                            4 => "D&#46; Ci&#231;ek"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mycopathologia"
                        "fecha" => "2004"
                        "volumen" => "158"
                        "paginaInicial" => "53"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15487321"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib0470"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous sporotrichosis treated with photodynamic therapy&#58; An in vitro and in vivo study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "Y&#46; Gilaberte"
                            1 => "C&#46; Aspiroz"
                            2 => "M&#46;C&#46; Alejandre"
                            3 => "E&#46; Andres-Ciriano"
                            4 => "B&#46; Fortu&#241;o"
                            5 => "L&#46; Charlez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1089/pho.2013.3590"
                      "Revista" => array:6 [
                        "tituloSerie" => "Photomed Laser Surg"
                        "fecha" => "2014"
                        "volumen" => "32"
                        "paginaInicial" => "54"
                        "paginaFinal" => "57"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24328608"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib0475"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromoblastomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "E&#46; Torres-Guerrero"
                            1 => "R&#46; Isa-Isa"
                            2 => "M&#46; Isa"
                            3 => "R&#46; Arenas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.011"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "403"
                        "paginaFinal" => "408"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682188"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0480"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromoblastomycosis due to Cladosporium carrionii"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "N&#46; Namratha"
                            1 => "S&#46; Nadgir"
                            2 => "M&#46; Kale"
                            3 => "R&#46; Rathod"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4103/0974-2727.66704"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Lab Physicians"
                        "fecha" => "2010"
                        "volumen" => "2"
                        "paginaInicial" => "47"
                        "paginaFinal" => "48"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21814409"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0485"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromoblastomycosis as an endemic disease in temperate Europe&#58; First confirmed case and review of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46; Pindycka-Piaszczy&#324;ska"
                            1 => "P&#46; Krzy&#347;ciak"
                            2 => "M&#46; Piaszczy&#324;ski"
                            3 => "S&#46; Cie&#347;lik"
                            4 => "K&#46; Januszewski"
                            5 => "G&#46; Izdebska-Straszak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s10096-013-1969-7"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Clin Microbiol Infect Dis"
                        "fecha" => "2014"
                        "volumen" => "33"
                        "paginaInicial" => "391"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24048727"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0490"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromoblastomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;M&#46; Krzy&#347;ciak"
                            1 => "M&#46; Pindycka-Piaszczy&#324;ska"
                            2 => "M&#46; Piaszczy&#324;ski"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.5114/pdia.2014.40949"
                      "Revista" => array:6 [
                        "tituloSerie" => "Postepy Dermatol Alergol"
                        "fecha" => "2014"
                        "volumen" => "31"
                        "paginaInicial" => "310"
                        "paginaFinal" => "321"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25395928"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0495"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chromomycosis&#58; Report of a disabling case"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Sol&#243;rzano"
                            1 => "R&#46; Garc&#237;a"
                            2 => "G&#46; Hern&#225;ndez-C&#243;rdova"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Peru Med Exp Salud Publica"
                        "fecha" => "2011"
                        "volumen" => "28"
                        "paginaInicial" => "552"
                        "paginaFinal" => "555"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22086640"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0500"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "rDNA-RFLP and ITS1 sequencing of species of the genus Fonsecaea&#44; agents of chromoblastomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "D&#46;S&#46; Attili"
                            1 => "G&#46;S&#46; de Hoog"
                            2 => "A&#46;A&#46; Pizzirani-Kleiner"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Mycol"
                        "fecha" => "1998"
                        "volumen" => "36"
                        "paginaInicial" => "219"
                        "paginaFinal" => "225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9776838"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib0505"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rapid identification of Fonsecaea by duplex polymerase chain reaction in isolates from patients with chromoblastomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46;S&#46; De Andrade"
                            1 => "A&#46;E&#46; Cury"
                            2 => "L&#46;G&#46; de Castro"
                            3 => "M&#46;H&#46; Hirata"
                            4 => "R&#46;D&#46; Hirata"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.diagmicrobio.2006.08.024"
                      "Revista" => array:6 [
                        "tituloSerie" => "Diagn Microbiol Infect Dis"
                        "fecha" => "2007"
                        "volumen" => "57"
                        "paginaInicial" => "267"
                        "paginaFinal" => "272"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17338941"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0510"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycetoma&#58; A review"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "V&#46; Lichon"
                            1 => "A&#46; Khachemoune"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Clin Dermatol"
                        "fecha" => "2006"
                        "volumen" => "7"
                        "paginaInicial" => "315"
                        "paginaFinal" => "321"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17007542"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib0515"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eumycetoma"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "R&#46; Estrada"
                            1 => "G&#46; Ch&#225;vez-L&#243;pez"
                            2 => "G&#46; Estrada-Ch&#225;vez"
                            3 => "R&#46; L&#243;pez-Mart&#237;nez"
                            4 => "O&#46; Welsh"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.009"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "389"
                        "paginaFinal" => "396"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682186"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0520"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Actinomycotic mycetoma due to Actinomadura madurae&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R&#46; Jerez"
                            1 => "F&#46; Schafer"
                            2 => "F&#46; Fich"
                            3 => "P&#46; Garc&#237;a"
                            4 => "P&#46; Le&#243;n"
                            5 => "S&#46; Gonz&#225;lez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4067/S0716-10182012000400018"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Chilena Infectol"
                        "fecha" => "2012"
                        "volumen" => "29"
                        "paginaInicial" => "459"
                        "paginaFinal" => "463"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23096551"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0525"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Eumycetoma and actinomycetoma--an update on causative agents&#44; epidemiology&#44; pathogenesis&#44; diagnostics and therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46; Nenoff"
                            1 => "W&#46;W&#46; van de Sande"
                            2 => "A&#46;H&#46; Fahal"
                            3 => "D&#46; Reinel"
                            4 => "H&#46; Sch&#246;fer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/jdv.13008"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Eur Acad Dermatol Venereol"
                        "fecha" => "2015"
                        "volumen" => "29"
                        "paginaInicial" => "1873"
                        "paginaFinal" => "1883"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25726758"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0530"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycetoma caused by Phaeoacremonium parasiticum--a case confirmed with B-tubulin sequence analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46; Aguilar-Donis"
                            1 => "E&#46; Torres-Guerrero"
                            2 => "R&#46; Arenas-Guzm&#225;n"
                            3 => "F&#46; Hern&#225;ndez-Hern&#225;ndez"
                            4 => "L&#46; L&#243;pez-Garc&#237;a"
                            5 => "S&#46; Criales-Vera"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1439-0507.2010.01929.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mycoses"
                        "fecha" => "2011"
                        "volumen" => "54"
                        "paginaInicial" => "e615"
                        "paginaFinal" => "e618"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20701685"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib0535"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Actinomycetoma and advances in its treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Welsh"
                            1 => "L&#46; Vera-Cabrera"
                            2 => "E&#46; Welsh"
                            3 => "M&#46;C&#46; Salinas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.06.027"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "372"
                        "paginaFinal" => "381"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22682184"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib0540"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous nocardiosis&#58; An underdiagnosed pathogenic infection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Pai"
                            1 => "K&#46; Pai"
                            2 => "S&#46; Sharma"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:3 [
                        "tituloSerie" => "BMJ Case Rep"
                        "fecha" => "2015"
                        "paginaInicial" => "2015"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib0545"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic infection with Nocardia asteroides cured with amoxicillin&#47;clavulanic acid&#44; erythromycin and ultrasound-guided transcutaneous aspiration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "P&#46;R&#46; Stella"
                            1 => "E&#46;J&#46; Vermeulen"
                            2 => "C&#46; Roggeveen"
                            3 => "E&#46;H&#46; Overbosch"
                            4 => "W&#46;T&#46; van Dorp"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Neth J Med"
                        "fecha" => "1994"
                        "volumen" => "44"
                        "paginaInicial" => "178"
                        "paginaFinal" => "181"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8028693"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0550"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of actinomycetoma due to Nocardia spp&#46; with amoxicillin-clavulanate"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Bonifaz"
                            1 => "P&#46; Flores"
                            2 => "A&#46; Sa&#250;l"
                            3 => "E&#46; Carrasco-Gerard"
                            4 => "R&#46;M&#46; Ponce"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-2133.2006.07557.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dermatol"
                        "fecha" => "2007"
                        "volumen" => "156"
                        "paginaInicial" => "308"
                        "paginaFinal" => "311"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17223871"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib0555"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Successful treatment of Nocardia actinomycetoma with meropenem and amikacin combination therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Ameen"
                            1 => "F&#46; Vargas"
                            2 => "R&#46; Arenas"
                            3 => "E&#46;V&#46; del Mercado"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1365-4632.2010.04748.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Dermatol"
                        "fecha" => "2011"
                        "volumen" => "50"
                        "paginaInicial" => "443"
                        "paginaFinal" => "445"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21413956"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib0560"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Actinomycetoma and Nocardia sp&#46; Report of five cases treated with imipenem or imipenem plus amikacin&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "A&#46; Fuentes"
                            1 => "R&#46; Arenas"
                            2 => "M&#46; Reyes"
                            3 => "R&#46;F&#46; Fern&#225;ndez"
                            4 => "R&#46; Zacar&#237;as"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Gac Med Mex"
                        "fecha" => "2006"
                        "volumen" => "142"
                        "paginaInicial" => "247"
                        "paginaFinal" => "252"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16875355"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0565"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mycetoma medical therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "O&#46; Welsh"
                            1 => "H&#46;M&#46; Al-Abdely"
                            2 => "M&#46;C&#46; Salinas-Carmona"
                            3 => "A&#46;H&#46; Fahal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1371/journal.pntd.0003218"
                      "Revista" => array:5 [
                        "tituloSerie" => "PLoS Negl Trop Dis"
                        "fecha" => "2014"
                        "volumen" => "8"
                        "paginaInicial" => "e3218"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25330342"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0570"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Phaeohyphomycosis caused by Cladophialophora bantiana"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "L&#46; Mart&#237;nez-Lamas"
                            1 => "M&#46; &#193;lvarez"
                            2 => "J&#46; Llovo"
                            3 => "J&#46; Gen&#233;"
                            4 => "J&#46; Cano"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.riam.2013.05.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Iberoam Micol"
                        "fecha" => "2014"
                        "volumen" => "31"
                        "paginaInicial" => "203"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23727472"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0575"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Opportunistic filamentous mycoses&#58; Aspergillosis&#44; mucormycosis&#44; phaeohyphomycosis and hyalohyphomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46;M&#46; Perusqu&#237;a-Ortiz"
                            1 => "D&#46; V&#225;zquez-Gonz&#225;lez"
                            2 => "A&#46; Bonifaz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/j.1610-0387.2012.07994.x"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dtsch Dermatol Ges"
                        "fecha" => "2012"
                        "volumen" => "10"
                        "paginaInicial" => "611"
                        "paginaFinal" => "621"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22925358"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0580"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Feohifomicosis causada por Colletotrichum gloeosporioides y Alternaria infectoria en un paciente trasplantado renal"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M&#46; Ogawa"
                            1 => "V&#46; Reis"
                            2 => "P&#46; Godoy"
                            3 => "F&#46; Gatti de Menezes"
                            4 => "M&#46; Enokihara"
                             …1
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.4067/S0716-10182014000400014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Chilena Infectol"
                        "fecha" => "2014"
                        "volumen" => "31"
                        "paginaInicial" => "468"
                        "paginaFinal" => "472"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib0585"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous and subcutaneous phaeohyphomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Skinmed"
                        "fecha" => "2010"
                        "volumen" => "8"
                        "paginaInicial" => "366"
                        "paginaFinal" => "369"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib0590"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Disseminated phaeohyphomycosis&#58; Review of an emerging mycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1086/338636"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Infect Dis"
                        "fecha" => "2002"
                        "volumen" => "34"
                        "paginaInicial" => "467"
                        "paginaFinal" => "476"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0595"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Case of cutaneous phaeohyphomycosis caused by Phaeoacremonium sp&#46; in a renal transplant recipient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1346-8138.12719"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Dermatol"
                        "fecha" => "2015"
                        "volumen" => "42"
                        "paginaInicial" => "263"
                        "paginaFinal" => "266"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib0600"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous phaeohyphomycosis caused by Exophiala equina&#44; with susceptibility to eight antifungal drugs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1099/jmm.0.057406-0"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Med Microbiol"
                        "fecha" => "2013"
                        "volumen" => "62"
                        "paginaInicial" => "797"
                        "paginaFinal" => "800"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib0605"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous phaeohyphomycosis due to Alternaria dennisii in an 85-year-old immunocompromised patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2340/00015555-2343"
                      "Revista" => array:6 [
                        "tituloSerie" => "Acta Derm Venereol"
                        "fecha" => "2016"
                        "volumen" => "96"
                        "paginaInicial" => "701"
                        "paginaFinal" => "702"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib0610"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Subcutaneous mycoses&#58; An aetiological study of 15 cases in a tertiary care hospital at Dibrugarh&#44; Assam&#44; Northeast India"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11046-015-9861-x"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mycopathologia"
                        "fecha" => "2015"
                        "volumen" => "179"
                        "paginaInicial" => "425"
                        "paginaFinal" => "435"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib0615"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyalohyphomycosis&#46; Cutaneous manifestations of infections in the immunocompromised host"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:5 [
                        "fecha" => "2012"
                        "paginaInicial" => "65"
                        "paginaFinal" => "88"
                        "editorial" => "Springer"
                        "editorialLocalizacion" => "New York"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib0620"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Micosis subcut&#225;nea postraum&#225;tica por Fusarium solani"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Iberoam Micol"
                        "fecha" => "2003"
                        "volumen" => "20"
                        "paginaInicial" => "29"
                        "paginaFinal" => "30"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib0625"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Localized cutaneous hyalohyphomycosis caused by a Fusarium species infection in a renal transplant patient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [ …5]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Clin Microbiol"
                        "fecha" => "2003"
                        "volumen" => "41"
                        "paginaInicial" => "905"
                        "paginaFinal" => "907"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib0630"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fusariosis diseminada en paciente con leucemia mielobl&#225;stica aguda"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Actas Dermosifioliogr"
                        "fecha" => "2002"
                        "volumen" => "93"
                        "paginaInicial" => "118"
                        "paginaFinal" => "121"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib0635"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "&#91;Splenic hyalohyphomycosis&#46; Case report&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.riam.2010.10.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Iberoam Micol"
                        "fecha" => "2010"
                        "volumen" => "27"
                        "paginaInicial" => "203"
                        "paginaFinal" => "206"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            59 => array:3 [
              "identificador" => "bib0640"
              "etiqueta" => "60"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Use of mycological&#44; nested PCR&#44; and real-time PCR methods on BAL fluids for detection of Aspergillus fumigatus and A&#46; flavus in solid organ transplant recipients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s11046-013-9657-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Mycopathologia"
                        "fecha" => "2013"
                        "volumen" => "176"
                        "paginaInicial" => "377"
                        "paginaFinal" => "385"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            60 => array:3 [
              "identificador" => "bib0645"
              "etiqueta" => "61"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis&#58; Fusarium spp&#46;&#44; Scedosporium spp&#46; and others"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1111/1469-0691.12660"
                      "Revista" => array:7 [
                        "tituloSerie" => "Clin Microbiol Infect"
                        "fecha" => "2014"
                        "volumen" => "20"
                        "numero" => "Suppl 3"
                        "paginaInicial" => "27"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            61 => array:3 [
              "identificador" => "bib0650"
              "etiqueta" => "62"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lobomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.014"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "420"
                        "paginaFinal" => "424"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            62 => array:3 [
              "identificador" => "bib0655"
              "etiqueta" => "63"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lobomicosis&#58; reporte de un caso"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [ …3]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Dermatol Peru"
                        "fecha" => "2012"
                        "volumen" => "22"
                        "paginaInicial" => "111"
                        "paginaFinal" => "114"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            63 => array:3 [
              "identificador" => "bib0660"
              "etiqueta" => "64"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enzymatic isolation of Lacazia loboi cells from skin lesions of lobomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [ …6]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/13693780802127177"
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Mycol"
                        "fecha" => "2009"
                        "volumen" => "47"
                        "paginaInicial" => "119"
                        "paginaFinal" => "123"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            64 => array:3 [
              "identificador" => "bib0665"
              "etiqueta" => "65"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cutaneous zygomycosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.013"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "413"
                        "paginaFinal" => "419"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            65 => array:3 [
              "identificador" => "bib0670"
              "etiqueta" => "66"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The sinus that breeds fungus&#58; Subcutaneous zygomycosis caused by basidiobolus ranarum at the injection site"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1155/2013/534192"
                      "Revista" => array:5 [
                        "tituloSerie" => "Case Rep Infect Dis"
                        "fecha" => "2013"
                        "volumen" => "2013"
                        "paginaInicial" => "534192"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            66 => array:3 [
              "identificador" => "bib0675"
              "etiqueta" => "67"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rhinofacial conidiobolus coronatus infection presenting with nasal enlargement"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s15010-008-8056-5"
                      "Revista" => array:6 [
                        "tituloSerie" => "Infection"
                        "fecha" => "2008"
                        "volumen" => "36"
                        "paginaInicial" => "594"
                        "paginaFinal" => "596"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            67 => array:3 [
              "identificador" => "bib0680"
              "etiqueta" => "68"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rhinofacial conidiobolomycosis &#40;entomophthoramycosis&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [ …4]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.clindermatol.2011.09.012"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Dermatol"
                        "fecha" => "2012"
                        "volumen" => "30"
                        "paginaInicial" => "409"
                        "paginaFinal" => "412"
                        "link" => array:1 [
                          0 => array:2 [ …2]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15782190/0000010700000010/v1_201611260103/S1578219016302402/v1_201611260103/en/main.assets"
  "Apartado" => array:4 [
    "identificador" => "6150"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Review"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/15782190/0000010700000010/v1_201611260103/S1578219016302402/v1_201611260103/en/main.pdf?idApp=UINPBA000044&text.app=https://actasdermo.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1578219016302402?idApp=UINPBA000044"
]

Article information

ISSN: 15782190
Original language: English

DOI:10.1016/j.adengl.2016.05.026

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	28	18	46
2024 October	268	126	394
2024 September	332	85	417
2024 August	305	110	415
2024 July	260	98	358
2024 June	288	107	395
2024 May	265	93	358
2024 April	208	62	270
2024 March	333	60	393
2024 February	347	89	436
2024 January	272	68	340
2023 December	395	87	482
2023 November	426	114	540
2023 October	434	79	513
2023 September	328	76	404
2023 August	292	48	340
2023 July	324	85	409
2023 June	263	93	356
2023 May	258	120	378
2023 April	253	83	336
2023 March	255	74	329
2023 February	216	56	272
2023 January	240	95	335
2022 December	203	80	283
2022 November	169	74	243
2022 October	157	48	205
2022 September	168	112	280
2022 August	75	44	119
2022 July	129	79	208
2022 June	179	43	222
2022 May	288	59	347
2022 April	375	64	439
2022 March	399	78	477
2022 February	384	74	458
2022 January	414	65	479
2021 December	307	61	368
2021 November	401	95	496
2021 October	410	95	505
2021 September	432	77	509
2021 August	357	99	456
2021 July	446	78	524
2021 June	480	100	580
2021 May	430	94	524
2021 April	806	150	956
2021 March	586	83	669
2021 February	295	97	392
2021 January	267	66	333
2020 December	328	46	374
2020 November	268	48	316
2020 October	213	33	246
2020 September	223	31	254
2020 August	176	31	207
2020 July	203	28	231
2020 June	208	49	257
2020 May	208	43	251
2020 April	281	37	318
2020 March	129	26	155
2020 February	5	1	6
2020 January	4	0	4
2019 December	8	0	8
2019 November	8	0	8
2019 September	4	0	4
2019 August	4	0	4
2019 July	4	0	4
2019 June	4	0	4
2019 May	6	2	8
2019 April	4	11	15
2019 March	4	0	4
2019 February	4	0	4
2019 January	3	0	3
2018 December	4	0	4
2018 November	5	0	5
2018 October	23	0	23
2018 September	28	0	28
2018 March	0	1	1
2018 February	72	12	84
2018 January	111	27	138
2017 December	102	17	119
2017 November	103	24	127
2017 October	89	21	110
2017 September	59	27	86
2017 August	58	23	81
2017 July	69	17	86
2017 June	87	22	109
2017 May	66	17	83
2017 April	56	25	81
2017 March	67	25	92
2017 February	125	26	151
2017 January	55	31	86
2016 December	128	73	201
2016 November	31	40	71
2016 October	2	5	7

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter